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The map label for this gene is rppH

Identifier: 238921120

GI number: 238921120

Start: 3137111

End: 3137644

Strand: Reverse

Name: rppH

Synonym: NT01EI_3259

Alternate gene names: 238921120

Gene position: 3137644-3137111 (Counterclockwise)

Preceding gene: 238921123

Following gene: 238921119

Centisome position: 82.3

GC content: 55.43

Gene sequence:

>534_bases
GTGATCGATGATGATGGCTACCGCCCGAACGTAGGTATTGTAATCTGTAACCGTCAGGGACAGGTGCTGTGGGCACGTCG
CTATGGGCAAAACTCCTGGCAGTTCCCGCAGGGCGGGATCAACGCCGGGGAGACCGCCGAGCAGGCGATGTACCGCGAAC
TGTTTGAAGAGGTGGGGCTGGGACGTAAGGATGTGAAAATTCTGGCCTCTACCCGCAACTGGTTACGCTATAAATTACCT
AAACGTTTGGTGCGTTGGGATACGAAGCCGGTATGTATCGGCCAAAAGCAGCGCTGGTTTTTACTGCAGCTGCAGTGCAG
TGAAGCGGAGATCAATATGCAGCGTAGCAATACACCGGAGTTTGATGGCTGGCGCTGGGTCAGCTATTGGTATCCGGTGC
GTCAGGTGGTGTCGTTTAAGCGCGATGTTTACCGCCGGGTGATGAAGGAGTTCTCATCCGTTGTCATGTCGTTGCAGGAG
AGCGTAGCCCAGGGAGGGCGTTCGGCTCCCGGCTATCGCCGTAAAAGAGGTTAA

Upstream 100 bases:

>100_bases
ACAGGTGTAGGAAATCTTGGCGTTGAGCCAATGGTTTACCGCTTGGTGCGAGTGTGAAACAATCATGTCATCTTGCGATT
TTGCTTCTTGAGGTAGTCTG

Downstream 100 bases:

>100_bases
GTGGCAGTAATCATGCTTACACGCCTGCGCGAGATCGTGGAAAAGGTGGCTGCGGCTGCCAGCCTGAATGACGCGCTGAA
TGTGCTGGTGGACGAAACCT

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MIDDDGYRPNVGIVICNRQGQVLWARRYGQNSWQFPQGGINAGETAEQAMYRELFEEVGLGRKDVKILASTRNWLRYKLP
KRLVRWDTKPVCIGQKQRWFLLQLQCSEAEINMQRSNTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFSSVVMSLQE
SVAQGGRSAPGYRRKRG

Sequences:

>Translated_177_residues
MIDDDGYRPNVGIVICNRQGQVLWARRYGQNSWQFPQGGINAGETAEQAMYRELFEEVGLGRKDVKILASTRNWLRYKLP
KRLVRWDTKPVCIGQKQRWFLLQLQCSEAEINMQRSNTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFSSVVMSLQE
SVAQGGRSAPGYRRKRG
>Mature_177_residues
MIDDDGYRPNVGIVICNRQGQVLWARRYGQNSWQFPQGGINAGETAEQAMYRELFEEVGLGRKDVKILASTRNWLRYKLP
KRLVRWDTKPVCIGQKQRWFLLQLQCSEAEINMQRSNTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFSSVVMSLQE
SVAQGGRSAPGYRRKRG

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=177, Percent_Identity=85.8757062146893, Blast_Score=315, Evalue=9e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_EDWI9 (C5BGJ4)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002934635.1
- ProteinModelPortal:   C5BGJ4
- GeneID:   7961092
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_3259
- OMA:   GQKQIWY
- ProtClustDB:   PRK00714
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 20874; Mature: 20874

Theoretical pI: Translated: 10.51; Mature: 10.51

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDDDGYRPNVGIVICNRQGQVLWARRYGQNSWQFPQGGINAGETAEQAMYRELFEEVGL
CCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
GRKDVKILASTRNWLRYKLPKRLVRWDTKPVCIGQKQRWFLLQLQCSEAEINMQRSNTPE
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEEECCCEEEECCCCCCC
FDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFSSVVMSLQESVAQGGRSAPGYRRKRG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MIDDDGYRPNVGIVICNRQGQVLWARRYGQNSWQFPQGGINAGETAEQAMYRELFEEVGL
CCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
GRKDVKILASTRNWLRYKLPKRLVRWDTKPVCIGQKQRWFLLQLQCSEAEINMQRSNTPE
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEEECCCEEEECCCCCCC
FDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFSSVVMSLQESVAQGGRSAPGYRRKRG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA