Click here to switch to the map view.

The map label for this gene is hemR [H]

Identifier: 238919805

GI number: 238919805

Start: 1837602

End: 1839599

Strand: Reverse

Name: hemR [H]

Synonym: NT01EI_1909

Alternate gene names: 238919805

Gene position: 1839599-1837602 (Counterclockwise)

Preceding gene: 238919806

Following gene: 238919804

Centisome position: 48.25

GC content: 63.41

Gene sequence:

>1998_bases
ATGCCTACGCTTTTCTCCCCTTCCCTACGCCCGCTCACCCTGACCATCAGCAGCCTCTTGTTAACCCCAGCCCTGCTACA
GGCTGCAGAGAACGGCGACAGCGTGACCGTTATCGCCACCGGAAACCAGCGCGACAGCTTCAGCGCTCCCATGATGGTCA
CCGTCATCGACCGGCAGGACCCAGTGGCCGCCAGCGCAGCGTCCGCGCCGGAAATGCTGCGTAATGTCCCGGGCCTGAAC
CTGAGCGGCGTCGGCCGCAGCAATGGCCAGGACATCACGCTGCGCGGCTACGATAACCGCGGCGTTCTGGTCCTGGTCGA
TGGCGTACGTCAGGGAACCGACACCGGTCATCTGAACGGGACGTTTCTCGATCCGGCACTCATCAAGCGGGTCGAGGTGG
TACGCGGTCCCGGCGCCTTGCTGTATGGCAACGGCGCACTGGGTGGCGTTATCGCCTACCAGACCGTCGATGCTGCCGAC
CTGCTGCTGGCGGGGAAAAACAGCGGCTACCGCCTGTTTGCCAGCGGCGCTACCCAGGATCACAGTCTGGGCCTGGGCGC
CAGCGCCTATGCCCGCAGCGATAGGCTGGACGGCCTGCTCTCCTTTAGCACCCGCCAGCGCGGCGACCTGCGCCTCGGCG
GGGGGGAGCGCGCCGCCAACCGCGAAACCATCGGCAACCTGTTGGCCAAAGGCACCTGGCTCATCGACGGTGCCCAATCG
CTGAACGCCAGCCTACGCTATTACGACAACGCCGCCCGTGAGCCCAAAAATCCGCAGGATATCCAGGCCAGCGCCAGCAA
TCTCATGACCCGTCGCGACACTATCCAGCGCGATCTGCAACTGGAGTACCGCCTCAAACCGATGGAGAATACCTGGCTCG
ATGCCAGCCTGCGGCCTTACTACTCCGACGTCCGGATTACCGCCACTCCCCAGGGAGAAAGCGAGGAAAGCCGAACCCAG
CGAACCCTGGGGCTACGGGCAGAAAACCGCAGTCAACTGTGGAGCGAAGGCCCCGCCGCCCACCTGTTGACCTACGGCAG
CGAAGCCTATGGACAAAGCCAGCGCCCGGGCGGCGGCGCCAGCACCTACCCCCAGGCGGATATCCGCTTTGCCTCGGGCT
GGCTGCAGGATGAGATAACCCTGCGCGATCTGCCCGTCAGTCTGGTAGCCGGTACCCGCTACGATAACTACCGGGCCCAT
AACGACAGCTATGGCGACATCAACGCGGACAAATGGTCATCCCGAGCCGCGATCACCGTCACCCCGGCCGACTGGTTAAT
GTTGTTTACCAGCTACGCCCAGGCCTTCCGGGCACCGACCATCGGAGAGATTTACAACGACGCCCGCCACTTCAGTATCG
GACCCTTTGTCAACTACTGGCGTCCCAACCCCAACCTGCGCCCGGAGAGCAACACCACCCAAGAGGCCGGCTTTGGGCTA
CGCTTCGACGATCTGCTGGCCGAGGGCGACAGCCTGCAGTTCAAGTCCAGCTACTTCGGCACCCGCGCCAGGAACTATAT
CGATACGCAGGTGGTCAACGACTTCGCCAAGCGCCAGTTCTATACCACCTCGATCAACGTTGACGATGTCAAACTGTGGG
GCTGGGACGTCGCGCTGAACTACCACAGCGATCGGTTCAGCTGGGAGTCCGCCTATAACCGTACCCGCGGCAAAAATAAC
CAAAGCGGCGACTGGATTGCCAACGGGACGCCGGACACCCTCAGCAACCGGCTGGATATTCCGCTGGCCCACAGCGGCTT
CTCCGTCGGCTGGGTCAGTACCTTTGCCGCTGCCTTCCACACCAACGACAGCCGGACACAGCCGCAGGCCGGCTATGGCG
TCAATGACTTCTATGTCAGCTACCGCACCCCAGCGCTGGGCAACCAGTTCAGCGCCACCACCGTCCTGAGCAATGCGTTT
GACAAGGCCTACTACGCGCCGAGCGGCGCGCTGCAGGATGGCCGCGGCGCCCGTCTGCTGCTCAGCTACCAGTGGTAG

Upstream 100 bases:

>100_bases
CCCTGATATTGTTTCGCCAGCCACCCAGTCCTCCGCATACCCGCGGTGTGGCAAGGCAGCCAGCAGTCCCAATGCCATAT
TACATTTGGAGTGTTGAGCC

Downstream 100 bases:

>100_bases
CGCGATTTTCACCCCGGGGCGCTAGCGCGCCCCGTTTTCACCTGCACCATAAAAAAGGATCTTTGCATGAGCCATGACCT
GTATACCCGCTACATGAACG

Product: TonB-dependent heme/hemoglobin receptor family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MPTLFSPSLRPLTLTISSLLLTPALLQAAENGDSVTVIATGNQRDSFSAPMMVTVIDRQDPVAASAASAPEMLRNVPGLN
LSGVGRSNGQDITLRGYDNRGVLVLVDGVRQGTDTGHLNGTFLDPALIKRVEVVRGPGALLYGNGALGGVIAYQTVDAAD
LLLAGKNSGYRLFASGATQDHSLGLGASAYARSDRLDGLLSFSTRQRGDLRLGGGERAANRETIGNLLAKGTWLIDGAQS
LNASLRYYDNAAREPKNPQDIQASASNLMTRRDTIQRDLQLEYRLKPMENTWLDASLRPYYSDVRITATPQGESEESRTQ
RTLGLRAENRSQLWSEGPAAHLLTYGSEAYGQSQRPGGGASTYPQADIRFASGWLQDEITLRDLPVSLVAGTRYDNYRAH
NDSYGDINADKWSSRAAITVTPADWLMLFTSYAQAFRAPTIGEIYNDARHFSIGPFVNYWRPNPNLRPESNTTQEAGFGL
RFDDLLAEGDSLQFKSSYFGTRARNYIDTQVVNDFAKRQFYTTSINVDDVKLWGWDVALNYHSDRFSWESAYNRTRGKNN
QSGDWIANGTPDTLSNRLDIPLAHSGFSVGWVSTFAAAFHTNDSRTQPQAGYGVNDFYVSYRTPALGNQFSATTVLSNAF
DKAYYAPSGALQDGRGARLLLSYQW

Sequences:

>Translated_665_residues
MPTLFSPSLRPLTLTISSLLLTPALLQAAENGDSVTVIATGNQRDSFSAPMMVTVIDRQDPVAASAASAPEMLRNVPGLN
LSGVGRSNGQDITLRGYDNRGVLVLVDGVRQGTDTGHLNGTFLDPALIKRVEVVRGPGALLYGNGALGGVIAYQTVDAAD
LLLAGKNSGYRLFASGATQDHSLGLGASAYARSDRLDGLLSFSTRQRGDLRLGGGERAANRETIGNLLAKGTWLIDGAQS
LNASLRYYDNAAREPKNPQDIQASASNLMTRRDTIQRDLQLEYRLKPMENTWLDASLRPYYSDVRITATPQGESEESRTQ
RTLGLRAENRSQLWSEGPAAHLLTYGSEAYGQSQRPGGGASTYPQADIRFASGWLQDEITLRDLPVSLVAGTRYDNYRAH
NDSYGDINADKWSSRAAITVTPADWLMLFTSYAQAFRAPTIGEIYNDARHFSIGPFVNYWRPNPNLRPESNTTQEAGFGL
RFDDLLAEGDSLQFKSSYFGTRARNYIDTQVVNDFAKRQFYTTSINVDDVKLWGWDVALNYHSDRFSWESAYNRTRGKNN
QSGDWIANGTPDTLSNRLDIPLAHSGFSVGWVSTFAAAFHTNDSRTQPQAGYGVNDFYVSYRTPALGNQFSATTVLSNAF
DKAYYAPSGALQDGRGARLLLSYQW
>Mature_664_residues
PTLFSPSLRPLTLTISSLLLTPALLQAAENGDSVTVIATGNQRDSFSAPMMVTVIDRQDPVAASAASAPEMLRNVPGLNL
SGVGRSNGQDITLRGYDNRGVLVLVDGVRQGTDTGHLNGTFLDPALIKRVEVVRGPGALLYGNGALGGVIAYQTVDAADL
LLAGKNSGYRLFASGATQDHSLGLGASAYARSDRLDGLLSFSTRQRGDLRLGGGERAANRETIGNLLAKGTWLIDGAQSL
NASLRYYDNAAREPKNPQDIQASASNLMTRRDTIQRDLQLEYRLKPMENTWLDASLRPYYSDVRITATPQGESEESRTQR
TLGLRAENRSQLWSEGPAAHLLTYGSEAYGQSQRPGGGASTYPQADIRFASGWLQDEITLRDLPVSLVAGTRYDNYRAHN
DSYGDINADKWSSRAAITVTPADWLMLFTSYAQAFRAPTIGEIYNDARHFSIGPFVNYWRPNPNLRPESNTTQEAGFGLR
FDDLLAEGDSLQFKSSYFGTRARNYIDTQVVNDFAKRQFYTTSINVDDVKLWGWDVALNYHSDRFSWESAYNRTRGKNNQ
SGDWIANGTPDTLSNRLDIPLAHSGFSVGWVSTFAAAFHTNDSRTQPQAGYGVNDFYVSYRTPALGNQFSATTVLSNAFD
KAYYAPSGALQDGRGARLLLSYQW

Specific function: This protein is involved in the initial step of iron uptake by binding hemin, an iron chelatin siderophore that allows the bacteria to extract iron from the environment [H]

COG id: COG1629

COG function: function code P; Outer membrane receptor proteins, mostly Fe transport

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=154, Percent_Identity=31.1688311688312, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786798, Length=135, Percent_Identity=34.8148148148148, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790405, Length=144, Percent_Identity=35.4166666666667, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR011276
- InterPro:   IPR010949 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 72905; Mature: 72774

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLFSPSLRPLTLTISSLLLTPALLQAAENGDSVTVIATGNQRDSFSAPMMVTVIDRQD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEECCCC
PVAASAASAPEMLRNVPGLNLSGVGRSNGQDITLRGYDNRGVLVLVDGVRQGTDTGHLNG
CCCCCCCCCHHHHHHCCCCCEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCC
TFLDPALIKRVEVVRGPGALLYGNGALGGVIAYQTVDAADLLLAGKNSGYRLFASGATQD
EEECHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCHHHEEEECCCCCEEEEECCCCCC
HSLGLGASAYARSDRLDGLLSFSTRQRGDLRLGGGERAANRETIGNLLAKGTWLIDGAQS
CCCCCCCHHHHCCHHHCHHEEECCCCCCCEEECCCCCCCCHHHHHHHHHCCEEEEECHHH
LNASLRYYDNAAREPKNPQDIQASASNLMTRRDTIQRDLQLEYRLKPMENTWLDASLRPY
CCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCEECCCCCCC
YSDVRITATPQGESEESRTQRTLGLRAENRSQLWSEGPAAHLLTYGSEAYGQSQRPGGGA
CCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCHHCCCCCCCCCCC
STYPQADIRFASGWLQDEITLRDLPVSLVAGTRYDNYRAHNDSYGDINADKWSSRAAITV
CCCCCCCEEEECCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
TPADWLMLFTSYAQAFRAPTIGEIYNDARHFSIGPFVNYWRPNPNLRPESNTTQEAGFGL
CCHHHHHHHHHHHHHHCCCCHHHHHCCCCCEECCCCCEEECCCCCCCCCCCCCHHCCCCC
RFDDLLAEGDSLQFKSSYFGTRARNYIDTQVVNDFAKRQFYTTSINVDDVKLWGWDVALN
CHHHHHCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEEEEEEEEE
YHSDRFSWESAYNRTRGKNNQSGDWIANGTPDTLSNRLDIPLAHSGFSVGWVSTFAAAFH
ECCCCCCHHHHHHHHCCCCCCCCCEEECCCCHHHCCCCCCEEECCCCCHHHHHHHHHHHC
TNDSRTQPQAGYGVNDFYVSYRTPALGNQFSATTVLSNAFDKAYYAPSGALQDGRGARLL
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCEEE
LSYQW
EEECC
>Mature Secondary Structure 
PTLFSPSLRPLTLTISSLLLTPALLQAAENGDSVTVIATGNQRDSFSAPMMVTVIDRQD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEECCCC
PVAASAASAPEMLRNVPGLNLSGVGRSNGQDITLRGYDNRGVLVLVDGVRQGTDTGHLNG
CCCCCCCCCHHHHHHCCCCCEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCC
TFLDPALIKRVEVVRGPGALLYGNGALGGVIAYQTVDAADLLLAGKNSGYRLFASGATQD
EEECHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCHHHEEEECCCCCEEEEECCCCCC
HSLGLGASAYARSDRLDGLLSFSTRQRGDLRLGGGERAANRETIGNLLAKGTWLIDGAQS
CCCCCCCHHHHCCHHHCHHEEECCCCCCCEEECCCCCCCCHHHHHHHHHCCEEEEECHHH
LNASLRYYDNAAREPKNPQDIQASASNLMTRRDTIQRDLQLEYRLKPMENTWLDASLRPY
CCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCEECCCCCCC
YSDVRITATPQGESEESRTQRTLGLRAENRSQLWSEGPAAHLLTYGSEAYGQSQRPGGGA
CCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCEEEEECCCHHCCCCCCCCCCC
STYPQADIRFASGWLQDEITLRDLPVSLVAGTRYDNYRAHNDSYGDINADKWSSRAAITV
CCCCCCCEEEECCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
TPADWLMLFTSYAQAFRAPTIGEIYNDARHFSIGPFVNYWRPNPNLRPESNTTQEAGFGL
CCHHHHHHHHHHHHHHCCCCHHHHHCCCCCEECCCCCEEECCCCCCCCCCCCCHHCCCCC
RFDDLLAEGDSLQFKSSYFGTRARNYIDTQVVNDFAKRQFYTTSINVDDVKLWGWDVALN
CHHHHHCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHCEEEEEECCCCEEEEEEEEEEEE
YHSDRFSWESAYNRTRGKNNQSGDWIANGTPDTLSNRLDIPLAHSGFSVGWVSTFAAAFH
ECCCCCCHHHHHHHHCCCCCCCCCEEECCCCHHHCCCCCCEEECCCCCHHHHHHHHHHHC
TNDSRTQPQAGYGVNDFYVSYRTPALGNQFSATTVLSNAFDKAYYAPSGALQDGRGARLL
CCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCEEE
LSYQW
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1425573 [H]