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The map label for this gene is cyoB [H]

Identifier: 238920120

GI number: 238920120

Start: 2139105

End: 2141096

Strand: Reverse

Name: cyoB [H]

Synonym: NT01EI_2226

Alternate gene names: 238920120

Gene position: 2141096-2139105 (Counterclockwise)

Preceding gene: 238920121

Following gene: 238920119

Centisome position: 56.16

GC content: 52.61

Gene sequence:

>1992_bases
ATGTTGGGAAAATTAACACTTGATGCGGTTCCGTACCATGAGCCGATCATCATGGTCGCTGTTGCTGGAATGCTTGTTGG
GGGGCTGGTGATCCTGGCGCTACTGACCTATTTTGGCAAATGGACGTGGCTGTGGCGCGAATGGTTGACATCGGTCGATC
ATAAGAGAATTGGTATCATGTATATCATCGTGGCGATGGTCATGTTGCTACGCGGCTTCGCCGACGCCATCATGATGCGC
GGTCAGCAGGCGTTGGCGTCCGCCGGTGAAGCCGGATTCCTGCCACCGCATCACTACGACCAAGTCTTTAGTGCGCACGG
CGTGATCATGATCTTCTTCATGGCGATGCCGATGGTCGTCGGCCTGATGAACGTCGTGGTACCGCTGCAAATTGGTGCGC
GTGACGTTGCATTCCCGTTCCTGAATTCACTGAGTTTTTGGCTCTTCGTGGTCGGTGTGGTATTGATCAACCTCTCTCTG
GGGGTCGGTGAGTTTGCGCAGACCGGTTGGCTGGCCTATCCGCCGCTGTCAGGTAAGGAGTTCAGTCCTGGTGTCGGCGT
TGATTACTGGATCTGGAGTCTACAAATTTCCGGTCTGGGCACACTGTTGACCGGTGTGAACTTTATCACCACCATCCTGA
AGATGCGCGCCCCTGGCATGTCTTTGATGAAAATGCCGGTATTCACCTGGACGGCGCTGTGTTCTAATATTTTGATCACC
GTTGCATTCCCTATTCTGACTGTCACTATCGCGCTACTGACCCTGGATCGTTATCTGGGTACCCATTTCTTCACCAATGA
GATGGGTGGCAATATGATGATGTACATCAACCTGATTTGGGCCTGGGGTCACCCAGAGGTGTATATCCTGGTTCTGCCGG
TATTCGGCGTATTTTCCGAAGTCACCGCCACTTTCTCTAAAAAACGACTCTTCGGCTATACCTCACTGGTATGGGCAACC
ATCGTGATCACCGTCCTGTCGTTTATCGTATGGCTACACCACTTCTTCACCATGGGTGCCGGCGCGAACGTTAACGCTTT
CTTCGGTATCGCCACCATGATCATTTCCATCCCGACCGGGGTGAAAATTTTCAACTGGCTTTTCACCATGTACCGGGGGC
GTATCCAGTTCAACACGGCGATGCTGTGGACCATTGGTTTTATCGTTACCTTCACCGTGGGGGGAATGACCGGCGTTCTG
CTGGCGGTACCGGGCGCAAACTTCGTGCTGCACAACAGCCTGTTCCTGATCGCACACTTCCATAACGTCATCATCGGTGG
TGTGGTGTTTGGTTGCTTTGCGGCCGTAAACTACTGGTTCCCGAAATCCTTCGGTTTCACGTTGAATGAAAAATGGGGCA
TTCGCGCCTTCTGGTTCTGGCTGATCGGCTTCTTCATCGCCTTTATGCCGCTATACGTATTGGGCTTTATGGGTATGACC
CGTCGTATCAGCCAGGACATCAACGCTGAGTTCCATCCGTTGCTGTTGGTCGCCGCCGGCGGTGCAGCACTGATTGCCTG
TGGTGTCTTGTGCCAGATAATCCAGATCGTCGTCAGCGTGCGCGACCGCGAACAGAATCGCGATCTGACCGGTGATCCGT
GGGACGCACGTACTTTGGAGTGGTCTACGTCGTCTCCACCACCGTTCTATAACTTTGCCATCGTCCCGCAAATCCATGAT
CGTGATGAATTTTGGGAGATGAAGGAAAGAGGTGACGCCTATAAAAAACCGGCACACTACGAACCGATTCATATGCCTAA
GAATACCGGCGCCGGCGTTATCATCGCCTGCTTCAGTTTGATATTCGGTTTCGCAATGATTTGGGAAATCTGGTGGATGG
CGCTGGTTGGCTTTATCGGTATCCTCGTTGTCTGGATCGGCAAGAGCTTCGATCACGATGTTGACTACTTTGTGCCGGTT
GATGAGATCGCGCGCATCGAGAACCAACACCACGAACAAATCCGTAACGCAGGCGTGAAACATGTCAACTGA

Upstream 100 bases:

>100_bases
GACGATGCACAATGGCGCTGGTGCGCACAAAGGCATGGACATGAACCAAGGTATGGACATGAGTGAACACACTGGTCACG
TCGGATCCGAGGAATAATTG

Downstream 100 bases:

>100_bases
AACTCTGACCCATCAGAATACAGCCCATGCAGAGCATGGACACCATGACGCAGGAGAGACCAAGGTCTTCGGATTCTGGA
TCTACCTGATGAGCGACTGC

Product: cytochrome o ubiquinol oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MLGKLTLDAVPYHEPIIMVAVAGMLVGGLVILALLTYFGKWTWLWREWLTSVDHKRIGIMYIIVAMVMLLRGFADAIMMR
GQQALASAGEAGFLPPHHYDQVFSAHGVIMIFFMAMPMVVGLMNVVVPLQIGARDVAFPFLNSLSFWLFVVGVVLINLSL
GVGEFAQTGWLAYPPLSGKEFSPGVGVDYWIWSLQISGLGTLLTGVNFITTILKMRAPGMSLMKMPVFTWTALCSNILIT
VAFPILTVTIALLTLDRYLGTHFFTNEMGGNMMMYINLIWAWGHPEVYILVLPVFGVFSEVTATFSKKRLFGYTSLVWAT
IVITVLSFIVWLHHFFTMGAGANVNAFFGIATMIISIPTGVKIFNWLFTMYRGRIQFNTAMLWTIGFIVTFTVGGMTGVL
LAVPGANFVLHNSLFLIAHFHNVIIGGVVFGCFAAVNYWFPKSFGFTLNEKWGIRAFWFWLIGFFIAFMPLYVLGFMGMT
RRISQDINAEFHPLLLVAAGGAALIACGVLCQIIQIVVSVRDREQNRDLTGDPWDARTLEWSTSSPPPFYNFAIVPQIHD
RDEFWEMKERGDAYKKPAHYEPIHMPKNTGAGVIIACFSLIFGFAMIWEIWWMALVGFIGILVVWIGKSFDHDVDYFVPV
DEIARIENQHHEQIRNAGVKHVN

Sequences:

>Translated_663_residues
MLGKLTLDAVPYHEPIIMVAVAGMLVGGLVILALLTYFGKWTWLWREWLTSVDHKRIGIMYIIVAMVMLLRGFADAIMMR
GQQALASAGEAGFLPPHHYDQVFSAHGVIMIFFMAMPMVVGLMNVVVPLQIGARDVAFPFLNSLSFWLFVVGVVLINLSL
GVGEFAQTGWLAYPPLSGKEFSPGVGVDYWIWSLQISGLGTLLTGVNFITTILKMRAPGMSLMKMPVFTWTALCSNILIT
VAFPILTVTIALLTLDRYLGTHFFTNEMGGNMMMYINLIWAWGHPEVYILVLPVFGVFSEVTATFSKKRLFGYTSLVWAT
IVITVLSFIVWLHHFFTMGAGANVNAFFGIATMIISIPTGVKIFNWLFTMYRGRIQFNTAMLWTIGFIVTFTVGGMTGVL
LAVPGANFVLHNSLFLIAHFHNVIIGGVVFGCFAAVNYWFPKSFGFTLNEKWGIRAFWFWLIGFFIAFMPLYVLGFMGMT
RRISQDINAEFHPLLLVAAGGAALIACGVLCQIIQIVVSVRDREQNRDLTGDPWDARTLEWSTSSPPPFYNFAIVPQIHD
RDEFWEMKERGDAYKKPAHYEPIHMPKNTGAGVIIACFSLIFGFAMIWEIWWMALVGFIGILVVWIGKSFDHDVDYFVPV
DEIARIENQHHEQIRNAGVKHVN
>Mature_663_residues
MLGKLTLDAVPYHEPIIMVAVAGMLVGGLVILALLTYFGKWTWLWREWLTSVDHKRIGIMYIIVAMVMLLRGFADAIMMR
GQQALASAGEAGFLPPHHYDQVFSAHGVIMIFFMAMPMVVGLMNVVVPLQIGARDVAFPFLNSLSFWLFVVGVVLINLSL
GVGEFAQTGWLAYPPLSGKEFSPGVGVDYWIWSLQISGLGTLLTGVNFITTILKMRAPGMSLMKMPVFTWTALCSNILIT
VAFPILTVTIALLTLDRYLGTHFFTNEMGGNMMMYINLIWAWGHPEVYILVLPVFGVFSEVTATFSKKRLFGYTSLVWAT
IVITVLSFIVWLHHFFTMGAGANVNAFFGIATMIISIPTGVKIFNWLFTMYRGRIQFNTAMLWTIGFIVTFTVGGMTGVL
LAVPGANFVLHNSLFLIAHFHNVIIGGVVFGCFAAVNYWFPKSFGFTLNEKWGIRAFWFWLIGFFIAFMPLYVLGFMGMT
RRISQDINAEFHPLLLVAAGGAALIACGVLCQIIQIVVSVRDREQNRDLTGDPWDARTLEWSTSSPPPFYNFAIVPQIHD
RDEFWEMKERGDAYKKPAHYEPIHMPKNTGAGVIIACFSLIFGFAMIWEIWWMALVGFIGILVVWIGKSFDHDVDYFVPV
DEIARIENQHHEQIRNAGVKHVN

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=510, Percent_Identity=39.4117647058824, Blast_Score=335, Evalue=7e-92,
Organism=Escherichia coli, GI1786634, Length=663, Percent_Identity=79.6380090497738, Blast_Score=1132, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=531, Percent_Identity=36.5348399246704, Blast_Score=325, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6226524, Length=327, Percent_Identity=40.9785932721713, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6226523, Length=252, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74408; Mature: 74408

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGKLTLDAVPYHEPIIMVAVAGMLVGGLVILALLTYFGKWTWLWREWLTSVDHKRIGIM
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
YIIVAMVMLLRGFADAIMMRGQQALASAGEAGFLPPHHYDQVFSAHGVIMIFFMAMPMVV
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHH
GLMNVVVPLQIGARDVAFPFLNSLSFWLFVVGVVLINLSLGVGEFAQTGWLAYPPLSGKE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEECCCCCCCC
FSPGVGVDYWIWSLQISGLGTLLTGVNFITTILKMRAPGMSLMKMPVFTWTALCSNILIT
CCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VAFPILTVTIALLTLDRYLGTHFFTNEMGGNMMMYINLIWAWGHPEVYILVLPVFGVFSE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEEEEEEHHHHHHHH
VTATFSKKRLFGYTSLVWATIVITVLSFIVWLHHFFTMGAGANVNAFFGIATMIISIPTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
VKIFNWLFTMYRGRIQFNTAMLWTIGFIVTFTVGGMTGVLLAVPGANFVLHNSLFLIAHF
HHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHCCHHEEEEECCCCCEEHHHHHHHHHHH
HNVIIGGVVFGCFAAVNYWFPKSFGFTLNEKWGIRAFWFWLIGFFIAFMPLYVLGFMGMT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRISQDINAEFHPLLLVAAGGAALIACGVLCQIIQIVVSVRDREQNRDLTGDPWDARTLE
HHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
WSTSSPPPFYNFAIVPQIHDRDEFWEMKERGDAYKKPAHYEPIHMPKNTGAGVIIACFSL
CCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHH
IFGFAMIWEIWWMALVGFIGILVVWIGKSFDHDVDYFVPVDEIARIENQHHEQIRNAGVK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCC
HVN
CCC
>Mature Secondary Structure
MLGKLTLDAVPYHEPIIMVAVAGMLVGGLVILALLTYFGKWTWLWREWLTSVDHKRIGIM
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
YIIVAMVMLLRGFADAIMMRGQQALASAGEAGFLPPHHYDQVFSAHGVIMIFFMAMPMVV
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHH
GLMNVVVPLQIGARDVAFPFLNSLSFWLFVVGVVLINLSLGVGEFAQTGWLAYPPLSGKE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEECCCCCCCC
FSPGVGVDYWIWSLQISGLGTLLTGVNFITTILKMRAPGMSLMKMPVFTWTALCSNILIT
CCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VAFPILTVTIALLTLDRYLGTHFFTNEMGGNMMMYINLIWAWGHPEVYILVLPVFGVFSE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCEEEEEEHHHHHHHH
VTATFSKKRLFGYTSLVWATIVITVLSFIVWLHHFFTMGAGANVNAFFGIATMIISIPTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
VKIFNWLFTMYRGRIQFNTAMLWTIGFIVTFTVGGMTGVLLAVPGANFVLHNSLFLIAHF
HHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHCCHHEEEEECCCCCEEHHHHHHHHHHH
HNVIIGGVVFGCFAAVNYWFPKSFGFTLNEKWGIRAFWFWLIGFFIAFMPLYVLGFMGMT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRISQDINAEFHPLLLVAAGGAALIACGVLCQIIQIVVSVRDREQNRDLTGDPWDARTLE
HHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
WSTSSPPPFYNFAIVPQIHDRDEFWEMKERGDAYKKPAHYEPIHMPKNTGAGVIIACFSL
CCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHH
IFGFAMIWEIWWMALVGFIGILVVWIGKSFDHDVDYFVPVDEIARIENQHHEQIRNAGVK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCC
HVN
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]