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The map label for this gene is mdtH

Identifier: 238919484

GI number: 238919484

Start: 1541116

End: 1542324

Strand: Reverse

Name: mdtH

Synonym: NT01EI_1580

Alternate gene names: 238919484

Gene position: 1542324-1541116 (Counterclockwise)

Preceding gene: 238919488

Following gene: 238919483

Centisome position: 40.46

GC content: 64.1

Gene sequence:

>1209_bases
ATGTCGCTGGTATTACAGGCCAGGCGATCGGGAAAATACTTTCTACTGATCGATAATCTACTGGTCGTGCTGGGCTTCTT
TGTCGTTTTTCCCCTCATCTCCATCCGCTTTGTCGACCAGTTGGGCTGGGCCGCCCTGATCGTCGGCATCGCCCTCGGCC
TGCGCCAGCTGCTGCAGCAGGGGCTGGGGATCTTTGGCGGGGCGATCGCCGATCGCGTCGGTGCCAAGCCGATGATCATC
AGCGGTATGCTGCTGCGCGCCGCCGGATTCGCCACGATGGCCGTCGCCAGTGAACCGTGGATCCTCTGGGCCTCCTGCAC
CCTTTCCGCCCTGGGTGGCACGCTGTTCGATCCCCCGCGAACCGCGCTGGTGATCAAGCTCACCCGCCCCCATGAGCGCG
GCCGCTTCTACTCCCTGCTGATGATGCAGGACAGCGCCGGCGCGGTGATCGGCGCCCTGATCGGCAGCTGGCTGCTGGCC
TATGACTTCCACTACGTGTGCTGGGCCGGCGCCGCCCTCTTTGTGCTGGCCGCCGCCTGGAACGCCTGGCTGCTGCCGGC
CTACCGTATTTCGACCATCCGGGCGCCGGTGCGTGAAGGCATGCTGCGCGTGGTGCGCGATCGGCGTTTTTTGACCTATG
TGCTCACCCTCACCGGTTACTATATGTTGGCGGTTCAGGTCATGCTGATGCTGCCGATCATGGTCAACGACATCGCCGGC
GGGCCGGGCGCGGTGAAATGGATGTACGCCATTGAGGCGGCACTGTCGCTGACCTTGCTCTATCCCATCGCCCGCTGGAG
CGAAAAGCGTTTCCGTCTGGAACAGCGCCTGATGTTCGGCCTGCTGCTGATGACCCTCAGCCTGTTTCCCCTGGGGCTGA
GCACCACGCTACAGTCGCTGTTCGCGCTGATCTGCTGCTTCTATCTCGGCTCAATCATCGCCGAGCCGGCACGCGAAACC
CTCAGCGCCTCGCTGGCCGATGCCCGGGCGCGCGGCAGCTACATGGGCTTTAGCCGCCTCGGGCTGGCGCTGGGGGGAGC
CCTCGGCTACACCGGCGGCGGTTGGATGTATGATATGGGGCGCAGCATGAACATGCCTGAGCTCCCCTGGGCACTTCTGG
GGATCATCGGTATGCTGACGCTGGCCCTGCTCTACTGGCAGTTTTCACTGCAGGTGCCCTGCGCCACGCACCAGCCCCGC
TCAAGCTAA

Upstream 100 bases:

>100_bases
TTTATTCGTCAAATCTATCATTTACCTGTCATTGCTTTCGTAAAACGGCGAAAATGATCACACTCTATACTATCGCTTCA
CTCGCGCTCAATGGTGGAAC

Downstream 100 bases:

>100_bases
CGCGGCAGCGGAATTCGGTCTTATCCGATCCCCGCCGCAGTCCCAACTATTTATGCTGTAACACTCGTACTGCGTGGCGC
TTCATCCCGTTACAGTGGTT

Product: multidrug resistance protein MdtH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MSLVLQARRSGKYFLLIDNLLVVLGFFVVFPLISIRFVDQLGWAALIVGIALGLRQLLQQGLGIFGGAIADRVGAKPMII
SGMLLRAAGFATMAVASEPWILWASCTLSALGGTLFDPPRTALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLA
YDFHYVCWAGAALFVLAAAWNAWLLPAYRISTIRAPVREGMLRVVRDRRFLTYVLTLTGYYMLAVQVMLMLPIMVNDIAG
GPGAVKWMYAIEAALSLTLLYPIARWSEKRFRLEQRLMFGLLLMTLSLFPLGLSTTLQSLFALICCFYLGSIIAEPARET
LSASLADARARGSYMGFSRLGLALGGALGYTGGGWMYDMGRSMNMPELPWALLGIIGMLTLALLYWQFSLQVPCATHQPR
SS

Sequences:

>Translated_402_residues
MSLVLQARRSGKYFLLIDNLLVVLGFFVVFPLISIRFVDQLGWAALIVGIALGLRQLLQQGLGIFGGAIADRVGAKPMII
SGMLLRAAGFATMAVASEPWILWASCTLSALGGTLFDPPRTALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLA
YDFHYVCWAGAALFVLAAAWNAWLLPAYRISTIRAPVREGMLRVVRDRRFLTYVLTLTGYYMLAVQVMLMLPIMVNDIAG
GPGAVKWMYAIEAALSLTLLYPIARWSEKRFRLEQRLMFGLLLMTLSLFPLGLSTTLQSLFALICCFYLGSIIAEPARET
LSASLADARARGSYMGFSRLGLALGGALGYTGGGWMYDMGRSMNMPELPWALLGIIGMLTLALLYWQFSLQVPCATHQPR
SS
>Mature_401_residues
SLVLQARRSGKYFLLIDNLLVVLGFFVVFPLISIRFVDQLGWAALIVGIALGLRQLLQQGLGIFGGAIADRVGAKPMIIS
GMLLRAAGFATMAVASEPWILWASCTLSALGGTLFDPPRTALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLAY
DFHYVCWAGAALFVLAAAWNAWLLPAYRISTIRAPVREGMLRVVRDRRFLTYVLTLTGYYMLAVQVMLMLPIMVNDIAGG
PGAVKWMYAIEAALSLTLLYPIARWSEKRFRLEQRLMFGLLLMTLSLFPLGLSTTLQSLFALICCFYLGSIIAEPARETL
SASLADARARGSYMGFSRLGLALGGALGYTGGGWMYDMGRSMNMPELPWALLGIIGMLTLALLYWQFSLQVPCATHQPRS
S

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily

Homologues:

Organism=Escherichia coli, GI87081828, Length=389, Percent_Identity=78.4061696658098, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI87081738, Length=345, Percent_Identity=23.4782608695652, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MDTH_EDWI9 (C5B828)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002932999.1
- GeneID:   7961908
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_1580
- OMA:   FDPPRAA
- ProtClustDB:   PRK11646
- HAMAP:   MF_01529
- InterPro:   IPR020846
- InterPro:   IPR022855
- InterPro:   IPR011701
- InterPro:   IPR016196

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 44143; Mature: 44012

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1c306b3c)-; HASH(0x1cc85784)-; HASH(0x1cb0aa84)-; HASH(0x1bdd4170)-; HASH(0x4085c92c)-; HASH(0x1cc4bdf0)-; HASH(0x1cc8c424)-; HASH(0x1cc555e4)-; HASH(0x1c719a20)-; HASH(0x1c552abc)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVLQARRSGKYFLLIDNLLVVLGFFVVFPLISIRFVDQLGWAALIVGIALGLRQLLQQ
CCCEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIFGGAIADRVGAKPMIISGMLLRAAGFATMAVASEPWILWASCTLSALGGTLFDPPR
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCC
TALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLAYDFHYVCWAGAALFVLAAAW
CEEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAWLLPAYRISTIRAPVREGMLRVVRDRRFLTYVLTLTGYYMLAVQVMLMLPIMVNDIAG
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPGAVKWMYAIEAALSLTLLYPIARWSEKRFRLEQRLMFGLLLMTLSLFPLGLSTTLQSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FALICCFYLGSIIAEPARETLSASLADARARGSYMGFSRLGLALGGALGYTGGGWMYDMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHCC
RSMNMPELPWALLGIIGMLTLALLYWQFSLQVPCATHQPRSS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCH
>Mature Secondary Structure 
SLVLQARRSGKYFLLIDNLLVVLGFFVVFPLISIRFVDQLGWAALIVGIALGLRQLLQQ
CCEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIFGGAIADRVGAKPMIISGMLLRAAGFATMAVASEPWILWASCTLSALGGTLFDPPR
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCC
TALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLAYDFHYVCWAGAALFVLAAAW
CEEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAWLLPAYRISTIRAPVREGMLRVVRDRRFLTYVLTLTGYYMLAVQVMLMLPIMVNDIAG
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GPGAVKWMYAIEAALSLTLLYPIARWSEKRFRLEQRLMFGLLLMTLSLFPLGLSTTLQSL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FALICCFYLGSIIAEPARETLSASLADARARGSYMGFSRLGLALGGALGYTGGGWMYDMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHCC
RSMNMPELPWALLGIIGMLTLALLYWQFSLQVPCATHQPRSS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA