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The map label for this gene is pth

Identifier: 238919462

GI number: 238919462

Start: 1518837

End: 1519427

Strand: Reverse

Name: pth

Synonym: NT01EI_1556

Alternate gene names: 238919462

Gene position: 1519427-1518837 (Counterclockwise)

Preceding gene: 238919465

Following gene: 238919461

Centisome position: 39.86

GC content: 59.9

Gene sequence:

>591_bases
ATGACGATTAAACTGATTGTCGGCCTGGCTAACCCTGGCGCTGAATATGCCCAGACCCGCCATAACGCCGGCGCCTGGTT
CGTTGACGCCCTCGCCGAACGCCACGGCCAGTCCCTGAAAGAAGAGAGCAAATTTTTTGGCTATACCGCCCGCCTCAGCC
TGGCAGGCCATGACCTGCGCCTGCTGGTGCCGACCACCTTTATGAACCTGAGCGGCAAAGCCGTCTCCGCCCTGGCCGGA
TTTTACCGCATCGCCCCGGATGAAATTCTGGTCGCACACGATGAACTGGATCTGCCGCCGGGCGTTGCCAAACTGAAACT
CGGCGGCGGCAACGGCGGTCATAATGGCCTGAAGGACATTCAAAGCAAACTGGGCAATAACCCCAACTTTCACCGCCTGC
GCATCGGCATTGGCCACCCCGGAGACAAAAGCAAGGTTGTCGGCTTTGTCCTGGGTAAACCGCTGGCCAGCGAACAGCCC
CTAATCGACGATGCCATCGACGAGGCGCTGCGCTGCACCGATCTGCTGATGCAGGATGGCATGGATAAGGCGATGAATCG
CCTCAACGGCTTCAGGGCCAGCGCCCGCTAG

Upstream 100 bases:

>100_bases
AGTGAGCGGCGACAAATTATGGTCTAATTACGGTTTGGCGCTTTGCCTACTATCTGCCGCGGCACTGCCCGCGCCTATCA
CATAAAGACTGAATGCACTG

Downstream 100 bases:

>100_bases
TGCGACGCAACAACGCCGCCCGCCACACGTGTTCTACGGATAAGTCGAGAAAATGACGCGTTGCGTGTATAATCGGGCGA
TATTTTCCTGTTTCTTTGGC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MTIKLIVGLANPGAEYAQTRHNAGAWFVDALAERHGQSLKEESKFFGYTARLSLAGHDLRLLVPTTFMNLSGKAVSALAG
FYRIAPDEILVAHDELDLPPGVAKLKLGGGNGGHNGLKDIQSKLGNNPNFHRLRIGIGHPGDKSKVVGFVLGKPLASEQP
LIDDAIDEALRCTDLLMQDGMDKAMNRLNGFRASAR

Sequences:

>Translated_196_residues
MTIKLIVGLANPGAEYAQTRHNAGAWFVDALAERHGQSLKEESKFFGYTARLSLAGHDLRLLVPTTFMNLSGKAVSALAG
FYRIAPDEILVAHDELDLPPGVAKLKLGGGNGGHNGLKDIQSKLGNNPNFHRLRIGIGHPGDKSKVVGFVLGKPLASEQP
LIDDAIDEALRCTDLLMQDGMDKAMNRLNGFRASAR
>Mature_195_residues
TIKLIVGLANPGAEYAQTRHNAGAWFVDALAERHGQSLKEESKFFGYTARLSLAGHDLRLLVPTTFMNLSGKAVSALAGF
YRIAPDEILVAHDELDLPPGVAKLKLGGGNGGHNGLKDIQSKLGNNPNFHRLRIGIGHPGDKSKVVGFVLGKPLASEQPL
IDDAIDEALRCTDLLMQDGMDKAMNRLNGFRASAR

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=175, Percent_Identity=36.5714285714286, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI1787455, Length=194, Percent_Identity=79.3814432989691, Blast_Score=300, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6321983, Length=176, Percent_Identity=30.6818181818182, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_EDWI9 (C5B806)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002932977.1
- GeneID:   7961037
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_1556
- OMA:   NESGRQV
- ProtClustDB:   CLSK2813077
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21079; Mature: 20948

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKLIVGLANPGAEYAQTRHNAGAWFVDALAERHGQSLKEESKFFGYTARLSLAGHDLR
CEEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCEEEEEEECCCCEE
LLVPTTFMNLSGKAVSALAGFYRIAPDEILVAHDELDLPPGVAKLKLGGGNGGHNGLKDI
EEECCHHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCHHHHH
QSKLGNNPNFHRLRIGIGHPGDKSKVVGFVLGKPLASEQPLIDDAIDEALRCTDLLMQDG
HHHHCCCCCEEEEEEECCCCCCCHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
MDKAMNRLNGFRASAR
HHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TIKLIVGLANPGAEYAQTRHNAGAWFVDALAERHGQSLKEESKFFGYTARLSLAGHDLR
EEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCEEEEEEECCCCEE
LLVPTTFMNLSGKAVSALAGFYRIAPDEILVAHDELDLPPGVAKLKLGGGNGGHNGLKDI
EEECCHHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCHHHHH
QSKLGNNPNFHRLRIGIGHPGDKSKVVGFVLGKPLASEQPLIDDAIDEALRCTDLLMQDG
HHHHCCCCCEEEEEEECCCCCCCHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
MDKAMNRLNGFRASAR
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA