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The map label for this gene is pdxH

Identifier: 238919993

GI number: 238919993

Start: 2019395

End: 2020048

Strand: Reverse

Name: pdxH

Synonym: NT01EI_2097

Alternate gene names: 238919993

Gene position: 2020048-2019395 (Counterclockwise)

Preceding gene: 238919994

Following gene: 238919992

Centisome position: 52.99

GC content: 58.87

Gene sequence:

>654_bases
ATGAGCGAAAACAACGAGTTTGATATTGCCGATCTGCGCCGCGACTATGTGCGCGGCGGCCTGCGCCGCCGTGATTTAAC
CACCAATCCGCTGGATCTGTTCGAACGCTGGCTGCGTCAGGCGTGCGATGCGCGTCTGGCCGATCCGACCGCCATGTGTG
TGGCGACGGTGGATAAATCCGGCCAGCCCCACCAGCGCATTGTGCTGCTGAAGCACTACGATGCACAGGGCATGGTGTTT
TATACCAATCTGGGCAGCAATAAGGCCCAGCAGCTGGAGGAGAATCCGCGTATTAGCCTGCACTTCCCCTGGCATATGCT
GGATCGACAGGTCAGTATCACCGGCACGGCTCACCGCCTTACGGCTCTTGAGGTGATGAAGTATTTTCACAGCAGGCCGA
AGGACAGTCAGATCGCCGCCTGGGTATCACACCAGTCGGCGCGTATCTCTACCCGCGGGATCCTGGAGAGCAAGTTTTTG
GAGCTGAAGCAGAAGTTTTTGCAGGGCGAGATCCCGCTGCCCAGCTTTTGGGGGGGCTACCGGGTATCGCTGGAGACCAT
TGAGTTCTGGCAGGGGCGCGAAAGCCGCCTACACGATCGCTTTCTATATCAGCGTGACGGGGATGGCTGGCAAATTGACC
GCCTGGCGCCCTAG

Upstream 100 bases:

>100_bases
CCGTTCCTCCCGCCCGACGGAGGACGGGGGAGCGCAGGCGATTGAGATTGTGACGGCCAGCGTGCAGAATGAATTCATCT
CCGCTGTCAGGACGTTGAAT

Downstream 100 bases:

>100_bases
GTTGAGGTCTGTTGCGGGGGACTGGACGGTAGCAGCATCGGCTATTTGGCTACGCCTTGACCTTCAAACGGTTACGGGCA
TAGCCTTACAGTGTAATTTC

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MSENNEFDIADLRRDYVRGGLRRRDLTTNPLDLFERWLRQACDARLADPTAMCVATVDKSGQPHQRIVLLKHYDAQGMVF
YTNLGSNKAQQLEENPRISLHFPWHMLDRQVSITGTAHRLTALEVMKYFHSRPKDSQIAAWVSHQSARISTRGILESKFL
ELKQKFLQGEIPLPSFWGGYRVSLETIEFWQGRESRLHDRFLYQRDGDGWQIDRLAP

Sequences:

>Translated_217_residues
MSENNEFDIADLRRDYVRGGLRRRDLTTNPLDLFERWLRQACDARLADPTAMCVATVDKSGQPHQRIVLLKHYDAQGMVF
YTNLGSNKAQQLEENPRISLHFPWHMLDRQVSITGTAHRLTALEVMKYFHSRPKDSQIAAWVSHQSARISTRGILESKFL
ELKQKFLQGEIPLPSFWGGYRVSLETIEFWQGRESRLHDRFLYQRDGDGWQIDRLAP
>Mature_216_residues
SENNEFDIADLRRDYVRGGLRRRDLTTNPLDLFERWLRQACDARLADPTAMCVATVDKSGQPHQRIVLLKHYDAQGMVFY
TNLGSNKAQQLEENPRISLHFPWHMLDRQVSITGTAHRLTALEVMKYFHSRPKDSQIAAWVSHQSARISTRGILESKFLE
LKQKFLQGEIPLPSFWGGYRVSLETIEFWQGRESRLHDRFLYQRDGDGWQIDRLAP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=229, Percent_Identity=38.8646288209607, Blast_Score=156, Evalue=1e-38,
Organism=Escherichia coli, GI1787926, Length=218, Percent_Identity=76.1467889908257, Blast_Score=352, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI17553712, Length=225, Percent_Identity=36.8888888888889, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319509, Length=208, Percent_Identity=39.4230769230769, Blast_Score=147, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45551845, Length=208, Percent_Identity=40.3846153846154, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24644901, Length=208, Percent_Identity=40.3846153846154, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24644903, Length=178, Percent_Identity=33.1460674157303, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_EDWI9 (C5BE32)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002933508.1
- GeneID:   7959075
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_2097
- OMA:   FTFFTNY
- ProtClustDB:   CLSK2813247
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 25342; Mature: 25211

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 66-66 BINDING 69-69 BINDING 71-71 BINDING 88-88 BINDING 128-128 BINDING 132-132 BINDING 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENNEFDIADLRRDYVRGGLRRRDLTTNPLDLFERWLRQACDARLADPTAMCVATVDKS
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCC
GQPHQRIVLLKHYDAQGMVFYTNLGSNKAQQLEENPRISLHFPWHMLDRQVSITGTAHRL
CCCCCEEEEEEEECCCCEEEEEECCCCHHHHHHCCCCEEEEECHHHHCCEEEECCCHHHH
TALEVMKYFHSRPKDSQIAAWVSHQSARISTRGILESKFLELKQKFLQGEIPLPSFWGGY
HHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
RVSLETIEFWQGRESRLHDRFLYQRDGDGWQIDRLAP
EEEEEHHHHHCCCHHHHHHHHHEEECCCCEEECCCCC
>Mature Secondary Structure 
SENNEFDIADLRRDYVRGGLRRRDLTTNPLDLFERWLRQACDARLADPTAMCVATVDKS
CCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCC
GQPHQRIVLLKHYDAQGMVFYTNLGSNKAQQLEENPRISLHFPWHMLDRQVSITGTAHRL
CCCCCEEEEEEEECCCCEEEEEECCCCHHHHHHCCCCEEEEECHHHHCCEEEECCCHHHH
TALEVMKYFHSRPKDSQIAAWVSHQSARISTRGILESKFLELKQKFLQGEIPLPSFWGGY
HHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
RVSLETIEFWQGRESRLHDRFLYQRDGDGWQIDRLAP
EEEEEHHHHHCCCHHHHHHHHHEEECCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA