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The map label for this gene is gmk [H]

Identifier: 238917058

GI number: 238917058

Start: 1138079

End: 1138708

Strand: Reverse

Name: gmk [H]

Synonym: EUBELI_01128

Alternate gene names: 238917058

Gene position: 1138708-1138079 (Counterclockwise)

Preceding gene: 238917059

Following gene: 238917057

Centisome position: 53.11

GC content: 37.94

Gene sequence:

>630_bases
ATGAGCAAAGGACTATTATTAGTTATTTCAGGATTTTCTGGTGCAGGAAAAGGAACTGTTATGAAGCGACTTTTAGAGCT
TCATGACGAGTATTCACTTTCTATATCAGCTACAACAAGAAAGCCAAGAGAAGGCGAAGCTGATGGAAGAGAATATTTCT
TTAAGACTGTAGAAGAATTCGAGAAGATGATTGCTGAAGATGCTTTAATAGAGCATGCACAGTATGTTGGCAATTATTAC
GGAACACCAAAGGCATATGTTGAAGAACAGCTTGATAAGGGTAACAATGTTATTCTTGAGATTGAGATACAGGGTGCCAT
GAATATCAAGAGAATGTTCCCGGATGCAGTGCTTATGTTTATAACACCACCGTCAGCGGCAGAACTTGAAAAGAGACTCC
GTGGCAGAGGAACAGAAGATGAGGCGACAATTAAAGCCCGTCTTTCAAGAGCAGCAGAGGAAGCAGAAGGTGTTGAGGAT
TATGATTACATAGTTATCAATGATGAAGTCGATTTATGTGTCGGCCGTATTCATGATATTGTGTTATCTGAGAAGATGAA
AGCTAAGTATAATCTTGGACTGATTAATAATATTAAAGAAGAATTAAAGGTTTATTCGAAAGGAGAATAA

Upstream 100 bases:

>100_bases
TCAATATATTTTTAATTGGTTTTGATTAAATTTACTTGATTGTTTCGGGCTTGTTAGGTATAATAACTTGTGCACTTTAT
GTGCAGAATGAGGTAATTAT

Downstream 100 bases:

>100_bases
TATAATGATACATCCATCGTATACTGAATTAATGGCTGTAATTAACAGTGAGGTTGAAGAGGGCGAGCAGCCTTTAGTAC
AGAGCAGATATTCAATTGTT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSKGLLLVISGFSGAGKGTVMKRLLELHDEYSLSISATTRKPREGEADGREYFFKTVEEFEKMIAEDALIEHAQYVGNYY
GTPKAYVEEQLDKGNNVILEIEIQGAMNIKRMFPDAVLMFITPPSAAELEKRLRGRGTEDEATIKARLSRAAEEAEGVED
YDYIVINDEVDLCVGRIHDIVLSEKMKAKYNLGLINNIKEELKVYSKGE

Sequences:

>Translated_209_residues
MSKGLLLVISGFSGAGKGTVMKRLLELHDEYSLSISATTRKPREGEADGREYFFKTVEEFEKMIAEDALIEHAQYVGNYY
GTPKAYVEEQLDKGNNVILEIEIQGAMNIKRMFPDAVLMFITPPSAAELEKRLRGRGTEDEATIKARLSRAAEEAEGVED
YDYIVINDEVDLCVGRIHDIVLSEKMKAKYNLGLINNIKEELKVYSKGE
>Mature_208_residues
SKGLLLVISGFSGAGKGTVMKRLLELHDEYSLSISATTRKPREGEADGREYFFKTVEEFEKMIAEDALIEHAQYVGNYYG
TPKAYVEEQLDKGNNVILEIEIQGAMNIKRMFPDAVLMFITPPSAAELEKRLRGRGTEDEATIKARLSRAAEEAEGVEDY
DYIVINDEVDLCVGRIHDIVLSEKMKAKYNLGLINNIKEELKVYSKGE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=197, Percent_Identity=38.0710659898477, Blast_Score=130, Evalue=8e-31,
Organism=Homo sapiens, GI4504221, Length=197, Percent_Identity=38.0710659898477, Blast_Score=130, Evalue=8e-31,
Organism=Homo sapiens, GI226874831, Length=197, Percent_Identity=38.0710659898477, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4505237, Length=175, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI262118259, Length=175, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI262118255, Length=175, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI262118263, Length=175, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI21361598, Length=193, Percent_Identity=24.8704663212435, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI148539578, Length=163, Percent_Identity=32.5153374233129, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI148539628, Length=163, Percent_Identity=32.5153374233129, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI38570142, Length=132, Percent_Identity=28.030303030303, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1790080, Length=189, Percent_Identity=41.2698412698413, Blast_Score=167, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17508835, Length=170, Percent_Identity=39.4117647058824, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=37.7777777777778, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6320662, Length=184, Percent_Identity=42.9347826086957, Blast_Score=150, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21356141, Length=196, Percent_Identity=41.3265306122449, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI161077626, Length=167, Percent_Identity=26.9461077844311, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24640542, Length=167, Percent_Identity=26.9461077844311, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45554489, Length=167, Percent_Identity=26.9461077844311, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007136, Length=167, Percent_Identity=26.9461077844311, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554481, Length=167, Percent_Identity=26.9461077844311, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85724806, Length=167, Percent_Identity=26.9461077844311, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554804, Length=163, Percent_Identity=31.9018404907975, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281360700, Length=163, Percent_Identity=31.9018404907975, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641280, Length=163, Percent_Identity=31.9018404907975, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641282, Length=163, Percent_Identity=31.9018404907975, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554818, Length=163, Percent_Identity=31.9018404907975, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23505; Mature: 23374

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKGLLLVISGFSGAGKGTVMKRLLELHDEYSLSISATTRKPREGEADGREYFFKTVEEF
CCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
EKMIAEDALIEHAQYVGNYYGTPKAYVEEQLDKGNNVILEIEIQGAMNIKRMFPDAVLMF
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHCCCEEEEE
ITPPSAAELEKRLRGRGTEDEATIKARLSRAAEEAEGVEDYDYIVINDEVDLCVGRIHDI
ECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHH
VLSEKMKAKYNLGLINNIKEELKVYSKGE
HHHHHHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKGLLLVISGFSGAGKGTVMKRLLELHDEYSLSISATTRKPREGEADGREYFFKTVEEF
CCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
EKMIAEDALIEHAQYVGNYYGTPKAYVEEQLDKGNNVILEIEIQGAMNIKRMFPDAVLMF
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHCCCEEEEE
ITPPSAAELEKRLRGRGTEDEATIKARLSRAAEEAEGVEDYDYIVINDEVDLCVGRIHDI
ECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHH
VLSEKMKAKYNLGLINNIKEELKVYSKGE
HHHHHHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA