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The map label for this gene is pntB [H]

Identifier: 238919857

GI number: 238919857

Start: 1889521

End: 1890912

Strand: Direct

Name: pntB [H]

Synonym: NT01EI_1961

Alternate gene names: 238919857

Gene position: 1889521-1890912 (Clockwise)

Preceding gene: 238919856

Following gene: 238919860

Centisome position: 49.56

GC content: 57.97

Gene sequence:

>1392_bases
ATGTCTGGAGGATTAGTCACCGCAGCATACATTGTTGCCGCCATCCTGTTTATTTTTAGTCTGGCCGGGCTGTCCAAGCA
CGAGACGTCCAAGCAGGGCAATACCTTTGGCATGGTCGGTATGGCCATTGCGCTGATCGCCACCATCTGTGGTCCCGACG
CCGGCAGCATAGGTTGGATCATCGTGGCGATGGTGATCGGCGGCGCTATCGGCATGCATTTGGCGCGTAAGGTCGAGATG
ACTGAAATGCCGGAGCTGGTCGCTATTCTGCATAGCTTCGTCGGTCTGGCGGCGGTTCTTGTGGGCTACAACAGCTACAT
CGATCATCAGCCGGGCAGCATGGAGGCAGTGCTGGAAAATATCCATCTGGTCGAGGTGTTCCTGGGGATCTTCATCGGGG
CTGTTACCTTTACCGGCTCTATCGTCGCCTTTGGCAAACTGCGTGGGGTTATCTCATCCAAGCCGCTGATACTGCCGCAT
CGCCATAAGCTGAATCTGGCGGCGCTGGTCATCTCTTTCCTGCTGATGCTGTGGTTCGTCAATACCGGTTCCAGCGTGGC
ACAGGTGTTTGCCCTGCTGCTGATGACGGTCATCGCGCTGGCCTTCGGCTGGCATTTGGTGGCCTCTATCGGCGGCGCGG
ATATGCCGGTGGTGGTTTCCATGCTGAACTCCTACTCCGGCTGGGCAGCAGCAGCGGCAGGCTTTATGCTGAGCAACGAT
CTGCTGATCGTGACCGGTGCCCTGGTCGGTTCGTCCGGTGCCATTCTGTCCTACATCATGTGTAAAGCGATGAACCGCTC
CTTTATCAGCGTGATCGCCGGGGGCTTCGGCACCGACGGCTCATCCACCGGTGATGAGGGAGAGATGGGCGAATACCGCG
AGGCCAGTGCGGAAGAGGTGGCTGACATGCTGAAGAGCTCATCAAGCGTGATCATCACGCCGGGATATGGCATGGCCGTA
GCGCAGGCGCAGTATCCGGTAGCGGAGATCACCCAGAAGCTGCGCGATCGCGGGATCAAGGTGCGCTTTGGCATCCACCC
GGTGGCGGGGCGCCTGCCCGGTCATATGAATGTCCTGCTGGCGGAAGCCAAGGTACCGTATGATGTGGTACTGGAGATGG
ATGAGATCAACGATGATTTCGCCGATACCGATACGGTACTGGTGATCGGTGCCAATGACACGGTCAACCCGGCGGCCATG
GAAGATCCGCGCAGTCCGATCGCCGGAATGCCGGTACTGGAAGTATGGAAAGCCCAGAACGTCATCGTATTCAAGCGCTC
CATGAATACCGGCTATGCCGGCGTTCAAAACCCGCTGTTCTTCAAGGAGAATACCCAAATGCTGTTCGGCGATGCCAAAG
ACAGCGTCGAGGCCATCCTACGCGCCCTGTAA

Upstream 100 bases:

>100_bases
CTTTATTGCGGTGCTGATCGCCAGTATCAACATCTTCGGTGGTTTCACCGTCACCCAGCGCATGCTGAAAATGTTTCGTA
AGAACTGAGGGAGGTAACAA

Downstream 100 bases:

>100_bases
GCGTCATTGGGATAAAAACGCAAGCGCCCCACAGTGGGGCGCTTTTTTCATTCAAGGGCGAGGCGCTGCTGACTTACTCG
TCATCATGCTCATCTTCGCA

Product: pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Pyridine nucleotide transhydrogenase subunit beta [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSGGLVTAAYIVAAILFIFSLAGLSKHETSKQGNTFGMVGMAIALIATICGPDAGSIGWIIVAMVIGGAIGMHLARKVEM
TEMPELVAILHSFVGLAAVLVGYNSYIDHQPGSMEAVLENIHLVEVFLGIFIGAVTFTGSIVAFGKLRGVISSKPLILPH
RHKLNLAALVISFLLMLWFVNTGSSVAQVFALLLMTVIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSND
LLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTDGSSTGDEGEMGEYREASAEEVADMLKSSSSVIITPGYGMAV
AQAQYPVAEITQKLRDRGIKVRFGIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFADTDTVLVIGANDTVNPAAM
EDPRSPIAGMPVLEVWKAQNVIVFKRSMNTGYAGVQNPLFFKENTQMLFGDAKDSVEAILRAL

Sequences:

>Translated_463_residues
MSGGLVTAAYIVAAILFIFSLAGLSKHETSKQGNTFGMVGMAIALIATICGPDAGSIGWIIVAMVIGGAIGMHLARKVEM
TEMPELVAILHSFVGLAAVLVGYNSYIDHQPGSMEAVLENIHLVEVFLGIFIGAVTFTGSIVAFGKLRGVISSKPLILPH
RHKLNLAALVISFLLMLWFVNTGSSVAQVFALLLMTVIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSND
LLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTDGSSTGDEGEMGEYREASAEEVADMLKSSSSVIITPGYGMAV
AQAQYPVAEITQKLRDRGIKVRFGIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFADTDTVLVIGANDTVNPAAM
EDPRSPIAGMPVLEVWKAQNVIVFKRSMNTGYAGVQNPLFFKENTQMLFGDAKDSVEAILRAL
>Mature_462_residues
SGGLVTAAYIVAAILFIFSLAGLSKHETSKQGNTFGMVGMAIALIATICGPDAGSIGWIIVAMVIGGAIGMHLARKVEMT
EMPELVAILHSFVGLAAVLVGYNSYIDHQPGSMEAVLENIHLVEVFLGIFIGAVTFTGSIVAFGKLRGVISSKPLILPHR
HKLNLAALVISFLLMLWFVNTGSSVAQVFALLLMTVIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDL
LIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTDGSSTGDEGEMGEYREASAEEVADMLKSSSSVIITPGYGMAVA
QAQYPVAEITQKLRDRGIKVRFGIHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFADTDTVLVIGANDTVNPAAME
DPRSPIAGMPVLEVWKAQNVIVFKRSMNTGYAGVQNPLFFKENTQMLFGDAKDSVEAILRAL

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=453, Percent_Identity=51.4348785871965, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI122939153, Length=453, Percent_Identity=51.4348785871965, Blast_Score=463, Evalue=1e-130,
Organism=Escherichia coli, GI1787886, Length=463, Percent_Identity=85.9611231101512, Blast_Score=802, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17550456, Length=460, Percent_Identity=48.4782608695652, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 48922; Mature: 48791

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGGLVTAAYIVAAILFIFSLAGLSKHETSKQGNTFGMVGMAIALIATICGPDAGSIGWI
CCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
IVAMVIGGAIGMHLARKVEMTEMPELVAILHSFVGLAAVLVGYNSYIDHQPGSMEAVLEN
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
IHLVEVFLGIFIGAVTFTGSIVAFGKLRGVISSKPLILPHRHKLNLAALVISFLLMLWFV
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHH
NTGSSVAQVFALLLMTVIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSND
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCC
LLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTDGSSTGDEGEMGEYREASAEEV
EEEEEEHHHCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCHHHH
ADMLKSSSSVIITPGYGMAVAQAQYPVAEITQKLRDRGIKVRFGIHPVAGRLPGHMNVLL
HHHHHCCCCEEEECCCCCCHHHCCCCHHHHHHHHHHCCCEEEECCCHHCCCCCCCCEEEE
AEAKVPYDVVLEMDEINDDFADTDTVLVIGANDTVNPAAMEDPRSPIAGMPVLEVWKAQN
ECCCCCHHHEEEHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCC
VIVFKRSMNTGYAGVQNPLFFKENTQMLFGDAKDSVEAILRAL
EEEEEECCCCCCCCCCCCEEEECCCCEEECCCHHHHHHHHHHC
>Mature Secondary Structure 
SGGLVTAAYIVAAILFIFSLAGLSKHETSKQGNTFGMVGMAIALIATICGPDAGSIGWI
CCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
IVAMVIGGAIGMHLARKVEMTEMPELVAILHSFVGLAAVLVGYNSYIDHQPGSMEAVLEN
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
IHLVEVFLGIFIGAVTFTGSIVAFGKLRGVISSKPLILPHRHKLNLAALVISFLLMLWFV
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHH
NTGSSVAQVFALLLMTVIALAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSND
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCC
LLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTDGSSTGDEGEMGEYREASAEEV
EEEEEEHHHCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCHHHH
ADMLKSSSSVIITPGYGMAVAQAQYPVAEITQKLRDRGIKVRFGIHPVAGRLPGHMNVLL
HHHHHCCCCEEEECCCCCCHHHCCCCHHHHHHHHHHCCCEEEECCCHHCCCCCCCCEEEE
AEAKVPYDVVLEMDEINDDFADTDTVLVIGANDTVNPAAMEDPRSPIAGMPVLEVWKAQN
ECCCCCHHHEEEHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCC
VIVFKRSMNTGYAGVQNPLFFKENTQMLFGDAKDSVEAILRAL
EEEEEECCCCCCCCCCCCEEEECCCCEEECCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]