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The map label for this gene is iclR [H]

Identifier: 238919048

GI number: 238919048

Start: 1110563

End: 1111387

Strand: Direct

Name: iclR [H]

Synonym: NT01EI_1116

Alternate gene names: 238919048

Gene position: 1110563-1111387 (Clockwise)

Preceding gene: 238919047

Following gene: 238919054

Centisome position: 29.13

GC content: 55.39

Gene sequence:

>825_bases
ATGGTTGCCCCTGTTCCCGCAAAACGCGGTAGAAAACCCGCCGCTATCGCTGCACCCGCAACCGGGCAGGTTCAGTCATT
AGCCCGCGGCCTGAAGCTGCTGGAGTGGATTGCGGAATCTAACGGTAGCGTGGCACTAACAGAGTTGGCACAGCAGGCTG
GTCTACCTAATTCCACTACTCACCGTTTGTTGACCACCATGCAACAGCAGGGGTTTATCCGCCAGGTGGGCGAATTAGGC
CACTGGGCTATAGGTGCGCATGCGTTTATCGTAGGCAGCGGCTTTTTGCAAAGCCGTAATCTGCTGGCGATTGTCCACCC
AATTCTGCGCAAGCTGATGGAAGACTCCGGTGAAACAGTAAACTTGGCCATGCTGGATCAAAGCGACCATCAGGCCATTA
TTATCGACCAGGTGCAGTGTACCCAACTGATGCGCATGTCCGCCCCCATCGGCGGTAAGCTACCGATGCACGCCTCCGGT
GCAGGTAAGGCGTTTTTATCTCAGTTAAGTGAAGAACAGGTGACTGACCTGCTGCACCGCAAAGGGCTGCACGCATACAC
CCACGCCACGCTGGTGTCGCCGGTACATTTAAAAGAGGATTTAGCCCAGACGCGTAAACGCGGCTACTCCTTTGATGACG
AGGAACATGCGCTGGGGCTGCGCTGTGTGGCAGCGTGCATTTATGACGAGCACAGCGAGCCGTTTGCCGCTATTTCCATA
TCAGGACCCATTTCGCGCATTACCGACGATCGGGTGACCGAATTTGGTGCCATGGCGATCAAAGCGGCGAAAGAAGTGAC
ACTGGCGTATGGCGGATTTCGTTAA

Upstream 100 bases:

>100_bases
GAGACATGTTCCGCTTCACTCATCCGATCAGTACAGGAATTCTTGCATTATAATTGAATAAAACGAAAATAATTTCCACA
ATACAGAAAAGGAATCCTCC

Downstream 100 bases:

>100_bases
GTCGCTTTCTGCGTGTGTATCCTGCGCACCCAGATAACCCGGATGAACAGTTTCAATTTCACCACAGGCCTCGTCATCAC
TGGCTTTACGTTCCAGCACT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MVAPVPAKRGRKPAAIAAPATGQVQSLARGLKLLEWIAESNGSVALTELAQQAGLPNSTTHRLLTTMQQQGFIRQVGELG
HWAIGAHAFIVGSGFLQSRNLLAIVHPILRKLMEDSGETVNLAMLDQSDHQAIIIDQVQCTQLMRMSAPIGGKLPMHASG
AGKAFLSQLSEEQVTDLLHRKGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCVAACIYDEHSEPFAAISI
SGPISRITDDRVTEFGAMAIKAAKEVTLAYGGFR

Sequences:

>Translated_274_residues
MVAPVPAKRGRKPAAIAAPATGQVQSLARGLKLLEWIAESNGSVALTELAQQAGLPNSTTHRLLTTMQQQGFIRQVGELG
HWAIGAHAFIVGSGFLQSRNLLAIVHPILRKLMEDSGETVNLAMLDQSDHQAIIIDQVQCTQLMRMSAPIGGKLPMHASG
AGKAFLSQLSEEQVTDLLHRKGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCVAACIYDEHSEPFAAISI
SGPISRITDDRVTEFGAMAIKAAKEVTLAYGGFR
>Mature_274_residues
MVAPVPAKRGRKPAAIAAPATGQVQSLARGLKLLEWIAESNGSVALTELAQQAGLPNSTTHRLLTTMQQQGFIRQVGELG
HWAIGAHAFIVGSGFLQSRNLLAIVHPILRKLMEDSGETVNLAMLDQSDHQAIIIDQVQCTQLMRMSAPIGGKLPMHASG
AGKAFLSQLSEEQVTDLLHRKGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCVAACIYDEHSEPFAAISI
SGPISRITDDRVTEFGAMAIKAAKEVTLAYGGFR

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=274, Percent_Identity=92.3357664233577, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI1786715, Length=264, Percent_Identity=41.2878787878788, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1786468, Length=237, Percent_Identity=32.0675105485232, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1788131, Length=248, Percent_Identity=29.0322580645161, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1789999, Length=226, Percent_Identity=31.4159292035398, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1790752, Length=253, Percent_Identity=26.0869565217391, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788581, Length=251, Percent_Identity=24.7011952191235, Blast_Score=84, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29573; Mature: 29573

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAPVPAKRGRKPAAIAAPATGQVQSLARGLKLLEWIAESNGSVALTELAQQAGLPNSTT
CCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHH
HRLLTTMQQQGFIRQVGELGHWAIGAHAFIVGSGFLQSRNLLAIVHPILRKLMEDSGETV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEECCHHHCCCHHHHHHHHHHHHHHCCCCEE
NLAMLDQSDHQAIIIDQVQCTQLMRMSAPIGGKLPMHASGAGKAFLSQLSEEQVTDLLHR
EEEEECCCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCVAACIYDEHSEPFAAISI
CCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEE
SGPISRITDDRVTEFGAMAIKAAKEVTLAYGGFR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVAPVPAKRGRKPAAIAAPATGQVQSLARGLKLLEWIAESNGSVALTELAQQAGLPNSTT
CCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHH
HRLLTTMQQQGFIRQVGELGHWAIGAHAFIVGSGFLQSRNLLAIVHPILRKLMEDSGETV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEECCHHHCCCHHHHHHHHHHHHHHCCCCEE
NLAMLDQSDHQAIIIDQVQCTQLMRMSAPIGGKLPMHASGAGKAFLSQLSEEQVTDLLHR
EEEEECCCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
KGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCVAACIYDEHSEPFAAISI
CCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEE
SGPISRITDDRVTEFGAMAIKAAKEVTLAYGGFR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]