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The map label for this gene is fucO [H]

Identifier: 238922113

GI number: 238922113

Start: 298259

End: 299407

Strand: Reverse

Name: fucO [H]

Synonym: EUBELI_20348

Alternate gene names: 238922113

Gene position: 299407-298259 (Counterclockwise)

Preceding gene: 238922120

Following gene: 238922110

Centisome position: 47.77

GC content: 39.34

Gene sequence:

>1149_bases
ATGGCACAGAGATTTATTTTGAATGGAACTTCTTATCATGGAGCAGGTGCAATACAGGAGATTGCAACAGAAGTTAAGTC
AAGAGGGTTTAAGAAAGCATTTGTATGTTCTGATCCTGATCTTGTTAAGTTTGGTGTGACAGCAAAGGTTCTTAAGGTTC
TTGATGACAATGGTTTTTCTTATGAATTATATTCTAACATCAAGCCTAATCCAACAATTGAGAATGTACAGACAGGTGTA
GAAGCATTCAAGAATGCAGGAACAGATTACTTGATCGCTATTGGTGGTGGTTCTTCTATGGATACAGCCAAGGCAATCGG
TATTATAATCAATAATCCTGAGTTTGCTGATGTAAGAAGTCTTGAGGGTGTTGCTGATACAAAGAATCCGGCAGTTCCTA
TTATTGCAGTTCCTACTACAGCTGGTACAGCCGCAGAAGTTACAATTAATTATGTTATTACTGATGCAGAGAAGAATCGT
AAGATGGTATGTGTAGATCCTCATGATATTCCTGTTGTTGCTGTTGTAGATCCTGACATGATGTCAAGCATGCCTAAAGG
TCTTACTGCTGCTACCGGTATGGATGCTCTTACACATGCTATTGAGGGTTATATTACTGCTGGTGCATGGGAATTATCTG
ATATGTTCCATCTTAAAGCAATTGAGATTATTGCCAAGAGTTTAAGAGGTGCAGTTGATAATACTCCTGAAGGAAGAGAA
GGAATGGCTTTAGGTCAGTACATAGCTGGTATGGGATTTTCTAATGTAGGTCTTGGTATTGTTCATTCTATGGCTCATCC
ACTTGGAGCACTTTATGATACACCACATGGTGTAGCTAATGCTATTATTCTTCCAACAGGCATGGAGTATAATGCACCTG
CTACTGGTGAAAAGTATCGTGATATTGCCAAGGCAATGGGTGTTGAAGGCACAGAAAAGATGACTCAGGATGAATACAGA
AAAGCTGCTATTGATGCTGTTAAGAAGCTTGCTGCTGATGTTGGAATTCCTGCTAATCTTAAGGATATTGTTAAGCCAGA
AGATATTCCATTCCTTGCACAGTCTGCATATGATGATGCATGCCGTCCAGGTAATCCAAGAGAAACAAGCGTAGAAGAGA
TTACAAAGCTTTATGAGAGTCTTATCTAA

Upstream 100 bases:

>100_bases
ATGCTTTTTTAATAAAATCAACTTGTTATTATTTTGTCATAGTGGTAAAATATAGTCAACTTTTAAAAGTGAACAATTTT
ATATTTATGGAGGCGTTTTT

Downstream 100 bases:

>100_bases
GTAATATATGTAAATAATAAACCGCGGTATAGTAAATTGCTATATCGCGGTTTATGTATATTATTAATTTTCAGCCATAT
CAATAAACATTACATTTAAT

Product: L-1,2-propanediol oxidoreductase

Products: NA

Alternate protein names: Propanediol oxidoreductase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MAQRFILNGTSYHGAGAIQEIATEVKSRGFKKAFVCSDPDLVKFGVTAKVLKVLDDNGFSYELYSNIKPNPTIENVQTGV
EAFKNAGTDYLIAIGGGSSMDTAKAIGIIINNPEFADVRSLEGVADTKNPAVPIIAVPTTAGTAAEVTINYVITDAEKNR
KMVCVDPHDIPVVAVVDPDMMSSMPKGLTAATGMDALTHAIEGYITAGAWELSDMFHLKAIEIIAKSLRGAVDNTPEGRE
GMALGQYIAGMGFSNVGLGIVHSMAHPLGALYDTPHGVANAIILPTGMEYNAPATGEKYRDIAKAMGVEGTEKMTQDEYR
KAAIDAVKKLAADVGIPANLKDIVKPEDIPFLAQSAYDDACRPGNPRETSVEEITKLYESLI

Sequences:

>Translated_382_residues
MAQRFILNGTSYHGAGAIQEIATEVKSRGFKKAFVCSDPDLVKFGVTAKVLKVLDDNGFSYELYSNIKPNPTIENVQTGV
EAFKNAGTDYLIAIGGGSSMDTAKAIGIIINNPEFADVRSLEGVADTKNPAVPIIAVPTTAGTAAEVTINYVITDAEKNR
KMVCVDPHDIPVVAVVDPDMMSSMPKGLTAATGMDALTHAIEGYITAGAWELSDMFHLKAIEIIAKSLRGAVDNTPEGRE
GMALGQYIAGMGFSNVGLGIVHSMAHPLGALYDTPHGVANAIILPTGMEYNAPATGEKYRDIAKAMGVEGTEKMTQDEYR
KAAIDAVKKLAADVGIPANLKDIVKPEDIPFLAQSAYDDACRPGNPRETSVEEITKLYESLI
>Mature_381_residues
AQRFILNGTSYHGAGAIQEIATEVKSRGFKKAFVCSDPDLVKFGVTAKVLKVLDDNGFSYELYSNIKPNPTIENVQTGVE
AFKNAGTDYLIAIGGGSSMDTAKAIGIIINNPEFADVRSLEGVADTKNPAVPIIAVPTTAGTAAEVTINYVITDAEKNRK
MVCVDPHDIPVVAVVDPDMMSSMPKGLTAATGMDALTHAIEGYITAGAWELSDMFHLKAIEIIAKSLRGAVDNTPEGREG
MALGQYIAGMGFSNVGLGIVHSMAHPLGALYDTPHGVANAIILPTGMEYNAPATGEKYRDIAKAMGVEGTEKMTQDEYRK
AAIDAVKKLAADVGIPANLKDIVKPEDIPFLAQSAYDDACRPGNPRETSVEEITKLYESLI

Specific function: Fucose metabolism; fourth step. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=409, Percent_Identity=26.4058679706601, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1789163, Length=381, Percent_Identity=62.992125984252, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI48994951, Length=382, Percent_Identity=41.3612565445026, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI87082107, Length=370, Percent_Identity=37.8378378378378, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1787493, Length=398, Percent_Identity=30.6532663316583, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1789386, Length=357, Percent_Identity=26.0504201680672, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=422, Percent_Identity=26.7772511848341, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321181, Length=384, Percent_Identity=38.0208333333333, Blast_Score=256, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24657991, Length=414, Percent_Identity=28.5024154589372, Blast_Score=124, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR013460 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.77 [H]

Molecular weight: Translated: 40611; Mature: 40480

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQRFILNGTSYHGAGAIQEIATEVKSRGFKKAFVCSDPDLVKFGVTAKVLKVLDDNGFS
CCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEECCHHHHHHHHHCCCCCE
YELYSNIKPNPTIENVQTGVEAFKNAGTDYLIAIGGGSSMDTAKAIGIIINNPEFADVRS
EEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHH
LEGVADTKNPAVPIIAVPTTAGTAAEVTINYVITDAEKNRKMVCVDPHDIPVVAVVDPDM
CCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCCCCEEEECCCCCCEEEEECCHH
MSSMPKGLTAATGMDALTHAIEGYITAGAWELSDMFHLKAIEIIAKSLRGAVDNTPEGRE
HHHCCCCCCHHHHHHHHHHHHHHHEECCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GMALGQYIAGMGFSNVGLGIVHSMAHPLGALYDTPHGVANAIILPTGMEYNAPATGEKYR
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCEEEEECCCCCCCCCCCHHHH
DIAKAMGVEGTEKMTQDEYRKAAIDAVKKLAADVGIPANLKDIVKPEDIPFLAQSAYDDA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHCCCCC
CRPGNPRETSVEEITKLYESLI
CCCCCCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
AQRFILNGTSYHGAGAIQEIATEVKSRGFKKAFVCSDPDLVKFGVTAKVLKVLDDNGFS
CCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEECCHHHHHHHHHCCCCCE
YELYSNIKPNPTIENVQTGVEAFKNAGTDYLIAIGGGSSMDTAKAIGIIINNPEFADVRS
EEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHH
LEGVADTKNPAVPIIAVPTTAGTAAEVTINYVITDAEKNRKMVCVDPHDIPVVAVVDPDM
CCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCCCCEEEECCCCCCEEEEECCHH
MSSMPKGLTAATGMDALTHAIEGYITAGAWELSDMFHLKAIEIIAKSLRGAVDNTPEGRE
HHHCCCCCCHHHHHHHHHHHHHHHEECCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GMALGQYIAGMGFSNVGLGIVHSMAHPLGALYDTPHGVANAIILPTGMEYNAPATGEKYR
CHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCEEEEECCCCCCCCCCCHHHH
DIAKAMGVEGTEKMTQDEYRKAAIDAVKKLAADVGIPANLKDIVKPEDIPFLAQSAYDDA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHCCCCC
CRPGNPRETSVEEITKLYESLI
CCCCCCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]