Click here to switch to the map view.

The map label for this gene is pcm [H]

Identifier: 238921113

GI number: 238921113

Start: 3130736

End: 3131374

Strand: Reverse

Name: pcm [H]

Synonym: NT01EI_3252

Alternate gene names: 238921113

Gene position: 3131374-3130736 (Counterclockwise)

Preceding gene: 238921114

Following gene: 238921112

Centisome position: 82.14

GC content: 61.97

Gene sequence:

>639_bases
ATGGTAGATGTTGATCGCCGGGTTCTGCTGCTGATCCAGCAGCTGATGCGTCAGGGGATCCGCGATGAGGCGGTGCTGAA
AGCCATTGCTTCTGTGCCGCGCGAGCGCTTTATCGATGAGGCCATGTCCCATAAGGCTTATGACAACACCGCGCTGCCGA
TAGGGCTGGGGCAGACTATCTCTCAGCCCTATATGGTGGCGCGGATGACTGAGCTGCTGGCGTTGCAGGCGGCTTCCCGG
GTGTTGGAGATAGGCACTGGCACCGGCTATCAGACGGCGGTGCTGGCGCATCTGGTGCCTCACGTCTATTCGGTCGAGCG
GATCAAGAGCCTGCAATGGCAGGCTAAACGACGTCTCAAGCAGTTGGATTTACACAATGTATCGACCCGTCACGGCGATG
GATGGCTGGGCTGGGCGTCGCGCGGTCCCTTTGATGCCATTATCGTGACCGCAGCAGCACCGGAGATCCCGCCGGTGCTG
CTGGCTCAGCTGGCCGAAGGGGGGCGCTTGGTGCTGCCGGTCGGCGAGCAGTCCCAGCCTCAGTTTCTGCGGCGTATCCA
GCGGCGCGGCGGCGAATACCTGGTCGAATCGATCGAGCCGGTGCGCTTTGTCCCGCTGGTGAGCGGTGAGCTTGCTTGA

Upstream 100 bases:

>100_bases
GCTATATCTCCGTGACGCCACTGCAGGTGGATCTGACCGCCCACGGTGCGCGTGGCCGCCTGGCGGAGTGGCTGGGCCGG
GTGGATAAGGGCGGTGCGGC

Downstream 100 bases:

>100_bases
CGGGCAATGGCACACCTCGCTGTGCAGAAGAGTGCCATTGCCGTTATGCTGAACTACGATGGCCTGCGGCGGAGCGCGCC
GTAGACGTTTCTGTCGCAGC

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MVDVDRRVLLLIQQLMRQGIRDEAVLKAIASVPRERFIDEAMSHKAYDNTALPIGLGQTISQPYMVARMTELLALQAASR
VLEIGTGTGYQTAVLAHLVPHVYSVERIKSLQWQAKRRLKQLDLHNVSTRHGDGWLGWASRGPFDAIIVTAAAPEIPPVL
LAQLAEGGRLVLPVGEQSQPQFLRRIQRRGGEYLVESIEPVRFVPLVSGELA

Sequences:

>Translated_212_residues
MVDVDRRVLLLIQQLMRQGIRDEAVLKAIASVPRERFIDEAMSHKAYDNTALPIGLGQTISQPYMVARMTELLALQAASR
VLEIGTGTGYQTAVLAHLVPHVYSVERIKSLQWQAKRRLKQLDLHNVSTRHGDGWLGWASRGPFDAIIVTAAAPEIPPVL
LAQLAEGGRLVLPVGEQSQPQFLRRIQRRGGEYLVESIEPVRFVPLVSGELA
>Mature_212_residues
MVDVDRRVLLLIQQLMRQGIRDEAVLKAIASVPRERFIDEAMSHKAYDNTALPIGLGQTISQPYMVARMTELLALQAASR
VLEIGTGTGYQTAVLAHLVPHVYSVERIKSLQWQAKRRLKQLDLHNVSTRHGDGWLGWASRGPFDAIIVTAAAPEIPPVL
LAQLAEGGRLVLPVGEQSQPQFLRRIQRRGGEYLVESIEPVRFVPLVSGELA

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=212, Percent_Identity=32.0754716981132, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1789100, Length=209, Percent_Identity=72.2488038277512, Blast_Score=308, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71983477, Length=193, Percent_Identity=33.160621761658, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI193207222, Length=144, Percent_Identity=34.0277777777778, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17981723, Length=215, Percent_Identity=33.4883720930233, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 23528; Mature: 23528

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS01279 PCMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDVDRRVLLLIQQLMRQGIRDEAVLKAIASVPRERFIDEAMSHKAYDNTALPIGLGQTI
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCHH
SQPYMVARMTELLALQAASRVLEIGTGTGYQTAVLAHLVPHVYSVERIKSLQWQAKRRLK
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLDLHNVSTRHGDGWLGWASRGPFDAIIVTAAAPEIPPVLLAQLAEGGRLVLPVGEQSQP
HHHHHCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCCH
QFLRRIQRRGGEYLVESIEPVRFVPLVSGELA
HHHHHHHHCCHHHHHHCCCCEEEEECCCCCCC
>Mature Secondary Structure
MVDVDRRVLLLIQQLMRQGIRDEAVLKAIASVPRERFIDEAMSHKAYDNTALPIGLGQTI
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCHH
SQPYMVARMTELLALQAASRVLEIGTGTGYQTAVLAHLVPHVYSVERIKSLQWQAKRRLK
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLDLHNVSTRHGDGWLGWASRGPFDAIIVTAAAPEIPPVLLAQLAEGGRLVLPVGEQSQP
HHHHHCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCCH
QFLRRIQRRGGEYLVESIEPVRFVPLVSGELA
HHHHHHHHCCHHHHHHCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA