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The map label for this gene is ltaE [H]

Identifier: 238920396

GI number: 238920396

Start: 2406345

End: 2407397

Strand: Direct

Name: ltaE [H]

Synonym: NT01EI_2506

Alternate gene names: 238920396

Gene position: 2406345-2407397 (Clockwise)

Preceding gene: 238920391

Following gene: 238920397

Centisome position: 63.12

GC content: 65.15

Gene sequence:

>1053_bases
ATGTTAGATCTGCGCAGCGATACCGTTACCCGCCCGAGCGAGGCTATGCGTCTGGCCATGTCACGCGCCGACGTCGGTGA
TGATGTCTACGGCGACGATCCCAGCGTCAACCGCCTGGAGCAGGAGGCCGCCGAGCTGAGCGGTAAAGCGGCGGCGCTGT
TTCTGCCCAGCGGCACCCAGGCCAATCTGGTGGCACTGCTGAGCCACTGCCAGCGCGGTGATGAGTATATCGTCGGGCAG
AAGGCCCATAACTACCTGTATGAGGCCGGTGGCGCGGCTGTGCTCGGCAGTATCCAGCCCCAGCCCATCGATGCCGCCGC
AGATGGCACCCTGCCCCTGGATAACGTGGCAGCGGTGATAAAACCGGACGACTTCCATTTTGCCCGCAGCCGTCTGCTCA
GTCTGGAAAACACCCATAACGGTAAGGTGCTGCCACTGGACTATCTGGCGCAGGCCTGGACATTCAGCCGTGAGAAGTGG
CTGGCGCTACACATCGACGGCGCCCGCATCATGAACGCAGCGGTGGCCCTTGACGTGCCGCTGACGGCCCTGACCCAATA
CTGCGATACCCTGACTGTCTGTCTGTCCAAGGGGCTTGGGGCACCGGTCGGCTCCCTCCTGTGCGCCGATGCCGAGTTTA
TTCAGCGTGCACGTCGCTGGCGCAAGATGACCGGTGGCGCCATGCGTCAGGCCGGTATTCTGGCGGAGGCCGGGCGCTAC
GCCCTGCGCCATAACGTCGAACGCCTGCGCGACGACCACGCCAACGCCGCCTGGCTGGCGCAGGCCGTGCAGGAGTTAGG
ATTGACGCTGCTGCCTCCCGGCGCCCAGACCAACATGCTGTTCGTTCGCATGCCTGCCGACGAGGCCGCCGCACTCGGCC
CCTGGATGCAGCGCCACGGCATCCTGATCAGCGCGGCAGCCACCACCCGCCTGGTGACACATCTGGATGTCAGCCGAGCC
GATCTGGAACGGTTGATCGCCCTGTGGCACACCTTCCGTCAGGCGTATCGTCCGGCGAACGGCGCGGTGCCGGCCCCAAC
CCCTTACGGCTAA

Upstream 100 bases:

>100_bases
CTCGTTGCGACTTTTTTCGCCGCTTTTTCTTTTGGCACTCTGCCGACAGCATGATACAACAGGAATTTCCCCATGGATTT
TGCCGACCAAGGAGTACCCC

Downstream 100 bases:

>100_bases
TTGATTCCCTGCGAGGTGTGCATGCGCGGATTGCGTATTCTGGTATTAGGCGCCAGCGGCTACATCGGCCAACATCTGAT
CCCCCAACTGTGCGCCCAGG

Product: L-threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MLDLRSDTVTRPSEAMRLAMSRADVGDDVYGDDPSVNRLEQEAAELSGKAAALFLPSGTQANLVALLSHCQRGDEYIVGQ
KAHNYLYEAGGAAVLGSIQPQPIDAAADGTLPLDNVAAVIKPDDFHFARSRLLSLENTHNGKVLPLDYLAQAWTFSREKW
LALHIDGARIMNAAVALDVPLTALTQYCDTLTVCLSKGLGAPVGSLLCADAEFIQRARRWRKMTGGAMRQAGILAEAGRY
ALRHNVERLRDDHANAAWLAQAVQELGLTLLPPGAQTNMLFVRMPADEAAALGPWMQRHGILISAAATTRLVTHLDVSRA
DLERLIALWHTFRQAYRPANGAVPAPTPYG

Sequences:

>Translated_350_residues
MLDLRSDTVTRPSEAMRLAMSRADVGDDVYGDDPSVNRLEQEAAELSGKAAALFLPSGTQANLVALLSHCQRGDEYIVGQ
KAHNYLYEAGGAAVLGSIQPQPIDAAADGTLPLDNVAAVIKPDDFHFARSRLLSLENTHNGKVLPLDYLAQAWTFSREKW
LALHIDGARIMNAAVALDVPLTALTQYCDTLTVCLSKGLGAPVGSLLCADAEFIQRARRWRKMTGGAMRQAGILAEAGRY
ALRHNVERLRDDHANAAWLAQAVQELGLTLLPPGAQTNMLFVRMPADEAAALGPWMQRHGILISAAATTRLVTHLDVSRA
DLERLIALWHTFRQAYRPANGAVPAPTPYG
>Mature_350_residues
MLDLRSDTVTRPSEAMRLAMSRADVGDDVYGDDPSVNRLEQEAAELSGKAAALFLPSGTQANLVALLSHCQRGDEYIVGQ
KAHNYLYEAGGAAVLGSIQPQPIDAAADGTLPLDNVAAVIKPDDFHFARSRLLSLENTHNGKVLPLDYLAQAWTFSREKW
LALHIDGARIMNAAVALDVPLTALTQYCDTLTVCLSKGLGAPVGSLLCADAEFIQRARRWRKMTGGAMRQAGILAEAGRY
ALRHNVERLRDDHANAAWLAQAVQELGLTLLPPGAQTNMLFVRMPADEAAALGPWMQRHGILISAAATTRLVTHLDVSRA
DLERLIALWHTFRQAYRPANGAVPAPTPYG

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=332, Percent_Identity=68.0722891566265, Blast_Score=463, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI193206522, Length=343, Percent_Identity=41.399416909621, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI193206520, Length=343, Percent_Identity=41.399416909621, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI193206524, Length=343, Percent_Identity=41.399416909621, Blast_Score=243, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6320789, Length=340, Percent_Identity=36.1764705882353, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI21355439, Length=298, Percent_Identity=43.6241610738255, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 37903; Mature: 37903

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLRSDTVTRPSEAMRLAMSRADVGDDVYGDDPSVNRLEQEAAELSGKAAALFLPSGTQ
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCC
ANLVALLSHCQRGDEYIVGQKAHNYLYEAGGAAVLGSIQPQPIDAAADGTLPLDNVAAVI
HHHHHHHHHHHCCCCEEECCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHCEEEE
KPDDFHFARSRLLSLENTHNGKVLPLDYLAQAWTFSREKWLALHIDGARIMNAAVALDVP
CCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCC
LTALTQYCDTLTVCLSKGLGAPVGSLLCADAEFIQRARRWRKMTGGAMRQAGILAEAGRY
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ALRHNVERLRDDHANAAWLAQAVQELGLTLLPPGAQTNMLFVRMPADEAAALGPWMQRHG
HHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCCEEEEEECCHHHHHHHHHHHHCC
ILISAAATTRLVTHLDVSRADLERLIALWHTFRQAYRPANGAVPAPTPYG
EEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDLRSDTVTRPSEAMRLAMSRADVGDDVYGDDPSVNRLEQEAAELSGKAAALFLPSGTQ
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCC
ANLVALLSHCQRGDEYIVGQKAHNYLYEAGGAAVLGSIQPQPIDAAADGTLPLDNVAAVI
HHHHHHHHHHHCCCCEEECCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHHCEEEE
KPDDFHFARSRLLSLENTHNGKVLPLDYLAQAWTFSREKWLALHIDGARIMNAAVALDVP
CCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCC
LTALTQYCDTLTVCLSKGLGAPVGSLLCADAEFIQRARRWRKMTGGAMRQAGILAEAGRY
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ALRHNVERLRDDHANAAWLAQAVQELGLTLLPPGAQTNMLFVRMPADEAAALGPWMQRHG
HHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCCCEEEEEECCHHHHHHHHHHHHCC
ILISAAATTRLVTHLDVSRADLERLIALWHTFRQAYRPANGAVPAPTPYG
EEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]