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The map label for this gene is neuA [H]

Identifier: 238919234

GI number: 238919234

Start: 1308142

End: 1309392

Strand: Direct

Name: neuA [H]

Synonym: NT01EI_1317

Alternate gene names: 238919234

Gene position: 1308142-1309392 (Clockwise)

Preceding gene: 238919233

Following gene: 238919235

Centisome position: 34.31

GC content: 34.93

Gene sequence:

>1251_bases
ATGAAAGTTGCCATCATTCCAGCTCGCTCTGGCTCAAAGGGATTGCGCAATAAAAACATTCTAATGTTAATGGATAAGCC
ATTAATTGCGTATACTATTGAGGCTGCTATAAACTCTGGTGTGTTTGATAGGGTGATTGTTTCTACTGACTCAGATGAGT
ATAAACGCATTGCAGAGTCATTTGGCGCAGAGGTTTTTATTAGAGATGCGGCGTTAGCCTCTGACTCAGCAACATCCTAT
ATGGTGGTTGAGGATGTTTTGAGTAAAGTTAGTGATATACAGTATTTTGCATTGCTGCAGCCAACATCGCCTTTTCGTAC
TGCGGAGCATATTAAGTCTGCTGCTGCTTTATTTTATTCATCAGAGCATAGCTTTTTAGTCTCAATGGTACAAAGTGATA
AACCCTCCTATCTTATTAAACCGTTGGCGGAAGATCTGACCTTAAAATATTTTGATATTGATTTTAGTTTATATCACCGA
CAGGATAATAAAGAATACTTTCCAAATGGTGCTATATTTATGGCTAAGCCAGAGGCTTATCTGAAGAGGCGGCATTTTTT
TGGTAGTGATAGCGTGGCCTTTATCATGAGTAAAGAAGACTCTCTTGATATTGATGATCGATATGACTTTGAAGTTGCTA
TAAATATACAGATGCGCCGGTGTAAAAAAGAAATTTTGCGAGAAAATATTATAAATAGAATTGCAGAAAAGAAAGAGCTA
ATGTGTTTAAATACATCGATAACATTGCTTGGTCATTCCATTTTTGATTATTGGCTGGTTGATAATATTAATGGTGAGGA
AGTAAACAACCTGGGTATTGCTGGAATTAATACTAAAGAATATATTGATCTTATTTTGGATAGATCATTAATAAAAAATA
TTGGTGATACTGCTATTATTATGTTGGGTACTAATGATATGGTGCTCAATGACTGGGATATTACATTTTCTGCTGAATGG
GTCAGGGAATTTATTGATAAAGTTAGAATAATAAAAAACAATGTGGCTATTTATTTTATTGCAGTACCACCAGTGAGGGG
GCGAGTTGATCGAAATAATGATATTATAACTCAATTGAATATAATATTAAGGAAGGTTTGTTTGGATAAATCTATTCATT
GGATCGGGCTTTCCAACGAGTTTTATGATGAATATGGGAATCTACCTGCATCATATACCTATGATGGATTGCATTTTTCA
CAACTTGCCTATACGAAATTGAAAGAAAACATTGAGACTGCATTGTCATGA

Upstream 100 bases:

>100_bases
TGCATTGGTATCAGGTCTTAGGCAGCATTGCAGAGCGAGATTTTTGTGAAGATGAACTGATCTATTGCTCTAACTTGAGC
ATGCAGGAGCTATAAGATAT

Downstream 100 bases:

>100_bases
AGCATTTGCTATGTGTTACTGGTTCACGCGCTGAATATGGAATTTTACGCCGATTATTAATGTTGCTATCTCGTACGGAG
GGGGTCAAGTTAAGTATCAT

Product: N-acylneuraminate cytidylyltransferase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKVAIIPARSGSKGLRNKNILMLMDKPLIAYTIEAAINSGVFDRVIVSTDSDEYKRIAESFGAEVFIRDAALASDSATSY
MVVEDVLSKVSDIQYFALLQPTSPFRTAEHIKSAAALFYSSEHSFLVSMVQSDKPSYLIKPLAEDLTLKYFDIDFSLYHR
QDNKEYFPNGAIFMAKPEAYLKRRHFFGSDSVAFIMSKEDSLDIDDRYDFEVAINIQMRRCKKEILRENIINRIAEKKEL
MCLNTSITLLGHSIFDYWLVDNINGEEVNNLGIAGINTKEYIDLILDRSLIKNIGDTAIIMLGTNDMVLNDWDITFSAEW
VREFIDKVRIIKNNVAIYFIAVPPVRGRVDRNNDIITQLNIILRKVCLDKSIHWIGLSNEFYDEYGNLPASYTYDGLHFS
QLAYTKLKENIETALS

Sequences:

>Translated_416_residues
MKVAIIPARSGSKGLRNKNILMLMDKPLIAYTIEAAINSGVFDRVIVSTDSDEYKRIAESFGAEVFIRDAALASDSATSY
MVVEDVLSKVSDIQYFALLQPTSPFRTAEHIKSAAALFYSSEHSFLVSMVQSDKPSYLIKPLAEDLTLKYFDIDFSLYHR
QDNKEYFPNGAIFMAKPEAYLKRRHFFGSDSVAFIMSKEDSLDIDDRYDFEVAINIQMRRCKKEILRENIINRIAEKKEL
MCLNTSITLLGHSIFDYWLVDNINGEEVNNLGIAGINTKEYIDLILDRSLIKNIGDTAIIMLGTNDMVLNDWDITFSAEW
VREFIDKVRIIKNNVAIYFIAVPPVRGRVDRNNDIITQLNIILRKVCLDKSIHWIGLSNEFYDEYGNLPASYTYDGLHFS
QLAYTKLKENIETALS
>Mature_416_residues
MKVAIIPARSGSKGLRNKNILMLMDKPLIAYTIEAAINSGVFDRVIVSTDSDEYKRIAESFGAEVFIRDAALASDSATSY
MVVEDVLSKVSDIQYFALLQPTSPFRTAEHIKSAAALFYSSEHSFLVSMVQSDKPSYLIKPLAEDLTLKYFDIDFSLYHR
QDNKEYFPNGAIFMAKPEAYLKRRHFFGSDSVAFIMSKEDSLDIDDRYDFEVAINIQMRRCKKEILRENIINRIAEKKEL
MCLNTSITLLGHSIFDYWLVDNINGEEVNNLGIAGINTKEYIDLILDRSLIKNIGDTAIIMLGTNDMVLNDWDITFSAEW
VREFIDKVRIIKNNVAIYFIAVPPVRGRVDRNNDIITQLNIILRKVCLDKSIHWIGLSNEFYDEYGNLPASYTYDGLHFS
QLAYTKLKENIETALS

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=217, Percent_Identity=29.9539170506912, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329
- InterPro:   IPR013830
- InterPro:   IPR013831 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 47516; Mature: 47516

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAIIPARSGSKGLRNKNILMLMDKPLIAYTIEAAINSGVFDRVIVSTDSDEYKRIAES
CEEEEEECCCCCCCCCCCCEEEEECCCEEEEEEEHHHCCCCCEEEEEECCCHHHHHHHHH
FGAEVFIRDAALASDSATSYMVVEDVLSKVSDIQYFALLQPTSPFRTAEHIKSAAALFYS
CCCEEEEEEHHHCCCCCCEEHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHEEC
SEHSFLVSMVQSDKPSYLIKPLAEDLTLKYFDIDFSLYHRQDNKEYFPNGAIFMAKPEAY
CCCHHHHHHHHCCCCCEEHHHHHCCCEEEEEEEEEEEEEECCCCCCCCCCEEEEECCHHH
LKRRHFFGSDSVAFIMSKEDSLDIDDRYDFEVAINIQMRRCKKEILRENIINRIAEKKEL
HHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCE
MCLNTSITLLGHSIFDYWLVDNINGEEVNNLGIAGINTKEYIDLILDRSLIKNIGDTAII
EEEECHHHHHHHHHHHHHEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCEEE
MLGTNDMVLNDWDITFSAEWVREFIDKVRIIKNNVAIYFIAVPPVRGRVDRNNDIITQLN
EECCCCEEEECCCEEEEHHHHHHHHHHHHEEECCEEEEEEEECCCCCCCCCCCCHHHHHH
IILRKVCLDKSIHWIGLSNEFYDEYGNLPASYTYDGLHFSQLAYTKLKENIETALS
HHHHHHHHCCCEEEEECCHHHHHHHCCCCCCEEECCEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVAIIPARSGSKGLRNKNILMLMDKPLIAYTIEAAINSGVFDRVIVSTDSDEYKRIAES
CEEEEEECCCCCCCCCCCCEEEEECCCEEEEEEEHHHCCCCCEEEEEECCCHHHHHHHHH
FGAEVFIRDAALASDSATSYMVVEDVLSKVSDIQYFALLQPTSPFRTAEHIKSAAALFYS
CCCEEEEEEHHHCCCCCCEEHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHEEC
SEHSFLVSMVQSDKPSYLIKPLAEDLTLKYFDIDFSLYHRQDNKEYFPNGAIFMAKPEAY
CCCHHHHHHHHCCCCCEEHHHHHCCCEEEEEEEEEEEEEECCCCCCCCCCEEEEECCHHH
LKRRHFFGSDSVAFIMSKEDSLDIDDRYDFEVAINIQMRRCKKEILRENIINRIAEKKEL
HHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCE
MCLNTSITLLGHSIFDYWLVDNINGEEVNNLGIAGINTKEYIDLILDRSLIKNIGDTAII
EEEECHHHHHHHHHHHHHEEECCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCEEE
MLGTNDMVLNDWDITFSAEWVREFIDKVRIIKNNVAIYFIAVPPVRGRVDRNNDIITQLN
EECCCCEEEECCCEEEEHHHHHHHHHHHHEEECCEEEEEEEECCCCCCCCCCCCHHHHHH
IILRKVCLDKSIHWIGLSNEFYDEYGNLPASYTYDGLHFSQLAYTKLKENIETALS
HHHHHHHHCCCEEEEECCHHHHHHHCCCCCCEEECCEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2549035 [H]