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The map label for this gene is dmsA [H]

Identifier: 238920367

GI number: 238920367

Start: 2367851

End: 2370298

Strand: Reverse

Name: dmsA [H]

Synonym: NT01EI_2477

Alternate gene names: 238920367

Gene position: 2370298-2367851 (Counterclockwise)

Preceding gene: 238920368

Following gene: 238920366

Centisome position: 62.17

GC content: 62.13

Gene sequence:

>2448_bases
ATGAAAAAAAACAGTCGGACGGCGTTACTGGATGCGTCGCTGAGTCGGCGGAGCGTGGTGAAAGGAGGGGCGATCGGCGG
ACTGGCAGCGGCCAGCGGCGCGCTGTCATTGCCCTTTGTCCGCCAGACTCAGGCCGCGCCAGCGCAGAATAAGCCGATGG
TGCAGGGTGAGAAGGTGATCTGGAGCGCCTGTACCGTTAACTGTGGCAGCCGTTGCCCGCTGCGGATGCACGTAGTCGAT
GGTGAAATCACCTATGCCGAAACCGATAATAGCGGCGACGATCGCTACGAGGGGCTGCATCAGGTGCGCGCCTGCCTGCG
CGGCCGTTCGATGCGTCGCCGGGTCTACAACGCCGATCGTTTAAAATATCCGATGAAGCGGGTCGGCAAGCGCGGCGAGG
GAAAATTTAAGCGCATCACCTGGGAAGAGGCGTTCGACACTGTCGCCGTCAGCATGAAGGAGATCATCAAGACCTACGGT
AACGAGGCCATTTACCTGAACTATGGCACCGGGACGCTGGGCGGCACCCTGACCCGATCATGGCCGCCGGGGGCGACGCT
GCTCGCCCGGCTGATGAACTGCTGCGGTGGTTATCTCAACCACTATGGCGACTACAGCACCGCGCAAATCGCCGCCGGAT
TGAACTACACCTATGGCGGCTGGGCCGACGGCAACAGTCCGTCGGACATTGAAAACAGCCAGCTGGTGGTGATGTTCGGT
AATAATCCGGGCGAAACCCGGATGAGCGGCGGCGGCGTGACCTACTATGTGGAGCAGGCGCGCGCCAAGTCCAATGCGAA
AATGATCATTATTGACCCGCGCTACACCGACACCGGCGCCGGGCGTGAGGATGAGTGGATCCCGATCCGTCCCGGTACCG
ATGCGGCGCTGGCGGCGGGACTGGCCCATGTGCTGATCACCGAGGCGATGGTCGATCAGCCATTCCTGGATCGCTACTGT
GTCGGTTATGACGAGCGTACCCTGCCCGCGGGCGCACCGGCCAACGGCCACTATAAGGCCTATATTCTGGGCCAGGGGCC
GGATAAAACCGCCAAGACACCGGCCTGGGCGGCGGCGATCACCGGGATCCCGCAGGATAAGATCATCAAGCTGGCGCGGG
AGATCGGTCGCGCCAAACCGGCCTATATCTGCCAGGGCTGGGGGCCGCAGCGTCACGCCAACGGTGAGCTGACGTCGCGC
GCCATCGCCATGCTGCCGATCCTGACCGGCAACGTGGGAATCAACGGGGGCAACAGTGGCGCCCGCGAAGGCTCCTACAG
CCTGCCGTTTGTGCGGATGCCGACGCTGGAGAACCCGGTGAAGACCAGCATCTCGATGTTCCTGTGGACCGATGCCATCG
TGCGGGGGGCGGAGATGACGGCTACGCGTGACGGGGTGCGCGGCAAGGAGAAGCTGGATGTCCCGATCAAGATGATCTGG
AACTACGCCGGTAACTGCTTAATTAACCAGCATTCAGAGGTCAACCGTACCCACGAAATCCTGCAGGATGACAGTAAGTG
CGAGATGATTGTGGTGATCGATAACCATATGACCGCCTCGGCCAAGTATGCCGATATCCTGCTGCCGGACTGCACCGCCT
CCGAGCAGATGGACTTCTGCCTGGATGCCTCCTGCGGCAATATGAGCTATGTGATCTTTGCCGACCAGGTCATTGCGCCG
CGCTTCGAATGCCGCACCATCTATGACATGACCAGTGAGATCGCCAAGCGAATGGGCGTCGGCCAGCAGTTTACCGAGGG
ACGCAGCCAAGAAGAGTGGCTACGCCACCTGTACGCCCAGTCGCAGCAGGCGATCCCGGGGCTGCCGTCGTTTGAGGCGT
TCCGCAGCCAGGGGATCTACAAGCAGCGAGATCCGCAGGGACACCACGTGGCCTACCGCGACTTCCGCACCGATCCAAAG
ACGTATCCCCTGAGCACGCCGTCGGGCAAAATCGAGATCTACTCCGCCGCGCTGGCCGAGATCGCCGCCACCTGGCAGCT
GGGGCCGGACGACGTCATCGATCCGCTGCCGATCTACAGCCCCGGATTTGAAAGCTATCAAGATCCGCTGATCGCCAGGT
TCCCACTGCAGCTGAGCGGTTTTCACTATAAGGCGCGCACCCACTCCACCTATGGCAACGTGGACGTGCTGAAGGCGGCT
TGTCCCCAGGAGATGTGGATCAATCCGCTGGATGCCGCTCCGCGCGGTATCGCCCAGGGCGATCTGGTGCGGATCTACAA
CGATCGCGGCGAGGTGCGCATCAGCGCCAAGGTGACGCCGCGCGTGCTGCCCGGTGTTGTGGCGCTGAGCGAAGGGGCCT
GGTATAGCCCGGACGGCGAGCGGGTCGACTACGGCGGCTGTATTAACGTCCTGACGACTCAGCGCCCGTCGCCGCTGGCC
AAGGGGAATCCGTCACACACCAATCTGGTACAGGTTGCCAAGGCCTAA

Upstream 100 bases:

>100_bases
TGGAGCCTATTACCTCTTTTCTGCTTTTTTGAGTATGCCGCTATTTCCAGTAGGGAAAGTGGTATTAACCAGTAGAAAGC
AAAATAAAAGTGAGCATGCT

Downstream 100 bases:

>100_bases
GGAGTCGCTGATGACAACGCAATACGGTTTTTATATCGACTCCAGCCGCTGCACCGGGTGTAAGACCTGCGAGCTGGCCT
GTAAGGATTACAAGGATCTG

Product: anaerobic dimethyl sulfoxide reductase chain A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 815; Mature: 815

Protein sequence:

>815_residues
MKKNSRTALLDASLSRRSVVKGGAIGGLAAASGALSLPFVRQTQAAPAQNKPMVQGEKVIWSACTVNCGSRCPLRMHVVD
GEITYAETDNSGDDRYEGLHQVRACLRGRSMRRRVYNADRLKYPMKRVGKRGEGKFKRITWEEAFDTVAVSMKEIIKTYG
NEAIYLNYGTGTLGGTLTRSWPPGATLLARLMNCCGGYLNHYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSQLVVMFG
NNPGETRMSGGGVTYYVEQARAKSNAKMIIIDPRYTDTGAGREDEWIPIRPGTDAALAAGLAHVLITEAMVDQPFLDRYC
VGYDERTLPAGAPANGHYKAYILGQGPDKTAKTPAWAAAITGIPQDKIIKLAREIGRAKPAYICQGWGPQRHANGELTSR
AIAMLPILTGNVGINGGNSGAREGSYSLPFVRMPTLENPVKTSISMFLWTDAIVRGAEMTATRDGVRGKEKLDVPIKMIW
NYAGNCLINQHSEVNRTHEILQDDSKCEMIVVIDNHMTASAKYADILLPDCTASEQMDFCLDASCGNMSYVIFADQVIAP
RFECRTIYDMTSEIAKRMGVGQQFTEGRSQEEWLRHLYAQSQQAIPGLPSFEAFRSQGIYKQRDPQGHHVAYRDFRTDPK
TYPLSTPSGKIEIYSAALAEIAATWQLGPDDVIDPLPIYSPGFESYQDPLIARFPLQLSGFHYKARTHSTYGNVDVLKAA
CPQEMWINPLDAAPRGIAQGDLVRIYNDRGEVRISAKVTPRVLPGVVALSEGAWYSPDGERVDYGGCINVLTTQRPSPLA
KGNPSHTNLVQVAKA

Sequences:

>Translated_815_residues
MKKNSRTALLDASLSRRSVVKGGAIGGLAAASGALSLPFVRQTQAAPAQNKPMVQGEKVIWSACTVNCGSRCPLRMHVVD
GEITYAETDNSGDDRYEGLHQVRACLRGRSMRRRVYNADRLKYPMKRVGKRGEGKFKRITWEEAFDTVAVSMKEIIKTYG
NEAIYLNYGTGTLGGTLTRSWPPGATLLARLMNCCGGYLNHYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSQLVVMFG
NNPGETRMSGGGVTYYVEQARAKSNAKMIIIDPRYTDTGAGREDEWIPIRPGTDAALAAGLAHVLITEAMVDQPFLDRYC
VGYDERTLPAGAPANGHYKAYILGQGPDKTAKTPAWAAAITGIPQDKIIKLAREIGRAKPAYICQGWGPQRHANGELTSR
AIAMLPILTGNVGINGGNSGAREGSYSLPFVRMPTLENPVKTSISMFLWTDAIVRGAEMTATRDGVRGKEKLDVPIKMIW
NYAGNCLINQHSEVNRTHEILQDDSKCEMIVVIDNHMTASAKYADILLPDCTASEQMDFCLDASCGNMSYVIFADQVIAP
RFECRTIYDMTSEIAKRMGVGQQFTEGRSQEEWLRHLYAQSQQAIPGLPSFEAFRSQGIYKQRDPQGHHVAYRDFRTDPK
TYPLSTPSGKIEIYSAALAEIAATWQLGPDDVIDPLPIYSPGFESYQDPLIARFPLQLSGFHYKARTHSTYGNVDVLKAA
CPQEMWINPLDAAPRGIAQGDLVRIYNDRGEVRISAKVTPRVLPGVVALSEGAWYSPDGERVDYGGCINVLTTQRPSPLA
KGNPSHTNLVQVAKA
>Mature_815_residues
MKKNSRTALLDASLSRRSVVKGGAIGGLAAASGALSLPFVRQTQAAPAQNKPMVQGEKVIWSACTVNCGSRCPLRMHVVD
GEITYAETDNSGDDRYEGLHQVRACLRGRSMRRRVYNADRLKYPMKRVGKRGEGKFKRITWEEAFDTVAVSMKEIIKTYG
NEAIYLNYGTGTLGGTLTRSWPPGATLLARLMNCCGGYLNHYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSQLVVMFG
NNPGETRMSGGGVTYYVEQARAKSNAKMIIIDPRYTDTGAGREDEWIPIRPGTDAALAAGLAHVLITEAMVDQPFLDRYC
VGYDERTLPAGAPANGHYKAYILGQGPDKTAKTPAWAAAITGIPQDKIIKLAREIGRAKPAYICQGWGPQRHANGELTSR
AIAMLPILTGNVGINGGNSGAREGSYSLPFVRMPTLENPVKTSISMFLWTDAIVRGAEMTATRDGVRGKEKLDVPIKMIW
NYAGNCLINQHSEVNRTHEILQDDSKCEMIVVIDNHMTASAKYADILLPDCTASEQMDFCLDASCGNMSYVIFADQVIAP
RFECRTIYDMTSEIAKRMGVGQQFTEGRSQEEWLRHLYAQSQQAIPGLPSFEAFRSQGIYKQRDPQGHHVAYRDFRTDPK
TYPLSTPSGKIEIYSAALAEIAATWQLGPDDVIDPLPIYSPGFESYQDPLIARFPLQLSGFHYKARTHSTYGNVDVLKAA
CPQEMWINPLDAAPRGIAQGDLVRIYNDRGEVRISAKVTPRVLPGVVALSEGAWYSPDGERVDYGGCINVLTTQRPSPLA
KGNPSHTNLVQVAKA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=814, Percent_Identity=80.958230958231, Blast_Score=1385, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=818, Percent_Identity=66.5036674816626, Blast_Score=1146, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=818, Percent_Identity=64.6699266503667, Blast_Score=1109, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=761, Percent_Identity=31.1432325886991, Blast_Score=295, Evalue=8e-81,
Organism=Escherichia coli, GI87081994, Length=855, Percent_Identity=30.9941520467836, Blast_Score=286, Evalue=4e-78,
Organism=Escherichia coli, GI145693196, Length=754, Percent_Identity=31.2997347480106, Blast_Score=278, Evalue=1e-75,
Organism=Escherichia coli, GI3868721, Length=772, Percent_Identity=25.1295336787565, Blast_Score=144, Evalue=3e-35,
Organism=Escherichia coli, GI3868720, Length=467, Percent_Identity=26.7665952890792, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI1787741, Length=309, Percent_Identity=26.8608414239482, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787477, Length=309, Percent_Identity=27.1844660194175, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI3868719, Length=471, Percent_Identity=24.416135881104, Blast_Score=90, Evalue=8e-19,
Organism=Escherichia coli, GI1788534, Length=433, Percent_Identity=23.5565819861432, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 89285; Mature: 89285

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNSRTALLDASLSRRSVVKGGAIGGLAAASGALSLPFVRQTQAAPAQNKPMVQGEKVI
CCCCCCEEEEECCCCHHHHHCCCCCCCHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCEEE
WSACTVNCGSRCPLRMHVVDGEITYAETDNSGDDRYEGLHQVRACLRGRSMRRRVYNADR
EEEEECCCCCCCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCHH
LKYPMKRVGKRGEGKFKRITWEEAFDTVAVSMKEIIKTYGNEAIYLNYGTGTLGGTLTRS
HHCHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
WPPGATLLARLMNCCGGYLNHYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSQLVVMFG
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
NNPGETRMSGGGVTYYVEQARAKSNAKMIIIDPRYTDTGAGREDEWIPIRPGTDAALAAG
CCCCCCEECCCCEEEEEEEHHCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHH
LAHVLITEAMVDQPFLDRYCVGYDERTLPAGAPANGHYKAYILGQGPDKTAKTPAWAAAI
HHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHH
TGIPQDKIIKLAREIGRAKPAYICQGWGPQRHANGELTSRAIAMLPILTGNVGINGGNSG
CCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHEEEEEEEECCEECCCCCCC
AREGSYSLPFVRMPTLENPVKTSISMFLWTDAIVRGAEMTATRDGVRGKEKLDVPIKMIW
CCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCHHEECCCCCCCCHHCCCHHHHHH
NYAGNCLINQHSEVNRTHEILQDDSKCEMIVVIDNHMTASAKYADILLPDCTASEQMDFC
CCCCCEEEECCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCEE
LDASCGNMSYVIFADQVIAPRFECRTIYDMTSEIAKRMGVGQQFTEGRSQEEWLRHLYAQ
EECCCCCEEEEEEECCHHCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHC
SQQAIPGLPSFEAFRSQGIYKQRDPQGHHVAYRDFRTDPKTYPLSTPSGKIEIYSAALAE
CCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHH
IAATWQLGPDDVIDPLPIYSPGFESYQDPLIARFPLQLSGFHYKARTHSTYGNVDVLKAA
HHHHCCCCCHHCCCCCCCCCCCCHHHCCCEEEECCCEECCEEEEEECCCCCCCCHHHHHC
CPQEMWINPLDAAPRGIAQGDLVRIYNDRGEVRISAKVTPRVLPGVVALSEGAWYSPDGE
CCHHHCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEEECCCCEECCCCC
RVDYGGCINVLTTQRPSPLAKGNPSHTNLVQVAKA
EECCCCEEEEEECCCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MKKNSRTALLDASLSRRSVVKGGAIGGLAAASGALSLPFVRQTQAAPAQNKPMVQGEKVI
CCCCCCEEEEECCCCHHHHHCCCCCCCHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCEEE
WSACTVNCGSRCPLRMHVVDGEITYAETDNSGDDRYEGLHQVRACLRGRSMRRRVYNADR
EEEEECCCCCCCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCHH
LKYPMKRVGKRGEGKFKRITWEEAFDTVAVSMKEIIKTYGNEAIYLNYGTGTLGGTLTRS
HHCHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
WPPGATLLARLMNCCGGYLNHYGDYSTAQIAAGLNYTYGGWADGNSPSDIENSQLVVMFG
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
NNPGETRMSGGGVTYYVEQARAKSNAKMIIIDPRYTDTGAGREDEWIPIRPGTDAALAAG
CCCCCCEECCCCEEEEEEEHHCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHH
LAHVLITEAMVDQPFLDRYCVGYDERTLPAGAPANGHYKAYILGQGPDKTAKTPAWAAAI
HHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHH
TGIPQDKIIKLAREIGRAKPAYICQGWGPQRHANGELTSRAIAMLPILTGNVGINGGNSG
CCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHEEEEEEEECCEECCCCCCC
AREGSYSLPFVRMPTLENPVKTSISMFLWTDAIVRGAEMTATRDGVRGKEKLDVPIKMIW
CCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCHHEECCCCCCCCHHCCCHHHHHH
NYAGNCLINQHSEVNRTHEILQDDSKCEMIVVIDNHMTASAKYADILLPDCTASEQMDFC
CCCCCEEEECCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCEE
LDASCGNMSYVIFADQVIAPRFECRTIYDMTSEIAKRMGVGQQFTEGRSQEEWLRHLYAQ
EECCCCCEEEEEEECCHHCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHC
SQQAIPGLPSFEAFRSQGIYKQRDPQGHHVAYRDFRTDPKTYPLSTPSGKIEIYSAALAE
CCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHH
IAATWQLGPDDVIDPLPIYSPGFESYQDPLIARFPLQLSGFHYKARTHSTYGNVDVLKAA
HHHHCCCCCHHCCCCCCCCCCCCHHHCCCEEEECCCEECCEEEEEECCCCCCCCHHHHHC
CPQEMWINPLDAAPRGIAQGDLVRIYNDRGEVRISAKVTPRVLPGVVALSEGAWYSPDGE
CCHHHCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEEECCCCEECCCCC
RVDYGGCINVLTTQRPSPLAKGNPSHTNLVQVAKA
EECCCCEEEEEECCCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]