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The map label for this gene is mprB [H]

Identifier: 238917444

GI number: 238917444

Start: 1577076

End: 1578341

Strand: Reverse

Name: mprB [H]

Synonym: EUBELI_01522

Alternate gene names: 238917444

Gene position: 1578341-1577076 (Counterclockwise)

Preceding gene: 238917445

Following gene: 238917443

Centisome position: 73.61

GC content: 38.55

Gene sequence:

>1266_bases
ATGGAATCAGGAGGTAAGGCAGTGACAAAGAGATATCGCAAGAAGATTACAGTAGTGCTCTCCTTGGTGGTGCCTGTCAT
AGTATTGTTTGCAATATTAAATTGCTTTACCACATATGTGTTTTATGAAGATTATAAATATAAAATGAATCTTATGACAG
AGATTGCTGCAAAGGAAGAATTTTCCGGGCTGGATGCTGTTTCGGAATTGCTTAAGGATAAGGATATTGAAACTAACGAA
CAGGGAAGGCGATTATTGGAGCAATATGGATACTGGGGGAATAAAGGGAATGCATTTTATTCGCAATTCCGGCATCAGGT
TATGGTGACCGGTGCTGTAAGCACTGTGATATGCGTGCTTCTTTTGACTTTTTTACTTTATTGGAAGAAAAAAGAAGATG
CGTGTCATCAGAAAATTTTAGACCAGTTGGAAGAAATTCTGATCAGATTCCGTGAAAATAAATTTGATGATTTACTGAAA
ACGGAAAATCATGCAGAACTGGAAAAATTGAATGACCAGCTTGAAGCAATCGGACATCATATTCAGTTGATAAAGGAAGA
AGCAAGGGCAGAAAAGGAGAACACGAAAGAAATGGTTTCTGATATTTCTCACCAGTTAAAGACACCGGTTGCAGCTTTGG
ATACATGTTTTAGTGTGCTGATGCAGAATGACTTAAGTGCCACAGAACAGGAGGAGTTTCGTATCCGTTGTCGGAGTGCT
CTGGATGGACTGGAGACATTATTGCAGTCGCTTCTTGAAATATCCAAGATGGAAACTGGACTGATTCAGATTAATAAGAA
AAAACTTCCGCTTATGGATACTGTCATATCTGCTGTGAACCGCACTTATCCTAAAGCGGATGAAAAAGAAATTGAATTCG
TTTTTGACTATGAAAAAGAGCTGGAAACATGCATGGTTATGCAGGATAAAAGATGGCTTGGTGAAGCTGTAATTAACGTT
TTAGATAATGCGGTCAAGTACAGTCCGGGTGGTTCAAAAATATTTATCCGGTTACAAAAAAGAAACGATCTTGTAAGAAT
GGAAATTGAGGATCAGGGAATCGGTGTTCCGCAGAATGAGTATCACAAAATTTTTCAACGATTTTACAGAGGAAGTTCCC
GGGAGGTCATGGAAAAGAGTGGTACAGGAATCGGACTTTTTCTATCGAGAGAAATTATCGAAAAACACGGAGGTACAATC
ACGGTAACCTCTGGCAAAAAGAAAAAAGGAAGCACGTTTGTGATTCAATTACCATATGTTAGTTAA

Upstream 100 bases:

>100_bases
AAAATACAATCGCTGTCAATATCAGAAGACTCCGTGAGAAAATTGAAGACAATCCGGCTGCACCGGTCTATATAAAGAAT
ATCAGAGGTCTTGGGTATAT

Downstream 100 bases:

>100_bases
ATTTTAAATGAGCAGAAATCTTACAATTCTGTAAGACTTCTGCTCGTTTTTTGAAAGTGAAATGAAAGATTGTCCTGATA
CAATTTGGATGAAGAATGAA

Product: hypothetical protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MESGGKAVTKRYRKKITVVLSLVVPVIVLFAILNCFTTYVFYEDYKYKMNLMTEIAAKEEFSGLDAVSELLKDKDIETNE
QGRRLLEQYGYWGNKGNAFYSQFRHQVMVTGAVSTVICVLLLTFLLYWKKKEDACHQKILDQLEEILIRFRENKFDDLLK
TENHAELEKLNDQLEAIGHHIQLIKEEARAEKENTKEMVSDISHQLKTPVAALDTCFSVLMQNDLSATEQEEFRIRCRSA
LDGLETLLQSLLEISKMETGLIQINKKKLPLMDTVISAVNRTYPKADEKEIEFVFDYEKELETCMVMQDKRWLGEAVINV
LDNAVKYSPGGSKIFIRLQKRNDLVRMEIEDQGIGVPQNEYHKIFQRFYRGSSREVMEKSGTGIGLFLSREIIEKHGGTI
TVTSGKKKKGSTFVIQLPYVS

Sequences:

>Translated_421_residues
MESGGKAVTKRYRKKITVVLSLVVPVIVLFAILNCFTTYVFYEDYKYKMNLMTEIAAKEEFSGLDAVSELLKDKDIETNE
QGRRLLEQYGYWGNKGNAFYSQFRHQVMVTGAVSTVICVLLLTFLLYWKKKEDACHQKILDQLEEILIRFRENKFDDLLK
TENHAELEKLNDQLEAIGHHIQLIKEEARAEKENTKEMVSDISHQLKTPVAALDTCFSVLMQNDLSATEQEEFRIRCRSA
LDGLETLLQSLLEISKMETGLIQINKKKLPLMDTVISAVNRTYPKADEKEIEFVFDYEKELETCMVMQDKRWLGEAVINV
LDNAVKYSPGGSKIFIRLQKRNDLVRMEIEDQGIGVPQNEYHKIFQRFYRGSSREVMEKSGTGIGLFLSREIIEKHGGTI
TVTSGKKKKGSTFVIQLPYVS
>Mature_421_residues
MESGGKAVTKRYRKKITVVLSLVVPVIVLFAILNCFTTYVFYEDYKYKMNLMTEIAAKEEFSGLDAVSELLKDKDIETNE
QGRRLLEQYGYWGNKGNAFYSQFRHQVMVTGAVSTVICVLLLTFLLYWKKKEDACHQKILDQLEEILIRFRENKFDDLLK
TENHAELEKLNDQLEAIGHHIQLIKEEARAEKENTKEMVSDISHQLKTPVAALDTCFSVLMQNDLSATEQEEFRIRCRSA
LDGLETLLQSLLEISKMETGLIQINKKKLPLMDTVISAVNRTYPKADEKEIEFVFDYEKELETCMVMQDKRWLGEAVINV
LDNAVKYSPGGSKIFIRLQKRNDLVRMEIEDQGIGVPQNEYHKIFQRFYRGSSREVMEKSGTGIGLFLSREIIEKHGGTI
TVTSGKKKKGSTFVIQLPYVS

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=31.2236286919831, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786783, Length=305, Percent_Identity=26.8852459016393, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=25.5905511811024, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786912, Length=239, Percent_Identity=26.3598326359833, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=24.4444444444444, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788279, Length=374, Percent_Identity=22.9946524064171, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081816, Length=282, Percent_Identity=25.177304964539, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=22.8, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788549, Length=239, Percent_Identity=27.1966527196653, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=24.2290748898678, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=21.8106995884774, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789403, Length=215, Percent_Identity=27.4418604651163, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082128, Length=250, Percent_Identity=23.2, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787374, Length=291, Percent_Identity=25.085910652921, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790436, Length=240, Percent_Identity=22.0833333333333, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790346, Length=264, Percent_Identity=25, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790551, Length=229, Percent_Identity=22.2707423580786, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48433; Mature: 48433

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESGGKAVTKRYRKKITVVLSLVVPVIVLFAILNCFTTYVFYEDYKYKMNLMTEIAAKEE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSGLDAVSELLKDKDIETNEQGRRLLEQYGYWGNKGNAFYSQFRHQVMVTGAVSTVICVL
CCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLTFLLYWKKKEDACHQKILDQLEEILIRFRENKFDDLLKTENHAELEKLNDQLEAIGHH
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
IQLIKEEARAEKENTKEMVSDISHQLKTPVAALDTCFSVLMQNDLSATEQEEFRIRCRSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LDGLETLLQSLLEISKMETGLIQINKKKLPLMDTVISAVNRTYPKADEKEIEFVFDYEKE
HHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHEEECHHHH
LETCMVMQDKRWLGEAVINVLDNAVKYSPGGSKIFIRLQKRNDLVRMEIEDQGIGVPQNE
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEECCCCCCCCCHH
YHKIFQRFYRGSSREVMEKSGTGIGLFLSREIIEKHGGTITVTSGKKKKGSTFVIQLPYV
HHHHHHHHHCCCCHHHHHHCCCCEEHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCC
S
C
>Mature Secondary Structure
MESGGKAVTKRYRKKITVVLSLVVPVIVLFAILNCFTTYVFYEDYKYKMNLMTEIAAKEE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSGLDAVSELLKDKDIETNEQGRRLLEQYGYWGNKGNAFYSQFRHQVMVTGAVSTVICVL
CCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LLTFLLYWKKKEDACHQKILDQLEEILIRFRENKFDDLLKTENHAELEKLNDQLEAIGHH
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
IQLIKEEARAEKENTKEMVSDISHQLKTPVAALDTCFSVLMQNDLSATEQEEFRIRCRSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LDGLETLLQSLLEISKMETGLIQINKKKLPLMDTVISAVNRTYPKADEKEIEFVFDYEKE
HHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHEEECHHHH
LETCMVMQDKRWLGEAVINVLDNAVKYSPGGSKIFIRLQKRNDLVRMEIEDQGIGVPQNE
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEECCCCCCCCCHH
YHKIFQRFYRGSSREVMEKSGTGIGLFLSREIIEKHGGTITVTSGKKKKGSTFVIQLPYV
HHHHHHHHHCCCCHHHHHHCCCCEEHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA