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The map label for this gene is leuD [H]

Identifier: 238920066

GI number: 238920066

Start: 2099146

End: 2099649

Strand: Direct

Name: leuD [H]

Synonym: NT01EI_2171

Alternate gene names: 238920066

Gene position: 2099146-2099649 (Clockwise)

Preceding gene: 238920065

Following gene: 238920067

Centisome position: 55.06

GC content: 59.92

Gene sequence:

>504_bases
ATGGATACGCTGCTACACGGCAATGTCTGGAAGTTTGGCGACAATATCAATACCGATATCATCTCGCCGCCGCAGTATAT
GGAGCTGAGCATCGCCGAGGCCGCCCCTTACTGCATGTCCGCCGTCAATCCCGACTTCGCCGCACAGGTGCGTCCCGGGG
ATATTCTGGTGGCCGGCAATAACCTGGGATCCGGCTCATCGCGCGAAACCTCGCCGCTCACCCTCAGGTATCTGGGGATC
CAGGCGGTGGTGGCCTGCTCCTTCGCCCGCATTTTCTACCGTAACTGCATCAATCTGGGGATCCCGGCGCTCAGCGCGCC
GCGCGCTGACGAGATCCGCCAGGGCGACGCGCTCTCCATCGATATCGCCCAGGGCATCATCCACAATATCACCCAGCAGG
AGATCTACCCCTGCACCCGTCTGCCGGATAACATTATGGCGATGATCCGCGCCGGCGGACTGGTAAACCATCTCAGACAA
ACCGGAGGTTGTGATGCAAACTGA

Upstream 100 bases:

>100_bases
GCCGCGATGCCAACATCTATCTGGCCTCTCCGCTCTCCGTGGCCGCCGCTGCCCTGACCGGCAGCATCATTTCACCGCAA
ACGCTTCTGTGAGGTCCCCG

Downstream 100 bases:

>100_bases
AGTGACTGCGCTCCCCGTCGCTATCGTACGCGGGGGCACCAGCAAGGGCATCTTCATCATGAAGAACGCCCTCCCCGCCG
ATCCCGCCCTGCGCGATCGG

Product: 3-isopropylmalate dehydratase small subunit 1

Products: NA

Alternate protein names: Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase [H]

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MDTLLHGNVWKFGDNINTDIISPPQYMELSIAEAAPYCMSAVNPDFAAQVRPGDILVAGNNLGSGSSRETSPLTLRYLGI
QAVVACSFARIFYRNCINLGIPALSAPRADEIRQGDALSIDIAQGIIHNITQQEIYPCTRLPDNIMAMIRAGGLVNHLRQ
TGGCDAN

Sequences:

>Translated_167_residues
MDTLLHGNVWKFGDNINTDIISPPQYMELSIAEAAPYCMSAVNPDFAAQVRPGDILVAGNNLGSGSSRETSPLTLRYLGI
QAVVACSFARIFYRNCINLGIPALSAPRADEIRQGDALSIDIAQGIIHNITQQEIYPCTRLPDNIMAMIRAGGLVNHLRQ
TGGCDAN
>Mature_167_residues
MDTLLHGNVWKFGDNINTDIISPPQYMELSIAEAAPYCMSAVNPDFAAQVRPGDILVAGNNLGSGSSRETSPLTLRYLGI
QAVVACSFARIFYRNCINLGIPALSAPRADEIRQGDALSIDIAQGIIHNITQQEIYPCTRLPDNIMAMIRAGGLVNHLRQ
TGGCDAN

Specific function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate [H]

COG id: COG0066

COG function: function code E; 3-isopropylmalate dehydratase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the leuD family. LeuD type 2 subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320440, Length=128, Percent_Identity=40.625, Blast_Score=78, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012305
- InterPro:   IPR015937
- InterPro:   IPR015928
- InterPro:   IPR000573
- InterPro:   IPR011824
- InterPro:   IPR011827 [H]

Pfam domain/function: PF00694 Aconitase_C [H]

EC number: =4.2.1.33 [H]

Molecular weight: Translated: 18016; Mature: 18016

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLLHGNVWKFGDNINTDIISPPQYMELSIAEAAPYCMSAVNPDFAAQVRPGDILVAGN
CCCCCCCCEEECCCCCCCCCCCCCCHHEEEHHHHCHHHHHHCCCCCEEEECCCCEEEECC
NLGSGSSRETSPLTLRYLGIQAVVACSFARIFYRNCINLGIPALSAPRADEIRQGDALSI
CCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCEEE
DIAQGIIHNITQQEIYPCTRLPDNIMAMIRAGGLVNHLRQTGGCDAN
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDTLLHGNVWKFGDNINTDIISPPQYMELSIAEAAPYCMSAVNPDFAAQVRPGDILVAGN
CCCCCCCCEEECCCCCCCCCCCCCCHHEEEHHHHCHHHHHHCCCCCEEEECCCCEEEECC
NLGSGSSRETSPLTLRYLGIQAVVACSFARIFYRNCINLGIPALSAPRADEIRQGDALSI
CCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCEEE
DIAQGIIHNITQQEIYPCTRLPDNIMAMIRAGGLVNHLRQTGGCDAN
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA