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The map label for this gene is mutS2

Identifier: 238917772

GI number: 238917772

Start: 1915771

End: 1918134

Strand: Direct

Name: mutS2

Synonym: EUBELI_01853

Alternate gene names: 238917772

Gene position: 1915771-1918134 (Clockwise)

Preceding gene: 238917768

Following gene: 238917773

Centisome position: 89.35

GC content: 40.52

Gene sequence:

>2364_bases
GTGAATAAGAAATCTTTATCCACTTTGGAATTTTATAAAATTACCGACCAGCTTGTTTCCTATGCATGCTGTGACGGAGC
TAAGAAAATACTTCGTAACTTAAAGCCTATGACTGATATAACAGACATCAACTTACGTCTCAATGAGACTAATGATGCAC
TTTCAAGAATTTTTCAGAAAGGTACTGTTGATTTCAGCCAGACTAAGGATATACGTGCTTCTGTTGCGAGACTTAAGGTT
GGAAGCTCCCTTAATATATCAGAACTTCTTAATATAAGTGCCATCCTTTCATGTGCAAAGCATGTTAAGGATTACTATGA
GCATCGTGAAGATTCTATATCAGGAATGCTTGAAAACCTTGCAACTGTTGATGCTCTCAATTCCCAGATTAAGAAATGTA
TTATCTCTGAAGATGAGATAAGTGATGACGCAAGTTCCAACTTAAGAAGTATCAGAAGAAGCAAATCAATAGCCAATGAC
AGAATACATTCTGAACTTAACAAATTGCTTAATTCTCCTACTTACAGGACTTATCTTCAGGATTATGTTATTACCACAAG
ACAGGGACGCTACTGTCTGCCTGTCAAAGCTGAATATAAGTCAGCATTTCCTGGTATGATACATGACCAGTCATCTACTG
GTTCTACTCTCTTTATTGAGCCTGCAGCAGTTGTAAAGCTCAATAATGATATCCGTGAGTTAGAGCTTAAGGAAGCAGCA
GAGATTGAAGTTATTCTTGCTGACTTAAGTGCAAAAGCCGGTGAACACACAGAGGAGCTTCTGTGTGATTATGAAATACT
TGTCGAACTTGACTGTATATTTGCAAAGGCACAGCTTGCCAGACATATGCATGCAAGCCGTCCAGTCATGAATACATCAG
GAATTATCAATATCAAAAAAGGACGTCACCCTCTTATTGAGTCACATACTGTTGTTCCTATTGACATCTATCTTGGAACA
GATTTTAAGCTTCTTATCATCACCGGTCCTAACACAGGTGGTAAGACTGTTTCATTAAAGACTGTAGGACTCCTCACACT
TATGGCACAGTCAGGTTTATTCATTCCGGCTCTTGACCATTCAGACATTGCCGTATTTAAGAATATATACGCTGATATTG
GTGATGAGCAGAGTATTGAACAGAGTTTAAGTACATTTTCATCACACATGACCAACACTGTTAAGATTCTTAAAGAAGCT
GATGAAAACTGCCTTGTACTTTTTGATGAGATTGGTGCCGGAACTGACCCTACAGAAGGTGCTGCCCTTGCTATCGCAAT
CCTTAATGACCTTAAGATGCGCGGTGTTACAACCATGGCAACAACTCACTACAGTGAAATCAAGCTTTATGCGCTTTCTA
CTGAAGGTGTTGAAAATGCAAGCTGTGAGTTCGATGTTGAATCGCTCCGTCCTACTTACAGACTGCTTATAGGCATTCCG
GGAAAAAGTAACGCATTTGCAATCTCTAAGAAACTCGGACTTCCTGATTATATTCTCTCTGACGCATCAGAAAGACTTAA
CGCGGAAGATGTACATTTTGAAGATATCGTATCTGACCTTGAGCATGCAAGAATTTCTCTTGAGAAGGAGCAGGCTGAGG
TTGAAAGTTATAAGGCTGAGATTGCCTCTCTTAAAGAAAAGCTTCAGGCTAAGAATGAAAGGCTTGATGAAAGAACTGAC
AACATTATCCGTAAGGCCAATGAACAGGCTGCTGCCATCTTAAAAGATGCCAAGGATTTCGCAGATGAAACTATCAAAGC
CATGAACAAGCACGGAATGACAGTTGCTGAGCTTGAAAAGCACCGTACTGCTGTCCGTGAGAAGATGAATAAGAATCAGG
CAAAGTTAAAGGTAGAGCCTGCCAAGGTTAAAGCACACAAGGCACATGATATATCTGAATTCAAGACAGGCATGCATGTA
AAAGTTCTTACTATGAATGTTTCCGGTACTGTTTCTGCAATTCATCCAGCCAAGAAGCAGGTTACTGTTCAAGTAGGTGC
ATTAAGCACTAAGATTGATATCAAGAATCTTGAAATTCTTTCAGACTATAAAGAGCCAAAGGAAGCTCCATCTAAGGCTG
CTGGCGGTTCCGGTAAGATTAAGATGAGCAAATCAGCAGGAATATCAACTGAGATTAATCTTCTCGGCTGTACAGTTGAC
GAGGCTGTTGCCCGCCTTGATAAATATCTTGATGACGCTTACATTGCCAGGATTCCACAGGTCCGTATCGTTCACGGTAA
AGGAACCGGCGCATTAAGAAACGGTGTAACCGCTTATCTTCGCGGTGTTCCATATATAAAGAGCTTCCGCCTCGGCGAAA
TCGGCGAGGGTGATGCTGGTGTAACTATTGTTGATTTCAAATAA

Upstream 100 bases:

>100_bases
TTACATGTAAATATTTATAAGCAAAATATAGTTTTTTTACCTTAAATGCTGTAAACTTATAAAGTATGAAAAGATTGTTT
TTAGTTTTTGGAGGTCTTTC

Downstream 100 bases:

>100_bases
TTATTATTGGGGGATATTATTATGGCATCTAAACAGCGAATACTTATTGTAGATGATGATGAAAATATTGCAGAACTTAT
ATCTTTGTATCTTACAAAAG

Product: DNA mismatch repair protein MutS2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 787; Mature: 787

Protein sequence:

>787_residues
MNKKSLSTLEFYKITDQLVSYACCDGAKKILRNLKPMTDITDINLRLNETNDALSRIFQKGTVDFSQTKDIRASVARLKV
GSSLNISELLNISAILSCAKHVKDYYEHREDSISGMLENLATVDALNSQIKKCIISEDEISDDASSNLRSIRRSKSIAND
RIHSELNKLLNSPTYRTYLQDYVITTRQGRYCLPVKAEYKSAFPGMIHDQSSTGSTLFIEPAAVVKLNNDIRELELKEAA
EIEVILADLSAKAGEHTEELLCDYEILVELDCIFAKAQLARHMHASRPVMNTSGIINIKKGRHPLIESHTVVPIDIYLGT
DFKLLIITGPNTGGKTVSLKTVGLLTLMAQSGLFIPALDHSDIAVFKNIYADIGDEQSIEQSLSTFSSHMTNTVKILKEA
DENCLVLFDEIGAGTDPTEGAALAIAILNDLKMRGVTTMATTHYSEIKLYALSTEGVENASCEFDVESLRPTYRLLIGIP
GKSNAFAISKKLGLPDYILSDASERLNAEDVHFEDIVSDLEHARISLEKEQAEVESYKAEIASLKEKLQAKNERLDERTD
NIIRKANEQAAAILKDAKDFADETIKAMNKHGMTVAELEKHRTAVREKMNKNQAKLKVEPAKVKAHKAHDISEFKTGMHV
KVLTMNVSGTVSAIHPAKKQVTVQVGALSTKIDIKNLEILSDYKEPKEAPSKAAGGSGKIKMSKSAGISTEINLLGCTVD
EAVARLDKYLDDAYIARIPQVRIVHGKGTGALRNGVTAYLRGVPYIKSFRLGEIGEGDAGVTIVDFK

Sequences:

>Translated_787_residues
MNKKSLSTLEFYKITDQLVSYACCDGAKKILRNLKPMTDITDINLRLNETNDALSRIFQKGTVDFSQTKDIRASVARLKV
GSSLNISELLNISAILSCAKHVKDYYEHREDSISGMLENLATVDALNSQIKKCIISEDEISDDASSNLRSIRRSKSIAND
RIHSELNKLLNSPTYRTYLQDYVITTRQGRYCLPVKAEYKSAFPGMIHDQSSTGSTLFIEPAAVVKLNNDIRELELKEAA
EIEVILADLSAKAGEHTEELLCDYEILVELDCIFAKAQLARHMHASRPVMNTSGIINIKKGRHPLIESHTVVPIDIYLGT
DFKLLIITGPNTGGKTVSLKTVGLLTLMAQSGLFIPALDHSDIAVFKNIYADIGDEQSIEQSLSTFSSHMTNTVKILKEA
DENCLVLFDEIGAGTDPTEGAALAIAILNDLKMRGVTTMATTHYSEIKLYALSTEGVENASCEFDVESLRPTYRLLIGIP
GKSNAFAISKKLGLPDYILSDASERLNAEDVHFEDIVSDLEHARISLEKEQAEVESYKAEIASLKEKLQAKNERLDERTD
NIIRKANEQAAAILKDAKDFADETIKAMNKHGMTVAELEKHRTAVREKMNKNQAKLKVEPAKVKAHKAHDISEFKTGMHV
KVLTMNVSGTVSAIHPAKKQVTVQVGALSTKIDIKNLEILSDYKEPKEAPSKAAGGSGKIKMSKSAGISTEINLLGCTVD
EAVARLDKYLDDAYIARIPQVRIVHGKGTGALRNGVTAYLRGVPYIKSFRLGEIGEGDAGVTIVDFK
>Mature_787_residues
MNKKSLSTLEFYKITDQLVSYACCDGAKKILRNLKPMTDITDINLRLNETNDALSRIFQKGTVDFSQTKDIRASVARLKV
GSSLNISELLNISAILSCAKHVKDYYEHREDSISGMLENLATVDALNSQIKKCIISEDEISDDASSNLRSIRRSKSIAND
RIHSELNKLLNSPTYRTYLQDYVITTRQGRYCLPVKAEYKSAFPGMIHDQSSTGSTLFIEPAAVVKLNNDIRELELKEAA
EIEVILADLSAKAGEHTEELLCDYEILVELDCIFAKAQLARHMHASRPVMNTSGIINIKKGRHPLIESHTVVPIDIYLGT
DFKLLIITGPNTGGKTVSLKTVGLLTLMAQSGLFIPALDHSDIAVFKNIYADIGDEQSIEQSLSTFSSHMTNTVKILKEA
DENCLVLFDEIGAGTDPTEGAALAIAILNDLKMRGVTTMATTHYSEIKLYALSTEGVENASCEFDVESLRPTYRLLIGIP
GKSNAFAISKKLGLPDYILSDASERLNAEDVHFEDIVSDLEHARISLEKEQAEVESYKAEIASLKEKLQAKNERLDERTD
NIIRKANEQAAAILKDAKDFADETIKAMNKHGMTVAELEKHRTAVREKMNKNQAKLKVEPAKVKAHKAHDISEFKTGMHV
KVLTMNVSGTVSAIHPAKKQVTVQVGALSTKIDIKNLEILSDYKEPKEAPSKAAGGSGKIKMSKSAGISTEINLLGCTVD
EAVARLDKYLDDAYIARIPQVRIVHGKGTGALRNGVTAYLRGVPYIKSFRLGEIGEGDAGVTIVDFK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain

Homologues:

Organism=Homo sapiens, GI284813531, Length=378, Percent_Identity=30.952380952381, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI26638666, Length=247, Percent_Identity=34.412955465587, Blast_Score=114, Evalue=5e-25,
Organism=Homo sapiens, GI4505253, Length=247, Percent_Identity=34.412955465587, Blast_Score=114, Evalue=5e-25,
Organism=Homo sapiens, GI26638664, Length=248, Percent_Identity=34.6774193548387, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI36949366, Length=622, Percent_Identity=24.2765273311897, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI262231786, Length=192, Percent_Identity=38.0208333333333, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4557761, Length=287, Percent_Identity=27.8745644599303, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4504191, Length=301, Percent_Identity=25.9136212624585, Blast_Score=93, Evalue=9e-19,
Organism=Escherichia coli, GI1789089, Length=258, Percent_Identity=31.7829457364341, Blast_Score=113, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17534743, Length=337, Percent_Identity=26.1127596439169, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17508445, Length=306, Percent_Identity=25.8169934640523, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17539736, Length=307, Percent_Identity=23.1270358306189, Blast_Score=77, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508447, Length=270, Percent_Identity=27.037037037037, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319935, Length=265, Percent_Identity=32.8301886792453, Blast_Score=103, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324482, Length=287, Percent_Identity=28.9198606271777, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321912, Length=262, Percent_Identity=26.3358778625954, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321109, Length=220, Percent_Identity=30, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320302, Length=178, Percent_Identity=28.6516853932584, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320047, Length=190, Percent_Identity=28.4210526315789, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24584320, Length=308, Percent_Identity=30.1948051948052, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24664545, Length=224, Percent_Identity=32.1428571428571, Blast_Score=102, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTS2_EUBE2 (C4Z417)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002931289.1
- GeneID:   7957910
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_01853
- OMA:   PGLVHDQ
- ProtClustDB:   CLSK2506010
- HAMAP:   MF_00092
- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625
- PANTHER:   PTHR11361
- PIRSF:   PIRSF005814
- SMART:   SM00534
- SMART:   SM00533
- TIGRFAMs:   TIGR01069

Pfam domain/function: PF00488 MutS_V; PF01713 Smr; SSF48334 DNA_repair_MutS_domIII

EC number: NA

Molecular weight: Translated: 86629; Mature: 86629

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2; PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKSLSTLEFYKITDQLVSYACCDGAKKILRNLKPMTDITDINLRLNETNDALSRIFQK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCHHHHHHHHHH
GTVDFSQTKDIRASVARLKVGSSLNISELLNISAILSCAKHVKDYYEHREDSISGMLENL
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATVDALNSQIKKCIISEDEISDDASSNLRSIRRSKSIANDRIHSELNKLLNSPTYRTYLQ
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
DYVITTRQGRYCLPVKAEYKSAFPGMIHDQSSTGSTLFIEPAAVVKLNNDIRELELKEAA
HHHEEECCCCEEEEECHHHHCCCCCCEECCCCCCCEEEECCEEEEEECCCHHHHHHHHHC
EIEVILADLSAKAGEHTEELLCDYEILVELDCIFAKAQLARHMHASRPVMNTSGIINIKK
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
GRHPLIESHTVVPIDIYLGTDFKLLIITGPNTGGKTVSLKTVGLLTLMAQSGLFIPALDH
CCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCEEEECCC
SDIAVFKNIYADIGDEQSIEQSLSTFSSHMTNTVKILKEADENCLVLFDEIGAGTDPTEG
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
AALAIAILNDLKMRGVTTMATTHYSEIKLYALSTEGVENASCEFDVESLRPTYRLLIGIP
CEEEEEEHHHHHHCCEEEEEEECCCEEEEEEEECCCCCCCCCCEEHHHCCCEEEEEEECC
GKSNAFAISKKLGLPDYILSDASERLNAEDVHFEDIVSDLEHARISLEKEQAEVESYKAE
CCCCCEEEEECCCCCHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IASLKEKLQAKNERLDERTDNIIRKANEQAAAILKDAKDFADETIKAMNKHGMTVAELEK
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
HRTAVREKMNKNQAKLKVEPAKVKAHKAHDISEFKTGMHVKVLTMNVSGTVSAIHPAKKQ
HHHHHHHHHCCCCCEEEEEHHHHHHHHCCCHHHHCCCCEEEEEEEECCCCEEECCCCCEE
VTVQVGALSTKIDIKNLEILSDYKEPKEAPSKAAGGSGKIKMSKSAGISTEINLLGCTVD
EEEEEECEEEEEEECHHHHHHHCCCHHHCCCCCCCCCCEEEEECCCCCCEEEEEEECCHH
EAVARLDKYLDDAYIARIPQVRIVHGKGTGALRNGVTAYLRGVPYIKSFRLGEIGEGDAG
HHHHHHHHHHCHHHHHCCCCEEEEECCCCCHHHHCHHHHHCCCCCHHCCCCCCCCCCCCC
VTIVDFK
EEEEECC
>Mature Secondary Structure
MNKKSLSTLEFYKITDQLVSYACCDGAKKILRNLKPMTDITDINLRLNETNDALSRIFQK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCHHHHHHHHHH
GTVDFSQTKDIRASVARLKVGSSLNISELLNISAILSCAKHVKDYYEHREDSISGMLENL
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATVDALNSQIKKCIISEDEISDDASSNLRSIRRSKSIANDRIHSELNKLLNSPTYRTYLQ
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
DYVITTRQGRYCLPVKAEYKSAFPGMIHDQSSTGSTLFIEPAAVVKLNNDIRELELKEAA
HHHEEECCCCEEEEECHHHHCCCCCCEECCCCCCCEEEECCEEEEEECCCHHHHHHHHHC
EIEVILADLSAKAGEHTEELLCDYEILVELDCIFAKAQLARHMHASRPVMNTSGIINIKK
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
GRHPLIESHTVVPIDIYLGTDFKLLIITGPNTGGKTVSLKTVGLLTLMAQSGLFIPALDH
CCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCEEEECCC
SDIAVFKNIYADIGDEQSIEQSLSTFSSHMTNTVKILKEADENCLVLFDEIGAGTDPTEG
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
AALAIAILNDLKMRGVTTMATTHYSEIKLYALSTEGVENASCEFDVESLRPTYRLLIGIP
CEEEEEEHHHHHHCCEEEEEEECCCEEEEEEEECCCCCCCCCCEEHHHCCCEEEEEEECC
GKSNAFAISKKLGLPDYILSDASERLNAEDVHFEDIVSDLEHARISLEKEQAEVESYKAE
CCCCCEEEEECCCCCHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IASLKEKLQAKNERLDERTDNIIRKANEQAAAILKDAKDFADETIKAMNKHGMTVAELEK
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
HRTAVREKMNKNQAKLKVEPAKVKAHKAHDISEFKTGMHVKVLTMNVSGTVSAIHPAKKQ
HHHHHHHHHCCCCCEEEEEHHHHHHHHCCCHHHHCCCCEEEEEEEECCCCEEECCCCCEE
VTVQVGALSTKIDIKNLEILSDYKEPKEAPSKAAGGSGKIKMSKSAGISTEINLLGCTVD
EEEEEECEEEEEEECHHHHHHHCCCHHHCCCCCCCCCCEEEEECCCCCCEEEEEEECCHH
EAVARLDKYLDDAYIARIPQVRIVHGKGTGALRNGVTAYLRGVPYIKSFRLGEIGEGDAG
HHHHHHHHHHCHHHHHCCCCEEEEECCCCCHHHHCHHHHHCCCCCHHCCCCCCCCCCCCC
VTIVDFK
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA