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The map label for this gene is ribA [H]

Identifier: 238920244

GI number: 238920244

Start: 2247533

End: 2248123

Strand: Direct

Name: ribA [H]

Synonym: NT01EI_2353

Alternate gene names: 238920244

Gene position: 2247533-2248123 (Clockwise)

Preceding gene: 238920238

Following gene: 238920248

Centisome position: 58.95

GC content: 55.5

Gene sequence:

>591_bases
ATGCAGCTTAAACGAGTGGCAGAGGCAAAACTGCCGACGCCATGGGGCGATTTTTTAATGGTCGGCTTTGAAGAGATTGC
CACCGGCCACGATCATCTGGCTTTAGTTTATGGAGATATCCGCGGCGAAAAACCGGTGCTGGCGCGTGTTCACTCCGAGT
GTCTGACCGGCGATGCGCTGTTCAGCCTGCGCTGTGACTGTGGCTTTCAACTCGAAGCCGCACTAGAGCATATCGCCGAA
GAGGGGCGCGGTATTCTGCTGTACCATCGCCAAGAGGGGCGTAACATTGGTCTGCTGAATAAAATCCGTGCCTATGCTCT
GCAGGATCAGGGTGCCGACACCGTCGAAGCCAATCATCAGCTGGGTTTTGCCACCGACGAGCGTGACTTTACCCTGTGTG
CCGATATGTTCAAGCTGCTGGACATCAGCCAGATCCGGCTGCTGACCAATAACCCCAACAAGGTCGATATTCTTACCCAG
GCGGGGATCAATATCGTCGAACGCGTTCCGCTGATCGTCGGACGTAACCCGAAGAACGAACGCTACCTGGCAACCAAAGC
CGCCAAAATGGGCCACCTGCTGAACGGCTGA

Upstream 100 bases:

>100_bases
CACGCACTCCGTTAGCGTCACTGTGTTATCTACATCCACAGTGCGCACCGAAAGGTGACGCTGTCACGATGACAAAAATG
ATATGGTTGTGGAGATAAAC

Downstream 100 bases:

>100_bases
GCACGGTCGGGGGCGGCCCTCTGCCGCCCCCAGTGTCCCCATGTTGAGATCGCACGCCCGCCTCACCGACCGGGCGTGCC
CGCTTAGAAACGATAGCGCA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MQLKRVAEAKLPTPWGDFLMVGFEEIATGHDHLALVYGDIRGEKPVLARVHSECLTGDALFSLRCDCGFQLEAALEHIAE
EGRGILLYHRQEGRNIGLLNKIRAYALQDQGADTVEANHQLGFATDERDFTLCADMFKLLDISQIRLLTNNPNKVDILTQ
AGINIVERVPLIVGRNPKNERYLATKAAKMGHLLNG

Sequences:

>Translated_196_residues
MQLKRVAEAKLPTPWGDFLMVGFEEIATGHDHLALVYGDIRGEKPVLARVHSECLTGDALFSLRCDCGFQLEAALEHIAE
EGRGILLYHRQEGRNIGLLNKIRAYALQDQGADTVEANHQLGFATDERDFTLCADMFKLLDISQIRLLTNNPNKVDILTQ
AGINIVERVPLIVGRNPKNERYLATKAAKMGHLLNG
>Mature_196_residues
MQLKRVAEAKLPTPWGDFLMVGFEEIATGHDHLALVYGDIRGEKPVLARVHSECLTGDALFSLRCDCGFQLEAALEHIAE
EGRGILLYHRQEGRNIGLLNKIRAYALQDQGADTVEANHQLGFATDERDFTLCADMFKLLDISQIRLLTNNPNKVDILTQ
AGINIVERVPLIVGRNPKNERYLATKAAKMGHLLNG

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=195, Percent_Identity=89.2307692307692, Blast_Score=363, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319438, Length=195, Percent_Identity=42.0512820512821, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 21802; Mature: 21802

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKRVAEAKLPTPWGDFLMVGFEEIATGHDHLALVYGDIRGEKPVLARVHSECLTGDAL
CCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCE
FSLRCDCGFQLEAALEHIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGADTVEANHQ
EEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEECCCC
LGFATDERDFTLCADMFKLLDISQIRLLTNNPNKVDILTQAGINIVERVPLIVGRNPKNE
CCCCCCCCCHHHHHHHHHHHCHHEEEEEECCCCEEEEEECCCCHHHHHCCEEECCCCCCC
RYLATKAAKMGHLLNG
CEEHHHHHHHHHCCCC
>Mature Secondary Structure
MQLKRVAEAKLPTPWGDFLMVGFEEIATGHDHLALVYGDIRGEKPVLARVHSECLTGDAL
CCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCE
FSLRCDCGFQLEAALEHIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGADTVEANHQ
EEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEECCCC
LGFATDERDFTLCADMFKLLDISQIRLLTNNPNKVDILTQAGINIVERVPLIVGRNPKNE
CCCCCCCCCHHHHHHHHHHHCHHEEEEEECCCCEEEEEECCCCHHHHHCCEEECCCCCCC
RYLATKAAKMGHLLNG
CEEHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA