Click here to switch to the map view.

The map label for this gene is rnb [H]

Identifier: 238919718

GI number: 238919718

Start: 1758113

End: 1759993

Strand: Reverse

Name: rnb [H]

Synonym: NT01EI_1821

Alternate gene names: 238919718

Gene position: 1759993-1758113 (Counterclockwise)

Preceding gene: 238919719

Following gene: 238919717

Centisome position: 46.17

GC content: 63.8

Gene sequence:

>1881_bases
GTGGAAGGCGTGGTCAAGGGAACCGACAAAGGCTTTGGCTTTTTAGAGGTTGACGCGCAGAAAAGCTATTTCATTCCACC
GCCGCAAATGAAGAAAGTGATGCACGGTGACCGCATCCGTGCCGCCGTTCAGGTTGATAAAGAGCGTGAAATCGCCGAGC
CGGAAGAGCTGTTGGAGCCATTCCTGACCCGTTTTGTCGGCCGTATTCAGAAAAAAGAGAACGATGAGCGCCTGTCCATT
ATCCCGGACCATCCGCTGTTGAAAGACGCCATCGGCTGTCGTCCGGCACGCGGTCTGGATCGCGCCTTCAGGCAGGGAGA
CTGGGTGCTGGCCGAAATGCGCCGCCACCCACTGAAGGGCGACCGCAGCTTCTTTGCCGAGATCACCGCCTTCATCACCG
ACGGCGGCGACCACTTTGCCCCTTGGTGGGTCACCCTGGCCCGTCACGATCTGGCGTGCAGTGCACCGCAGTGGCAGGCG
GGAACCCTGCTGGAGGAGGGACTGGATCGCGAAGATCTGTGCGCGCTGCCGTTTGTCACCATCGACAGCGCCAGCACCGA
AGACATGGATGATGCGCTGCACGTGCGCGAGAACCCCGACGGCAGCCTGCGTCTGACCATTGCCATCGCCGATCCGACGG
CCTACGTCAGCGCCGACAGCCCGCTGGACGCCGAAGCGTGTCATCGCGCCTTCACCACCTATCTCCCGGGCTTTAACATC
CCGATGCTGCCGCGCGATCTCTCCGACGACCTGTGCTCACTGCGCGAAGGGCAGCGCCGTCCGGTGCTGGCCTGCGAGGT
CACCCTCGACGCCGACGGCGGTCTGCGCAACGACATCCGCTTCTTCAGCGGCTGGATCGAGTCCAAAGCCAAGCTGGCCT
ACGATCGGGTTTCCGACTGGCTGGAGGACTGCGGCGACTGGCAGCCGCCGAGCGACGATATCGCTGCCCAGATCCGCCTG
CTGCACCGCGTGGCCAACGCCCGTACCCAGTGGCGTCAGCAGCATGCCCTGGTGTTCCGCGATCGCCCGGACTACCGCTT
TGTCCTCGACGATCACGGCAACGTCACCGATATCGTCGCGGAGCCGCGCCGCGTGGCCAACCGCATCGTGGAAGAGTGCA
TGATCACTGCCAACGTCTGTGCGGCGCTGGTGCTGCGCGAAGGCCTCGGATTCGGGATCTACAACGTCCATACCGGCTTC
GATCCGGCGCTGGTGGAACAGGCCGTCTCATTACTGAACGCCAACGACGTCGCCACCAACGCCGAAGCGCTGCTGACCCT
GGACGGCTTCTGCACCCTGCGCCGCCATCTCGACTCGCTGCCGGGCACCTTCCTGGATAGCCGTATCCGCCGCTTCCAGA
CCTTTGCCGAAATCAGCACCGAGCCGGGGCCGCACTTTGGCCTGGGGCTGGAGGCCTACGCCACCTGGACTTCACCGATC
CGCAAGTATGGCGATATGGTCAACCACCGTCTGCTGAAGGCACTGATCGCCGGTAAGCCGACGACGCGGCCGGTCCAGGC
AATGACGCAGCAGCTGGCCGAGCGCCGCCGCCAGAACCGGATGGCGGAGCGCGACGTCGGCGACTGGCTGTACGCCCGCT
TCCTGAAGGAGAGGGTTAACGCCCCGATTCCATTCAACGCCGAGATCATCGATATCTCACGCGGTGGCATGCGCGTCCGC
CTGCTGGAAAATGGCGCGGTGGCCTTTATTCCGGCCTCCTTTATCCATGCCGTGCGCGACGAGATGGTATGCAGTCAGGA
GAACGGCACCCTTCAGGTGAAAGGCCGCGTCGTCTACCGCCAGGGCGATACCGTTCCGGTGACCCTGAGCGAGGTTCGCC
TCGATACCCGCAGCCTGATCGCCCGCCCCTTCAGCGCCTGA

Upstream 100 bases:

>100_bases
CACGATCGCTCACCAGCCGGAATCACTATTTCACACTATGTTTCAGGACAACCCGCTGCTTGCCCAGCTAAAACAGCAAC
TTCACTCGCAGACTCCCCGT

Downstream 100 bases:

>100_bases
TCTGAAGGCTCTGGCCCGCCCCGCGCGGGCCATTTTTTTAGGCGATCCCCTGATGCCCAACGGCCCTTTTTGTGCCCTCT
CCCGCCGCGACGCGTTCCAA

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MEGVVKGTDKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIRAAVQVDKEREIAEPEELLEPFLTRFVGRIQKKENDERLSI
IPDHPLLKDAIGCRPARGLDRAFRQGDWVLAEMRRHPLKGDRSFFAEITAFITDGGDHFAPWWVTLARHDLACSAPQWQA
GTLLEEGLDREDLCALPFVTIDSASTEDMDDALHVRENPDGSLRLTIAIADPTAYVSADSPLDAEACHRAFTTYLPGFNI
PMLPRDLSDDLCSLREGQRRPVLACEVTLDADGGLRNDIRFFSGWIESKAKLAYDRVSDWLEDCGDWQPPSDDIAAQIRL
LHRVANARTQWRQQHALVFRDRPDYRFVLDDHGNVTDIVAEPRRVANRIVEECMITANVCAALVLREGLGFGIYNVHTGF
DPALVEQAVSLLNANDVATNAEALLTLDGFCTLRRHLDSLPGTFLDSRIRRFQTFAEISTEPGPHFGLGLEAYATWTSPI
RKYGDMVNHRLLKALIAGKPTTRPVQAMTQQLAERRRQNRMAERDVGDWLYARFLKERVNAPIPFNAEIIDISRGGMRVR
LLENGAVAFIPASFIHAVRDEMVCSQENGTLQVKGRVVYRQGDTVPVTLSEVRLDTRSLIARPFSA

Sequences:

>Translated_626_residues
MEGVVKGTDKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIRAAVQVDKEREIAEPEELLEPFLTRFVGRIQKKENDERLSI
IPDHPLLKDAIGCRPARGLDRAFRQGDWVLAEMRRHPLKGDRSFFAEITAFITDGGDHFAPWWVTLARHDLACSAPQWQA
GTLLEEGLDREDLCALPFVTIDSASTEDMDDALHVRENPDGSLRLTIAIADPTAYVSADSPLDAEACHRAFTTYLPGFNI
PMLPRDLSDDLCSLREGQRRPVLACEVTLDADGGLRNDIRFFSGWIESKAKLAYDRVSDWLEDCGDWQPPSDDIAAQIRL
LHRVANARTQWRQQHALVFRDRPDYRFVLDDHGNVTDIVAEPRRVANRIVEECMITANVCAALVLREGLGFGIYNVHTGF
DPALVEQAVSLLNANDVATNAEALLTLDGFCTLRRHLDSLPGTFLDSRIRRFQTFAEISTEPGPHFGLGLEAYATWTSPI
RKYGDMVNHRLLKALIAGKPTTRPVQAMTQQLAERRRQNRMAERDVGDWLYARFLKERVNAPIPFNAEIIDISRGGMRVR
LLENGAVAFIPASFIHAVRDEMVCSQENGTLQVKGRVVYRQGDTVPVTLSEVRLDTRSLIARPFSA
>Mature_626_residues
MEGVVKGTDKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIRAAVQVDKEREIAEPEELLEPFLTRFVGRIQKKENDERLSI
IPDHPLLKDAIGCRPARGLDRAFRQGDWVLAEMRRHPLKGDRSFFAEITAFITDGGDHFAPWWVTLARHDLACSAPQWQA
GTLLEEGLDREDLCALPFVTIDSASTEDMDDALHVRENPDGSLRLTIAIADPTAYVSADSPLDAEACHRAFTTYLPGFNI
PMLPRDLSDDLCSLREGQRRPVLACEVTLDADGGLRNDIRFFSGWIESKAKLAYDRVSDWLEDCGDWQPPSDDIAAQIRL
LHRVANARTQWRQQHALVFRDRPDYRFVLDDHGNVTDIVAEPRRVANRIVEECMITANVCAALVLREGLGFGIYNVHTGF
DPALVEQAVSLLNANDVATNAEALLTLDGFCTLRRHLDSLPGTFLDSRIRRFQTFAEISTEPGPHFGLGLEAYATWTSPI
RKYGDMVNHRLLKALIAGKPTTRPVQAMTQQLAERRRQNRMAERDVGDWLYARFLKERVNAPIPFNAEIIDISRGGMRVR
LLENGAVAFIPASFIHAVRDEMVCSQENGTLQVKGRVVYRQGDTVPVTLSEVRLDTRSLIARPFSA

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=356, Percent_Identity=27.247191011236, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI190014623, Length=359, Percent_Identity=27.8551532033426, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI134288890, Length=444, Percent_Identity=25.4504504504505, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI219521928, Length=442, Percent_Identity=26.0180995475113, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI19115966, Length=442, Percent_Identity=26.0180995475113, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1787542, Length=624, Percent_Identity=69.3910256410256, Blast_Score=901, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=664, Percent_Identity=28.6144578313253, Blast_Score=194, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17553506, Length=439, Percent_Identity=26.6514806378132, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI212645896, Length=465, Percent_Identity=26.2365591397849, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324552, Length=479, Percent_Identity=22.5469728601253, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24649634, Length=356, Percent_Identity=29.4943820224719, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI19922976, Length=448, Percent_Identity=25.6696428571429, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24654597, Length=448, Percent_Identity=25.6696428571429, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24654592, Length=433, Percent_Identity=25.1732101616628, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 70378; Mature: 70378

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGVVKGTDKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIRAAVQVDKEREIAEPEELLEP
CCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCHHHEEEEECCCCCCCCHHHHHHH
FLTRFVGRIQKKENDERLSIIPDHPLLKDAIGCRPARGLDRAFRQGDWVLAEMRRHPLKG
HHHHHHHHHHHCCCCCCEEECCCCCHHHHHHCCCCCHHHHHHHHCCCHHHHHHHCCCCCC
DRSFFAEITAFITDGGDHFAPWWVTLARHDLACSAPQWQAGTLLEEGLDREDLCALPFVT
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEE
IDSASTEDMDDALHVRENPDGSLRLTIAIADPTAYVSADSPLDAEACHRAFTTYLPGFNI
ECCCCCCCCHHHHEECCCCCCCEEEEEEEECCCEEECCCCCCCHHHHHHHHHHHCCCCCC
PMLPRDLSDDLCSLREGQRRPVLACEVTLDADGGLRNDIRFFSGWIESKAKLAYDRVSDW
CCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEDCGDWQPPSDDIAAQIRLLHRVANARTQWRQQHALVFRDRPDYRFVLDDHGNVTDIVA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCEEEEECCCCCCHHHHC
EPRRVANRIVEECMITANVCAALVLREGLGFGIYNVHTGFDPALVEQAVSLLNANDVATN
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCC
AEALLTLDGFCTLRRHLDSLPGTFLDSRIRRFQTFAEISTEPGPHFGLGLEAYATWTSPI
CCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RKYGDMVNHRLLKALIAGKPTTRPVQAMTQQLAERRRQNRMAERDVGDWLYARFLKERVN
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APIPFNAEIIDISRGGMRVRLLENGAVAFIPASFIHAVRDEMVCSQENGTLQVKGRVVYR
CCCCCCCEEEEECCCCEEEEEEECCCEEEEHHHHHHHHHHHHHCCCCCCEEEEEEEEEEE
QGDTVPVTLSEVRLDTRSLIARPFSA
CCCEEEEEHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEGVVKGTDKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIRAAVQVDKEREIAEPEELLEP
CCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCHHHEEEEECCCCCCCCHHHHHHH
FLTRFVGRIQKKENDERLSIIPDHPLLKDAIGCRPARGLDRAFRQGDWVLAEMRRHPLKG
HHHHHHHHHHHCCCCCCEEECCCCCHHHHHHCCCCCHHHHHHHHCCCHHHHHHHCCCCCC
DRSFFAEITAFITDGGDHFAPWWVTLARHDLACSAPQWQAGTLLEEGLDREDLCALPFVT
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEE
IDSASTEDMDDALHVRENPDGSLRLTIAIADPTAYVSADSPLDAEACHRAFTTYLPGFNI
ECCCCCCCCHHHHEECCCCCCCEEEEEEEECCCEEECCCCCCCHHHHHHHHHHHCCCCCC
PMLPRDLSDDLCSLREGQRRPVLACEVTLDADGGLRNDIRFFSGWIESKAKLAYDRVSDW
CCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEDCGDWQPPSDDIAAQIRLLHRVANARTQWRQQHALVFRDRPDYRFVLDDHGNVTDIVA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCEEEEECCCCCCHHHHC
EPRRVANRIVEECMITANVCAALVLREGLGFGIYNVHTGFDPALVEQAVSLLNANDVATN
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCC
AEALLTLDGFCTLRRHLDSLPGTFLDSRIRRFQTFAEISTEPGPHFGLGLEAYATWTSPI
CCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RKYGDMVNHRLLKALIAGKPTTRPVQAMTQQLAERRRQNRMAERDVGDWLYARFLKERVN
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APIPFNAEIIDISRGGMRVRLLENGAVAFIPASFIHAVRDEMVCSQENGTLQVKGRVVYR
CCCCCCCEEEEECCCCEEEEEEECCCEEEEHHHHHHHHHHHHHCCCCCCEEEEEEEEEEE
QGDTVPVTLSEVRLDTRSLIARPFSA
CCCEEEEEHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA