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The map label for this gene is glpK [H]

Identifier: 238921637

GI number: 238921637

Start: 3672728

End: 3674236

Strand: Reverse

Name: glpK [H]

Synonym: NT01EI_3792

Alternate gene names: 238921637

Gene position: 3674236-3672728 (Counterclockwise)

Preceding gene: 238921638

Following gene: 238921636

Centisome position: 96.38

GC content: 59.97

Gene sequence:

>1509_bases
ATGACAACCGAACAAAAATACATTGTCGCTCTTGACCAGGGCACCACCAGCTCCCGCGCCGTGATCCTCGATCACGATGC
CAATATCATCAGCGCCTCCCAGCGCGAGTTCGAACAGATTTATCCCAAGGCCGGCTGGGTGGAGCACGACCCGATGGAGA
TCTGGGCAACCCAGAGTTCTACCCTGACAGAGGCGATGGCCAAAGCCGATATCGAATCCGATCAGATTGCCGCCATCGGC
ATCACCAACCAGCGTGAAACCACCATCGTTTGGGAAAAAGAGACCGGTAAACCGGTCTACAACGCCATCGTCTGGCAGTG
CCGCCGTACCGCCGATATCTGTGAAAAGCTCAAGCGCGATGGACTGGAAGAGTACATCCGCCACAACACTGGCCTGGTGG
TCGACCCCTACTTCTCCGGCACCAAGGTGAAGTGGATCCTGGACCATGTCGAAGGCGCCCGTGAACGCGCTGAGCGCGGC
GAGCTGCTGTTCGGTACCGTCGATACCTGGCTGGTATGGAAGATGACTCAAGGCCGGGTACACGTCACCGACTATACCAA
CGCTTCCCGCACCATGCTGTTCAACATCCACACGCTGGACTGGGATGAGCGCATGCTGAAGGTATTGGATATCCCGCGTG
CGATGCTGCCGCAGGTGCGCGCCTCCTCCGAAATCTATGGGAAAACCAACATCGGCGGTAAGGGTGGAACCCGTATCCCT
ATCGCCGGTATCGCCGGTGATCAGCAGGCGGCGCTGTTTGGCCAGCTGTGTGTACAGCCGGGGATGGCAAAGAACACCTA
CGGCACTGGCTGCTTCCTGCTGATGAACACCGGCAAAAAGGCGGTACCGTCACAGCACGGCCTGCTGACCACCATCGCCT
GCGGCCCGCGCGGCGAGGTGAACTACGCACTGGAAGGAGCTGTATTCATCGGCGGCGCCTCCATTCAGTGGCTGCGCGAC
GAGCTGAAGCTCATCAACGACGCGGCGGACTCCGAGTATTTTGCCACTAAGGTGAAAGACAGCAACGGCGTCTACGTGGT
ACCGGCCTTTACCGGTCTGGGTGCCCCTTACTGGGATCCCTATGCCCGCGGCGCCATCTTTGGCCTGACCCGCGGCGTCA
ACAATAACCACATCATCCGTGCCACCCTGGAGTCCATAGCCTACCAGACCCGCGACGTGCTGGATGCCATGCAGGCCGAT
GCCAATACCCGCCTGCAGTCCCTGCGCGTCGATGGCGGCGCGGTCGCCAACAACTTCCTGATGCAGTTCCAGTCAGACAT
TCTCGGTACTCGGGTTGAACGTCCGGCGGTACTGGAAGTCACGGCACTCGGCGCGGCCTACCTGGCGGGTTTGGCCGTTG
GTTACTGGAGCGATCTGGAGGAGCTTAGCAGTAAGGCCAGCATTGAGCGTGAGTTCCGCCCCGGCATTGAAACCGTCGAG
CGCAACTATCGCTACAGCGGCTGGAAGAAAGCGGTGGTACGCGCGCAGGCCTGGGAAGATCACGACTGA

Upstream 100 bases:

>100_bases
AGAACAGCGAGAAATCCAAAGCCTGATAAGGTTTCCGGGGAGGGTTCTCCCCGGCATTTGAGCGAACTCCGTACACCGAC
CCCCAACCAGGACAACGATC

Downstream 100 bases:

>100_bases
TAACCGGTGGCAGGCCGACGGCGGGGGCGAATGAATCGCCCCCTTTTTTATTTTTGGTCAAGGTTATGGCGTTCTTCCGA
CGCAAACGTTTCACTGTGCC

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MTTEQKYIVALDQGTTSSRAVILDHDANIISASQREFEQIYPKAGWVEHDPMEIWATQSSTLTEAMAKADIESDQIAAIG
ITNQRETTIVWEKETGKPVYNAIVWQCRRTADICEKLKRDGLEEYIRHNTGLVVDPYFSGTKVKWILDHVEGARERAERG
ELLFGTVDTWLVWKMTQGRVHVTDYTNASRTMLFNIHTLDWDERMLKVLDIPRAMLPQVRASSEIYGKTNIGGKGGTRIP
IAGIAGDQQAALFGQLCVQPGMAKNTYGTGCFLLMNTGKKAVPSQHGLLTTIACGPRGEVNYALEGAVFIGGASIQWLRD
ELKLINDAADSEYFATKVKDSNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGVNNNHIIRATLESIAYQTRDVLDAMQAD
ANTRLQSLRVDGGAVANNFLMQFQSDILGTRVERPAVLEVTALGAAYLAGLAVGYWSDLEELSSKASIEREFRPGIETVE
RNYRYSGWKKAVVRAQAWEDHD

Sequences:

>Translated_502_residues
MTTEQKYIVALDQGTTSSRAVILDHDANIISASQREFEQIYPKAGWVEHDPMEIWATQSSTLTEAMAKADIESDQIAAIG
ITNQRETTIVWEKETGKPVYNAIVWQCRRTADICEKLKRDGLEEYIRHNTGLVVDPYFSGTKVKWILDHVEGARERAERG
ELLFGTVDTWLVWKMTQGRVHVTDYTNASRTMLFNIHTLDWDERMLKVLDIPRAMLPQVRASSEIYGKTNIGGKGGTRIP
IAGIAGDQQAALFGQLCVQPGMAKNTYGTGCFLLMNTGKKAVPSQHGLLTTIACGPRGEVNYALEGAVFIGGASIQWLRD
ELKLINDAADSEYFATKVKDSNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGVNNNHIIRATLESIAYQTRDVLDAMQAD
ANTRLQSLRVDGGAVANNFLMQFQSDILGTRVERPAVLEVTALGAAYLAGLAVGYWSDLEELSSKASIEREFRPGIETVE
RNYRYSGWKKAVVRAQAWEDHD
>Mature_501_residues
TTEQKYIVALDQGTTSSRAVILDHDANIISASQREFEQIYPKAGWVEHDPMEIWATQSSTLTEAMAKADIESDQIAAIGI
TNQRETTIVWEKETGKPVYNAIVWQCRRTADICEKLKRDGLEEYIRHNTGLVVDPYFSGTKVKWILDHVEGARERAERGE
LLFGTVDTWLVWKMTQGRVHVTDYTNASRTMLFNIHTLDWDERMLKVLDIPRAMLPQVRASSEIYGKTNIGGKGGTRIPI
AGIAGDQQAALFGQLCVQPGMAKNTYGTGCFLLMNTGKKAVPSQHGLLTTIACGPRGEVNYALEGAVFIGGASIQWLRDE
LKLINDAADSEYFATKVKDSNGVYVVPAFTGLGAPYWDPYARGAIFGLTRGVNNNHIIRATLESIAYQTRDVLDAMQADA
NTRLQSLRVDGGAVANNFLMQFQSDILGTRVERPAVLEVTALGAAYLAGLAVGYWSDLEELSSKASIEREFRPGIETVER
NYRYSGWKKAVVRAQAWEDHD

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=502, Percent_Identity=47.808764940239, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI4504007, Length=502, Percent_Identity=47.808764940239, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI42794763, Length=506, Percent_Identity=47.6284584980237, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI41393575, Length=502, Percent_Identity=46.4143426294821, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI88196792, Length=510, Percent_Identity=34.9019607843137, Blast_Score=326, Evalue=2e-89,
Organism=Escherichia coli, GI1790361, Length=500, Percent_Identity=87.4, Blast_Score=929, Evalue=0.0,
Organism=Escherichia coli, GI1789987, Length=498, Percent_Identity=23.8955823293173, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1787789, Length=505, Percent_Identity=25.5445544554455, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790005, Length=488, Percent_Identity=22.1311475409836, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789138, Length=505, Percent_Identity=22.3762376237624, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789168, Length=497, Percent_Identity=21.9315895372233, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17535599, Length=502, Percent_Identity=40.6374501992032, Blast_Score=393, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71986140, Length=520, Percent_Identity=26.3461538461538, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71986147, Length=299, Percent_Identity=32.4414715719064, Blast_Score=137, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6321755, Length=547, Percent_Identity=36.9287020109689, Blast_Score=319, Evalue=6e-88,
Organism=Drosophila melanogaster, GI17864214, Length=511, Percent_Identity=45.0097847358121, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24655555, Length=500, Percent_Identity=42, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24655560, Length=500, Percent_Identity=42, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24655570, Length=500, Percent_Identity=42, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24655574, Length=500, Percent_Identity=42, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24655565, Length=500, Percent_Identity=42, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24654573, Length=440, Percent_Identity=46.5909090909091, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19922058, Length=530, Percent_Identity=33.0188679245283, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24652871, Length=497, Percent_Identity=33.4004024144869, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24656367, Length=514, Percent_Identity=27.8210116731518, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21357867, Length=529, Percent_Identity=27.0321361058601, Blast_Score=213, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24656372, Length=362, Percent_Identity=30.939226519337, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI45552909, Length=300, Percent_Identity=30, Blast_Score=128, Evalue=8e-30,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 55697; Mature: 55565

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEQKYIVALDQGTTSSRAVILDHDANIISASQREFEQIYPKAGWVEHDPMEIWATQSS
CCCCCEEEEEEECCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCCCCCEEEECCCH
TLTEAMAKADIESDQIAAIGITNQRETTIVWEKETGKPVYNAIVWQCRRTADICEKLKRD
HHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
GLEEYIRHNTGLVVDPYFSGTKVKWILDHVEGARERAERGELLFGTVDTWLVWKMTQGRV
CHHHHHHCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHCCCEEEEECCEEEEEEEECCEE
HVTDYTNASRTMLFNIHTLDWDERMLKVLDIPRAMLPQVRASSEIYGKTNIGGKGGTRIP
EEEECCCCCEEEEEEEEECCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEE
IAGIAGDQQAALFGQLCVQPGMAKNTYGTGCFLLMNTGKKAVPSQHGLLTTIACGPRGEV
EEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCE
NYALEGAVFIGGASIQWLRDELKLINDAADSEYFATKVKDSNGVYVVPAFTGLGAPYWDP
EEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCH
YARGAIFGLTRGVNNNHIIRATLESIAYQTRDVLDAMQADANTRLQSLRVDGGAVANNFL
HHCCEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHEEECCCCHHHHHHH
MQFQSDILGTRVERPAVLEVTALGAAYLAGLAVGYWSDLEELSSKASIEREFRPGIETVE
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RNYRYSGWKKAVVRAQAWEDHD
HCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTEQKYIVALDQGTTSSRAVILDHDANIISASQREFEQIYPKAGWVEHDPMEIWATQSS
CCCCEEEEEEECCCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCCCCCEEEECCCH
TLTEAMAKADIESDQIAAIGITNQRETTIVWEKETGKPVYNAIVWQCRRTADICEKLKRD
HHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHC
GLEEYIRHNTGLVVDPYFSGTKVKWILDHVEGARERAERGELLFGTVDTWLVWKMTQGRV
CHHHHHHCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHCCCEEEEECCEEEEEEEECCEE
HVTDYTNASRTMLFNIHTLDWDERMLKVLDIPRAMLPQVRASSEIYGKTNIGGKGGTRIP
EEEECCCCCEEEEEEEEECCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEE
IAGIAGDQQAALFGQLCVQPGMAKNTYGTGCFLLMNTGKKAVPSQHGLLTTIACGPRGEV
EEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCE
NYALEGAVFIGGASIQWLRDELKLINDAADSEYFATKVKDSNGVYVVPAFTGLGAPYWDP
EEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCH
YARGAIFGLTRGVNNNHIIRATLESIAYQTRDVLDAMQADANTRLQSLRVDGGAVANNFL
HHCCEEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHEEECCCCHHHHHHH
MQFQSDILGTRVERPAVLEVTALGAAYLAGLAVGYWSDLEELSSKASIEREFRPGIETVE
HHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RNYRYSGWKKAVVRAQAWEDHD
HCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA