Click here to switch to the map view.

The map label for this gene is mscL [H]

Identifier: 238921415

GI number: 238921415

Start: 3468223

End: 3468456

Strand: Direct

Name: mscL [H]

Synonym: NT01EI_3566

Alternate gene names: 238921415

Gene position: 3468223-3468456 (Clockwise)

Preceding gene: 238921414

Following gene: 238921438

Centisome position: 90.97

GC content: 51.28

Gene sequence:

>234_bases
ATGCGCAAGGCGATCGGCAGCACCCCAGCCTTGGTAGCCAACTATGGTCAGTTCATACAGGCTATCTTTGACTTTATCAT
CGTCACATTCGCCATTTTTATGGCGATCAAGCCGATAAACAAACTGCGGCGCCAAAAGACGGCAGAAACGCCGCCGGCAC
CCAGCGCAGAAGCGGTACTGCTAACGGAAATCCGTGAATTGCTTAAGGCACAGCTGAAAGACAAATACACCTGA

Upstream 100 bases:

>100_bases
CGTATTCGGTAAAATCGTATCCCCGCGGAGCGGGGATGTGATCATGCCGCTGCTCAGGCTATTGATCGGTGGCACCGGCT
TTAAACAGTTTCACTGAGTG

Downstream 100 bases:

>100_bases
CATACCGGCGACAGGCTCTTCTGCCGTCCTCCCTGCTTAGCTATCCGACTGCGGAGTAAAGTGACCACGCAAATCCACGC
GGGGTAAAAACGCCTCTGCC

Product: hypothetical protein

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 77; Mature: 77

Protein sequence:

>77_residues
MRKAIGSTPALVANYGQFIQAIFDFIIVTFAIFMAIKPINKLRRQKTAETPPAPSAEAVLLTEIRELLKAQLKDKYT

Sequences:

>Translated_77_residues
MRKAIGSTPALVANYGQFIQAIFDFIIVTFAIFMAIKPINKLRRQKTAETPPAPSAEAVLLTEIRELLKAQLKDKYT
>Mature_77_residues
MRKAIGSTPALVANYGQFIQAIFDFIIVTFAIFMAIKPINKLRRQKTAETPPAPSAEAVLLTEIRELLKAQLKDKYT

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

Organism=Escherichia coli, GI1789686, Length=74, Percent_Identity=63.5135135135135, Blast_Score=87, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019823
- InterPro:   IPR001185 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 8622; Mature: 8622

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKAIGSTPALVANYGQFIQAIFDFIIVTFAIFMAIKPINKLRRQKTAETPPAPSAEAVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LTEIRELLKAQLKDKYT
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRKAIGSTPALVANYGQFIQAIFDFIIVTFAIFMAIKPINKLRRQKTAETPPAPSAEAVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LTEIRELLKAQLKDKYT
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA