Click here to switch to the map view.

The map label for this gene is tdh [H]

Identifier: 238919152

GI number: 238919152

Start: 1218938

End: 1220053

Strand: Direct

Name: tdh [H]

Synonym: NT01EI_1223

Alternate gene names: 238919152

Gene position: 1218938-1220053 (Clockwise)

Preceding gene: 238919150

Following gene: 238919153

Centisome position: 31.97

GC content: 56.27

Gene sequence:

>1116_bases
ATGAGCCAGTGTTGCGGAGCAAACGCGGTAACGGTGCGCGAGGGGATCCCAGCGACGATGCAAGCGGTGGTGGCATATGC
CCCCCACGACTACCGTTTGGAGGAGGTCGCCGTTCCAACGATTGGTGAGGGTGAGATCTTGGTGAAGGTGGAGGCCTGCG
GTATCTGCGCCGGTGACACGAAAGCCTTTGAAGGGGCGGCCAGCTTTTGGGGAGATGAGACTCAGCCGGCCTACATCAAA
GCGCCCATGATCCCGGGTCATGAATTTATTGGTCATGTCGTTGGGTTCGGCGCTGGCGTGGTGGATTTTGCGCTAGGCGA
TCGGGTTATCGCGGAGCAGATCGTACCGTGCTGGTCATGCCGGTTTTGTCAGCGCGGTCAGTACTGGATGTGTGAGAAGC
ATGACCTGTATGGCTTTCAGAGCAACGTGAATGGCGGAATGGCGGAATATATGAAATTTACGCCGCAGTCCATCAATTAT
CGGATCCCCGACGATCTGCCGATGGAGAAAGCGATTCTGATTGAGCCCTACGCCTGTTCATTCCATGCGGTACAGCGCGC
GAAGATCCAGCTGGGGGATACGGTGGTATTAGCGGGTGCCGGGACCCTGGGGCTGGGGATGATTGGCGCGATTAAAAAGT
CAGGGGCGGGCAGACTGATTGTTCTGGACCTGTCAGACGAGCGTTTGGCCCTCGCGCAGAAATTTGGCGCCGATCGGGTA
CTCAATCCGGCCCGGGATGACGTCGTATCCATCGTTAAAACGATGACCGACGGGTATGGCTGCGATGTGTATATCGAGGC
AACGGGAGCCGCGGCGTCGGTTGAACAAGGGCTACGGATGATCCGTAAGCTGGGGACATTCGTTGAGTTTTCGGTATTTA
AGGAGCCGGTGAGCGTGGACTGGAGCATTATCAGCGATCGTAAAGAGCTGGATGTGCTGGGGTCACACCTTGGCCCCTAT
TGCTATCCGCTGGTGATCGAGGGAATTGCCAATGGCGATTTACCTACCGAGGGCGTAGTAACGCATGTCCTGCCGTTATC
GCAGTTTGCCGAGGGATTTGCACTCATGCAGCGCGGCGTAGGCTCAATTAAGGTTGTGCTGAATCCAAATCTATAA

Upstream 100 bases:

>100_bases
TTTTTGGCACGACCTCTGTTCAATATGCTCCTCGTCAACAGTGTGTATTTGTTCTTTATGTGAACAAATGAATCATGGGG
AAACGAGAGGAGTGACGTTT

Downstream 100 bases:

>100_bases
GGTCTGGTGCGGCGTTACATCCATGTTATGGGGGGCAATATGTTAGAAAACGTTGTTCACCGCAGTGGTTTACCATCCCG
ACTGTGGTTCGGTTATGTCG

Product: alcohol dehydrogenase zinc-binding domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSQCCGANAVTVREGIPATMQAVVAYAPHDYRLEEVAVPTIGEGEILVKVEACGICAGDTKAFEGAASFWGDETQPAYIK
APMIPGHEFIGHVVGFGAGVVDFALGDRVIAEQIVPCWSCRFCQRGQYWMCEKHDLYGFQSNVNGGMAEYMKFTPQSINY
RIPDDLPMEKAILIEPYACSFHAVQRAKIQLGDTVVLAGAGTLGLGMIGAIKKSGAGRLIVLDLSDERLALAQKFGADRV
LNPARDDVVSIVKTMTDGYGCDVYIEATGAAASVEQGLRMIRKLGTFVEFSVFKEPVSVDWSIISDRKELDVLGSHLGPY
CYPLVIEGIANGDLPTEGVVTHVLPLSQFAEGFALMQRGVGSIKVVLNPNL

Sequences:

>Translated_371_residues
MSQCCGANAVTVREGIPATMQAVVAYAPHDYRLEEVAVPTIGEGEILVKVEACGICAGDTKAFEGAASFWGDETQPAYIK
APMIPGHEFIGHVVGFGAGVVDFALGDRVIAEQIVPCWSCRFCQRGQYWMCEKHDLYGFQSNVNGGMAEYMKFTPQSINY
RIPDDLPMEKAILIEPYACSFHAVQRAKIQLGDTVVLAGAGTLGLGMIGAIKKSGAGRLIVLDLSDERLALAQKFGADRV
LNPARDDVVSIVKTMTDGYGCDVYIEATGAAASVEQGLRMIRKLGTFVEFSVFKEPVSVDWSIISDRKELDVLGSHLGPY
CYPLVIEGIANGDLPTEGVVTHVLPLSQFAEGFALMQRGVGSIKVVLNPNL
>Mature_370_residues
SQCCGANAVTVREGIPATMQAVVAYAPHDYRLEEVAVPTIGEGEILVKVEACGICAGDTKAFEGAASFWGDETQPAYIKA
PMIPGHEFIGHVVGFGAGVVDFALGDRVIAEQIVPCWSCRFCQRGQYWMCEKHDLYGFQSNVNGGMAEYMKFTPQSINYR
IPDDLPMEKAILIEPYACSFHAVQRAKIQLGDTVVLAGAGTLGLGMIGAIKKSGAGRLIVLDLSDERLALAQKFGADRVL
NPARDDVVSIVKTMTDGYGCDVYIEATGAAASVEQGLRMIRKLGTFVEFSVFKEPVSVDWSIISDRKELDVLGSHLGPYC
YPLVIEGIANGDLPTEGVVTHVLPLSQFAEGFALMQRGVGSIKVVLNPNL

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=349, Percent_Identity=30.0859598853868, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI4501929, Length=367, Percent_Identity=27.5204359673025, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=27.2972972972973, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI34577061, Length=379, Percent_Identity=27.9683377308707, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI262073058, Length=388, Percent_Identity=25.7731958762887, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71743840, Length=376, Percent_Identity=26.063829787234, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI71565152, Length=384, Percent_Identity=24.21875, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI71565154, Length=379, Percent_Identity=23.7467018469657, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501939, Length=374, Percent_Identity=25.9358288770053, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI156523966, Length=374, Percent_Identity=25.9358288770053, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1788073, Length=338, Percent_Identity=30.7692307692308, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1790045, Length=338, Percent_Identity=27.5147928994083, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1787863, Length=340, Percent_Identity=26.7647058823529, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1788407, Length=361, Percent_Identity=27.1468144044321, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI226510992, Length=342, Percent_Identity=29.8245614035088, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788075, Length=351, Percent_Identity=25.3561253561254, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082125, Length=356, Percent_Identity=28.6516853932584, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786825, Length=406, Percent_Identity=25.3694581280788, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790718, Length=249, Percent_Identity=30.5220883534137, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1786552, Length=378, Percent_Identity=26.4550264550265, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081918, Length=241, Percent_Identity=30.7053941908714, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562876, Length=340, Percent_Identity=32.9411764705882, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17562878, Length=344, Percent_Identity=31.6860465116279, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17562584, Length=321, Percent_Identity=27.1028037383178, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=292, Percent_Identity=25.3424657534247, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562582, Length=283, Percent_Identity=27.208480565371, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=347, Percent_Identity=29.1066282420749, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6322619, Length=341, Percent_Identity=25.8064516129032, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319258, Length=380, Percent_Identity=24.4736842105263, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319257, Length=365, Percent_Identity=26.3013698630137, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319955, Length=341, Percent_Identity=25.8064516129032, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6320033, Length=383, Percent_Identity=25.065274151436, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=282, Percent_Identity=26.5957446808511, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=355, Percent_Identity=27.0422535211268, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=281, Percent_Identity=25.9786476868327, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=283, Percent_Identity=26.8551236749117, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17137530, Length=353, Percent_Identity=30.028328611898, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17737897, Length=353, Percent_Identity=30.5949008498584, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17737895, Length=386, Percent_Identity=27.720207253886, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 39931; Mature: 39800

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQCCGANAVTVREGIPATMQAVVAYAPHDYRLEEVAVPTIGEGEILVKVEACGICAGDT
CCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCHHHEECCCCCCCEEEEEEEECEEECCCC
KAFEGAASFWGDETQPAYIKAPMIPGHEFIGHVVGFGAGVVDFALGDRVIAEQIVPCWSC
HHHCCHHHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCHHHHHHCCHHHHHHHCCHHCC
RFCQRGQYWMCEKHDLYGFQSNVNGGMAEYMKFTPQSINYRIPDDLPMEKAILIEPYACS
HHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCEECCCCCCCCCEEEECCCCCC
FHAVQRAKIQLGDTVVLAGAGTLGLGMIGAIKKSGAGRLIVLDLSDERLALAQKFGADRV
HHHHHHHEEEECCEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCCCC
LNPARDDVVSIVKTMTDGYGCDVYIEATGAAASVEQGLRMIRKLGTFVEFSVFKEPVSVD
CCCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
WSIISDRKELDVLGSHLGPYCYPLVIEGIANGDLPTEGVVTHVLPLSQFAEGFALMQRGV
EEEECCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GSIKVVLNPNL
CEEEEEECCCC
>Mature Secondary Structure 
SQCCGANAVTVREGIPATMQAVVAYAPHDYRLEEVAVPTIGEGEILVKVEACGICAGDT
CCCCCCCCEEECCCCCHHHHHHHHCCCCCCCHHHEECCCCCCCEEEEEEEECEEECCCC
KAFEGAASFWGDETQPAYIKAPMIPGHEFIGHVVGFGAGVVDFALGDRVIAEQIVPCWSC
HHHCCHHHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCHHHHHHCCHHHHHHHCCHHCC
RFCQRGQYWMCEKHDLYGFQSNVNGGMAEYMKFTPQSINYRIPDDLPMEKAILIEPYACS
HHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCEECCCCCCCCCEEEECCCCCC
FHAVQRAKIQLGDTVVLAGAGTLGLGMIGAIKKSGAGRLIVLDLSDERLALAQKFGADRV
HHHHHHHEEEECCEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCCCC
LNPARDDVVSIVKTMTDGYGCDVYIEATGAAASVEQGLRMIRKLGTFVEFSVFKEPVSVD
CCCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
WSIISDRKELDVLGSHLGPYCYPLVIEGIANGDLPTEGVVTHVLPLSQFAEGFALMQRGV
EEEECCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
GSIKVVLNPNL
CEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]