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The map label for this gene is hpt [H]

Identifier: 238917788

GI number: 238917788

Start: 1933293

End: 1933829

Strand: Reverse

Name: hpt [H]

Synonym: EUBELI_01869

Alternate gene names: 238917788

Gene position: 1933829-1933293 (Counterclockwise)

Preceding gene: 238917789

Following gene: 238917787

Centisome position: 90.19

GC content: 38.18

Gene sequence:

>537_bases
ATGAAAGAACCATTTATCAGTGTCCTTATATCTGAGGAAAAGCTGAATGAAAGGATTGCACAGCTTGGAGAGCAGATAAG
TAAAGACTATGAGGGTAAGGAGGTTAAACTTATCTGTATTCTTAAGGGAAGTATTATATTTACATGCGAGCTTGCCAAGA
GAATTACTGTACCTGTTAAGTTTGATTTTATGCAGGTATCAAGTTATGGAAGCGGGACATCATCAAGCGGTCAGATTAAG
ATTAAGAAGGACCTTGATGAGAGCATTGAGGGAGAGCATGTAATTGTTATTGAGGATATTATCGATTCGGGTAATACTCT
TGCAAGACTTATGCCTATGTTAGAGGAGAGAAAGCCGGCAGATATATGTATATGTACTCTGCTTGATAAGCCTGAAAGAA
GAGAGGTTGAGGTGGATGTTAAGTATAATGGCTTTAACATTCCTGATGAATTTGTTGTCGGTTATGGACTTGATTATGAC
CAGAGCTATAGAAACCTTCCTTTTGTAGGAGTTTTACACCTTGACGAAGAGGCATAA

Upstream 100 bases:

>100_bases
AAGAAGAAGTGAGTGCGCCCTGATCGATGATGAAACAAGGAATGTGCTGGATATAACTATACAATAGAGTGAATATTAAG
ATTGACAAAGGAGAGAAACG

Downstream 100 bases:

>100_bases
TTAATAAGGAGGAAGTGATGGATACTAAGAAAAAAAGGTCTGGAGGATTTGGAAGCATTTTCTTCATGATTATTATAATT
GGTATTGTCTGGGCTGTTAT

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MKEPFISVLISEEKLNERIAQLGEQISKDYEGKEVKLICILKGSIIFTCELAKRITVPVKFDFMQVSSYGSGTSSSGQIK
IKKDLDESIEGEHVIVIEDIIDSGNTLARLMPMLEERKPADICICTLLDKPERREVEVDVKYNGFNIPDEFVVGYGLDYD
QSYRNLPFVGVLHLDEEA

Sequences:

>Translated_178_residues
MKEPFISVLISEEKLNERIAQLGEQISKDYEGKEVKLICILKGSIIFTCELAKRITVPVKFDFMQVSSYGSGTSSSGQIK
IKKDLDESIEGEHVIVIEDIIDSGNTLARLMPMLEERKPADICICTLLDKPERREVEVDVKYNGFNIPDEFVVGYGLDYD
QSYRNLPFVGVLHLDEEA
>Mature_178_residues
MKEPFISVLISEEKLNERIAQLGEQISKDYEGKEVKLICILKGSIIFTCELAKRITVPVKFDFMQVSSYGSGTSSSGQIK
IKKDLDESIEGEHVIVIEDIIDSGNTLARLMPMLEERKPADICICTLLDKPERREVEVDVKYNGFNIPDEFVVGYGLDYD
QSYRNLPFVGVLHLDEEA

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=175, Percent_Identity=32.5714285714286, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI9910262, Length=175, Percent_Identity=31.4285714285714, Blast_Score=93, Evalue=1e-19,
Organism=Escherichia coli, GI87081689, Length=174, Percent_Identity=51.7241379310345, Blast_Score=184, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17510817, Length=174, Percent_Identity=37.3563218390805, Blast_Score=107, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20122; Mature: 20122

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEPFISVLISEEKLNERIAQLGEQISKDYEGKEVKLICILKGSIIFTCELAKRITVPVK
CCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCEEEEEEEHHEEEEEEE
FDFMQVSSYGSGTSSSGQIKIKKDLDESIEGEHVIVIEDIIDSGNTLARLMPMLEERKPA
EEEEEEECCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCC
DICICTLLDKPERREVEVDVKYNGFNIPDEFVVGYGLDYDQSYRNLPFVGVLHLDEEA
CEEEEEECCCCCCCEEEEEEEECCCCCCHHHEEEECCCCCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MKEPFISVLISEEKLNERIAQLGEQISKDYEGKEVKLICILKGSIIFTCELAKRITVPVK
CCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCEEEEEEEHHEEEEEEE
FDFMQVSSYGSGTSSSGQIKIKKDLDESIEGEHVIVIEDIIDSGNTLARLMPMLEERKPA
EEEEEEECCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCC
DICICTLLDKPERREVEVDVKYNGFNIPDEFVVGYGLDYDQSYRNLPFVGVLHLDEEA
CEEEEEECCCCCCCEEEEEEEECCCCCCHHHEEEECCCCCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]