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The map label for this gene is fhs

Identifier: 238917397

GI number: 238917397

Start: 1529605

End: 1531275

Strand: Reverse

Name: fhs

Synonym: EUBELI_01474

Alternate gene names: 238917397

Gene position: 1531275-1529605 (Counterclockwise)

Preceding gene: 238917400

Following gene: 238917392

Centisome position: 71.42

GC content: 40.81

Gene sequence:

>1671_bases
ATGAAGACAGACATTGAAATTGCACAGGAAGCAGTAATGGAGCCAATTAAGAATGTTGCAGCCAGATGCGGCATAAGCGA
GGATGATCTTGAATTATACGGAAAGTATAAGGCTAAGATATCAGATGAGTACATCAACAGTGTCAAAGGCAATGAAGATG
GAAAGTTAATTCTTGTTACAGCCATAAATCCAACTCCGGCAGGAGAGGGAAAGACAACAATTACTGTAGGGCTTGGAGAA
GCATTTGGAAAGCTTGGCAAGAAGGCAGTTATAGCACTTCGTGAGCCATCACTTGGTCCATGTTTCGGTATCAAAGGTGG
AGCAGCAGGTGGTGGATATGCACAGGTTGTTCCTATGGAAGAATTGAATCTGCATTTTACAGGCGATTTCCATGCAATCA
CATCAGCTAACAACTTATGTGCAGCACTTCTTGATAACCATATACAGCAGGGCAACGAACTTGGAATTGACCCAAGATGT
GTTACATGGAAAAGATGTATGGATATGAACGACCGTGTTCTTAGAAATATAGTTGTAGGTCTTGGTTCTAAGGTTGACGG
AACTGTAAGAGAAGATCATTTTGTTATCACAGTTGCGTCAGAGATTATGGCAGTATTATGTCTTGCAACAGATATGAAGG
ATTTAAAGGAAAGACTTGGCAAGATGGTAGTTGCTTACAATTATCAGGGACAGCCTGTTACTGCTGCAGATATCAAGGCA
GTAGGTTCAATGGCAGCATTGTTAAAGGATGCATTAAAGCCTAACCTTATCCAGACACTTGAACATACTCCTGCATTAGT
ACATGGTGGACCATTTGCTAATATCGCACATGGATGTAATTCAGTAAGAGCAACTAAGACTGCACTTAAGATGGCAGATT
ATGTTATCACAGAGGCAGGATTTGGAGCAGATTTAGGTGCAGAGAAATTCTTCGATATAAAGTGCCGTAAGTCAGGCTTA
AAGCCAGATGCAGTTGTATTAGTAGCAACAGTAAGAGCACTTAAGTACAACGGTGGAGTACCTAAGACAGAATTATCAGC
AGAGAATCTTGACGCATTAAAGAAGGGAATCGTAAACCTTGAAAAGCATATTGAGAATCTTCAGAAATATGGTGTGCCTG
TAGTTGTTACACTAAATGCGTTTGTATCAGATACACAGGCAGAATTAGATTATATACAGAAGTTCTGTGAAGATAAAGGC
TGTGAATTCGCCCTTGCCAAAGTATGGGAAAAGGGTGGAGAAGGCGGAATTGAGCTTGCAGAAAAGGTTCTTAAGACACT
TGAGACAAAGAAGAGCAATTTCCATTGCCTGTATGAGACAGACCAGCCAGTTAAAGCAAAGATTGAGACAATTGCCAAAG
AAATATATGGCGCAGGAAGTGTTAATTATTCGGCAGCAGCTAATAAGCAGATTGCACAGCTTGAACAGTTAGGATTTGGT
AATCTTCCAATCTGTATGGCTAAGACACAGTATTCGCTTTCAGACGATCCAACATTACTTGGCCGTCCGGAAGGATTTGA
GATGAATGTAAGAGAAGCATATGTATCAGCCGGTGCAGGCTTCATAGTAGTGCTTACAGGTTCAGTAATGACAATGCCAG
GACTTTCAAAATCACCAGCGGCATATAATATAGATGTTAATGATGATGGGGTAATAACTGGGTTATTCTAG

Upstream 100 bases:

>100_bases
GTTTTTATGTAAAGATATATTAGGAAGGAAATCTTCTTAGGAATCTTGATAAGGCAGGATTGCAAGGCACGAAAAGGCTA
AAGCAAAGGAGAGAAACATT

Downstream 100 bases:

>100_bases
AAAAGTGACTCCCGGGAGTGGGAGGCAGGTGGTTGTGTAGTGTATTTTCAAACGCGCTCTCGCTCGGACGAAAACGCAGC
GGTACTAAGATTTTGTGAGG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MKTDIEIAQEAVMEPIKNVAARCGISEDDLELYGKYKAKISDEYINSVKGNEDGKLILVTAINPTPAGEGKTTITVGLGE
AFGKLGKKAVIALREPSLGPCFGIKGGAAGGGYAQVVPMEELNLHFTGDFHAITSANNLCAALLDNHIQQGNELGIDPRC
VTWKRCMDMNDRVLRNIVVGLGSKVDGTVREDHFVITVASEIMAVLCLATDMKDLKERLGKMVVAYNYQGQPVTAADIKA
VGSMAALLKDALKPNLIQTLEHTPALVHGGPFANIAHGCNSVRATKTALKMADYVITEAGFGADLGAEKFFDIKCRKSGL
KPDAVVLVATVRALKYNGGVPKTELSAENLDALKKGIVNLEKHIENLQKYGVPVVVTLNAFVSDTQAELDYIQKFCEDKG
CEFALAKVWEKGGEGGIELAEKVLKTLETKKSNFHCLYETDQPVKAKIETIAKEIYGAGSVNYSAAANKQIAQLEQLGFG
NLPICMAKTQYSLSDDPTLLGRPEGFEMNVREAYVSAGAGFIVVLTGSVMTMPGLSKSPAAYNIDVNDDGVITGLF

Sequences:

>Translated_556_residues
MKTDIEIAQEAVMEPIKNVAARCGISEDDLELYGKYKAKISDEYINSVKGNEDGKLILVTAINPTPAGEGKTTITVGLGE
AFGKLGKKAVIALREPSLGPCFGIKGGAAGGGYAQVVPMEELNLHFTGDFHAITSANNLCAALLDNHIQQGNELGIDPRC
VTWKRCMDMNDRVLRNIVVGLGSKVDGTVREDHFVITVASEIMAVLCLATDMKDLKERLGKMVVAYNYQGQPVTAADIKA
VGSMAALLKDALKPNLIQTLEHTPALVHGGPFANIAHGCNSVRATKTALKMADYVITEAGFGADLGAEKFFDIKCRKSGL
KPDAVVLVATVRALKYNGGVPKTELSAENLDALKKGIVNLEKHIENLQKYGVPVVVTLNAFVSDTQAELDYIQKFCEDKG
CEFALAKVWEKGGEGGIELAEKVLKTLETKKSNFHCLYETDQPVKAKIETIAKEIYGAGSVNYSAAANKQIAQLEQLGFG
NLPICMAKTQYSLSDDPTLLGRPEGFEMNVREAYVSAGAGFIVVLTGSVMTMPGLSKSPAAYNIDVNDDGVITGLF
>Mature_556_residues
MKTDIEIAQEAVMEPIKNVAARCGISEDDLELYGKYKAKISDEYINSVKGNEDGKLILVTAINPTPAGEGKTTITVGLGE
AFGKLGKKAVIALREPSLGPCFGIKGGAAGGGYAQVVPMEELNLHFTGDFHAITSANNLCAALLDNHIQQGNELGIDPRC
VTWKRCMDMNDRVLRNIVVGLGSKVDGTVREDHFVITVASEIMAVLCLATDMKDLKERLGKMVVAYNYQGQPVTAADIKA
VGSMAALLKDALKPNLIQTLEHTPALVHGGPFANIAHGCNSVRATKTALKMADYVITEAGFGADLGAEKFFDIKCRKSGL
KPDAVVLVATVRALKYNGGVPKTELSAENLDALKKGIVNLEKHIENLQKYGVPVVVTLNAFVSDTQAELDYIQKFCEDKG
CEFALAKVWEKGGEGGIELAEKVLKTLETKKSNFHCLYETDQPVKAKIETIAKEIYGAGSVNYSAAANKQIAQLEQLGFG
NLPICMAKTQYSLSDDPTLLGRPEGFEMNVREAYVSAGAGFIVVLTGSVMTMPGLSKSPAAYNIDVNDDGVITGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=44.6054750402576, Blast_Score=487, Evalue=1e-137,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=45.5573505654281, Blast_Score=484, Evalue=1e-137,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=45.3488372093023, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=44.3729903536978, Blast_Score=475, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=44.3729903536978, Blast_Score=475, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=42.7892234548336, Blast_Score=485, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=43.4504792332268, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=45.8064516129032, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=45.8064516129032, Blast_Score=492, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=45.8064516129032, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=45.8064516129032, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_EUBE2 (C4Z1V6)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002930914.1
- GeneID:   7957135
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_01474
- OMA:   EIMAVLC
- ProtClustDB:   CLSK2402475
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59572; Mature: 59572

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDIEIAQEAVMEPIKNVAARCGISEDDLELYGKYKAKISDEYINSVKGNEDGKLILVT
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCEEEEE
AINPTPAGEGKTTITVGLGEAFGKLGKKAVIALREPSLGPCFGIKGGAAGGGYAQVVPME
EECCCCCCCCCEEEEEECHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHH
ELNLHFTGDFHAITSANNLCAALLDNHIQQGNELGIDPRCVTWKRCMDMNDRVLRNIVVG
HCCEEECCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHCCCCHHHHHHHHHH
LGSKVDGTVREDHFVITVASEIMAVLCLATDMKDLKERLGKMVVAYNYQGQPVTAADIKA
CCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCHHHHHHHHCCEEEEEECCCCCCCHHHHHH
VGSMAALLKDALKPNLIQTLEHTPALVHGGPFANIAHGCNSVRATKTALKMADYVITEAG
HHHHHHHHHHHHCCHHHHHHHCCCCEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
FGADLGAEKFFDIKCRKSGLKPDAVVLVATVRALKYNGGVPKTELSAENLDALKKGIVNL
CCCCCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
EKHIENLQKYGVPVVVTLNAFVSDTQAELDYIQKFCEDKGCEFALAKVWEKGGEGGIELA
HHHHHHHHHCCCCEEEEEEHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHH
EKVLKTLETKKSNFHCLYETDQPVKAKIETIAKEIYGAGSVNYSAAANKQIAQLEQLGFG
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHCCCC
NLPICMAKTQYSLSDDPTLLGRPEGFEMNVREAYVSAGAGFIVVLTGSVMTMPGLSKSPA
CCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHCCCCEEEEEECCEEECCCCCCCCC
AYNIDVNDDGVITGLF
EEEEECCCCCEEEECC
>Mature Secondary Structure
MKTDIEIAQEAVMEPIKNVAARCGISEDDLELYGKYKAKISDEYINSVKGNEDGKLILVT
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCEEEEE
AINPTPAGEGKTTITVGLGEAFGKLGKKAVIALREPSLGPCFGIKGGAAGGGYAQVVPME
EECCCCCCCCCEEEEEECHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHH
ELNLHFTGDFHAITSANNLCAALLDNHIQQGNELGIDPRCVTWKRCMDMNDRVLRNIVVG
HCCEEECCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHHHCCCCHHHHHHHHHH
LGSKVDGTVREDHFVITVASEIMAVLCLATDMKDLKERLGKMVVAYNYQGQPVTAADIKA
CCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCHHHHHHHHCCEEEEEECCCCCCCHHHHHH
VGSMAALLKDALKPNLIQTLEHTPALVHGGPFANIAHGCNSVRATKTALKMADYVITEAG
HHHHHHHHHHHHCCHHHHHHHCCCCEEECCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
FGADLGAEKFFDIKCRKSGLKPDAVVLVATVRALKYNGGVPKTELSAENLDALKKGIVNL
CCCCCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
EKHIENLQKYGVPVVVTLNAFVSDTQAELDYIQKFCEDKGCEFALAKVWEKGGEGGIELA
HHHHHHHHHCCCCEEEEEEHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHH
EKVLKTLETKKSNFHCLYETDQPVKAKIETIAKEIYGAGSVNYSAAANKQIAQLEQLGFG
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHCCHHHHHHHHCCCC
NLPICMAKTQYSLSDDPTLLGRPEGFEMNVREAYVSAGAGFIVVLTGSVMTMPGLSKSPA
CCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHCCCCEEEEEECCEEECCCCCCCCC
AYNIDVNDDGVITGLF
EEEEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA