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The map label for this gene is 238917336

Identifier: 238917336

GI number: 238917336

Start: 1460416

End: 1462029

Strand: Reverse

Name: 238917336

Synonym: EUBELI_01413

Alternate gene names: NA

Gene position: 1462029-1460416 (Counterclockwise)

Preceding gene: 238917337

Following gene: 238917335

Centisome position: 68.19

GC content: 40.21

Gene sequence:

>1614_bases
ATGAAACTAACATTTTTAGGCGCGGATCATGAGGTAACAGGAAGCTGTCATTTCTTACAGGCGGCAGGTCTTAATATTCT
TGTAGACTGCGGTATGGAACAGGGTAATGATGTATATGAGAATCAGGAGCTTCCGGTTGTGGCATCTGATGTGGATTGCA
TATTGCTGACACACGCACACATTGACCATTCAGGTCTTATTCCACTTATGTATGTGAATGGATTCAGGGGGCAGGTGTAT
TCAACATCGGCTACAGCACAGTTATGTGAGATAATGTTAAGAGACAGCGCACATATCCAGATGTTTGAAGCTGAATGGAG
AAACAGAAAGGCTGCAAGATCAGGTGGAAAGCTTAAGGAATTCGTTCCATTGTATGATATGGATGCAGCAGTTAATGTCT
GCAAGCAGTTCGTAGGCTGTGAGTATGACAGGGTATATGATATTGCAGAAGGAATTAAGATAAGATTTACAGATGTAGGA
CATCTTCTTGGTTCAGCAAGTATTGAGGTATGGGCAACAGAGAAGACAGAGAATGGTGATGTAACAGAGAAGATTGTGTT
TTCGGGTGATATAGGTAATATTAACAAGCCTATAATTAAAGACCCGAAGCATGTTACAGACGCTGATTATGTAGTCATGG
AATCAACCTATGGTAACAGAAGCCACGGTGGAACTCCTAACTATGTTGAAGATTTAACGAATATATTCAAGAGAACATTT
GAAAGAGGAGGTAATGTTGTTATTCCTTCATTCGCTGTCGGAAGGACACAGGAGCTTCTCTATATTATAAGAAAGATTAA
AGAAGATAATCTTGTTGGCAGGGACTTTGATGTATATATGGACAGTCCGCTTGCAATTGAGGCAACTAACATATTTATTA
AGAATGTTGAGAGCTGCTTTGATGATGAAGCAGTCGAGCTTGTAAGAAAGGGGATTAATCCGCTTTCATTTCCAGGACTT
AAGTATGCAACTACGGGTGATGAATCAAAGCAGATTAACTTTGATCCTAATCCTAAGGTTATTATTTCTTCATCAGGTAT
GTGTGAAGCGGGAAGAATAAGACATCACCTGAAGCATAATTTGTGGAGACCAGAGTGTACAATTGTATTTGTCGGTTATC
AGGCTGTTGGAACAACAGGCCGTATAATAGTTGATGGCGCAGAGGAGATTAAACTGTTTGGTGAACCGATACAGATAAAG
GCAGAGATTGTACAGCTTAAGGGTTCAAGTGGTCATGCTGATAAAGATGGGCTTCTTTGTTGGATTAATGCATTTGACAC
AAAGCCTAAAAAGGTGTTTGTTGTGCATGGCGAAGACAGTGTGTGTGACGAGTTTACGGAATGCCTTAAAGAAGAATATG
GTTATGATGCCATGGCACCATATACAGGCGGAAGTTATGATTTTATTGCAGACAGAGTTATCTCTGAAGGAGTTAAGGAA
AGAAAGACTAGAAGAACGACGAGTACACAGCGTGGTAAAACTGTATTTGACAGACTTGTTGCTGCTGGAAAGCGTCTCAT
GACAGTTATTACACACAATGAGGGTGGTACGAATAAAGATCTGGCTAAGTTTACAGATCAGATTAATGCATTATGTGATA
AATGGGACAGGTGA

Upstream 100 bases:

>100_bases
ATTTTTATATATGATTGTATTTAATTTTACATAGGAAAATGTTACAATTACATCAGAAATATCGTGAAAAAATAGCGTTG
ACGCGGAAATGAGGCATATT

Downstream 100 bases:

>100_bases
TTATGATGAAGATGCTGTTTGTTTTTAATCCAAACTCAGGAAAAGCTCAGATTAAGAATCAGCTGATGAAGATAATACAG
GTGTTTTCTAAGGCTGGATA

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MKLTFLGADHEVTGSCHFLQAAGLNILVDCGMEQGNDVYENQELPVVASDVDCILLTHAHIDHSGLIPLMYVNGFRGQVY
STSATAQLCEIMLRDSAHIQMFEAEWRNRKAARSGGKLKEFVPLYDMDAAVNVCKQFVGCEYDRVYDIAEGIKIRFTDVG
HLLGSASIEVWATEKTENGDVTEKIVFSGDIGNINKPIIKDPKHVTDADYVVMESTYGNRSHGGTPNYVEDLTNIFKRTF
ERGGNVVIPSFAVGRTQELLYIIRKIKEDNLVGRDFDVYMDSPLAIEATNIFIKNVESCFDDEAVELVRKGINPLSFPGL
KYATTGDESKQINFDPNPKVIISSSGMCEAGRIRHHLKHNLWRPECTIVFVGYQAVGTTGRIIVDGAEEIKLFGEPIQIK
AEIVQLKGSSGHADKDGLLCWINAFDTKPKKVFVVHGEDSVCDEFTECLKEEYGYDAMAPYTGGSYDFIADRVISEGVKE
RKTRRTTSTQRGKTVFDRLVAAGKRLMTVITHNEGGTNKDLAKFTDQINALCDKWDR

Sequences:

>Translated_537_residues
MKLTFLGADHEVTGSCHFLQAAGLNILVDCGMEQGNDVYENQELPVVASDVDCILLTHAHIDHSGLIPLMYVNGFRGQVY
STSATAQLCEIMLRDSAHIQMFEAEWRNRKAARSGGKLKEFVPLYDMDAAVNVCKQFVGCEYDRVYDIAEGIKIRFTDVG
HLLGSASIEVWATEKTENGDVTEKIVFSGDIGNINKPIIKDPKHVTDADYVVMESTYGNRSHGGTPNYVEDLTNIFKRTF
ERGGNVVIPSFAVGRTQELLYIIRKIKEDNLVGRDFDVYMDSPLAIEATNIFIKNVESCFDDEAVELVRKGINPLSFPGL
KYATTGDESKQINFDPNPKVIISSSGMCEAGRIRHHLKHNLWRPECTIVFVGYQAVGTTGRIIVDGAEEIKLFGEPIQIK
AEIVQLKGSSGHADKDGLLCWINAFDTKPKKVFVVHGEDSVCDEFTECLKEEYGYDAMAPYTGGSYDFIADRVISEGVKE
RKTRRTTSTQRGKTVFDRLVAAGKRLMTVITHNEGGTNKDLAKFTDQINALCDKWDR
>Mature_537_residues
MKLTFLGADHEVTGSCHFLQAAGLNILVDCGMEQGNDVYENQELPVVASDVDCILLTHAHIDHSGLIPLMYVNGFRGQVY
STSATAQLCEIMLRDSAHIQMFEAEWRNRKAARSGGKLKEFVPLYDMDAAVNVCKQFVGCEYDRVYDIAEGIKIRFTDVG
HLLGSASIEVWATEKTENGDVTEKIVFSGDIGNINKPIIKDPKHVTDADYVVMESTYGNRSHGGTPNYVEDLTNIFKRTF
ERGGNVVIPSFAVGRTQELLYIIRKIKEDNLVGRDFDVYMDSPLAIEATNIFIKNVESCFDDEAVELVRKGINPLSFPGL
KYATTGDESKQINFDPNPKVIISSSGMCEAGRIRHHLKHNLWRPECTIVFVGYQAVGTTGRIIVDGAEEIKLFGEPIQIK
AEIVQLKGSSGHADKDGLLCWINAFDTKPKKVFVVHGEDSVCDEFTECLKEEYGYDAMAPYTGGSYDFIADRVISEGVKE
RKTRRTTSTQRGKTVFDRLVAAGKRLMTVITHNEGGTNKDLAKFTDQINALCDKWDR

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=494, Percent_Identity=23.4817813765182, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI7706427, Length=467, Percent_Identity=27.4089935760171, Blast_Score=131, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32564696, Length=506, Percent_Identity=24.703557312253, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32566029, Length=452, Percent_Identity=25.8849557522124, Blast_Score=125, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6323307, Length=453, Percent_Identity=24.9448123620309, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24648013, Length=477, Percent_Identity=25.5765199161426, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21358523, Length=557, Percent_Identity=23.8779174147217, Blast_Score=126, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 59801; Mature: 59801

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTFLGADHEVTGSCHFLQAAGLNILVDCGMEQGNDVYENQELPVVASDVDCILLTHAH
CEEEEECCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCEEECCCCEEEEEEEE
IDHSGLIPLMYVNGFRGQVYSTSATAQLCEIMLRDSAHIQMFEAEWRNRKAARSGGKLKE
CCCCCCEEEEEECCCCCEEEECHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHCCCCHHH
FVPLYDMDAAVNVCKQFVGCEYDRVYDIAEGIKIRFTDVGHLLGSASIEVWATEKTENGD
HCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEHHHHHCCCCEEEEEECCCCCCC
VTEKIVFSGDIGNINKPIIKDPKHVTDADYVVMESTYGNRSHGGTPNYVEDLTNIFKRTF
CEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
ERGGNVVIPSFAVGRTQELLYIIRKIKEDNLVGRDFDVYMDSPLAIEATNIFIKNVESCF
HCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEHHHHHHHHHHHC
DDEAVELVRKGINPLSFPGLKYATTGDESKQINFDPNPKVIISSSGMCEAGRIRHHLKHN
CHHHHHHHHHCCCCCCCCCEEEEECCCCCCEECCCCCCCEEEECCCCCCHHHHHHHHHHC
LWRPECTIVFVGYQAVGTTGRIIVDGAEEIKLFGEPIQIKAEIVQLKGSSGHADKDGLLC
CCCCCEEEEEEEEEEECCCCEEEEECHHHHEECCCCEEEEEEEEEEECCCCCCCCCCEEE
WINAFDTKPKKVFVVHGEDSVCDEFTECLKEEYGYDAMAPYTGGSYDFIADRVISEGVKE
EEECCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RKTRRTTSTQRGKTVFDRLVAAGKRLMTVITHNEGGTNKDLAKFTDQINALCDKWDR
HHHHHCCCHHCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLTFLGADHEVTGSCHFLQAAGLNILVDCGMEQGNDVYENQELPVVASDVDCILLTHAH
CEEEEECCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCEEECCCCEEEEEEEE
IDHSGLIPLMYVNGFRGQVYSTSATAQLCEIMLRDSAHIQMFEAEWRNRKAARSGGKLKE
CCCCCCEEEEEECCCCCEEEECHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHCCCCHHH
FVPLYDMDAAVNVCKQFVGCEYDRVYDIAEGIKIRFTDVGHLLGSASIEVWATEKTENGD
HCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEHHHHHCCCCEEEEEECCCCCCC
VTEKIVFSGDIGNINKPIIKDPKHVTDADYVVMESTYGNRSHGGTPNYVEDLTNIFKRTF
CEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
ERGGNVVIPSFAVGRTQELLYIIRKIKEDNLVGRDFDVYMDSPLAIEATNIFIKNVESCF
HCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEHHHHHHHHHHHC
DDEAVELVRKGINPLSFPGLKYATTGDESKQINFDPNPKVIISSSGMCEAGRIRHHLKHN
CHHHHHHHHHCCCCCCCCCEEEEECCCCCCEECCCCCCCEEEECCCCCCHHHHHHHHHHC
LWRPECTIVFVGYQAVGTTGRIIVDGAEEIKLFGEPIQIKAEIVQLKGSSGHADKDGLLC
CCCCCEEEEEEEEEEECCCCEEEEECHHHHEECCCCEEEEEEEEEEECCCCCCCCCCEEE
WINAFDTKPKKVFVVHGEDSVCDEFTECLKEEYGYDAMAPYTGGSYDFIADRVISEGVKE
EEECCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RKTRRTTSTQRGKTVFDRLVAAGKRLMTVITHNEGGTNKDLAKFTDQINALCDKWDR
HHHHHCCCHHCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA