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The map label for this gene is panF [H]

Identifier: 238921359

GI number: 238921359

Start: 3398594

End: 3400048

Strand: Direct

Name: panF [H]

Synonym: NT01EI_3503

Alternate gene names: 238921359

Gene position: 3398594-3400048 (Clockwise)

Preceding gene: 238921358

Following gene: 238921360

Centisome position: 89.15

GC content: 63.3

Gene sequence:

>1455_bases
ATGCAGACTGACGTAATCCTGCCGCTGGTAGGCTACCTCGCCTTGGTGTTCGGCCTGTCGATTTACGCCTACCGTCGCCG
CCAGAAAGGCAACTTCCTCAACGACTATTTTCTGGGCGACCGCTCGATGGGCGGGTTTGTCCTGGCGATGACCCTGACCG
CCACCTACATCAGCGCCAGCTCCTTTATCGGCGGCCCGGGGGCAGCCTATAAATATGGCCTTGGCTGGGTGCTGCTGGCG
ATGATCCAGTTGCCGGCCGTATGGCTCTCGCTGGGCATCTTGGGCAAGAAGTTCGCCATTCTGGCGCGCCGCTACCAGGC
GGTCACCCTCAATGACATGCTGTACGCGCGCTACGGCAGCCGTCTGCTGGTGTGGGTCGCCAGCCTCAGCCTGCTGGTCG
CCTTTATCGGAGCGATGACGGTGCAGTTTATCGGCGGCGCGCGCCTGCTGGAGAGCGCCGCCGGTATTCCCTATGACGTC
GGGCTGCTGATCTTCGGGGTCACCATCGCCCTGTACACCGCCTTCGGCGGCTTTCGCGCCAGCGTGCTCAACGATGCCAT
GCAGGGCGTGGTGATGCTGCTGGGCACCCTGCTGCTGTTGGTCGGCATTATCCACGCCGCCGGTGGCATGCACGCCGCCG
TAGAGACCCTGCAACGCATCGATCCAAAGCTGGTCTCCCCCCATGGGGCCGACGATATCCTGAGCCTGCCGTTTATGGCG
TCGTTCTGGATCCTGGTCTGCTTTGGCGTCATCGGTCTGCCGCACACCGCCGTCCGCTGCATCTCCTACAAGGACAGCAA
GGCGGTTCACCGCGCCATCATCATCGGCACCATCGTGGTGGCGCTACTGATGTTTGGCATGCATCTGGCCGGTGCCCTTG
GCCGGGCGGTGCTGCCGGATCTGACAGTGCCGGATATGGTGATCCCCACGCTGATGGTACGGGTGCTGCCCCCCTTCGCT
GCCGGGATCTTCCTGGCGGCGCCGATGGCGGCGATCATGTCGACGATCAATGCCCAGCTGCTGCAATCTTCGGCGACCAT
CGTCAAAGATCTCTATCTGGGGCTGCGTCCTCAGGCGTTGCACAATGAGCGCCGTCTGGCCCGCCTCTCGGCCGCCTCAA
CCCTGATCCTCGGCGCCTTGCTGCTGCTGGCAGCCTGGCATCCGCCGCAGATGATCATTTGGCTTAACCTGCTGGCCTTC
GGCGGCCTGGAGGCCGTATTCCTGTGGCCGCTGGTGCTGGGACTCTACTGGGAGCGGGCCAATGCGCACGGCGCCCTGTG
CTCCATGATCGTCGGCGCCGCCAGTTACGCACTGCTGGCCAGCCTGAAGATCCAGCTGTTCCAGCTGCACCCTATCGTGC
CTTCCCTACTGCTGGGCCTGCTGGCCTTCTGGGCAGGCAACCATTTTGGCAGCCGTCCGAATACTGCGATCGCTGCCAAC
GAATCAACTGACTAA

Upstream 100 bases:

>100_bases
TGGTTCGAAATGGCCTGCCTGCTGCTGCCACTGCTGTTTATTCTGCTGTGCTGGACCATGGTCCGCCTGATATTCAAGTC
TATACCGCTGGGGAGCGATG

Downstream 100 bases:

>100_bases
AAAGAGACATGCCATGCCTTGGATCCAAATTAAAATCAACTCAACCGGCGGCCAGGCGGAAACCCTGAGCGATGCGCTGA
TGGAGAACGGCGCCGTCTCC

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MQTDVILPLVGYLALVFGLSIYAYRRRQKGNFLNDYFLGDRSMGGFVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYQAVTLNDMLYARYGSRLLVWVASLSLLVAFIGAMTVQFIGGARLLESAAGIPYDV
GLLIFGVTIALYTAFGGFRASVLNDAMQGVVMLLGTLLLLVGIIHAAGGMHAAVETLQRIDPKLVSPHGADDILSLPFMA
SFWILVCFGVIGLPHTAVRCISYKDSKAVHRAIIIGTIVVALLMFGMHLAGALGRAVLPDLTVPDMVIPTLMVRVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIVKDLYLGLRPQALHNERRLARLSAASTLILGALLLLAAWHPPQMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAHGALCSMIVGAASYALLASLKIQLFQLHPIVPSLLLGLLAFWAGNHFGSRPNTAIAAN
ESTD

Sequences:

>Translated_484_residues
MQTDVILPLVGYLALVFGLSIYAYRRRQKGNFLNDYFLGDRSMGGFVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYQAVTLNDMLYARYGSRLLVWVASLSLLVAFIGAMTVQFIGGARLLESAAGIPYDV
GLLIFGVTIALYTAFGGFRASVLNDAMQGVVMLLGTLLLLVGIIHAAGGMHAAVETLQRIDPKLVSPHGADDILSLPFMA
SFWILVCFGVIGLPHTAVRCISYKDSKAVHRAIIIGTIVVALLMFGMHLAGALGRAVLPDLTVPDMVIPTLMVRVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIVKDLYLGLRPQALHNERRLARLSAASTLILGALLLLAAWHPPQMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAHGALCSMIVGAASYALLASLKIQLFQLHPIVPSLLLGLLAFWAGNHFGSRPNTAIAAN
ESTD
>Mature_484_residues
MQTDVILPLVGYLALVFGLSIYAYRRRQKGNFLNDYFLGDRSMGGFVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGILGKKFAILARRYQAVTLNDMLYARYGSRLLVWVASLSLLVAFIGAMTVQFIGGARLLESAAGIPYDV
GLLIFGVTIALYTAFGGFRASVLNDAMQGVVMLLGTLLLLVGIIHAAGGMHAAVETLQRIDPKLVSPHGADDILSLPFMA
SFWILVCFGVIGLPHTAVRCISYKDSKAVHRAIIIGTIVVALLMFGMHLAGALGRAVLPDLTVPDMVIPTLMVRVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIVKDLYLGLRPQALHNERRLARLSAASTLILGALLLLAAWHPPQMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAHGALCSMIVGAASYALLASLKIQLFQLHPIVPSLLLGLLAFWAGNHFGSRPNTAIAAN
ESTD

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=472, Percent_Identity=26.4830508474576, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI14140236, Length=477, Percent_Identity=24.3186582809224, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4507031, Length=473, Percent_Identity=24.9471458773784, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4507033, Length=405, Percent_Identity=25.1851851851852, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4507035, Length=373, Percent_Identity=24.3967828418231, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI109659836, Length=496, Percent_Identity=25.6048387096774, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI17941285, Length=472, Percent_Identity=23.9406779661017, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI157671931, Length=358, Percent_Identity=20.391061452514, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI256985183, Length=424, Percent_Identity=22.4056603773585, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI109659839, Length=512, Percent_Identity=24.21875, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI87082237, Length=483, Percent_Identity=80.7453416149068, Blast_Score=756, Evalue=0.0,
Organism=Escherichia coli, GI1787251, Length=482, Percent_Identity=26.1410788381743, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790113, Length=462, Percent_Identity=24.6753246753247, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790503, Length=500, Percent_Identity=22, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574994, Length=365, Percent_Identity=25.7534246575342, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573698, Length=429, Percent_Identity=22.8438228438228, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24651739, Length=440, Percent_Identity=21.5909090909091, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51898; Mature: 51898

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCC
>Mature Secondary Structure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CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]