Click here to switch to the map view.

The map label for this gene is hsrA [H]

Identifier: 238921721

GI number: 238921721

Start: 3766070

End: 3767431

Strand: Direct

Name: hsrA [H]

Synonym: NT01EI_3891

Alternate gene names: 238921721

Gene position: 3766070-3767431 (Clockwise)

Preceding gene: 238921720

Following gene: 238921729

Centisome position: 98.79

GC content: 57.12

Gene sequence:

>1362_bases
ATGCAGGCGCTGGATGCCACTATCCTGAATACCGCACTGCCCGCCATCGCCCGCAGTCTGGCCTGCTCCCCGCTGGTGAT
GCAGTCTGCCATCATCAGTTATACCCTGACAGTCGCAATGCTGATCCCCATCAGTGGCTGGATAGCCGATAGGATGGGGA
CCCGGCGCGTCTTTATTGCCGCCGTTTCGCTATTCTCACTTGGCTCCCTGTTGTGCGCGCTGTCGGGATCACTGGAAATG
CTGGTCGCCTCCCGCGTTCTACAGGGTGTAGGCGGGGCGATGATGATGCCGGTTGCCCGTCTCGCGCTCCTGCGCGCCTA
TCCGCGCGATGAGCTATTGACGGTACTCAACTTCATCAGCTTACCCGGTCTGGTGGGTCCAGTGCTCGGCCCTTTGCTCG
GCGGTTGGCTCGTCACCTATGCAACCTGGCACTGGATTTTCCTGATCAATATCCCGATTGGCATCATCGGAATCCTCTAT
GCCCTGCGCTATATGCCTGACTTTACCGCCCCAACACACGGCTTTGATATGCTTGGCTTTATGCTATTTGGTCTGGGGCT
GGTGCTGCTCTCATGTGGCATGGAGCTATTCGGTAAGCCGACGCTACCGCAGCCCTATGCCTGGGGCATCATATTGACAG
GCCTCGGCTCATTGCTACTGTATATCCTGCACGCCAGACGCCACCCTCACCCGCTTATCGCCCTTCCTCTATTTCGTACC
CATACCTTCTCTATTGGCATCGTGGGTAACATAGCCTCACGCCTGGGCACCGGCTGCATTCCATTTCTGATGCCGCTCAT
GCTGCAGGTAGGGTTCGGCTATAGTGCCATTGTCTCGGGCTGCATGATGGCACCAACGGCGCTGGGGTCGATGTTGGGAA
AATCACTGGTTACCGGCGTACTGCACCGCCAGGGATATCGTAACACGTTGGTTGGGGTGACGCTGATTATCGGTCTGACG
ATCGCGCAGTTCTCCCTACAGAAGCCTGAAATGCCCCTGTGGCTGCTGATCTTGCCGCTGTTCCTGCTGGGGATGTTTAT
ATCCACCCAATTTACCGCAATGAACACGCTTACCCTTGGCGATCTGAGCGACCAAAATGCCAGCGCAGGCAACTGCGTAC
TGGCGGTGACCCAGCAGCTGTCCATCAGCTTTGGCGTTGCGGTCAGCGCCGCGGTGCTGCGCTTTTATGATACTCGGATT
ACCGGGTCACTGGTCGATCACTTCCACTATACCTTTATTACAATGGGCGCCATCACCCTGCTGTCTGCCAACGTATTCAT
GTTACTCCATCCCAGGGACGGCGACCATTTGCTGAAGGGCCGCCGCCACCCATATCACCGTGATACTCCCCCTCAACCGT
GA

Upstream 100 bases:

>100_bases
CTGTCAGGGCTTGCTGGGTATAGAGGGAGTCTAACACTCGACGGAAAATTTATGACCCAGATGGCTGGCTTGCCTTGGAT
TGCAGCAATGGCTTTTTTTT

Downstream 100 bases:

>100_bases
TGGATGGCGACCGATCCCCGCTCAATAAGCTGGGGCGTTAATACCAGTGTCTGTGGCTCCCGCGAGGGATGCTGCAGACG
GTGTACCAGCGTATCGACGG

Product: hypothetical protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: High-copy suppressor of rspA [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MQALDATILNTALPAIARSLACSPLVMQSAIISYTLTVAMLIPISGWIADRMGTRRVFIAAVSLFSLGSLLCALSGSLEM
LVASRVLQGVGGAMMMPVARLALLRAYPRDELLTVLNFISLPGLVGPVLGPLLGGWLVTYATWHWIFLINIPIGIIGILY
ALRYMPDFTAPTHGFDMLGFMLFGLGLVLLSCGMELFGKPTLPQPYAWGIILTGLGSLLLYILHARRHPHPLIALPLFRT
HTFSIGIVGNIASRLGTGCIPFLMPLMLQVGFGYSAIVSGCMMAPTALGSMLGKSLVTGVLHRQGYRNTLVGVTLIIGLT
IAQFSLQKPEMPLWLLILPLFLLGMFISTQFTAMNTLTLGDLSDQNASAGNCVLAVTQQLSISFGVAVSAAVLRFYDTRI
TGSLVDHFHYTFITMGAITLLSANVFMLLHPRDGDHLLKGRRHPYHRDTPPQP

Sequences:

>Translated_453_residues
MQALDATILNTALPAIARSLACSPLVMQSAIISYTLTVAMLIPISGWIADRMGTRRVFIAAVSLFSLGSLLCALSGSLEM
LVASRVLQGVGGAMMMPVARLALLRAYPRDELLTVLNFISLPGLVGPVLGPLLGGWLVTYATWHWIFLINIPIGIIGILY
ALRYMPDFTAPTHGFDMLGFMLFGLGLVLLSCGMELFGKPTLPQPYAWGIILTGLGSLLLYILHARRHPHPLIALPLFRT
HTFSIGIVGNIASRLGTGCIPFLMPLMLQVGFGYSAIVSGCMMAPTALGSMLGKSLVTGVLHRQGYRNTLVGVTLIIGLT
IAQFSLQKPEMPLWLLILPLFLLGMFISTQFTAMNTLTLGDLSDQNASAGNCVLAVTQQLSISFGVAVSAAVLRFYDTRI
TGSLVDHFHYTFITMGAITLLSANVFMLLHPRDGDHLLKGRRHPYHRDTPPQP
>Mature_453_residues
MQALDATILNTALPAIARSLACSPLVMQSAIISYTLTVAMLIPISGWIADRMGTRRVFIAAVSLFSLGSLLCALSGSLEM
LVASRVLQGVGGAMMMPVARLALLRAYPRDELLTVLNFISLPGLVGPVLGPLLGGWLVTYATWHWIFLINIPIGIIGILY
ALRYMPDFTAPTHGFDMLGFMLFGLGLVLLSCGMELFGKPTLPQPYAWGIILTGLGSLLLYILHARRHPHPLIALPLFRT
HTFSIGIVGNIASRLGTGCIPFLMPLMLQVGFGYSAIVSGCMMAPTALGSMLGKSLVTGVLHRQGYRNTLVGVTLIIGLT
IAQFSLQKPEMPLWLLILPLFLLGMFISTQFTAMNTLTLGDLSDQNASAGNCVLAVTQQLSISFGVAVSAAVLRFYDTRI
TGSLVDHFHYTFITMGAITLLSANVFMLLHPRDGDHLLKGRRHPYHRDTPPQP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=452, Percent_Identity=70.7964601769911, Blast_Score=637, Evalue=0.0,
Organism=Escherichia coli, GI1788392, Length=449, Percent_Identity=45.43429844098, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI1789042, Length=402, Percent_Identity=28.8557213930348, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1788710, Length=434, Percent_Identity=28.5714285714286, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI87081983, Length=306, Percent_Identity=29.7385620915033, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322958, Length=275, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321663, Length=153, Percent_Identity=32.6797385620915, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325455, Length=127, Percent_Identity=30.7086614173228, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48986; Mature: 48986

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQALDATILNTALPAIARSLACSPLVMQSAIISYTLTVAMLIPISGWIADRMGTRRVFIA
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AVSLFSLGSLLCALSGSLEMLVASRVLQGVGGAMMMPVARLALLRAYPRDELLTVLNFIS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LPGLVGPVLGPLLGGWLVTYATWHWIFLINIPIGIIGILYALRYMPDFTAPTHGFDMLGF
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
MLFGLGLVLLSCGMELFGKPTLPQPYAWGIILTGLGSLLLYILHARRHPHPLIALPLFRT
HHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHH
HTFSIGIVGNIASRLGTGCIPFLMPLMLQVGFGYSAIVSGCMMAPTALGSMLGKSLVTGV
HEEEEHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHRQGYRNTLVGVTLIIGLTIAQFSLQKPEMPLWLLILPLFLLGMFISTQFTAMNTLTLG
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEC
DLSDQNASAGNCVLAVTQQLSISFGVAVSAAVLRFYDTRITGSLVDHFHYTFITMGAITL
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSANVFMLLHPRDGDHLLKGRRHPYHRDTPPQP
HHCCEEEEEECCCCCHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQALDATILNTALPAIARSLACSPLVMQSAIISYTLTVAMLIPISGWIADRMGTRRVFIA
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AVSLFSLGSLLCALSGSLEMLVASRVLQGVGGAMMMPVARLALLRAYPRDELLTVLNFIS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LPGLVGPVLGPLLGGWLVTYATWHWIFLINIPIGIIGILYALRYMPDFTAPTHGFDMLGF
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
MLFGLGLVLLSCGMELFGKPTLPQPYAWGIILTGLGSLLLYILHARRHPHPLIALPLFRT
HHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHH
HTFSIGIVGNIASRLGTGCIPFLMPLMLQVGFGYSAIVSGCMMAPTALGSMLGKSLVTGV
HEEEEHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHRQGYRNTLVGVTLIIGLTIAQFSLQKPEMPLWLLILPLFLLGMFISTQFTAMNTLTLG
HHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEC
DLSDQNASAGNCVLAVTQQLSISFGVAVSAAVLRFYDTRITGSLVDHFHYTFITMGAITL
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSANVFMLLHPRDGDHLLKGRRHPYHRDTPPQP
HHCCEEEEEECCCCCHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]