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The map label for this gene is hbd [H]

Identifier: 238917574

GI number: 238917574

Start: 1711696

End: 1712673

Strand: Reverse

Name: hbd [H]

Synonym: EUBELI_01653

Alternate gene names: 238917574

Gene position: 1712673-1711696 (Counterclockwise)

Preceding gene: 238917575

Following gene: 238917573

Centisome position: 79.88

GC content: 38.85

Gene sequence:

>978_bases
ATGAGAAAGGGGATAAGTATGAAATATTCAAATGTTGTTGTTGCCGGAGGCGGAGTGCTTGGAAGCCAGATTGCTTTTCA
GGCAGCATATTGTGGATTTAATGTAACTATCTGGTTAAGAAGCGAGGGGTCTATTGGAAGAACACAGCCTAAGATTGACC
ATCTTAAGCAGACTTATATTGAAGCTATTGAGAAGATGGCAGAGGATAAGAATGCGTGGTGTGCAGGACTTGCGGATGAA
GATACATTTGACAAGGAAGAGTGTCTTAAGAAGGTTGAAAATGCATACGCTAATCTTAAGCTTGAACTTGATATGGCTAA
GGCTGTTGCTGATGCAGACCTTGTGATTGAGTCTATGGCTGAGAACGAAAAGGATAAGATTGCTTTCTATGAAAAGCTTT
CACCACTTCTTCCAGAAAAGACTGTGATTGTAACTAATTCATCGACACTTCTTCCATCAATGTTTGCAAAATATACTGGC
AGACCAGACAAATATTTGTCATTACATTTTGCTAATTCTATATGGAAGAATAATACTGCAGAAATTATGACACAGGCACA
GACTGATGAAAAATATTTTAACGAGGTTATGCAGTTTGCCAACGACATACGAATGATCGGACTTCCTGTAAGAAAGGAAA
AGAGCGGATATCTGCTTAATTCTATGCTTGTTCCATTCCTTTTAAGCGGGCTTGATTTGTACGCAGCAGGAATATCTGAT
CCTGAAAGTATTGATATTGCATGGACAAGAGGAACTGGAGCACCTAAAGGACCATTCCAGATATTTGACACAGTAGGACT
TAATACTGCCTACAATATTGTTCACCAGTACCAGAGCGTTCCGGGAATTTTCTCACCACTTCTTAAGAAGATGATGATGC
CATATAATTTCAAGAAGATGGAAGCAATCCTTAAGAAATATATTGATGAGGGCAAGCTTGGAATGTCTTCTGGCGAAGGC
TTTTACAAATATAATTAA

Upstream 100 bases:

>100_bases
GGCATTGAGAAGAGAGCCAGAAAAGCCTGATTATGACATAATGATTGGACGAAATGATGTGCTTGATACATTTAGAAGTC
TTATGGCGTAGTGAGTATTC

Downstream 100 bases:

>100_bases
GGACTGATGATATGACGACTAGGGAAGAAGCACTCGAATATGGACTTTCTTTTCCAGATACTTATCAGGAAGCACCGTTT
CATGATCAGAACTGGCAGCT

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MRKGISMKYSNVVVAGGGVLGSQIAFQAAYCGFNVTIWLRSEGSIGRTQPKIDHLKQTYIEAIEKMAEDKNAWCAGLADE
DTFDKEECLKKVENAYANLKLELDMAKAVADADLVIESMAENEKDKIAFYEKLSPLLPEKTVIVTNSSTLLPSMFAKYTG
RPDKYLSLHFANSIWKNNTAEIMTQAQTDEKYFNEVMQFANDIRMIGLPVRKEKSGYLLNSMLVPFLLSGLDLYAAGISD
PESIDIAWTRGTGAPKGPFQIFDTVGLNTAYNIVHQYQSVPGIFSPLLKKMMMPYNFKKMEAILKKYIDEGKLGMSSGEG
FYKYN

Sequences:

>Translated_325_residues
MRKGISMKYSNVVVAGGGVLGSQIAFQAAYCGFNVTIWLRSEGSIGRTQPKIDHLKQTYIEAIEKMAEDKNAWCAGLADE
DTFDKEECLKKVENAYANLKLELDMAKAVADADLVIESMAENEKDKIAFYEKLSPLLPEKTVIVTNSSTLLPSMFAKYTG
RPDKYLSLHFANSIWKNNTAEIMTQAQTDEKYFNEVMQFANDIRMIGLPVRKEKSGYLLNSMLVPFLLSGLDLYAAGISD
PESIDIAWTRGTGAPKGPFQIFDTVGLNTAYNIVHQYQSVPGIFSPLLKKMMMPYNFKKMEAILKKYIDEGKLGMSSGEG
FYKYN
>Mature_325_residues
MRKGISMKYSNVVVAGGGVLGSQIAFQAAYCGFNVTIWLRSEGSIGRTQPKIDHLKQTYIEAIEKMAEDKNAWCAGLADE
DTFDKEECLKKVENAYANLKLELDMAKAVADADLVIESMAENEKDKIAFYEKLSPLLPEKTVIVTNSSTLLPSMFAKYTG
RPDKYLSLHFANSIWKNNTAEIMTQAQTDEKYFNEVMQFANDIRMIGLPVRKEKSGYLLNSMLVPFLLSGLDLYAAGISD
PESIDIAWTRGTGAPKGPFQIFDTVGLNTAYNIVHQYQSVPGIFSPLLKKMMMPYNFKKMEAILKKYIDEGKLGMSSGEG
FYKYN

Specific function: Unknown

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=319, Percent_Identity=30.4075235109718, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI296179427, Length=336, Percent_Identity=29.1666666666667, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI20127408, Length=233, Percent_Identity=24.0343347639485, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788682, Length=219, Percent_Identity=25.1141552511416, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787661, Length=320, Percent_Identity=22.1875, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790281, Length=213, Percent_Identity=27.6995305164319, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17549919, Length=322, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17563036, Length=318, Percent_Identity=25.4716981132075, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17553560, Length=320, Percent_Identity=25.625, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17508951, Length=323, Percent_Identity=22.9102167182663, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508953, Length=323, Percent_Identity=22.9102167182663, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144276, Length=323, Percent_Identity=22.9102167182663, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583077, Length=315, Percent_Identity=22.2222222222222, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583079, Length=315, Percent_Identity=22.2222222222222, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921000, Length=315, Percent_Identity=22.2222222222222, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 36347; Mature: 36347

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKGISMKYSNVVVAGGGVLGSQIAFQAAYCGFNVTIWLRSEGSIGRTQPKIDHLKQTYI
CCCCCCEEECCEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
EAIEKMAEDKNAWCAGLADEDTFDKEECLKKVENAYANLKLELDMAKAVADADLVIESMA
HHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHH
ENEKDKIAFYEKLSPLLPEKTVIVTNSSTLLPSMFAKYTGRPDKYLSLHFANSIWKNNTA
CCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEEHHHHHCCCHH
EIMTQAQTDEKYFNEVMQFANDIRMIGLPVRKEKSGYLLNSMLVPFLLSGLDLYAAGISD
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHCHHHEECCCCC
PESIDIAWTRGTGAPKGPFQIFDTVGLNTAYNIVHQYQSVPGIFSPLLKKMMMPYNFKKM
CCCEEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHH
EAILKKYIDEGKLGMSSGEGFYKYN
HHHHHHHHCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MRKGISMKYSNVVVAGGGVLGSQIAFQAAYCGFNVTIWLRSEGSIGRTQPKIDHLKQTYI
CCCCCCEEECCEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHH
EAIEKMAEDKNAWCAGLADEDTFDKEECLKKVENAYANLKLELDMAKAVADADLVIESMA
HHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHH
ENEKDKIAFYEKLSPLLPEKTVIVTNSSTLLPSMFAKYTGRPDKYLSLHFANSIWKNNTA
CCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEEEHHHHHCCCHH
EIMTQAQTDEKYFNEVMQFANDIRMIGLPVRKEKSGYLLNSMLVPFLLSGLDLYAAGISD
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHCHHHEECCCCC
PESIDIAWTRGTGAPKGPFQIFDTVGLNTAYNIVHQYQSVPGIFSPLLKKMMMPYNFKKM
CCCEEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHH
EAILKKYIDEGKLGMSSGEGFYKYN
HHHHHHHHCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8001771 [H]