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The map label for this gene is thrC [H]

Identifier: 238917289

GI number: 238917289

Start: 1403527

End: 1405014

Strand: Reverse

Name: thrC [H]

Synonym: EUBELI_01364

Alternate gene names: 238917289

Gene position: 1405014-1403527 (Counterclockwise)

Preceding gene: 238917291

Following gene: 238917287

Centisome position: 65.53

GC content: 36.76

Gene sequence:

>1488_bases
ATGAGCATGTTCTACAGAAGTACTAGAGACGACAGTGTTAAGGTTACTGCATCGCAGGCTATATTAAAGGGGCTGGCAGC
AGACGGAGGACTTTTTGTACCAGAGAGTATTCCATCATTAGATAAAAGCTTAGAAGAGTTGTCTAAGATGAATTATAAGG
AAGTTGCTTATGAAGTTATGAAGCTTATGCTTGATGATTTCACAGAGGAAGAACTTAAGAGCTGTATAGACAGAGCTTAT
GATTCTAAGTTTGATACAGAGGAGATGACTCCACTTGTTAAAGTTGAGAATGAATATTTCCTTGAACTTTTCCATGGAGC
TACAATAGCTTTCAAGGATATGGCACTTTCTATACTTCCACATCTTCTTACAACTTCTGCAAAGAAGAACAATGTTAAGA
ATGAAATTGTCATTCTTACAGCTACATCAGGAGATACAGGAAAGGCAGCTTTAGCTGGATTTGCTAATGTTCCTGGAACT
AAGATTATCGTATTCTATCCTAAGAATGGTGTAAGCCCAATTCAGGAGAAGCAGATGGTTACACAGAAGGGTGACAATAC
ATATGTAATCGGGATCAAGGGTAACTTTGATGATGCGCAGACAGGTGTTAAGAATATTTTCTCTGATAAGGAATTAGAGA
AGGTTATGAATGATGCCGGATTCCAGTTCTCATCAGCTAATTCAATCAATATCGGAAGACTTGTTCCTCAGATTGTCTAC
TATGTATATGCATATGCCAAGTTATTAGCTAATGGAGAGATTAAGGATGGCGAGAAGATAAATGTAGTTGTTCCTACAGG
TAACTTTGGTAATATCTTAGCTGCATTTTATGCTAAGAACATGGGACTTCCTATTAATAAGTTTATCTGCGCATCTAATG
AGAATAAGGTATTATATGATTTCTTTACAACAGGTGAGTACGACAGAAACAGAGAATTCGTTCTTACAACTTCACCATCT
ATGGATATTCTTATTTCAAGCAACCTTGAGAGACTTATATACAGAATTGCCGGCAATAATGCAGCTAAGAATGCAGAGCT
TATGGCATCATTAAAGTCAGAAGGAAAATACAAGATTACAGATGATATGAAAGCACAGTTAGCTGACTTCTATGGCAATT
ATGCTACAGAGGCAGAGGACGCTGCTACAATCAAGAAGATATATGAAGATTGCGGATATGTAATCGATACACATACATCA
GTTGCTGCAACTGTATATGATAAGTACAGAAAGGAAACTGGCGATACAACTAAAACAGTTATTGCTTCAACAGCAAGCCC
ATATAAGTTTACAAGAAGTGTTATGAATGCTATTGATTCTAAGTATGATTCAATGGGAGACTTCGAACTTGTAGATGAGC
TTAGCAAGATAAGCAATGTCAAAGTTCCTAACGCAATTGAAGAAATCAGAACAGCACCAGTTCTTCATGATACTGTATGT
GATTCTGATAAGATGTGTGATGAAGTTAAGAAGATTCTTGGAATCTAA

Upstream 100 bases:

>100_bases
TATATAAAGGTATTGTTTTTGCACAGAAGTCTGTTGTATAATATCAAAAGCCTACGACGTTTTCGCAGGCACACTATATT
AATTATGAGGTGTATTAAAG

Downstream 100 bases:

>100_bases
TATTATAAGAAAATAAAAATCTCCGGACCGTGTGATGATGGTCCGGAGTTTTTTTATTTATCTGTCAACAATTACTCCCT
GACAGCCAAGTTCAAGCCAT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MSMFYRSTRDDSVKVTASQAILKGLAADGGLFVPESIPSLDKSLEELSKMNYKEVAYEVMKLMLDDFTEEELKSCIDRAY
DSKFDTEEMTPLVKVENEYFLELFHGATIAFKDMALSILPHLLTTSAKKNNVKNEIVILTATSGDTGKAALAGFANVPGT
KIIVFYPKNGVSPIQEKQMVTQKGDNTYVIGIKGNFDDAQTGVKNIFSDKELEKVMNDAGFQFSSANSINIGRLVPQIVY
YVYAYAKLLANGEIKDGEKINVVVPTGNFGNILAAFYAKNMGLPINKFICASNENKVLYDFFTTGEYDRNREFVLTTSPS
MDILISSNLERLIYRIAGNNAAKNAELMASLKSEGKYKITDDMKAQLADFYGNYATEAEDAATIKKIYEDCGYVIDTHTS
VAATVYDKYRKETGDTTKTVIASTASPYKFTRSVMNAIDSKYDSMGDFELVDELSKISNVKVPNAIEEIRTAPVLHDTVC
DSDKMCDEVKKILGI

Sequences:

>Translated_495_residues
MSMFYRSTRDDSVKVTASQAILKGLAADGGLFVPESIPSLDKSLEELSKMNYKEVAYEVMKLMLDDFTEEELKSCIDRAY
DSKFDTEEMTPLVKVENEYFLELFHGATIAFKDMALSILPHLLTTSAKKNNVKNEIVILTATSGDTGKAALAGFANVPGT
KIIVFYPKNGVSPIQEKQMVTQKGDNTYVIGIKGNFDDAQTGVKNIFSDKELEKVMNDAGFQFSSANSINIGRLVPQIVY
YVYAYAKLLANGEIKDGEKINVVVPTGNFGNILAAFYAKNMGLPINKFICASNENKVLYDFFTTGEYDRNREFVLTTSPS
MDILISSNLERLIYRIAGNNAAKNAELMASLKSEGKYKITDDMKAQLADFYGNYATEAEDAATIKKIYEDCGYVIDTHTS
VAATVYDKYRKETGDTTKTVIASTASPYKFTRSVMNAIDSKYDSMGDFELVDELSKISNVKVPNAIEEIRTAPVLHDTVC
DSDKMCDEVKKILGI
>Mature_494_residues
SMFYRSTRDDSVKVTASQAILKGLAADGGLFVPESIPSLDKSLEELSKMNYKEVAYEVMKLMLDDFTEEELKSCIDRAYD
SKFDTEEMTPLVKVENEYFLELFHGATIAFKDMALSILPHLLTTSAKKNNVKNEIVILTATSGDTGKAALAGFANVPGTK
IIVFYPKNGVSPIQEKQMVTQKGDNTYVIGIKGNFDDAQTGVKNIFSDKELEKVMNDAGFQFSSANSINIGRLVPQIVYY
VYAYAKLLANGEIKDGEKINVVVPTGNFGNILAAFYAKNMGLPINKFICASNENKVLYDFFTTGEYDRNREFVLTTSPSM
DILISSNLERLIYRIAGNNAAKNAELMASLKSEGKYKITDDMKAQLADFYGNYATEAEDAATIKKIYEDCGYVIDTHTSV
AATVYDKYRKETGDTTKTVIASTASPYKFTRSVMNAIDSKYDSMGDFELVDELSKISNVKVPNAIEEIRTAPVLHDTVCD
SDKMCDEVKKILGI

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=448, Percent_Identity=39.7321428571429, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI149193323, Length=441, Percent_Identity=29.9319727891156, Blast_Score=213, Evalue=5e-55,
Organism=Escherichia coli, GI1786185, Length=431, Percent_Identity=31.554524361949, Blast_Score=181, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6319901, Length=468, Percent_Identity=38.4615384615385, Blast_Score=303, Evalue=4e-83,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 54832; Mature: 54701

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMFYRSTRDDSVKVTASQAILKGLAADGGLFVPESIPSLDKSLEELSKMNYKEVAYEVM
CCCCCCCCCCCCEEEEHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHCCHHHHHHHHH
KLMLDDFTEEELKSCIDRAYDSKFDTEEMTPLVKVENEYFLELFHGATIAFKDMALSILP
HHHHHCCCHHHHHHHHHHHHCCCCCHHHCCCEEEECHHHHHHHHHCCHHHHHHHHHHHHH
HLLTTSAKKNNVKNEIVILTATSGDTGKAALAGFANVPGTKIIVFYPKNGVSPIQEKQMV
HHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHH
TQKGDNTYVIGIKGNFDDAQTGVKNIFSDKELEKVMNDAGFQFSSANSINIGRLVPQIVY
HHCCCCEEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHH
YVYAYAKLLANGEIKDGEKINVVVPTGNFGNILAAFYAKNMGLPINKFICASNENKVLYD
HHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHEEEECCCCCEEEE
FFTTGEYDRNREFVLTTSPSMDILISSNLERLIYRIAGNNAAKNAELMASLKSEGKYKIT
EECCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEC
DDMKAQLADFYGNYATEAEDAATIKKIYEDCGYVIDTHTSVAATVYDKYRKETGDTTKTV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCHHHHH
IASTASPYKFTRSVMNAIDSKYDSMGDFELVDELSKISNVKVPNAIEEIRTAPVLHDTVC
EECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHC
DSDKMCDEVKKILGI
CCHHHHHHHHHHHCC
>Mature Secondary Structure 
SMFYRSTRDDSVKVTASQAILKGLAADGGLFVPESIPSLDKSLEELSKMNYKEVAYEVM
CCCCCCCCCCCEEEEHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHCCHHHHHHHHH
KLMLDDFTEEELKSCIDRAYDSKFDTEEMTPLVKVENEYFLELFHGATIAFKDMALSILP
HHHHHCCCHHHHHHHHHHHHCCCCCHHHCCCEEEECHHHHHHHHHCCHHHHHHHHHHHHH
HLLTTSAKKNNVKNEIVILTATSGDTGKAALAGFANVPGTKIIVFYPKNGVSPIQEKQMV
HHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHH
TQKGDNTYVIGIKGNFDDAQTGVKNIFSDKELEKVMNDAGFQFSSANSINIGRLVPQIVY
HHCCCCEEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHH
YVYAYAKLLANGEIKDGEKINVVVPTGNFGNILAAFYAKNMGLPINKFICASNENKVLYD
HHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHEEEECCCCCEEEE
FFTTGEYDRNREFVLTTSPSMDILISSNLERLIYRIAGNNAAKNAELMASLKSEGKYKIT
EECCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEC
DDMKAQLADFYGNYATEAEDAATIKKIYEDCGYVIDTHTSVAATVYDKYRKETGDTTKTV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCHHHHH
IASTASPYKFTRSVMNAIDSKYDSMGDFELVDELSKISNVKVPNAIEEIRTAPVLHDTVC
EECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHC
DSDKMCDEVKKILGI
CCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]