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The map label for this gene is atoB [H]

Identifier: 238920103

GI number: 238920103

Start: 2128894

End: 2130078

Strand: Direct

Name: atoB [H]

Synonym: NT01EI_2209

Alternate gene names: 238920103

Gene position: 2128894-2130078 (Clockwise)

Preceding gene: 238920102

Following gene: 238920104

Centisome position: 55.84

GC content: 66.41

Gene sequence:

>1185_bases
ATGAAAAATTGTGTCATCGTCAGCGCAGTGCGCACCGCCATCGGCAGCTTCAACGGCGCCCTGGCGGCAACCAGCGCCAT
CGATCTTGGCGCCACGGTCATCAGGGCCGCCCTGGAACGCGCCCGCCTCGACCCGCAACGGGTGGATGAGGTGATCATGG
GCAACGTACTGCAGGCCGGGCTGGGACAAAACCCGGCGCGTCAGGCGCTGTTAAAAAGTGGCCTCAGCGAACAGGTCTGC
GGATTTACCGTCAACAAGGTCTGCGGCTCGGGCCTCAAAAGCGTGGCGCTGGCCGCCCAGGCCATTCAGGCGGGCCAGGC
GCAGGCAGTGATCGCCGGTGGCATGGAAAACATGAGTCAGGCGCCATATCTGCTGAATGCACAGGCGCGCTGGGGCTACC
GCCTCGGCGACGGGACGCTGACCGACGTTATCCTGCAGGATGGCCTGCTGTGCGCCACCCACGGCTACCCGATGGGGATC
ACCGCCGAAAACATCGCCCGCGAATATGACATCAGCCGTGAGATGCAGGACGCACTGGCCCTGCTCTCCCAGCAAAAGGC
GCTGGCGGCCATCCATGCCGGTGCCTTCCGGGCCGAGATTGTCCCGGTCAGCGTGACGTCGCGTAAAAAAACTACCCTCT
TTGAGCGCGACGAATTCCCCAAAGCCGACTCCACGGCGGAAGGACTTGCCGCCCTGCGCCCGGCGTTCGATAAGGCGGGC
AGCGTCACCGCCGGTAACGCCTCAGGGATCAACGACGGCGCGGCGGCGCTGGTGGTGATGGAGGAAAACGCCGCCCGGGC
GGCGGGACTGACACCGCTGGCGCGGATTAAGGGCTATGCCAGCGGCGGCGTCGCACCGGCGCTGATGGGGATGGGGCCGG
TCCCCGCCACCCAGAAGGCGCTGCGACAGTGCGGGCTGCAGATGGCCGATATCGATCTGATTGAGGCCAATGAAGCCTTT
GCCGCGCAGTTCCTGGCCGTCGGAAAGGCGCTGGGGCTGGATGCCGAAAAGGTGAACGTCAACGGCGGCGCCATCGCGCT
GGGCCACCCCATCGGCGCCAGCGGCGCCCGGGTTCTGGTCACCCTGCTGCACGCGCTCTCCGCCCGGGATAAGAGCCTGG
GGCTGGCGACACTGTGCATCGGCGGCGGCCAGGGGATCGCCCTGATCGTGGAGAGGATCAGCTGA

Upstream 100 bases:

>100_bases
TCATGGGCTACTGCATCACCGCCCTGCTGTTCTCCGGCGTTATTTTTGTTGTCGGTCTGACCCTCTTCTGACGGTATCGA
CCCACCTTAAGGAAAAGAAG

Downstream 100 bases:

>100_bases
GACCGGAGCGGGCGCGCGTCGGCGCGTCTGCAGGGCAGGCGGTTATCCCCCGGCCCGCCTGTCCGCATGGCACAACGGAA
TACCGTGCCTCCGGCCAGCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MKNCVIVSAVRTAIGSFNGALAATSAIDLGATVIRAALERARLDPQRVDEVIMGNVLQAGLGQNPARQALLKSGLSEQVC
GFTVNKVCGSGLKSVALAAQAIQAGQAQAVIAGGMENMSQAPYLLNAQARWGYRLGDGTLTDVILQDGLLCATHGYPMGI
TAENIAREYDISREMQDALALLSQQKALAAIHAGAFRAEIVPVSVTSRKKTTLFERDEFPKADSTAEGLAALRPAFDKAG
SVTAGNASGINDGAAALVVMEENAARAAGLTPLARIKGYASGGVAPALMGMGPVPATQKALRQCGLQMADIDLIEANEAF
AAQFLAVGKALGLDAEKVNVNGGAIALGHPIGASGARVLVTLLHALSARDKSLGLATLCIGGGQGIALIVERIS

Sequences:

>Translated_394_residues
MKNCVIVSAVRTAIGSFNGALAATSAIDLGATVIRAALERARLDPQRVDEVIMGNVLQAGLGQNPARQALLKSGLSEQVC
GFTVNKVCGSGLKSVALAAQAIQAGQAQAVIAGGMENMSQAPYLLNAQARWGYRLGDGTLTDVILQDGLLCATHGYPMGI
TAENIAREYDISREMQDALALLSQQKALAAIHAGAFRAEIVPVSVTSRKKTTLFERDEFPKADSTAEGLAALRPAFDKAG
SVTAGNASGINDGAAALVVMEENAARAAGLTPLARIKGYASGGVAPALMGMGPVPATQKALRQCGLQMADIDLIEANEAF
AAQFLAVGKALGLDAEKVNVNGGAIALGHPIGASGARVLVTLLHALSARDKSLGLATLCIGGGQGIALIVERIS
>Mature_394_residues
MKNCVIVSAVRTAIGSFNGALAATSAIDLGATVIRAALERARLDPQRVDEVIMGNVLQAGLGQNPARQALLKSGLSEQVC
GFTVNKVCGSGLKSVALAAQAIQAGQAQAVIAGGMENMSQAPYLLNAQARWGYRLGDGTLTDVILQDGLLCATHGYPMGI
TAENIAREYDISREMQDALALLSQQKALAAIHAGAFRAEIVPVSVTSRKKTTLFERDEFPKADSTAEGLAALRPAFDKAG
SVTAGNASGINDGAAALVVMEENAARAAGLTPLARIKGYASGGVAPALMGMGPVPATQKALRQCGLQMADIDLIEANEAF
AAQFLAVGKALGLDAEKVNVNGGAIALGHPIGASGARVLVTLLHALSARDKSLGLATLCIGGGQGIALIVERIS

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=54.1025641025641, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=44.4444444444444, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI4557237, Length=396, Percent_Identity=43.1818181818182, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI4501853, Length=401, Percent_Identity=41.1471321695761, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=33.0232558139535, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI194353979, Length=396, Percent_Identity=33.0808080808081, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=83.248730964467, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=59.4387755102041, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=46.6334164588529, Blast_Score=310, Evalue=8e-86,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=43.640897755611, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1788683, Length=422, Percent_Identity=33.6492890995261, Blast_Score=191, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI133906874, Length=393, Percent_Identity=46.5648854961832, Blast_Score=329, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=40.9669211195929, Blast_Score=280, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=41.2658227848101, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17535917, Length=398, Percent_Identity=32.6633165829146, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=31.6901408450704, Blast_Score=177, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=45.2261306532663, Blast_Score=308, Evalue=9e-85,
Organism=Saccharomyces cerevisiae, GI6322031, Length=394, Percent_Identity=38.3248730964467, Blast_Score=225, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=56.0913705583756, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI17648125, Length=394, Percent_Identity=44.9238578680203, Blast_Score=301, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=43.3673469387755, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=31.7757009345794, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40304; Mature: 40304

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNCVIVSAVRTAIGSFNGALAATSAIDLGATVIRAALERARLDPQRVDEVIMGNVLQAG
CCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
LGQNPARQALLKSGLSEQVCGFTVNKVCGSGLKSVALAAQAIQAGQAQAVIAGGMENMSQ
CCCCHHHHHHHHCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHHCC
APYLLNAQARWGYRLGDGTLTDVILQDGLLCATHGYPMGITAENIAREYDISREMQDALA
CCEEEECCCCCCEEECCCHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
LLSQQKALAAIHAGAFRAEIVPVSVTSRKKTTLFERDEFPKADSTAEGLAALRPAFDKAG
HHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
SVTAGNASGINDGAAALVVMEENAARAAGLTPLARIKGYASGGVAPALMGMGPVPATQKA
CEECCCCCCCCCCCEEEEEEECCCCHHCCCCHHHHHCCCCCCCCHHHHHCCCCCCHHHHH
LRQCGLQMADIDLIEANEAFAAQFLAVGKALGLDAEKVNVNGGAIALGHPIGASGARVLV
HHHCCCEEECEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCHHHHHH
TLLHALSARDKSLGLATLCIGGGQGIALIVERIS
HHHHHHHCCCCCCCEEEEEEECCCCHHHHEEECC
>Mature Secondary Structure
MKNCVIVSAVRTAIGSFNGALAATSAIDLGATVIRAALERARLDPQRVDEVIMGNVLQAG
CCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
LGQNPARQALLKSGLSEQVCGFTVNKVCGSGLKSVALAAQAIQAGQAQAVIAGGMENMSQ
CCCCHHHHHHHHCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCHHHHCC
APYLLNAQARWGYRLGDGTLTDVILQDGLLCATHGYPMGITAENIAREYDISREMQDALA
CCEEEECCCCCCEEECCCHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
LLSQQKALAAIHAGAFRAEIVPVSVTSRKKTTLFERDEFPKADSTAEGLAALRPAFDKAG
HHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
SVTAGNASGINDGAAALVVMEENAARAAGLTPLARIKGYASGGVAPALMGMGPVPATQKA
CEECCCCCCCCCCCEEEEEEECCCCHHCCCCHHHHHCCCCCCCCHHHHHCCCCCCHHHHH
LRQCGLQMADIDLIEANEAFAAQFLAVGKALGLDAEKVNVNGGAIALGHPIGASGARVLV
HHHCCCEEECEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCHHHHHH
TLLHALSARDKSLGLATLCIGGGQGIALIVERIS
HHHHHHHCCCCCCCEEEEEEECCCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]