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The map label for this gene is thiD [H]

Identifier: 238919084

GI number: 238919084

Start: 1148583

End: 1148777

Strand: Direct

Name: thiD [H]

Synonym: NT01EI_1154

Alternate gene names: 238919084

Gene position: 1148583-1148777 (Clockwise)

Preceding gene: 238919083

Following gene: 238919086

Centisome position: 30.13

GC content: 68.21

Gene sequence:

>195_bases
GTGGCGACGCGCCATACTCACGGGACGGGCTGCACCCTGTCCGCGGCGCTGGCGGCGCTGCGTCCGCGTCATGAAGACTG
GCGCGCTACCGTTGCCGCCGCGAAGGTGTATCTGCAGGGGGCGTTGATGGCCGCGGATTCCCTGCAGGTGGGACAGGGCA
TTGGCCCGGTGCACCACTTTTACCGCTGGTGGTAA

Upstream 100 bases:

>100_bases
CAGGCGGTTCTGATGAAGGGGGGACACCTGCGGTGCGGGGAGAGCCCTGACTGGTTGCTGACCCGCGACGGCGCCGCCGA
GCGTTTTTAGTGCGGCGCGC

Downstream 100 bases:

>100_bases
GCGGGGCTAAGCGGCGTGCTGCGCCGCCAGCGCATTCAGCGCGGCGAGCCTCTGGAGGTGCTCGGCGTCGAAGCGGTTGA
GGGTGAAAAATGGCATCTCC

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 64; Mature: 63

Protein sequence:

>64_residues
MATRHTHGTGCTLSAALAALRPRHEDWRATVAAAKVYLQGALMAADSLQVGQGIGPVHHFYRWW

Sequences:

>Translated_64_residues
MATRHTHGTGCTLSAALAALRPRHEDWRATVAAAKVYLQGALMAADSLQVGQGIGPVHHFYRWW
>Mature_63_residues
ATRHTHGTGCTLSAALAALRPRHEDWRATVAAAKVYLQGALMAADSLQVGQGIGPVHHFYRWW

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=64, Percent_Identity=67.1875, Blast_Score=94, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 7012; Mature: 6881

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRHTHGTGCTLSAALAALRPRHEDWRATVAAAKVYLQGALMAADSLQVGQGIGPVHHF
CCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
YRWW
HHCC
>Mature Secondary Structure 
ATRHTHGTGCTLSAALAALRPRHEDWRATVAAAKVYLQGALMAADSLQVGQGIGPVHHF
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
YRWW
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]