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The map label for this gene is lysP [H]

Identifier: 238919211

GI number: 238919211

Start: 1281256

End: 1282656

Strand: Direct

Name: lysP [H]

Synonym: NT01EI_1294

Alternate gene names: 238919211

Gene position: 1281256-1282656 (Clockwise)

Preceding gene: 238919210

Following gene: 238919213

Centisome position: 33.61

GC content: 57.82

Gene sequence:

>1401_bases
ATGATCGCTATCGGCGGTTCTATTGGTACTGGGCTGTTTGTTGCATCAGGCGCTACGGTGTCCCAGGCCGGCCCCGGCGG
AGCGCTGTTGTCGTATATCATCATCGGGATGATGGTGTACTTCCTGATGACCAGCCTGGGTGAGCTGGCGGCGTTTATGC
CGGTGTCAGGCTCGTTTTCTACCTACGGCTCACGTTACGTGGAAGAGGGCTTTGGCTTCGCGCTGGGCTGGAATTATTGG
TATAACTGGGCGGTGACCATCGCCGTCGATCTGGTAGCCGCACAGCTGGTGATGGGCTACTGGTTTCCCGATATGCCCGG
CTGGATCTGGAGCGCGCTGTTCCTGTGCCTGATATTCCTGCTGAACTATATTTCGGTGAAGGGCTTTGGCGAGGCGGAGT
ACTGGTTCTCGCTGATCAAAGTCAGCACCGTGATCATCTTTATCGCCGTGGGGCTGATGATGATCGCCGGTATCCTGAAG
GGCGGCGAAGGTGCCGGTTTCCATAACTGGACCATCGGTGATGCGCCGTTTGCCGGGGGTTTTGCCTCGATGATCGGGGT
GGCGATGATCGTCGGTTTCTCCTTCCAGGGCACCGAGCTTATCGGCATTGCCGCCGGGGAGTCTAAGGATCCGGGTAAAA
ATATTCCGATGGCGGTGCGTCAGGTCTTCTGGCGCATTCTGTTGTTCTATGTGTTCGCTATTCTGATCATCAGTCTGCTG
ATCCCCTATACCGATCCCAGCCTGCTGCGTAATGACGTGAAGGATATCTCCGTCAGCCCGTTCACCCTGGTGTTCAAGAA
TGCCGGTCTGCTCTCTGCGGCGGCGGTGATGAACGCGGTGATCCTGACGGCGGTGCTGTCAGCGGGGAACTCTGGGATGT
ATGCCTCGACGCGTATGCTGTACACCCTGGCGACGGAGGGCAAGGCACCGCGTATTTTCGGCCGTCTGTCCAAGGGGGGC
GTGCCACGCAATGCGCTGTACGCCACCACGGTGGTCGCCGGTCTGTGCTTCCTGACTTCGATGTTCGGCAACCAGGAGGT
CTATCTGTGGCTGCTGAACACCTCGGGGATGACCGGGTTTATCGCCTGGCTGGGGATCGCCATCAGCCACTACCGTTTCC
GTCGCGGCTACGTGATGGCGGGACTCGACCTGAATGCGCTGCCCTATAAATCCGGCTTCTTCCCGCTCGGGCCAATCTTT
GCCTTTGTGCTGTGTCTGATCATCACGCTGGGACAGAACTATGAGGCGTTCCTGAAGGATCGCATCGACTGGTACGGTGT
AACTGCGACCTATATCGGTCTGCCGCTGTTCCTGATCATCTGGTTTGGCTATAAGCTGACGCAGGGAACCCGGTTTGTCC
GCTATAGCGAGATGACCTTCCCGACGACCAAGGTCGACTAA

Upstream 100 bases:

>100_bases
AAACAACGATAGGGTTCTAATGGCTCAGACAAAAACTACCGTCCCCGATGCGGGACAAGGACCGGCGCTGCGCCGGGAGT
TAAAAGCGCGGCACTTGTCG

Downstream 100 bases:

>100_bases
GCGACCCACCGCGAAAAATCGCTCCGGATGCCTGTGCTCCGGGGCGTTTTTTTTGCGGCCTTCGCTGACAGAGCACATTG
CTGAGGCCGGGGCGATAAAA

Product: lysine transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MIAIGGSIGTGLFVASGATVSQAGPGGALLSYIIIGMMVYFLMTSLGELAAFMPVSGSFSTYGSRYVEEGFGFALGWNYW
YNWAVTIAVDLVAAQLVMGYWFPDMPGWIWSALFLCLIFLLNYISVKGFGEAEYWFSLIKVSTVIIFIAVGLMMIAGILK
GGEGAGFHNWTIGDAPFAGGFASMIGVAMIVGFSFQGTELIGIAAGESKDPGKNIPMAVRQVFWRILLFYVFAILIISLL
IPYTDPSLLRNDVKDISVSPFTLVFKNAGLLSAAAVMNAVILTAVLSAGNSGMYASTRMLYTLATEGKAPRIFGRLSKGG
VPRNALYATTVVAGLCFLTSMFGNQEVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVMAGLDLNALPYKSGFFPLGPIF
AFVLCLIITLGQNYEAFLKDRIDWYGVTATYIGLPLFLIIWFGYKLTQGTRFVRYSEMTFPTTKVD

Sequences:

>Translated_466_residues
MIAIGGSIGTGLFVASGATVSQAGPGGALLSYIIIGMMVYFLMTSLGELAAFMPVSGSFSTYGSRYVEEGFGFALGWNYW
YNWAVTIAVDLVAAQLVMGYWFPDMPGWIWSALFLCLIFLLNYISVKGFGEAEYWFSLIKVSTVIIFIAVGLMMIAGILK
GGEGAGFHNWTIGDAPFAGGFASMIGVAMIVGFSFQGTELIGIAAGESKDPGKNIPMAVRQVFWRILLFYVFAILIISLL
IPYTDPSLLRNDVKDISVSPFTLVFKNAGLLSAAAVMNAVILTAVLSAGNSGMYASTRMLYTLATEGKAPRIFGRLSKGG
VPRNALYATTVVAGLCFLTSMFGNQEVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVMAGLDLNALPYKSGFFPLGPIF
AFVLCLIITLGQNYEAFLKDRIDWYGVTATYIGLPLFLIIWFGYKLTQGTRFVRYSEMTFPTTKVD
>Mature_466_residues
MIAIGGSIGTGLFVASGATVSQAGPGGALLSYIIIGMMVYFLMTSLGELAAFMPVSGSFSTYGSRYVEEGFGFALGWNYW
YNWAVTIAVDLVAAQLVMGYWFPDMPGWIWSALFLCLIFLLNYISVKGFGEAEYWFSLIKVSTVIIFIAVGLMMIAGILK
GGEGAGFHNWTIGDAPFAGGFASMIGVAMIVGFSFQGTELIGIAAGESKDPGKNIPMAVRQVFWRILLFYVFAILIISLL
IPYTDPSLLRNDVKDISVSPFTLVFKNAGLLSAAAVMNAVILTAVLSAGNSGMYASTRMLYTLATEGKAPRIFGRLSKGG
VPRNALYATTVVAGLCFLTSMFGNQEVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVMAGLDLNALPYKSGFFPLGPIF
AFVLCLIITLGQNYEAFLKDRIDWYGVTATYIGLPLFLIIWFGYKLTQGTRFVRYSEMTFPTTKVD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=464, Percent_Identity=87.2844827586207, Blast_Score=821, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=38.2608695652174, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI48994972, Length=420, Percent_Identity=38.3333333333333, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI1786789, Length=399, Percent_Identity=39.0977443609023, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI1786302, Length=398, Percent_Identity=35.1758793969849, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1790653, Length=329, Percent_Identity=40.4255319148936, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI87081915, Length=378, Percent_Identity=36.2433862433862, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1789017, Length=375, Percent_Identity=33.0666666666667, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1786602, Length=394, Percent_Identity=37.0558375634518, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI87081869, Length=365, Percent_Identity=23.2876712328767, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082023, Length=282, Percent_Identity=26.241134751773, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=462, Percent_Identity=36.7965367965368, Blast_Score=306, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6324061, Length=462, Percent_Identity=35.7142857142857, Blast_Score=295, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6324990, Length=481, Percent_Identity=33.6798336798337, Blast_Score=283, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6324924, Length=483, Percent_Identity=34.7826086956522, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6322892, Length=476, Percent_Identity=36.9747899159664, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6324059, Length=457, Percent_Identity=36.5426695842451, Blast_Score=270, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6321629, Length=474, Percent_Identity=32.2784810126582, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6324553, Length=414, Percent_Identity=35.2657004830918, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6319824, Length=457, Percent_Identity=29.3216630196937, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6320717, Length=462, Percent_Identity=28.5714285714286, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321053, Length=452, Percent_Identity=28.7610619469027, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6322967, Length=421, Percent_Identity=31.5914489311164, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6324981, Length=484, Percent_Identity=30.9917355371901, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6320251, Length=483, Percent_Identity=26.5010351966874, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319542, Length=478, Percent_Identity=26.7782426778243, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319543, Length=452, Percent_Identity=28.5398230088496, Blast_Score=196, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6319608, Length=462, Percent_Identity=28.3549783549784, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320364, Length=546, Percent_Identity=27.6556776556777, Blast_Score=169, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50741; Mature: 50741

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIGGSIGTGLFVASGATVSQAGPGGALLSYIIIGMMVYFLMTSLGELAAFMPVSGSFS
CEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
TYGSRYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMGYWFPDMPGWIWSALFLCLIFL
HHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LNYISVKGFGEAEYWFSLIKVSTVIIFIAVGLMMIAGILKGGEGAGFHNWTIGDAPFAGG
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCH
FASMIGVAMIVGFSFQGTELIGIAAGESKDPGKNIPMAVRQVFWRILLFYVFAILIISLL
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IPYTDPSLLRNDVKDISVSPFTLVFKNAGLLSAAAVMNAVILTAVLSAGNSGMYASTRML
HCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHEEE
YTLATEGKAPRIFGRLSKGGVPRNALYATTVVAGLCFLTSMFGNQEVYLWLLNTSGMTGF
EEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHH
IAWLGIAISHYRFRRGYVMAGLDLNALPYKSGFFPLGPIFAFVLCLIITLGQNYEAFLKD
HHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
RIDWYGVTATYIGLPLFLIIWFGYKLTQGTRFVRYSEMTFPTTKVD
CCHHEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MIAIGGSIGTGLFVASGATVSQAGPGGALLSYIIIGMMVYFLMTSLGELAAFMPVSGSFS
CEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
TYGSRYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMGYWFPDMPGWIWSALFLCLIFL
HHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LNYISVKGFGEAEYWFSLIKVSTVIIFIAVGLMMIAGILKGGEGAGFHNWTIGDAPFAGG
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCH
FASMIGVAMIVGFSFQGTELIGIAAGESKDPGKNIPMAVRQVFWRILLFYVFAILIISLL
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IPYTDPSLLRNDVKDISVSPFTLVFKNAGLLSAAAVMNAVILTAVLSAGNSGMYASTRML
HCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHEEE
YTLATEGKAPRIFGRLSKGGVPRNALYATTVVAGLCFLTSMFGNQEVYLWLLNTSGMTGF
EEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHH
IAWLGIAISHYRFRRGYVMAGLDLNALPYKSGFFPLGPIFAFVLCLIITLGQNYEAFLKD
HHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
RIDWYGVTATYIGLPLFLIIWFGYKLTQGTRFVRYSEMTFPTTKVD
CCHHEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]