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The map label for this gene is cysK [H]

Identifier: 238919795

GI number: 238919795

Start: 1827908

End: 1828846

Strand: Reverse

Name: cysK [H]

Synonym: NT01EI_1899

Alternate gene names: 238919795

Gene position: 1828846-1827908 (Counterclockwise)

Preceding gene: 238919796

Following gene: 238919794

Centisome position: 47.97

GC content: 36.85

Gene sequence:

>939_bases
ATGGATGTCGAACAGATCGGAAACACCGAACTTATTGAACTAACAAATATATCAAGCAATGGAAATAGATTATTTGTAAA
GTGTGAATACAAGAACCCCACAGGGAGCCATAAAGATCGCACATTTCTACATATAATAGAATCACTTGAGCTGCATGGTA
AAATTTCTCCCGGCATGACACTGATAGATTGCTCAACGGGAAACGGTGGCGCTGCACTAGCATGGATTGGGCAACAGAAA
GGATACAATGTTGTTATATTTATGCCAGAAGGCATGACGAGAGAACGAATTCAACAAATAAAAAGCTTTGGTGCGGAAAT
CATTGAAACACCAAAGGAAAAATTCCTGAATGGCTCTGATGATGAAGCAATTGCATACGCTAAAGTCAATAAAAATTCAT
TCTATATAAACCAGTCAGAGAATATATTAAACATGGAGTCATGGTATGAGTGCGGACGCGAAATAATTAAACAGCTAGCA
TCAAAAAATATAAATCCGGATTATTTTATTTGCTCGATAGGAACAGGTGGAACATTTTCAGGAATATCAAAAATATTAAA
AGAAGAATTCCCAAAACTCAAGTCAATTGGCATTGAGGTTGATAAATCATCACCTATCCACGCAAAGATAAATAAAAAGA
TTTTCACGCATCGCCCACATAATATGATGGGTCTAGGCGCGGGAAAGATATCAGGTAATACAAAAATAGATCTAATAGAC
GAAATAAAAGTCATTAGTGGAGAACACGCATGGGCGCGAATGCGGAGGTTCATAAAAACAAACAATAAAGAAATCGGCCC
AACTTGCGGCGCCAACATTTTAATAAGTGAAGAGATCATGAGGAGCGTATCCAATAAAGTAATCATAACAATTTTCTTCG
ACAGCTCATGGAAATATAAGAGCCGATGGAATGGCATATATCCAGAATATAATATGTAA

Upstream 100 bases:

>100_bases
AGCATCCCTCATGCAATAAAATCGCTCTACACTTATTGATTTACCATCAAAACAAGCGTATTAAAAACAAACAGATTAAT
AAATTTAAAAGGTGTAAGAA

Downstream 100 bases:

>100_bases
AATGGAGATCATCATGCTTCTTGAGGAAATTTATACGAATGCTAAAGTTGTTAAATCAGGCCGTATGTTAACAACCGTTA
ATGAATTTAGCGACCAGTTA

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MDVEQIGNTELIELTNISSNGNRLFVKCEYKNPTGSHKDRTFLHIIESLELHGKISPGMTLIDCSTGNGGAALAWIGQQK
GYNVVIFMPEGMTRERIQQIKSFGAEIIETPKEKFLNGSDDEAIAYAKVNKNSFYINQSENILNMESWYECGREIIKQLA
SKNINPDYFICSIGTGGTFSGISKILKEEFPKLKSIGIEVDKSSPIHAKINKKIFTHRPHNMMGLGAGKISGNTKIDLID
EIKVISGEHAWARMRRFIKTNNKEIGPTCGANILISEEIMRSVSNKVIITIFFDSSWKYKSRWNGIYPEYNM

Sequences:

>Translated_312_residues
MDVEQIGNTELIELTNISSNGNRLFVKCEYKNPTGSHKDRTFLHIIESLELHGKISPGMTLIDCSTGNGGAALAWIGQQK
GYNVVIFMPEGMTRERIQQIKSFGAEIIETPKEKFLNGSDDEAIAYAKVNKNSFYINQSENILNMESWYECGREIIKQLA
SKNINPDYFICSIGTGGTFSGISKILKEEFPKLKSIGIEVDKSSPIHAKINKKIFTHRPHNMMGLGAGKISGNTKIDLID
EIKVISGEHAWARMRRFIKTNNKEIGPTCGANILISEEIMRSVSNKVIITIFFDSSWKYKSRWNGIYPEYNM
>Mature_312_residues
MDVEQIGNTELIELTNISSNGNRLFVKCEYKNPTGSHKDRTFLHIIESLELHGKISPGMTLIDCSTGNGGAALAWIGQQK
GYNVVIFMPEGMTRERIQQIKSFGAEIIETPKEKFLNGSDDEAIAYAKVNKNSFYINQSENILNMESWYECGREIIKQLA
SKNINPDYFICSIGTGGTFSGISKILKEEFPKLKSIGIEVDKSSPIHAKINKKIFTHRPHNMMGLGAGKISGNTKIDLID
EIKVISGEHAWARMRRFIKTNNKEIGPTCGANILISEEIMRSVSNKVIITIFFDSSWKYKSRWNGIYPEYNM

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=310, Percent_Identity=28.7096774193548, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI295821200, Length=310, Percent_Identity=28.7096774193548, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4557415, Length=310, Percent_Identity=28.7096774193548, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI2367138, Length=308, Percent_Identity=29.2207792207792, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1788754, Length=310, Percent_Identity=29.3548387096774, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1789235, Length=175, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17535051, Length=309, Percent_Identity=31.7152103559871, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=31.2292358803987, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=31.2292358803987, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17561720, Length=304, Percent_Identity=31.5789473684211, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI115535073, Length=301, Percent_Identity=27.2425249169435, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25147552, Length=322, Percent_Identity=27.9503105590062, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17534315, Length=212, Percent_Identity=31.1320754716981, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=26.046511627907, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17539640, Length=204, Percent_Identity=26.4705882352941, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=318, Percent_Identity=31.1320754716981, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=25.4545454545455, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24643623, Length=206, Percent_Identity=34.4660194174757, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI20129101, Length=206, Percent_Identity=34.4660194174757, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35112; Mature: 35112

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVEQIGNTELIELTNISSNGNRLFVKCEYKNPTGSHKDRTFLHIIESLELHGKISPGMT
CCHHHCCCCEEEEEEECCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCE
LIDCSTGNGGAALAWIGQQKGYNVVIFMPEGMTRERIQQIKSFGAEIIETPKEKFLNGSD
EEEECCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCHHHHCCCHHHHCCCCC
DEAIAYAKVNKNSFYINQSENILNMESWYECGREIIKQLASKNINPDYFICSIGTGGTFS
CCEEEEEEECCCEEEEECCCCEECHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
GISKILKEEFPKLKSIGIEVDKSSPIHAKINKKIFTHRPHNMMGLGAGKISGNTKIDLID
HHHHHHHHHCCHHHHCCEEECCCCCCEEEECCEEEECCCCCEEEECCCEECCCCEEEEEE
EIKVISGEHAWARMRRFIKTNNKEIGPTCGANILISEEIMRSVSNKVIITIFFDSSWKYK
EEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHCCCCEEEEEEECCCCCCH
SRWNGIYPEYNM
HHCCCCCCCCCC
>Mature Secondary Structure
MDVEQIGNTELIELTNISSNGNRLFVKCEYKNPTGSHKDRTFLHIIESLELHGKISPGMT
CCHHHCCCCEEEEEEECCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCE
LIDCSTGNGGAALAWIGQQKGYNVVIFMPEGMTRERIQQIKSFGAEIIETPKEKFLNGSD
EEEECCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHCCHHHHCCCHHHHCCCCC
DEAIAYAKVNKNSFYINQSENILNMESWYECGREIIKQLASKNINPDYFICSIGTGGTFS
CCEEEEEEECCCEEEEECCCCEECHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHH
GISKILKEEFPKLKSIGIEVDKSSPIHAKINKKIFTHRPHNMMGLGAGKISGNTKIDLID
HHHHHHHHHCCHHHHCCEEECCCCCCEEEECCEEEECCCCCEEEECCCEECCCCEEEEEE
EIKVISGEHAWARMRRFIKTNNKEIGPTCGANILISEEIMRSVSNKVIITIFFDSSWKYK
EEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHCCCCEEEEEEECCCCCCH
SRWNGIYPEYNM
HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA