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The map label for this gene is tpiA [H]

Identifier: 238917117

GI number: 238917117

Start: 1200276

End: 1201025

Strand: Reverse

Name: tpiA [H]

Synonym: EUBELI_01188

Alternate gene names: 238917117

Gene position: 1201025-1200276 (Counterclockwise)

Preceding gene: 238917118

Following gene: 238917116

Centisome position: 56.01

GC content: 38.93

Gene sequence:

>750_bases
ATGAGAAGAAAAGTAATAGCAGGCAATTGGAAGATGAATATGACACCAAGCCAGGCAGTTAAGCTCGTTACTGAATTGAG
ACCGAATGTTAATAATCCGGATGTTGATGTTGTGTTCTGTGTACCATCTATTGACATTGTACCTGTAGTGGAGGCAGTGA
AAGGATCTAATATACATATTGGTGCAGAGAATGTATATTATCAGGAGAAAGGAGCATTTACCGGTGAGTTATCGCCTGAG
ATGCTTGTTGATGCCGGGGTAAGCCATGTTATCATAGGACATTCAGAAAGAAGAATGTACTTTAATGAAAGTAATACAGT
GCTTAATCTCAAGATGCATAAGGTACTTGAACATGGAATTATCCCAATTCTTTGTTGTGGAGAGACACTTGAACAGAGAG
AAAAAGGGATTACACTTGATTTCATTAAAGAACAGATAGTAGAAGCATATGTTGGTGTTACTAAAGAGCAGGTGCTTCAT
ACAATAGTTGCTTATGAGCCAATCTGGGCTATTGGAACAGGAAAGGTTGCAACTACAGCGCAGGCACAGGAAGTATGTGG
ATTTATAAGAACTGTATTCGAAGAGTTATATGATAAAGAAACAGCGGATCAGATAAGGATTCTTTATGGAGGAAGTGTTA
ATGCTTCTAATGCAGCAGAGCTTTTTGCCCAGCCTGATATTGATGGTGGACTGGTAGGAGGTGCAAGTCTCAAGCCGGAT
TTTGCGGATATAGTTAATTATAATAAGTAA

Upstream 100 bases:

>100_bases
ATGCTATTATCTATTTTACTAGGATAGTTATATCGGAATAATTTAATAGGATTGTCCATATATATGTTATTATGGATAAT
TTCCTGTGGGGAGGCGTAGA

Downstream 100 bases:

>100_bases
ATAAGCATGAAAAGACCTTGTTTTGATGATAATATTCAAGACAAGGTCTTTGATTTTTTTTACAAATGTGCTATCATGCT
ATAGGCAATTAATTAGAATA

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MRRKVIAGNWKMNMTPSQAVKLVTELRPNVNNPDVDVVFCVPSIDIVPVVEAVKGSNIHIGAENVYYQEKGAFTGELSPE
MLVDAGVSHVIIGHSERRMYFNESNTVLNLKMHKVLEHGIIPILCCGETLEQREKGITLDFIKEQIVEAYVGVTKEQVLH
TIVAYEPIWAIGTGKVATTAQAQEVCGFIRTVFEELYDKETADQIRILYGGSVNASNAAELFAQPDIDGGLVGGASLKPD
FADIVNYNK

Sequences:

>Translated_249_residues
MRRKVIAGNWKMNMTPSQAVKLVTELRPNVNNPDVDVVFCVPSIDIVPVVEAVKGSNIHIGAENVYYQEKGAFTGELSPE
MLVDAGVSHVIIGHSERRMYFNESNTVLNLKMHKVLEHGIIPILCCGETLEQREKGITLDFIKEQIVEAYVGVTKEQVLH
TIVAYEPIWAIGTGKVATTAQAQEVCGFIRTVFEELYDKETADQIRILYGGSVNASNAAELFAQPDIDGGLVGGASLKPD
FADIVNYNK
>Mature_249_residues
MRRKVIAGNWKMNMTPSQAVKLVTELRPNVNNPDVDVVFCVPSIDIVPVVEAVKGSNIHIGAENVYYQEKGAFTGELSPE
MLVDAGVSHVIIGHSERRMYFNESNTVLNLKMHKVLEHGIIPILCCGETLEQREKGITLDFIKEQIVEAYVGVTKEQVLH
TIVAYEPIWAIGTGKVATTAQAQEVCGFIRTVFEELYDKETADQIRILYGGSVNASNAAELFAQPDIDGGLVGGASLKPD
FADIVNYNK

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=248, Percent_Identity=40.7258064516129, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI4507645, Length=245, Percent_Identity=41.2244897959184, Blast_Score=184, Evalue=8e-47,
Organism=Escherichia coli, GI1790353, Length=248, Percent_Identity=46.7741935483871, Blast_Score=199, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17536593, Length=247, Percent_Identity=47.3684210526316, Blast_Score=207, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6320255, Length=246, Percent_Identity=42.2764227642276, Blast_Score=186, Evalue=2e-48,
Organism=Drosophila melanogaster, GI28572008, Length=245, Percent_Identity=44.4897959183673, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI28572006, Length=245, Percent_Identity=44.4897959183673, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI28572004, Length=245, Percent_Identity=44.4897959183673, Blast_Score=201, Evalue=4e-52,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 27378; Mature: 27378

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRKVIAGNWKMNMTPSQAVKLVTELRPNVNNPDVDVVFCVPSIDIVPVVEAVKGSNIHI
CCCCEEECCEEECCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHCCCEEEE
GAENVYYQEKGAFTGELSPEMLVDAGVSHVIIGHSERRMYFNESNTVLNLKMHKVLEHGI
ECCCEEEECCCCCCCCCCHHHHHHCCCCEEEEECCCCEEEECCCCCEEEHHHHHHHHCCC
IPILCCGETLEQREKGITLDFIKEQIVEAYVGVTKEQVLHTIVAYEPIWAIGTGKVATTA
EEEEECCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCEECHH
QAQEVCGFIRTVFEELYDKETADQIRILYGGSVNASNAAELFAQPDIDGGLVGGASLKPD
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCEECCCCCCCC
FADIVNYNK
HHHHCCCCC
>Mature Secondary Structure
MRRKVIAGNWKMNMTPSQAVKLVTELRPNVNNPDVDVVFCVPSIDIVPVVEAVKGSNIHI
CCCCEEECCEEECCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHCCCEEEE
GAENVYYQEKGAFTGELSPEMLVDAGVSHVIIGHSERRMYFNESNTVLNLKMHKVLEHGI
ECCCEEEECCCCCCCCCCHHHHHHCCCCEEEEECCCCEEEECCCCCEEEHHHHHHHHCCC
IPILCCGETLEQREKGITLDFIKEQIVEAYVGVTKEQVLHTIVAYEPIWAIGTGKVATTA
EEEEECCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCEECHH
QAQEVCGFIRTVFEELYDKETADQIRILYGGSVNASNAAELFAQPDIDGGLVGGASLKPD
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCEECCCCCCCC
FADIVNYNK
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA