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The map label for this gene is hmuU [H]

Identifier: 238919802

GI number: 238919802

Start: 1834673

End: 1835674

Strand: Reverse

Name: hmuU [H]

Synonym: NT01EI_1906

Alternate gene names: 238919802

Gene position: 1835674-1834673 (Counterclockwise)

Preceding gene: 238919803

Following gene: 238919801

Centisome position: 48.15

GC content: 65.87

Gene sequence:

>1002_bases
ATGATCCGCCGCTCTCCGCGTCTGACGCTGGCGTTGCTGTTGGGTCTATTGATGTTGATCACGCTGACCGCCGCCCACCT
GGGCGCACTGCGCCTGTCGCCCGTCGCGCTGCTGCGCGACGGCGATCCCCTCCAGTGGCAGATCTGGCTCAACATCCGCC
TGCCGCGGGTGCTTCTGGCAGTGGTGATCGGTATTGCGCTGGCCGTCTCCGGCACGATTATGCAGGGGCTGTTCCGCAAC
CCGCTGGCCGATCCCGCCCTGCTGGGGATCAGCAGCGGCGCGGCGCTGTGCGTGGCGCTGACCATCGTGCTCCCGCTGGC
GCTCTCGCCGCTGCTGGCACTGTATACCCAAATGCTGGCGGCGTTTGGCGGTAGCCTGGCCATTTCGCTGCTGATTTATC
TCCTCAGTCGCGGCGCACATGTGACACTGTCACGATTATTGCTCGCCGGCATCGCTATTAACGCCCTCTGTTTTGCCCTG
GTCGGGGTGCTGAGCTACCTGAGCGACGATCAGCAGCTGCGCCAGTTCACCCTGTGGAGCATGGGAACCCTGTCGCGCAG
TGAATGGCATACGCTGGGCGTCAGCGCCCTGCTGATCCTGCCGGCCAGCCTGTTCGCGCTCACGCTGGCCCAGCGCCTGA
ACCTGCTGCAGCTGGGCGATGAGGAGGCCCACTACCTCGGACTTGATGTGGCGCGCACCAAGCGCCAGCTCTTGCTTCTC
AGCGCCGTCCTGGTCGGCAGCGCGGTGGCTGTCAGCGGCGTCATCGGCTTTATCGGCCTGGTGGTTCCCCACCTGTTCCG
CCTGCGGCTCGGCGCCGATCACCGCTGGCTATTGCCCTGCTCGGCCTTGGGCGGTGCCTGCCTGCTGCTGCTGGCCGACA
CCCTGGCCCGCACCCTGGCGGCCCCGGCGGAAATACCGGTCGGGATGCTGACCAGCCTACTGGGCGGCCCCTATTTTCTC
TGGCTGATACTGCGCTACCGGGAGGTAAGTCATGGCCAATAA

Upstream 100 bases:

>100_bases
GGGTACTGGTGCTTGACGACATGGTGCTGCTGGGCTTTACCCTCGGCACACCGGATGCGCTGGCCGCACTGCGTAGCGCG
GCCGAACAGGCGCAGCGGCC

Downstream 100 bases:

>100_bases
CCCCAGGTTACAGGCCGAGCGGCTCACCTACAGCGATCATGGCCGGACGTTAATCCACCAGGTGTCGCTGACCCTGCCCT
GCACCGAGCTGGTGGTCATT

Product: HmuU protein

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIRRSPRLTLALLLGLLMLITLTAAHLGALRLSPVALLRDGDPLQWQIWLNIRLPRVLLAVVIGIALAVSGTIMQGLFRN
PLADPALLGISSGAALCVALTIVLPLALSPLLALYTQMLAAFGGSLAISLLIYLLSRGAHVTLSRLLLAGIAINALCFAL
VGVLSYLSDDQQLRQFTLWSMGTLSRSEWHTLGVSALLILPASLFALTLAQRLNLLQLGDEEAHYLGLDVARTKRQLLLL
SAVLVGSAVAVSGVIGFIGLVVPHLFRLRLGADHRWLLPCSALGGACLLLLADTLARTLAAPAEIPVGMLTSLLGGPYFL
WLILRYREVSHGQ

Sequences:

>Translated_333_residues
MIRRSPRLTLALLLGLLMLITLTAAHLGALRLSPVALLRDGDPLQWQIWLNIRLPRVLLAVVIGIALAVSGTIMQGLFRN
PLADPALLGISSGAALCVALTIVLPLALSPLLALYTQMLAAFGGSLAISLLIYLLSRGAHVTLSRLLLAGIAINALCFAL
VGVLSYLSDDQQLRQFTLWSMGTLSRSEWHTLGVSALLILPASLFALTLAQRLNLLQLGDEEAHYLGLDVARTKRQLLLL
SAVLVGSAVAVSGVIGFIGLVVPHLFRLRLGADHRWLLPCSALGGACLLLLADTLARTLAAPAEIPVGMLTSLLGGPYFL
WLILRYREVSHGQ
>Mature_333_residues
MIRRSPRLTLALLLGLLMLITLTAAHLGALRLSPVALLRDGDPLQWQIWLNIRLPRVLLAVVIGIALAVSGTIMQGLFRN
PLADPALLGISSGAALCVALTIVLPLALSPLLALYTQMLAAFGGSLAISLLIYLLSRGAHVTLSRLLLAGIAINALCFAL
VGVLSYLSDDQQLRQFTLWSMGTLSRSEWHTLGVSALLILPASLFALTLAQRLNLLQLGDEEAHYLGLDVARTKRQLLLL
SAVLVGSAVAVSGVIGFIGLVVPHLFRLRLGADHRWLLPCSALGGACLLLLADTLARTLAAPAEIPVGMLTSLLGGPYFL
WLILRYREVSHGQ

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790741, Length=278, Percent_Identity=42.4460431654676, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1790740, Length=304, Percent_Identity=39.4736842105263, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1788004, Length=285, Percent_Identity=42.1052631578947, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1786805, Length=282, Percent_Identity=40.7801418439716, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1786804, Length=273, Percent_Identity=37.7289377289377, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786347, Length=299, Percent_Identity=34.4481605351171, Blast_Score=103, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35577; Mature: 35577

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRSPRLTLALLLGLLMLITLTAAHLGALRLSPVALLRDGDPLQWQIWLNIRLPRVLLA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCEEEEEEEEECHHHHHHH
VVIGIALAVSGTIMQGLFRNPLADPALLGISSGAALCVALTIVLPLALSPLLALYTQMLA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFGGSLAISLLIYLLSRGAHVTLSRLLLAGIAINALCFALVGVLSYLSDDQQLRQFTLWS
HHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MGTLSRSEWHTLGVSALLILPASLFALTLAQRLNLLQLGDEEAHYLGLDVARTKRQLLLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHH
SAVLVGSAVAVSGVIGFIGLVVPHLFRLRLGADHRWLLPCSALGGACLLLLADTLARTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHC
APAEIPVGMLTSLLGGPYFLWLILRYREVSHGQ
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIRRSPRLTLALLLGLLMLITLTAAHLGALRLSPVALLRDGDPLQWQIWLNIRLPRVLLA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCEEEEEEEEECHHHHHHH
VVIGIALAVSGTIMQGLFRNPLADPALLGISSGAALCVALTIVLPLALSPLLALYTQMLA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFGGSLAISLLIYLLSRGAHVTLSRLLLAGIAINALCFALVGVLSYLSDDQQLRQFTLWS
HHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MGTLSRSEWHTLGVSALLILPASLFALTLAQRLNLLQLGDEEAHYLGLDVARTKRQLLLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHH
SAVLVGSAVAVSGVIGFIGLVVPHLFRLRLGADHRWLLPCSALGGACLLLLADTLARTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHC
APAEIPVGMLTSLLGGPYFLWLILRYREVSHGQ
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]