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The map label for this gene is hom [H]

Identifier: 238917360

GI number: 238917360

Start: 1490865

End: 1492163

Strand: Reverse

Name: hom [H]

Synonym: EUBELI_01437

Alternate gene names: 238917360

Gene position: 1492163-1490865 (Counterclockwise)

Preceding gene: 238917361

Following gene: 238917359

Centisome position: 69.59

GC content: 40.11

Gene sequence:

>1299_bases
ATGAGGGCGTACAAAGTAATGAGCAGAAAGATTTATGCGGCTATATTAGGAGCAGGAACAGTTGGAACAGGTGTATACAA
GTTATGTCAGAGTATGAAAGATGATGTGATTAGTAAGACGGGTGCAGAACTTGTAGTTAAGAAGGTTCTTGTAAGAAATC
TTGATAAAGACCGTGATCCAATTGACAGAGAATTACTGACTGACAACTGGAAGGATATTATTGAAGATAAGGATATTGAG
ATTGTAATAGAGCTTATGGGTGGAACTACTCCTGCAAAGCAGTATATTCTTGAGGCACTTGAGGCTGGAAAGCAGGTTGT
TACTGCCAATAAGGATCTTCTTGCTGAGCATGGTGAAGAGGTTATGGGAATGGCAGACAAAATGCATGCTGACCTTCAGT
TTGAGGCGGCTGTTGCGGGAGCAATTCCAATAATCAGACCATTAAAGCAGAGCATGGCTGGCAACAATATCACAGAGATT
ATTGGTATTGTTAACGGAACAACTAATTATATCCTTACAAAGATGACTGAATCAGGAATGAATTATAAGGACGCTCTTGC
AAAGGCTACAGAATTAGGATATGCAGAGGCAGACCCTACAGCAGATGTTGAAGGATATGATGCAGGAAGAAAGATGGCTA
TTATGTCATCAATCGCATTTAATTCAAGGGTAACATTTAATCAGGTATATACAGAGGGTATTACTAAGATTACAGCAGAA
GATATTAAGTATGCTAAGGAATTCGGATATGTTATCAAGCTTCTTGGACTTGCCAGAAATACACCGGATGGAATAGAAGT
TAAGGTTCATCCTATGCTTATTGACGAGAATCACCCTCTGGCTACAGTAAGAGATTCATTTAATGCAGTATTTGTTCATG
GTGAGGCAAGTGATGATACTATGTTTATGGGCAGGGGCGCAGGTCAGATGCCAACAGCTTCTGCTGTTATGGGGGACATT
ATAGATGTATGCCGTAACATAGTTCATGGCTCATGCGGCAAGATTGGCTGCTCATGCTACAAAGAGCTTCCTGTTAAGGA
TATATCTGAAACCAAGAGCAAATTCTTCTTAAGAATAGAAGCATTAGACAAGCAGGGGGTTCTTGCTAACATTGCAAGTG
TTCTTGGAAACAATGATGTAAGTATTGCGCAGGTGGTCCAGAAGAGCCGTAAGGACGGTGTTGCTGAACTTGTTATTATT
ACAGATGTTGTTGCAGAGAAGAATTTTAATGATGCAATGACAGTATTTAACGGACTTTCAGTGGTAAAAGAGATTGCCGG
AGTAATCCGAGTTTATTAA

Upstream 100 bases:

>100_bases
CTGGGAAGGCTATAAAGAACTTTAAGGATCAGGTTGATGCTGTAGATATGAAATAAATGTATCACAGATTAATATAATAA
ACTTAACATAATAAACAGGA

Downstream 100 bases:

>100_bases
TCAGAATAGGGAAATATATATGGCTAAGAAATATTATGCTGTGCGTGTAGGTAAAGTTCCCGGAATATATCAGACATGGG
ACGAATGTAAGAAGAATGTA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MRAYKVMSRKIYAAILGAGTVGTGVYKLCQSMKDDVISKTGAELVVKKVLVRNLDKDRDPIDRELLTDNWKDIIEDKDIE
IVIELMGGTTPAKQYILEALEAGKQVVTANKDLLAEHGEEVMGMADKMHADLQFEAAVAGAIPIIRPLKQSMAGNNITEI
IGIVNGTTNYILTKMTESGMNYKDALAKATELGYAEADPTADVEGYDAGRKMAIMSSIAFNSRVTFNQVYTEGITKITAE
DIKYAKEFGYVIKLLGLARNTPDGIEVKVHPMLIDENHPLATVRDSFNAVFVHGEASDDTMFMGRGAGQMPTASAVMGDI
IDVCRNIVHGSCGKIGCSCYKELPVKDISETKSKFFLRIEALDKQGVLANIASVLGNNDVSIAQVVQKSRKDGVAELVII
TDVVAEKNFNDAMTVFNGLSVVKEIAGVIRVY

Sequences:

>Translated_432_residues
MRAYKVMSRKIYAAILGAGTVGTGVYKLCQSMKDDVISKTGAELVVKKVLVRNLDKDRDPIDRELLTDNWKDIIEDKDIE
IVIELMGGTTPAKQYILEALEAGKQVVTANKDLLAEHGEEVMGMADKMHADLQFEAAVAGAIPIIRPLKQSMAGNNITEI
IGIVNGTTNYILTKMTESGMNYKDALAKATELGYAEADPTADVEGYDAGRKMAIMSSIAFNSRVTFNQVYTEGITKITAE
DIKYAKEFGYVIKLLGLARNTPDGIEVKVHPMLIDENHPLATVRDSFNAVFVHGEASDDTMFMGRGAGQMPTASAVMGDI
IDVCRNIVHGSCGKIGCSCYKELPVKDISETKSKFFLRIEALDKQGVLANIASVLGNNDVSIAQVVQKSRKDGVAELVII
TDVVAEKNFNDAMTVFNGLSVVKEIAGVIRVY
>Mature_432_residues
MRAYKVMSRKIYAAILGAGTVGTGVYKLCQSMKDDVISKTGAELVVKKVLVRNLDKDRDPIDRELLTDNWKDIIEDKDIE
IVIELMGGTTPAKQYILEALEAGKQVVTANKDLLAEHGEEVMGMADKMHADLQFEAAVAGAIPIIRPLKQSMAGNNITEI
IGIVNGTTNYILTKMTESGMNYKDALAKATELGYAEADPTADVEGYDAGRKMAIMSSIAFNSRVTFNQVYTEGITKITAE
DIKYAKEFGYVIKLLGLARNTPDGIEVKVHPMLIDENHPLATVRDSFNAVFVHGEASDDTMFMGRGAGQMPTASAVMGDI
IDVCRNIVHGSCGKIGCSCYKELPVKDISETKSKFFLRIEALDKQGVLANIASVLGNNDVSIAQVVQKSRKDGVAELVII
TDVVAEKNFNDAMTVFNGLSVVKEIAGVIRVY

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=267, Percent_Identity=25.4681647940075, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790376, Length=354, Percent_Identity=23.728813559322, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46945; Mature: 46945

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAYKVMSRKIYAAILGAGTVGTGVYKLCQSMKDDVISKTGAELVVKKVLVRNLDKDRDP
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IDRELLTDNWKDIIEDKDIEIVIELMGGTTPAKQYILEALEAGKQVVTANKDLLAEHGEE
HHHHHHHCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCHHHHHHCCHH
VMGMADKMHADLQFEAAVAGAIPIIRPLKQSMAGNNITEIIGIVNGTTNYILTKMTESGM
HHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHEEEEHHHCCC
NYKDALAKATELGYAEADPTADVEGYDAGRKMAIMSSIAFNSRVTFNQVYTEGITKITAE
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
DIKYAKEFGYVIKLLGLARNTPDGIEVKVHPMLIDENHPLATVRDSFNAVFVHGEASDDT
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCEEEECCCCEEEEECCCCCCE
MFMGRGAGQMPTASAVMGDIIDVCRNIVHGSCGKIGCSCYKELPVKDISETKSKFFLRIE
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHEEEEEE
ALDKQGVLANIASVLGNNDVSIAQVVQKSRKDGVAELVIITDVVAEKNFNDAMTVFNGLS
ECCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHCCCCCHHHHHHHHHH
VVKEIAGVIRVY
HHHHHHHHHCCC
>Mature Secondary Structure
MRAYKVMSRKIYAAILGAGTVGTGVYKLCQSMKDDVISKTGAELVVKKVLVRNLDKDRDP
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IDRELLTDNWKDIIEDKDIEIVIELMGGTTPAKQYILEALEAGKQVVTANKDLLAEHGEE
HHHHHHHCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCHHHHHHCCHH
VMGMADKMHADLQFEAAVAGAIPIIRPLKQSMAGNNITEIIGIVNGTTNYILTKMTESGM
HHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHEEEEHHHCCC
NYKDALAKATELGYAEADPTADVEGYDAGRKMAIMSSIAFNSRVTFNQVYTEGITKITAE
CHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
DIKYAKEFGYVIKLLGLARNTPDGIEVKVHPMLIDENHPLATVRDSFNAVFVHGEASDDT
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCEEEECCCCEEEEECCCCCCE
MFMGRGAGQMPTASAVMGDIIDVCRNIVHGSCGKIGCSCYKELPVKDISETKSKFFLRIE
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHEEEEEE
ALDKQGVLANIASVLGNNDVSIAQVVQKSRKDGVAELVIITDVVAEKNFNDAMTVFNGLS
ECCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHCCCCCHHHHHHHHHH
VVKEIAGVIRVY
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2835591; 3320973; 9362124; 12948626; 1902466 [H]