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The map label for this gene is phoP [H]

Identifier: 238920215

GI number: 238920215

Start: 2222304

End: 2222978

Strand: Direct

Name: phoP [H]

Synonym: NT01EI_2324

Alternate gene names: 238920215

Gene position: 2222304-2222978 (Clockwise)

Preceding gene: 238920213

Following gene: 238920216

Centisome position: 58.29

GC content: 59.7

Gene sequence:

>675_bases
ATGCGTATCTTAGTCGTCGAAGACAATAATCTGCTACGCCATCACCTGTCGGTACAGATACGTGAGCTGGGCCACCAGGT
CGATGCCGCGGAAAACGCCAAAGAGGCGGACTTTTTCGTGCGCGAACAGGGCCCTGATATCGCGATCGTCGACCTCGGGC
TGCCGGGGGAAGACGGTATGAGCATGATCCGCCGCTGGCGTAGCGAGCAGATAACCCTGCCCATTCTGGTGCTCACCGCC
CGGGAAAGCTGGCAGGAAAAGGTAGCAGCACTGGAGGCGGGCGCCGATGACTATGTCACCAAGCCCTTCCATTTAGAAGA
GGTGCTGGCACGCATGCAGGCCCTGATGCGCCGCAACAGCGGTCTGGCCTCGCAGATCATCAGCATGCCCCCGTTCCAGG
CTGATCTCTCTCGCCGTGAGCTGCGGGTCAACGAGACGCTGATCAAACTTACCGCCTTTGAGTACACCATCATGGAGACC
CTGATCCGCAACAGCGGCAAGGTGGTCAGCAAAGATGCCCTGATGCTGCAGCTCTATCCCGACGCCGAGCTGCGTGAAAG
CCACACTATCGACGTACTGATGGGGCGCCTGCGCAAAAAGCTGCAGAGTGAATACCCGGCCGATGTCATCACCACCGTAC
GCGGTCAGGGCTACCGCTTCGACGTGCCGGCATGA

Upstream 100 bases:

>100_bases
GGCATCATTTGCATGGACGCTACCCAGACTTTCCGCTAGGGTGAAACAGTGGATCCGGCGAAGGGCCGGTAACCTGATTC
GGGAGTGAAAGAACCTAGAC

Downstream 100 bases:

>100_bases
TGCTACAGCGCTGGCAGGCATGGAAAGCCCGCCCCTTATCGCTGCGCACCCGCTTTATGCTGGCTACCGCCGCGATGGTG
TTCCTGCTCTCGCTGGCCTA

Product: DNA-binding transcriptional regulator PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRILVVEDNNLLRHHLSVQIRELGHQVDAAENAKEADFFVREQGPDIAIVDLGLPGEDGMSMIRRWRSEQITLPILVLTA
RESWQEKVAALEAGADDYVTKPFHLEEVLARMQALMRRNSGLASQIISMPPFQADLSRRELRVNETLIKLTAFEYTIMET
LIRNSGKVVSKDALMLQLYPDAELRESHTIDVLMGRLRKKLQSEYPADVITTVRGQGYRFDVPA

Sequences:

>Translated_224_residues
MRILVVEDNNLLRHHLSVQIRELGHQVDAAENAKEADFFVREQGPDIAIVDLGLPGEDGMSMIRRWRSEQITLPILVLTA
RESWQEKVAALEAGADDYVTKPFHLEEVLARMQALMRRNSGLASQIISMPPFQADLSRRELRVNETLIKLTAFEYTIMET
LIRNSGKVVSKDALMLQLYPDAELRESHTIDVLMGRLRKKLQSEYPADVITTVRGQGYRFDVPA
>Mature_224_residues
MRILVVEDNNLLRHHLSVQIRELGHQVDAAENAKEADFFVREQGPDIAIVDLGLPGEDGMSMIRRWRSEQITLPILVLTA
RESWQEKVAALEAGADDYVTKPFHLEEVLARMQALMRRNSGLASQIISMPPFQADLSRRELRVNETLIKLTAFEYTIMET
LIRNSGKVVSKDALMLQLYPDAELRESHTIDVLMGRLRKKLQSEYPADVITTVRGQGYRFDVPA

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=79.7297297297297, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=36.697247706422, Blast_Score=133, Evalue=7e-33,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=34.2222222222222, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=34.6846846846847, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=33.9449541284404, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=35.5263157894737, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=33.7837837837838, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=29.0909090909091, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=32.8767123287671, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=32.3008849557522, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=30.1310043668122, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=31.1111111111111, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=27.7056277056277, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI2367329, Length=176, Percent_Identity=30.1136363636364, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI145693157, Length=108, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=28.7037037037037, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25497; Mature: 25497

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVEDNNLLRHHLSVQIRELGHQVDAAENAKEADFFVREQGPDIAIVDLGLPGEDGM
CEEEEEECCCHHHHHHHHHHHHHCCHHCCCCCCCHHHEEEECCCCCEEEEEECCCCHHHH
SMIRRWRSEQITLPILVLTARESWQEKVAALEAGADDYVTKPFHLEEVLARMQALMRRNS
HHHHHHCCCCCEEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLASQIISMPPFQADLSRRELRVNETLIKLTAFEYTIMETLIRNSGKVVSKDALMLQLYP
CHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEEECC
DAELRESHTIDVLMGRLRKKLQSEYPADVITTVRGQGYRFDVPA
CCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEECCCC
>Mature Secondary Structure
MRILVVEDNNLLRHHLSVQIRELGHQVDAAENAKEADFFVREQGPDIAIVDLGLPGEDGM
CEEEEEECCCHHHHHHHHHHHHHCCHHCCCCCCCHHHEEEECCCCCEEEEEECCCCHHHH
SMIRRWRSEQITLPILVLTARESWQEKVAALEAGADDYVTKPFHLEEVLARMQALMRRNS
HHHHHHCCCCCEEEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLASQIISMPPFQADLSRRELRVNETLIKLTAFEYTIMETLIRNSGKVVSKDALMLQLYP
CHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEEECC
DAELRESHTIDVLMGRLRKKLQSEYPADVITTVRGQGYRFDVPA
CCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA