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The map label for this gene is ndoA [H]

Identifier: 238917303

GI number: 238917303

Start: 1418690

End: 1419043

Strand: Reverse

Name: ndoA [H]

Synonym: EUBELI_01378

Alternate gene names: 238917303

Gene position: 1419043-1418690 (Counterclockwise)

Preceding gene: 238917304

Following gene: 238917302

Centisome position: 66.18

GC content: 38.14

Gene sequence:

>354_bases
GTGACAGTTGTGGTAATAAAAAGAGGAGATATTTTTTATGCAGATTTAAGACCTGTGGTTGGCTCGGAGCAAGGGGGAAT
AAGACCGGTACTTATTATACAGAATGATACAGGAAATAAGCACAGTCCAACAGTTATATGTGCTGCAATAACGAGCCAGA
TGCATAAGAGTAAGCTTCCAACTCATGTAGAGCTGGATTCATCAAGATATGACATGGTTAAGGATTCAGTAATACTTTTA
GAACAGTTAAGAACGATAGATAAAAGAAGACTCAAGGATAAGGTGTGCCATCTGGATAATGACATCATCGGACAGGTTAA
TAAAGCACTGTCTGTAAGCTTAGAGATGAATTGA

Upstream 100 bases:

>100_bases
AAATGCAGTTGCAGATGCTATTAAAAGATAAAAGATAACTGAATACACACTTAAAAGTAGGCAATACTAATGCCAGAGGA
AACAATTTAGCTTTAGGAGT

Downstream 100 bases:

>100_bases
CTGTCAGCATAAAACTGTGTTATTATAGACAGGATAATTGTTATCGTACAATAGGATATTATTTATGGAGGAATATTATG
AATGACGGCCATCCCGCGGA

Product: hypothetical protein

Products: NA

Alternate protein names: Endoribonuclease EndoA; Toxin EndoA [H]

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MTVVVIKRGDIFYADLRPVVGSEQGGIRPVLIIQNDTGNKHSPTVICAAITSQMHKSKLPTHVELDSSRYDMVKDSVILL
EQLRTIDKRRLKDKVCHLDNDIIGQVNKALSVSLEMN

Sequences:

>Translated_117_residues
MTVVVIKRGDIFYADLRPVVGSEQGGIRPVLIIQNDTGNKHSPTVICAAITSQMHKSKLPTHVELDSSRYDMVKDSVILL
EQLRTIDKRRLKDKVCHLDNDIIGQVNKALSVSLEMN
>Mature_116_residues
TVVVIKRGDIFYADLRPVVGSEQGGIRPVLIIQNDTGNKHSPTVICAAITSQMHKSKLPTHVELDSSRYDMVKDSVILLE
QLRTIDKRRLKDKVCHLDNDIIGQVNKALSVSLEMN

Specific function: Part of a toxin-antitoxin (TA) module. Has specificity for UAC sequences, yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single

COG id: COG2337

COG function: function code T; Growth inhibitor

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PemK/MazF family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003477
- InterPro:   IPR011067 [H]

Pfam domain/function: PF02452 PemK [H]

EC number: NA

Molecular weight: Translated: 13080; Mature: 12949

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVVVIKRGDIFYADLRPVVGSEQGGIRPVLIIQNDTGNKHSPTVICAAITSQMHKSKLP
CEEEEEECCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEHHHHHHHHHHCCC
THVELDSSRYDMVKDSVILLEQLRTIDKRRLKDKVCHLDNDIIGQVNKALSVSLEMN
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEEEECC
>Mature Secondary Structure 
TVVVIKRGDIFYADLRPVVGSEQGGIRPVLIIQNDTGNKHSPTVICAAITSQMHKSKLP
EEEEEECCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEHHHHHHHHHHCCC
THVELDSSRYDMVKDSVILLEQLRTIDKRRLKDKVCHLDNDIIGQVNKALSVSLEMN
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]