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The map label for this gene is ispA [C]

Identifier: 238917015

GI number: 238917015

Start: 1099386

End: 1100279

Strand: Reverse

Name: ispA [C]

Synonym: EUBELI_01085

Alternate gene names: 238917015

Gene position: 1100279-1099386 (Counterclockwise)

Preceding gene: 238917016

Following gene: 238917014

Centisome position: 51.31

GC content: 37.58

Gene sequence:

>894_bases
ATGAGTGATTTTAAGAATGAATTGGAACAGGAAGTAGTTTTTATTAATGATATAATATTAAGATATCTTCCTGAGGAAAC
AGGACTTGATAAGAAGATAAGAGAATCCATGAATTACAGTGTTAATGCAGGCGGCAAGAGAGTAAGGCCGATGCTTATGC
TTGAAGTATATAAACTTTGTGGCGGCAATGACTGTCAGGTTGTCTATCCGTTTATGGCAGCACTGGAATGTATTCATTCA
TACTCACTTGTGCATGATGATCTTCCTGCAATGGATAATGATGATTACAGAAGAGGAAGACTTACAACACATAAGGTATT
CGGAGAAGATTTCGGAATACTTGCAGGAGACGGACTTCTTAATCTTGCTTATGAGATTATGGCTGAAGCGCTTGTATCAG
GTGAAGGTGATATAGAAACAAAAGCCAAAGCAATGGAGGTTATTGCAAGAAAAGCAGGAATAAAAGGCATGGTAGGCGGA
CAGGCTGTTGATGTAGAACTTACAGGCAGGACTTTATCAGAAGAACAGCTTGATTTTATATTCAGATTAAAAACAGGTGC
ACTGATTGAAGCAGCATTTCTTGCCGGAGCATATCTTGCAGGTTGTGATGATGAGACTGCTGACAAGTTATGCAGGGCAG
CATCACTTATAGGATTTGCATTCCAGATAAGAGACGATATCCTTGATGTCACAAGTTCTTTAGAAGAGCTTGGAAAGCCT
GTATTTTCAGATGAAAAGAACAATAAAACAACATATGTTACTTTATATGGAATGGAAAAAGCTGAGGCAGATGTAGAGTC
TATGTCTGATGAGGCTTTAGATATAATTAAAAGTGTTGGAAAGAATGAATTCTTAGAGGAGCTTGTTCTTAACCTTATAC
ACAGAAACAAATAA

Upstream 100 bases:

>100_bases
ATGTATCAGGAGGGGATGAAGCTTGTCGAAAGCTGTAATAACCAGCTTGACAAGGTTGAGAAACAAATCATAGTTTTGAA
TGATGATGGAGAACAGGACG

Downstream 100 bases:

>100_bases
AGCAGGTGCATTATGATTCTTGAAAAGATAAATAAACCGAATGATATTAAACAATTATCTCCAATTGAATATAATCAGCT
TGCGGATGAAATCCGTGGAT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSDFKNELEQEVVFINDIILRYLPEETGLDKKIRESMNYSVNAGGKRVRPMLMLEVYKLCGGNDCQVVYPFMAALECIHS
YSLVHDDLPAMDNDDYRRGRLTTHKVFGEDFGILAGDGLLNLAYEIMAEALVSGEGDIETKAKAMEVIARKAGIKGMVGG
QAVDVELTGRTLSEEQLDFIFRLKTGALIEAAFLAGAYLAGCDDETADKLCRAASLIGFAFQIRDDILDVTSSLEELGKP
VFSDEKNNKTTYVTLYGMEKAEADVESMSDEALDIIKSVGKNEFLEELVLNLIHRNK

Sequences:

>Translated_297_residues
MSDFKNELEQEVVFINDIILRYLPEETGLDKKIRESMNYSVNAGGKRVRPMLMLEVYKLCGGNDCQVVYPFMAALECIHS
YSLVHDDLPAMDNDDYRRGRLTTHKVFGEDFGILAGDGLLNLAYEIMAEALVSGEGDIETKAKAMEVIARKAGIKGMVGG
QAVDVELTGRTLSEEQLDFIFRLKTGALIEAAFLAGAYLAGCDDETADKLCRAASLIGFAFQIRDDILDVTSSLEELGKP
VFSDEKNNKTTYVTLYGMEKAEADVESMSDEALDIIKSVGKNEFLEELVLNLIHRNK
>Mature_296_residues
SDFKNELEQEVVFINDIILRYLPEETGLDKKIRESMNYSVNAGGKRVRPMLMLEVYKLCGGNDCQVVYPFMAALECIHSY
SLVHDDLPAMDNDDYRRGRLTTHKVFGEDFGILAGDGLLNLAYEIMAEALVSGEGDIETKAKAMEVIARKAGIKGMVGGQ
AVDVELTGRTLSEEQLDFIFRLKTGALIEAAFLAGAYLAGCDDETADKLCRAASLIGFAFQIRDDILDVTSSLEELGKPV
FSDEKNNKTTYVTLYGMEKAEADVESMSDEALDIIKSVGKNEFLEELVLNLIHRNK

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=236, Percent_Identity=28.8135593220339, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786623, Length=300, Percent_Identity=39.3333333333333, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1789578, Length=272, Percent_Identity=30.5147058823529, Blast_Score=99, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319475, Length=219, Percent_Identity=29.2237442922374, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651612, Length=254, Percent_Identity=30.3149606299213, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32908; Mature: 32777

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFKNELEQEVVFINDIILRYLPEETGLDKKIRESMNYSVNAGGKRVRPMLMLEVYKLC
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
GGNDCQVVYPFMAALECIHSYSLVHDDLPAMDNDDYRRGRLTTHKVFGEDFGILAGDGLL
CCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCEEECCHHH
NLAYEIMAEALVSGEGDIETKAKAMEVIARKAGIKGMVGGQAVDVELTGRTLSEEQLDFI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHH
FRLKTGALIEAAFLAGAYLAGCDDETADKLCRAASLIGFAFQIRDDILDVTSSLEELGKP
HHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VFSDEKNNKTTYVTLYGMEKAEADVESMSDEALDIIKSVGKNEFLEELVLNLIHRNK
CCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDFKNELEQEVVFINDIILRYLPEETGLDKKIRESMNYSVNAGGKRVRPMLMLEVYKLC
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
GGNDCQVVYPFMAALECIHSYSLVHDDLPAMDNDDYRRGRLTTHKVFGEDFGILAGDGLL
CCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCEEECCHHH
NLAYEIMAEALVSGEGDIETKAKAMEVIARKAGIKGMVGGQAVDVELTGRTLSEEQLDFI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHHH
FRLKTGALIEAAFLAGAYLAGCDDETADKLCRAASLIGFAFQIRDDILDVTSSLEELGKP
HHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VFSDEKNNKTTYVTLYGMEKAEADVESMSDEALDIIKSVGKNEFLEELVLNLIHRNK
CCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]