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The map label for this gene is focA [H]

Identifier: 238917400

GI number: 238917400

Start: 1534730

End: 1535554

Strand: Reverse

Name: focA [H]

Synonym: EUBELI_01478

Alternate gene names: 238917400

Gene position: 1535554-1534730 (Counterclockwise)

Preceding gene: 238917401

Following gene: 238917397

Centisome position: 71.61

GC content: 38.42

Gene sequence:

>825_bases
ATGAAAGAAGCGATAGAGAATTATGTGGAAGGTTGTGTTGGGAAGGTTGACTGTCCAGCATACAAGCTTTTTATGAAAGC
CATACTTGCAGGAATGATGATTGCATTTGGCGCAGCCGGAAGCAGTGTGGCAGCACATGATATCGTCAATGTAGGAATTG
CACGTCTGGTTGCAGGAGTTGTATTCCCAATGGGACTTATGATGGTTGTTATGACAGGAGCAGAACTTTTTACAGGAGAC
TGTCTGGCAATTATGGCAACTGTACAGAAGAAGCACACAGCACTTAAGCTTATACGAATGCTTATTGTAGTATATCTGGG
AAATCTTCTTGGCTCGTTAATGCTTACATGTATTGATTATGTAAGCGGGCAGTATAATTATTCATCGGGAATACTTGGTG
CATATACAATTAAAGTAGCACTTGGAAAATGTAATCTTGATTTTACAACAGCGCTTGCATCGGGAATATTATGTAACATA
CTTGTGTGTGCAGCAGTTATGCTTGCGGCACGTGCAAAGGATGTAACCGGAAAACTGTTATGTTGTTTTTTTATAATACT
GCTTTTTGTTGTAAGCGGTTATGAGCATTGTGTTGCTAATATGTATTATGTACCTGCAGGAATGATAGCAAAACTTAATC
CGTTATATGTGAAAGATGCTATGGAGCAATATGGTTATACAGCACAGCAGCTTAGTACATTGAATATACCGAATTTTATA
TTTAATAATCTTATTCCTGTTACAATAGGTAATATTGTGGGAGGAATGGCATTCTTCGGAATACCGTTGATGTATATTAA
TGGTGTTGGTGGAAAGAAGGCGTGA

Upstream 100 bases:

>100_bases
CAGCTTGCTATAATATGCAAGCGTATTTTGTATACACAGTTAAAACAAAACGATTGAAGTGTAGGAATACACAATCAGGG
AGGAACTTAAGATGTTATCT

Downstream 100 bases:

>100_bases
TACATATCTTAAAGTATATGGATACGGATTGATGATTTAGAAGAAAATATATTATTACCTATGATTATTCCTTTAGAAAC
CATTAAAGCATAGGAAGATG

Product: formate transporter

Products: formate [Periplasm]; formate [Cytoplasm] [C]

Alternate protein names: Formate channel [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MKEAIENYVEGCVGKVDCPAYKLFMKAILAGMMIAFGAAGSSVAAHDIVNVGIARLVAGVVFPMGLMMVVMTGAELFTGD
CLAIMATVQKKHTALKLIRMLIVVYLGNLLGSLMLTCIDYVSGQYNYSSGILGAYTIKVALGKCNLDFTTALASGILCNI
LVCAAVMLAARAKDVTGKLLCCFFIILLFVVSGYEHCVANMYYVPAGMIAKLNPLYVKDAMEQYGYTAQQLSTLNIPNFI
FNNLIPVTIGNIVGGMAFFGIPLMYINGVGGKKA

Sequences:

>Translated_274_residues
MKEAIENYVEGCVGKVDCPAYKLFMKAILAGMMIAFGAAGSSVAAHDIVNVGIARLVAGVVFPMGLMMVVMTGAELFTGD
CLAIMATVQKKHTALKLIRMLIVVYLGNLLGSLMLTCIDYVSGQYNYSSGILGAYTIKVALGKCNLDFTTALASGILCNI
LVCAAVMLAARAKDVTGKLLCCFFIILLFVVSGYEHCVANMYYVPAGMIAKLNPLYVKDAMEQYGYTAQQLSTLNIPNFI
FNNLIPVTIGNIVGGMAFFGIPLMYINGVGGKKA
>Mature_274_residues
MKEAIENYVEGCVGKVDCPAYKLFMKAILAGMMIAFGAAGSSVAAHDIVNVGIARLVAGVVFPMGLMMVVMTGAELFTGD
CLAIMATVQKKHTALKLIRMLIVVYLGNLLGSLMLTCIDYVSGQYNYSSGILGAYTIKVALGKCNLDFTTALASGILCNI
LVCAAVMLAARAKDVTGKLLCCFFIILLFVVSGYEHCVANMYYVPAGMIAKLNPLYVKDAMEQYGYTAQQLSTLNIPNFI
FNNLIPVTIGNIVGGMAFFGIPLMYINGVGGKKA

Specific function: Involved in the bidirectional transport of formate [H]

COG id: COG2116

COG function: function code P; Formate/nitrite family of transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FNT transporter (TC 2.A.44) family [H]

Homologues:

Organism=Escherichia coli, GI1787132, Length=248, Percent_Identity=33.8709677419355, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788837, Length=256, Percent_Identity=27.734375, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082249, Length=224, Percent_Identity=27.6785714285714, Blast_Score=79, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321779, Length=252, Percent_Identity=30.952380952381, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000292 [H]

Pfam domain/function: PF01226 Form_Nir_trans [H]

EC number: NA

Molecular weight: Translated: 29217; Mature: 29217

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS01005 FORMATE_NITRITE_TP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
9.9 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
9.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEAIENYVEGCVGKVDCPAYKLFMKAILAGMMIAFGAAGSSVAAHDIVNVGIARLVAGV
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VFPMGLMMVVMTGAELFTGDCLAIMATVQKKHTALKLIRMLIVVYLGNLLGSLMLTCIDY
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSGQYNYSSGILGAYTIKVALGKCNLDFTTALASGILCNILVCAAVMLAARAKDVTGKLL
HCCCCCCCCCCHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CCFFIILLFVVSGYEHCVANMYYVPAGMIAKLNPLYVKDAMEQYGYTAQQLSTLNIPNFI
HHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCHHH
FNNLIPVTIGNIVGGMAFFGIPLMYINGVGGKKA
HHCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MKEAIENYVEGCVGKVDCPAYKLFMKAILAGMMIAFGAAGSSVAAHDIVNVGIARLVAGV
CHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VFPMGLMMVVMTGAELFTGDCLAIMATVQKKHTALKLIRMLIVVYLGNLLGSLMLTCIDY
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSGQYNYSSGILGAYTIKVALGKCNLDFTTALASGILCNILVCAAVMLAARAKDVTGKLL
HCCCCCCCCCCHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CCFFIILLFVVSGYEHCVANMYYVPAGMIAKLNPLYVKDAMEQYGYTAQQLSTLNIPNFI
HHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCHHH
FNNLIPVTIGNIVGGMAFFGIPLMYINGVGGKKA
HHCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formate [Cytoplasm]; formate [Periplasm] [C]

Specific reaction: formate [Cytoplasm] = formate [Periplasm] formate [Periplasm] = formate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]