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The map label for this gene is apt

Identifier: 238919039

GI number: 238919039

Start: 1102334

End: 1102885

Strand: Direct

Name: apt

Synonym: NT01EI_1107

Alternate gene names: 238919039

Gene position: 1102334-1102885 (Clockwise)

Preceding gene: 238919038

Following gene: 238919040

Centisome position: 28.92

GC content: 58.88

Gene sequence:

>552_bases
ATGACCGCTACAGCACAACAACTCGAATTCCTTAAACAAAATATTAAGACCATCCCTGACTACCCTAAGCCAGGTATCCT
TTTCCGTGACGTGACCAGTCTGCTGGAAAAGCCCGACGCCTATGCTCTGAGTATCGAGCTGCTGGCGGCGCGTTACCGTG
CCGCCGGGATCACTAAGGTGGTGGGAACGGAAGCGCGTGGCTTTCTGTTCGGCGCTCCGGTAGCACTGGCGCTGGGCGTG
GGTTTTGTGCCGGTGCGTAAGCCGGGTAAACTGCCGCGGGCGACGTTGGCGGAAAGCTATGCACTGGAGTACGGCACCGA
TACGTTGGAGATCCATCAGGATGCCATTGACGCGAACGATCGCGTACTGATGGTGGATGATTTGCTGGCGACCGGCGGCA
CTATCGAGGCGACGACCCGCCTGATCCGCCGCCTGGGCGGCGTGGTACACGACGCGGCGTTTATCATCGACTTGCCTGCG
CTGGGCGGTGAGGCACGCCTGGAGGCGATGAATATTAACTGCTACAGCCTGGTCTCCTTCGACGGACATTAA

Upstream 100 bases:

>100_bases
CCTGTTCCGAGGGCGACGGCGATTAATGTCGGGCCATGTTTGGGGGGGATTGCAGGTGGCTTGCGTTAGCCCGGACCCGG
TGTTTATCAGGCAACAAGTT

Downstream 100 bases:

>100_bases
TCTGTAGCGTGCGTCATACGCTATCTCTCCGGGCCATCGCCAGTGCGGTGGCCCGGCTGTTTTTGCCGCCGCCCGGCGGC
GGAATAAAGTGATGGGTATT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MTATAQQLEFLKQNIKTIPDYPKPGILFRDVTSLLEKPDAYALSIELLAARYRAAGITKVVGTEARGFLFGAPVALALGV
GFVPVRKPGKLPRATLAESYALEYGTDTLEIHQDAIDANDRVLMVDDLLATGGTIEATTRLIRRLGGVVHDAAFIIDLPA
LGGEARLEAMNINCYSLVSFDGH

Sequences:

>Translated_183_residues
MTATAQQLEFLKQNIKTIPDYPKPGILFRDVTSLLEKPDAYALSIELLAARYRAAGITKVVGTEARGFLFGAPVALALGV
GFVPVRKPGKLPRATLAESYALEYGTDTLEIHQDAIDANDRVLMVDDLLATGGTIEATTRLIRRLGGVVHDAAFIIDLPA
LGGEARLEAMNINCYSLVSFDGH
>Mature_182_residues
TATAQQLEFLKQNIKTIPDYPKPGILFRDVTSLLEKPDAYALSIELLAARYRAAGITKVVGTEARGFLFGAPVALALGVG
FVPVRKPGKLPRATLAESYALEYGTDTLEIHQDAIDANDRVLMVDDLLATGGTIEATTRLIRRLGGVVHDAAFIIDLPAL
GGEARLEAMNINCYSLVSFDGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=178, Percent_Identity=41.0112359550562, Blast_Score=139, Evalue=9e-34,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=46.5116279069767, Blast_Score=120, Evalue=6e-28,
Organism=Escherichia coli, GI1786675, Length=183, Percent_Identity=78.1420765027322, Blast_Score=283, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=44.5086705202312, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323619, Length=166, Percent_Identity=40.9638554216867, Blast_Score=114, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=33.5260115606936, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17136334, Length=180, Percent_Identity=39.4444444444444, Blast_Score=129, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_EDWI9 (C5BCZ7)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002932553.1
- ProteinModelPortal:   C5BCZ7
- GeneID:   7960692
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_1107
- OMA:   GILFYDI
- ProtClustDB:   CLSK2812960
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19698; Mature: 19567

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATAQQLEFLKQNIKTIPDYPKPGILFRDVTSLLEKPDAYALSIELLAARYRAAGITKV
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCHHHH
VGTEARGFLFGAPVALALGVGFVPVRKPGKLPRATLAESYALEYGTDTLEIHQDAIDAND
HCCCCCCEEEECHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHCCCCC
RVLMVDDLLATGGTIEATTRLIRRLGGVVHDAAFIIDLPALGGEARLEAMNINCYSLVSF
CEEEEEHHHHCCCCHHHHHHHHHHHCHHHHHHEEEEEECCCCCCCEEEEECCCEEEEEEE
DGH
CCC
>Mature Secondary Structure 
TATAQQLEFLKQNIKTIPDYPKPGILFRDVTSLLEKPDAYALSIELLAARYRAAGITKV
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCHHHH
VGTEARGFLFGAPVALALGVGFVPVRKPGKLPRATLAESYALEYGTDTLEIHQDAIDAND
HCCCCCCEEEECHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHCCCCC
RVLMVDDLLATGGTIEATTRLIRRLGGVVHDAAFIIDLPALGGEARLEAMNINCYSLVSF
CEEEEEHHHHCCCCHHHHHHHHHHHCHHHHHHEEEEEECCCCCCCEEEEECCCEEEEEEE
DGH
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA