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The map label for this gene is mscL [H]

Identifier: 238921414

GI number: 238921414

Start: 3468043

End: 3468219

Strand: Direct

Name: mscL [H]

Synonym: NT01EI_3565

Alternate gene names: 238921414

Gene position: 3468043-3468219 (Clockwise)

Preceding gene: 238921413

Following gene: 238921415

Centisome position: 90.97

GC content: 51.98

Gene sequence:

>177_bases
ATGAGGCTACTTAAAGAGTTTCGTGAGTTTGCCATGTGCGGTAAGGTCGTGGATATGGCCTTCGGGGTTATCATCGCTGC
CGTATTCGGTAAAATCGTATCCCCGCGGAGCGGGGATGTGATCATGCCGCTGCTCAGGCTATTGATCGGTGGCACCGGCT
TTAAACAGTTTCACTGA

Upstream 100 bases:

>100_bases
CAGTTTCTGGCGACACTGAAGCATCTTGATGCTCGTCTTCTAGCAAAGGGGCGGCAAGTGATTACACTTGCAGTATGAAT
AATGTGGTTTGGCGATAGTT

Downstream 100 bases:

>100_bases
GTGATGCGCAAGGCGATCGGCAGCACCCCAGCCTTGGTAGCCAACTATGGTCAGTTCATACAGGCTATCTTTGACTTTAT
CATCGTCACATTCGCCATTT

Product: large-conductance mechanosensitive channel

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 58; Mature: 58

Protein sequence:

>58_residues
MRLLKEFREFAMCGKVVDMAFGVIIAAVFGKIVSPRSGDVIMPLLRLLIGGTGFKQFH

Sequences:

>Translated_58_residues
MRLLKEFREFAMCGKVVDMAFGVIIAAVFGKIVSPRSGDVIMPLLRLLIGGTGFKQFH
>Mature_58_residues
MRLLKEFREFAMCGKVVDMAFGVIIAAVFGKIVSPRSGDVIMPLLRLLIGGTGFKQFH

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

Organism=Escherichia coli, GI1789686, Length=57, Percent_Identity=68.4210526315789, Blast_Score=76, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019823
- InterPro:   IPR001185 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 6413; Mature: 6413

Theoretical pI: Translated: 10.77; Mature: 10.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
6.9 %Met     (Translated Protein)
8.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
6.9 %Met     (Mature Protein)
8.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLKEFREFAMCGKVVDMAFGVIIAAVFGKIVSPRSGDVIMPLLRLLIGGTGFKQFH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRLLKEFREFAMCGKVVDMAFGVIIAAVFGKIVSPRSGDVIMPLLRLLIGGTGFKQFH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA