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The map label for this gene is nadC [H]

Identifier: 238917352

GI number: 238917352

Start: 1483181

End: 1484041

Strand: Reverse

Name: nadC [H]

Synonym: EUBELI_01429

Alternate gene names: 238917352

Gene position: 1484041-1483181 (Counterclockwise)

Preceding gene: 238917353

Following gene: 238917351

Centisome position: 69.21

GC content: 38.21

Gene sequence:

>861_bases
ATGTTTGATAAAGTTACTTTAAAGTTAAATGTGGATCCGCTCATTCTTGGAGCACTTAAAGAAGATATTACAAGTGAGGA
TGTGTCAACTAACAGTGTTATGCCAGAACCAAAACTTGGAGAAGTCGAGCTTATATGCAAGCAGGACGGAATAATATGTG
GCTTGCAGGTATTTGCAAGAACATTTGAACTGCTTGATGAAGATGTAGAGATTACATTTTTTGCAAAAGACGGGGATGAG
GTTAAGAAAGGTCAGAAGATGGCAGTTGTAAGAGGAGATATAAGAGTTCTTCTGTGTGGAGAAAGAACAGCACTTAATTA
TCTCCAGAGAATGAGTGGAATTGCGACATATACTAATGGTGTTGCGAAGCTGCTTGCAGGAACTAAGACAAAGCTTCTTG
ATACAAGAAAGACATCACCTAATAACCGTATATTTGAGAAGTATGCTGTCAGAATCGGAGGTGGTAATAACCACAGATAT
AATCTTACAGACGGAGTACTCCTTAAGGATAACCATATAGGTGCTGCAGGCGGAGTTAAGCAGGCAGTTACAATGGCTAA
GGAATATGCACCATTTGTAAGAAAGATAGAAGTTGAAGTTGAGAACCTTTCAATGGTGCGTGAAGCTGTTGAGGCAGGCG
CTGATATTATTATGCTTGATAATATGAGTCATGAGGATATGCGAGAGGCTATGAATATAATTGGTGGAAAAGCTTTAGTT
GAAGTTTCTGGAAATGTAACTAAAGAAAACATTGCAAAAATTACTGACCTTGGTGTAGACTTTGTATCAAGTGGTGCACT
TACACATTCTGCACCAATTATGGACATTTCATTAAAAAATCTTCATCCTGTACAGGAGTAA

Upstream 100 bases:

>100_bases
TATGCAAAATTAGTCAATAAAAAGATTGAAGAGGCAGATAAAGCCTATGAAGAAAGCCAGAAGAAGAATTACGCATAATA
TATAGAAATGGAGAAATGAT

Downstream 100 bases:

>100_bases
TCATTGTCGGGGTGAACCGGGGAGTTGTAGCAATGAATGGAGAAGAGAGAAGAAATCAGATAGTAGATATATTAAAACAT
TCGTCAAGTCCTGTGCCGGG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MFDKVTLKLNVDPLILGALKEDITSEDVSTNSVMPEPKLGEVELICKQDGIICGLQVFARTFELLDEDVEITFFAKDGDE
VKKGQKMAVVRGDIRVLLCGERTALNYLQRMSGIATYTNGVAKLLAGTKTKLLDTRKTSPNNRIFEKYAVRIGGGNNHRY
NLTDGVLLKDNHIGAAGGVKQAVTMAKEYAPFVRKIEVEVENLSMVREAVEAGADIIMLDNMSHEDMREAMNIIGGKALV
EVSGNVTKENIAKITDLGVDFVSSGALTHSAPIMDISLKNLHPVQE

Sequences:

>Translated_286_residues
MFDKVTLKLNVDPLILGALKEDITSEDVSTNSVMPEPKLGEVELICKQDGIICGLQVFARTFELLDEDVEITFFAKDGDE
VKKGQKMAVVRGDIRVLLCGERTALNYLQRMSGIATYTNGVAKLLAGTKTKLLDTRKTSPNNRIFEKYAVRIGGGNNHRY
NLTDGVLLKDNHIGAAGGVKQAVTMAKEYAPFVRKIEVEVENLSMVREAVEAGADIIMLDNMSHEDMREAMNIIGGKALV
EVSGNVTKENIAKITDLGVDFVSSGALTHSAPIMDISLKNLHPVQE
>Mature_286_residues
MFDKVTLKLNVDPLILGALKEDITSEDVSTNSVMPEPKLGEVELICKQDGIICGLQVFARTFELLDEDVEITFFAKDGDE
VKKGQKMAVVRGDIRVLLCGERTALNYLQRMSGIATYTNGVAKLLAGTKTKLLDTRKTSPNNRIFEKYAVRIGGGNNHRY
NLTDGVLLKDNHIGAAGGVKQAVTMAKEYAPFVRKIEVEVENLSMVREAVEAGADIIMLDNMSHEDMREAMNIIGGKALV
EVSGNVTKENIAKITDLGVDFVSSGALTHSAPIMDISLKNLHPVQE

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=285, Percent_Identity=34.7368421052632, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI1786299, Length=279, Percent_Identity=44.0860215053763, Blast_Score=201, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6321162, Length=286, Percent_Identity=35.6643356643357, Blast_Score=159, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31251; Mature: 31251

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDKVTLKLNVDPLILGALKEDITSEDVSTNSVMPEPKLGEVELICKQDGIICGLQVFAR
CCCEEEEEEECCCEEHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHH
TFELLDEDVEITFFAKDGDEVKKGQKMAVVRGDIRVLLCGERTALNYLQRMSGIATYTNG
HHHHCCCCEEEEEEECCCHHHHCCCEEEEEECCEEEEEECCHHHHHHHHHHHCHHHHHHH
VAKLLAGTKTKLLDTRKTSPNNRIFEKYAVRIGGGNNHRYNLTDGVLLKDNHIGAAGGVK
HHHHHHCCHHHHEECCCCCCCCCEEEEEEEEECCCCCCEEECCCCEEEECCCCCCCCCHH
QAVTMAKEYAPFVRKIEVEVENLSMVREAVEAGADIIMLDNMSHEDMREAMNIIGGKALV
HHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCEEEE
EVSGNVTKENIAKITDLGVDFVSSGALTHSAPIMDISLKNLHPVQE
EECCCCCHHHHHHHHHHCHHHHCCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MFDKVTLKLNVDPLILGALKEDITSEDVSTNSVMPEPKLGEVELICKQDGIICGLQVFAR
CCCEEEEEEECCCEEHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHH
TFELLDEDVEITFFAKDGDEVKKGQKMAVVRGDIRVLLCGERTALNYLQRMSGIATYTNG
HHHHCCCCEEEEEEECCCHHHHCCCEEEEEECCEEEEEECCHHHHHHHHHHHCHHHHHHH
VAKLLAGTKTKLLDTRKTSPNNRIFEKYAVRIGGGNNHRYNLTDGVLLKDNHIGAAGGVK
HHHHHHCCHHHHEECCCCCCCCCEEEEEEEEECCCCCCEEECCCCEEEECCCCCCCCCHH
QAVTMAKEYAPFVRKIEVEVENLSMVREAVEAGADIIMLDNMSHEDMREAMNIIGGKALV
HHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCEEEE
EVSGNVTKENIAKITDLGVDFVSSGALTHSAPIMDISLKNLHPVQE
EECCCCCHHHHHHHHHHCHHHHCCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]