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The map label for this gene is kdpD [H]

Identifier: 238921932

GI number: 238921932

Start: 130890

End: 131978

Strand: Reverse

Name: kdpD [H]

Synonym: EUBELI_20166

Alternate gene names: 238921932

Gene position: 131978-130890 (Counterclockwise)

Preceding gene: 238921933

Following gene: 238921931

Centisome position: 21.06

GC content: 33.61

Gene sequence:

>1089_bases
GTGGTAATTATAACGGAAAAGACATTAAAAAAACTTGTAAAAGAATTCTTAATAACAATAGGCCTTTTAAGCATTGCAAC
AGTAATAGGAATGCTGCTTATATATATTGGATTTACAGAATCAAATGTTATTATGGTATATCTTCTGTGCGTGCTTTTGA
TTTCGATATTCACTAATGGATATATCTGGAGTGTGGCGGGTTCGCTTGTAAGTGTTGTTCTGATGAATTTCTTCCTGACA
GAACCAAGATTTACTTTACATACATATGACACAGGATATCCGCTCACATGTGTTATTATGCTTGCTGCGTCAATGCTTAC
AGGAACTCTGGCATCTAAACTGAAAAAACATGTTCGTATGTCAGAACAGGCTGCTTACAGGGAAAAGACACTACAGTTAA
GGGCTAATCTTTTAAGGACGATTTCACACGATTTAAGAACACCACTCACATCAATATCAGGTAATGCCAATAATCTTATG
TACAATTATGATAAGCTTGATAATGATACGAGAGAGCAGATATTTACAGATATATATGATGATTCAGAATGGTTAATCAG
TCTTGTAGAGAATATATTGTTTGTAACAAGATTTGAGGATGGAACAGTAACTCTTAATATGTCTGACCAGCTGATAGATG
AAGTTATTGCTGAAGCGTTAAAACATATCAACAGAAAAAGCTGTGAACATAAAATACATGTGGATTGCGGCAAAGAACTG
CTTCTTGTGAGAATGGACGTCAGACTTATAATACAGGTTATTATTAACATAGTTGATAATGCGATAAAGTATACACAGGA
AGGCTCTGATATATATATTAAAGCAAGAAAAGAAGGCAGATATGTAATTATATCCATTGAAGATAATGGCGAGGGAATAC
CTGATGATATGAAAGAAAATGTATTTGATACATTTTTTACCTGTAACAATGAAATCGCAGATAACAGAAGAAGTCTCGGA
CTTGGGTTATCTTTATGTAAAACTATTATAAATGCACATGGAAGTGAACTGGAATTAAGGGATAATACACCACATGGATG
CATTTTCGAATTCAAACTGCAGTTAAGTGAGGTACATTTAAATGAATAA

Upstream 100 bases:

>100_bases
TGACAAAGATACAATGAATGCTGTATTGAATGAAAGTGATGATAACGAAAAAAAGAGATATTAAATTGAAAATGTGTTAT
TATATACAAAATAAAATAAG

Downstream 100 bases:

>100_bases
AACACAGATTCTTGTAGTTGAGGATGATTCACCAATAAGAAATCTCATAACAACAACATTAAAAACTAATAATTACAGGT
ATTTAACTGCTGTGAATGGA

Product: two-component system, OmpR family, sensor histidine kinase KdpD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MVIITEKTLKKLVKEFLITIGLLSIATVIGMLLIYIGFTESNVIMVYLLCVLLISIFTNGYIWSVAGSLVSVVLMNFFLT
EPRFTLHTYDTGYPLTCVIMLAASMLTGTLASKLKKHVRMSEQAAYREKTLQLRANLLRTISHDLRTPLTSISGNANNLM
YNYDKLDNDTREQIFTDIYDDSEWLISLVENILFVTRFEDGTVTLNMSDQLIDEVIAEALKHINRKSCEHKIHVDCGKEL
LLVRMDVRLIIQVIINIVDNAIKYTQEGSDIYIKARKEGRYVIISIEDNGEGIPDDMKENVFDTFFTCNNEIADNRRSLG
LGLSLCKTIINAHGSELELRDNTPHGCIFEFKLQLSEVHLNE

Sequences:

>Translated_362_residues
MVIITEKTLKKLVKEFLITIGLLSIATVIGMLLIYIGFTESNVIMVYLLCVLLISIFTNGYIWSVAGSLVSVVLMNFFLT
EPRFTLHTYDTGYPLTCVIMLAASMLTGTLASKLKKHVRMSEQAAYREKTLQLRANLLRTISHDLRTPLTSISGNANNLM
YNYDKLDNDTREQIFTDIYDDSEWLISLVENILFVTRFEDGTVTLNMSDQLIDEVIAEALKHINRKSCEHKIHVDCGKEL
LLVRMDVRLIIQVIINIVDNAIKYTQEGSDIYIKARKEGRYVIISIEDNGEGIPDDMKENVFDTFFTCNNEIADNRRSLG
LGLSLCKTIINAHGSELELRDNTPHGCIFEFKLQLSEVHLNE
>Mature_362_residues
MVIITEKTLKKLVKEFLITIGLLSIATVIGMLLIYIGFTESNVIMVYLLCVLLISIFTNGYIWSVAGSLVSVVLMNFFLT
EPRFTLHTYDTGYPLTCVIMLAASMLTGTLASKLKKHVRMSEQAAYREKTLQLRANLLRTISHDLRTPLTSISGNANNLM
YNYDKLDNDTREQIFTDIYDDSEWLISLVENILFVTRFEDGTVTLNMSDQLIDEVIAEALKHINRKSCEHKIHVDCGKEL
LLVRMDVRLIIQVIINIVDNAIKYTQEGSDIYIKARKEGRYVIISIEDNGEGIPDDMKENVFDTFFTCNNEIADNRRSLG
LGLSLCKTIINAHGSELELRDNTPHGCIFEFKLQLSEVHLNE

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=30.327868852459, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=26.4, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786600, Length=279, Percent_Identity=24.0143369175627, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081816, Length=236, Percent_Identity=27.9661016949153, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=22.8070175438596, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789149, Length=262, Percent_Identity=24.0458015267176, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790861, Length=223, Percent_Identity=26.0089686098655, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788549, Length=263, Percent_Identity=24.3346007604563, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788713, Length=223, Percent_Identity=24.6636771300448, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082128, Length=240, Percent_Identity=24.5833333333333, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790436, Length=233, Percent_Identity=24.8927038626609, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR014729
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41130; Mature: 41130

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIITEKTLKKLVKEFLITIGLLSIATVIGMLLIYIGFTESNVIMVYLLCVLLISIFTNG
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
YIWSVAGSLVSVVLMNFFLTEPRFTLHTYDTGYPLTCVIMLAASMLTGTLASKLKKHVRM
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEQAAYREKTLQLRANLLRTISHDLRTPLTSISGNANNLMYNYDKLDNDTREQIFTDIYD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEECHHCCCHHHHHHHHHHCC
DSEWLISLVENILFVTRFEDGTVTLNMSDQLIDEVIAEALKHINRKSCEHKIHVDCGKEL
CHHHHHHHHHHHHEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEE
LLVRMDVRLIIQVIINIVDNAIKYTQEGSDIYIKARKEGRYVIISIEDNGEGIPDDMKEN
EHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHH
VFDTFFTCNNEIADNRRSLGLGLSLCKTIINAHGSELELRDNTPHGCIFEFKLQLSEVHL
HHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEEECCCC
NE
CC
>Mature Secondary Structure
MVIITEKTLKKLVKEFLITIGLLSIATVIGMLLIYIGFTESNVIMVYLLCVLLISIFTNG
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
YIWSVAGSLVSVVLMNFFLTEPRFTLHTYDTGYPLTCVIMLAASMLTGTLASKLKKHVRM
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEQAAYREKTLQLRANLLRTISHDLRTPLTSISGNANNLMYNYDKLDNDTREQIFTDIYD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEECHHCCCHHHHHHHHHHCC
DSEWLISLVENILFVTRFEDGTVTLNMSDQLIDEVIAEALKHINRKSCEHKIHVDCGKEL
CHHHHHHHHHHHHEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEE
LLVRMDVRLIIQVIINIVDNAIKYTQEGSDIYIKARKEGRYVIISIEDNGEGIPDDMKEN
EHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHH
VFDTFFTCNNEIADNRRSLGLGLSLCKTIINAHGSELELRDNTPHGCIFEFKLQLSEVHL
HHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEEEEECCCC
NE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9226259; 11466286 [H]