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The map label for this gene is hisI [H]

Identifier: 238920460

GI number: 238920460

Start: 2462670

End: 2463302

Strand: Direct

Name: hisI [H]

Synonym: NT01EI_2571

Alternate gene names: 238920460

Gene position: 2462670-2463302 (Clockwise)

Preceding gene: 238920459

Following gene: 238920461

Centisome position: 64.6

GC content: 59.72

Gene sequence:

>633_bases
GTGCTGACTCAAGGTTTTCTTTCGCAACAGCAAAAAGAGCGTCTGGACTGGAGCAAAGTGGACGATATGATGCCGGCGAT
CGTGCAGCACGCCGGCTCTGGCGATGTCCTGATGCTGGGCTATATGACGCCAGAGGCGCTGGATCAGACCGAGCGCTGCG
GTAAGGTCACCTTCTATTCCCGCACCAAACAGCGGCTATGGACCAAGGGCGAAAGCTCCGGCCACACCCTGAACGTGGTC
AGTATCACCCCGGACTGTGACCGCGATACGCTGCTGATTCTGGCCGATCCCCAGGGGCCGACCTGCCATCTCGGCAGCGA
CAGCTGCTTTGCCCCGGCCCGAGCACAATGGCCGTTCCTGTATCATTTGGAGCAACTGCTGGCCGCACGCAAAACGGCCG
ATCCACAAAGCTCGTATACCGCCCGGCTGTACGCCAGCGGCACCAAACGTATCGCCCAGAAGGTCGGCGAAGAGGGAGTG
GAAACGGCGCTGGCGGCCACCGTACATGACCGCAATGAGCTGATCAACGAATCCGCCGATCTGCTCTACCATCTACTGGT
ACTGTTACAGGATCAGCAGCTGTCACTGGGCGATGTCATCAGCTGTCTGCAAACCCGCCACCACCGGGCTTAA

Upstream 100 bases:

>100_bases
ACGTGGACGGCGCGCTGGCGGCCTCGGTATTTCATAAACAGATTATTCAAATCGGTGAACTCAAGCGCTATCTGGCGCTC
AACGGAGTGGAGATTCGATT

Downstream 100 bases:

>100_bases
CCCGACCATTGCCACCGCTCAGCGCGGTGGCACCTCTCCCGGCCCGCCGGAGTAGCCAAAGTGTGACCCACCTGTAGCAC
CGGGTTAATCCCGGCGTTCA

Product: histidine biosynthesis bifunctional protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MLTQGFLSQQQKERLDWSKVDDMMPAIVQHAGSGDVLMLGYMTPEALDQTERCGKVTFYSRTKQRLWTKGESSGHTLNVV
SITPDCDRDTLLILADPQGPTCHLGSDSCFAPARAQWPFLYHLEQLLAARKTADPQSSYTARLYASGTKRIAQKVGEEGV
ETALAATVHDRNELINESADLLYHLLVLLQDQQLSLGDVISCLQTRHHRA

Sequences:

>Translated_210_residues
MLTQGFLSQQQKERLDWSKVDDMMPAIVQHAGSGDVLMLGYMTPEALDQTERCGKVTFYSRTKQRLWTKGESSGHTLNVV
SITPDCDRDTLLILADPQGPTCHLGSDSCFAPARAQWPFLYHLEQLLAARKTADPQSSYTARLYASGTKRIAQKVGEEGV
ETALAATVHDRNELINESADLLYHLLVLLQDQQLSLGDVISCLQTRHHRA
>Mature_210_residues
MLTQGFLSQQQKERLDWSKVDDMMPAIVQHAGSGDVLMLGYMTPEALDQTERCGKVTFYSRTKQRLWTKGESSGHTLNVV
SITPDCDRDTLLILADPQGPTCHLGSDSCFAPARAQWPFLYHLEQLLAARKTADPQSSYTARLYASGTKRIAQKVGEEGV
ETALAATVHDRNELINESADLLYHLLVLLQDQQLSLGDVISCLQTRHHRA

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=203, Percent_Identity=72.4137931034483, Blast_Score=310, Evalue=6e-86,
Organism=Saccharomyces cerevisiae, GI6319819, Length=186, Percent_Identity=32.7956989247312, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23383; Mature: 23383

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTQGFLSQQQKERLDWSKVDDMMPAIVQHAGSGDVLMLGYMTPEALDQTERCGKVTFYS
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCEEEHH
RTKQRLWTKGESSGHTLNVVSITPDCDRDTLLILADPQGPTCHLGSDSCFAPARAQWPFL
HHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCHH
YHLEQLLAARKTADPQSSYTARLYASGTKRIAQKVGEEGVETALAATVHDRNELINESAD
HHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
LLYHLLVLLQDQQLSLGDVISCLQTRHHRA
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTQGFLSQQQKERLDWSKVDDMMPAIVQHAGSGDVLMLGYMTPEALDQTERCGKVTFYS
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCEEEHH
RTKQRLWTKGESSGHTLNVVSITPDCDRDTLLILADPQGPTCHLGSDSCFAPARAQWPFL
HHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCHH
YHLEQLLAARKTADPQSSYTARLYASGTKRIAQKVGEEGVETALAATVHDRNELINESAD
HHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
LLYHLLVLLQDQQLSLGDVISCLQTRHHRA
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9370271 [H]