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The map label for this gene is dxs [H]

Identifier: 238917014

GI number: 238917014

Start: 1097484

End: 1099373

Strand: Reverse

Name: dxs [H]

Synonym: EUBELI_01084

Alternate gene names: 238917014

Gene position: 1099373-1097484 (Counterclockwise)

Preceding gene: 238917015

Following gene: 238917013

Centisome position: 51.27

GC content: 38.25

Gene sequence:

>1890_bases
ATGATTCTTGAAAAGATAAATAAACCGAATGATATTAAACAATTATCTCCAATTGAATATAATCAGCTTGCGGATGAAAT
CCGTGGATTTCTTATAGAAAAGATTAGTAAGACAGGTGGACATCTGGCATCTAATCTTGGTGTGGTTGAGCTTACAATGG
CACTTCATCTGGCATTTAATCTGCCGCAGGACAAGCTTATATGGGATGTTGGACACCAGTCATATACCCATAAGATTCTT
ACAGGAAGAAAGAACCAGTTTGACCAGTTAAGAAAATTTGGCGGAATGAGCGGATTTCCTAAGAGAAATGAAAGTCATTT
TGATGCATTTGACACAGGACACAGTTCGACTTCAATATCGGCAGGACTTGGTCTTGTCAAGGCAAGAGATTTAAAAAATG
AGCATTACAATGTTGTCTCTGTTATAGGAGATGGTGCGCTTACTGGCGGAATGGCCTATGAGGCACTTAATAATGCTTCT
TCACTTAAGACTAATTTTATTATTGTGTTAAATGATAATACTATGTCAATAGCCAAGAATGTTGGCGGTGTACCACATAT
GCTTAGTAATATAAGGTCATCAGATTCATATTATGACCTTAAGGAAAATGTGACTAATACTCTGTATAAGCTTCCGGGTG
GAGACCATATTGTAGAAAGAATCAAGAAAACCAAGAGTAATCTTAAGCAGATAATACTTCCAGGACAAATGTTTGAATGT
ATGGGAATATCTTATCTTGGCCCAGTTAATGGACATGATATTGAGAAGCTTATTAAGGTGTTTCATGTTGCTAAACGAAT
TAACGGTGCAGTTATCATCCATGTTGTAACACATAAAGGACATGGATATAAACCTGCAGAGCGTAATCCGGCTAAGTTTC
ATGGAATAGGACCATTTGATATTGTAACAGGAAAAGAATTGAAATCATCTGATAAGCCGACTTATTCTGATGTATTTTCG
GAAAAAATATGCCAGCTTGCCAAAAAGGATAAGTCAATTGTTGCGGTTACTGCAGCAATGCCTGATGGAACAGGACTTAA
TAAATTCTCTAAATGGTTTCCTGACAGATTTTTTGATGTCGGAATCGCAGAAGAGCATGCTGTTACGTTTTCGGCTGGAA
TGGCAGCAGGTGGTCTTAAACCTGTATTTGCTGTGTATTCTTCATTTTTACAAAGAGCTTATGACCAGATACTTCACGAT
GTATGTATCCAGCATCTTCATGTGGTATTTGCAATTGACAGGGCAGGGCTTGTTGGAAGTGATGGTGAGACACATCAGGG
TATATTCGACCTTTCATTTCTGACTTCAATTCCAAACATGACTGTTATGGCACCTAAGAATGGCAGTGAACTTTCAGCAA
TGCTTGAATTCGCTCTGCTTAACTTTAATTCCCCGGTTGCAATAAGATATCCAAGAGGTCAGGCGTATGATGGTCTTGAA
GAGCATAATGCACCAATCCGGTACGGAAAAGCCGAGATGATTATTGAAGAGTCTGACATTGCATTTGTTGCAGCAGGCAA
TATGCTTATTACGGCACAGGCAGTCAGAGAAAAGCTTAAAGAAAAGGGTTATAATATAACAATTGTCAATGAGCGTTTTA
TTAAGCCGGTTGATACCGATATGTTGGACAGATTATCAGAGTCTCACAGACTTATAGTTACTATGGAAGAAAATGTTTTG
TCAGGTGGCTTTGGTGAAGCGGTCTGTCAATATTATGATGATACATGCAATGACATAGATGTACTTAATATTGCACTGCC
AGATGATTATGTTGAACATGGCAATGTTGATATTCTGCGACGGGAATCAGGTGTTGACAGAGACAGTATTATTGCGAAGG
TGCTTAACAGATGGGCAAATGTATTGAATAAGGACAAGAGAAATGAGTAA

Upstream 100 bases:

>100_bases
TGATGAGGCTTTAGATATAATTAAAAGTGTTGGAAAGAATGAATTCTTAGAGGAGCTTGTTCTTAACCTTATACACAGAA
ACAAATAAAGCAGGTGCATT

Downstream 100 bases:

>100_bases
AGAAAGATTAGATGTTTTATTAGTTAATAAAGGGCTTGCGACTTCAAGAGAGAAGGCAAAAGCTATTATTATGTCTGGCA
ATGTATATGTTGACGGACAG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MILEKINKPNDIKQLSPIEYNQLADEIRGFLIEKISKTGGHLASNLGVVELTMALHLAFNLPQDKLIWDVGHQSYTHKIL
TGRKNQFDQLRKFGGMSGFPKRNESHFDAFDTGHSSTSISAGLGLVKARDLKNEHYNVVSVIGDGALTGGMAYEALNNAS
SLKTNFIIVLNDNTMSIAKNVGGVPHMLSNIRSSDSYYDLKENVTNTLYKLPGGDHIVERIKKTKSNLKQIILPGQMFEC
MGISYLGPVNGHDIEKLIKVFHVAKRINGAVIIHVVTHKGHGYKPAERNPAKFHGIGPFDIVTGKELKSSDKPTYSDVFS
EKICQLAKKDKSIVAVTAAMPDGTGLNKFSKWFPDRFFDVGIAEEHAVTFSAGMAAGGLKPVFAVYSSFLQRAYDQILHD
VCIQHLHVVFAIDRAGLVGSDGETHQGIFDLSFLTSIPNMTVMAPKNGSELSAMLEFALLNFNSPVAIRYPRGQAYDGLE
EHNAPIRYGKAEMIIEESDIAFVAAGNMLITAQAVREKLKEKGYNITIVNERFIKPVDTDMLDRLSESHRLIVTMEENVL
SGGFGEAVCQYYDDTCNDIDVLNIALPDDYVEHGNVDILRRESGVDRDSIIAKVLNRWANVLNKDKRNE

Sequences:

>Translated_629_residues
MILEKINKPNDIKQLSPIEYNQLADEIRGFLIEKISKTGGHLASNLGVVELTMALHLAFNLPQDKLIWDVGHQSYTHKIL
TGRKNQFDQLRKFGGMSGFPKRNESHFDAFDTGHSSTSISAGLGLVKARDLKNEHYNVVSVIGDGALTGGMAYEALNNAS
SLKTNFIIVLNDNTMSIAKNVGGVPHMLSNIRSSDSYYDLKENVTNTLYKLPGGDHIVERIKKTKSNLKQIILPGQMFEC
MGISYLGPVNGHDIEKLIKVFHVAKRINGAVIIHVVTHKGHGYKPAERNPAKFHGIGPFDIVTGKELKSSDKPTYSDVFS
EKICQLAKKDKSIVAVTAAMPDGTGLNKFSKWFPDRFFDVGIAEEHAVTFSAGMAAGGLKPVFAVYSSFLQRAYDQILHD
VCIQHLHVVFAIDRAGLVGSDGETHQGIFDLSFLTSIPNMTVMAPKNGSELSAMLEFALLNFNSPVAIRYPRGQAYDGLE
EHNAPIRYGKAEMIIEESDIAFVAAGNMLITAQAVREKLKEKGYNITIVNERFIKPVDTDMLDRLSESHRLIVTMEENVL
SGGFGEAVCQYYDDTCNDIDVLNIALPDDYVEHGNVDILRRESGVDRDSIIAKVLNRWANVLNKDKRNE
>Mature_629_residues
MILEKINKPNDIKQLSPIEYNQLADEIRGFLIEKISKTGGHLASNLGVVELTMALHLAFNLPQDKLIWDVGHQSYTHKIL
TGRKNQFDQLRKFGGMSGFPKRNESHFDAFDTGHSSTSISAGLGLVKARDLKNEHYNVVSVIGDGALTGGMAYEALNNAS
SLKTNFIIVLNDNTMSIAKNVGGVPHMLSNIRSSDSYYDLKENVTNTLYKLPGGDHIVERIKKTKSNLKQIILPGQMFEC
MGISYLGPVNGHDIEKLIKVFHVAKRINGAVIIHVVTHKGHGYKPAERNPAKFHGIGPFDIVTGKELKSSDKPTYSDVFS
EKICQLAKKDKSIVAVTAAMPDGTGLNKFSKWFPDRFFDVGIAEEHAVTFSAGMAAGGLKPVFAVYSSFLQRAYDQILHD
VCIQHLHVVFAIDRAGLVGSDGETHQGIFDLSFLTSIPNMTVMAPKNGSELSAMLEFALLNFNSPVAIRYPRGQAYDGLE
EHNAPIRYGKAEMIIEESDIAFVAAGNMLITAQAVREKLKEKGYNITIVNERFIKPVDTDMLDRLSESHRLIVTMEENVL
SGGFGEAVCQYYDDTCNDIDVLNIALPDDYVEHGNVDILRRESGVDRDSIIAKVLNRWANVLNKDKRNE

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=535, Percent_Identity=24.4859813084112, Blast_Score=103, Evalue=7e-22,
Organism=Homo sapiens, GI4507521, Length=535, Percent_Identity=24.4859813084112, Blast_Score=103, Evalue=7e-22,
Organism=Homo sapiens, GI225637461, Length=369, Percent_Identity=23.3062330623306, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI225637459, Length=369, Percent_Identity=23.3062330623306, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI225637463, Length=369, Percent_Identity=23.3062330623306, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI133778974, Length=477, Percent_Identity=21.3836477987421, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1786622, Length=616, Percent_Identity=43.5064935064935, Blast_Score=533, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17539652, Length=417, Percent_Identity=24.9400479616307, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24666278, Length=261, Percent_Identity=26.0536398467433, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45551847, Length=580, Percent_Identity=21.8965517241379, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45550715, Length=580, Percent_Identity=21.8965517241379, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24645119, Length=369, Percent_Identity=23.0352303523035, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69626; Mature: 69626

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILEKINKPNDIKQLSPIEYNQLADEIRGFLIEKISKTGGHLASNLGVVELTMALHLAFN
CCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHC
LPQDKLIWDVGHQSYTHKILTGRKNQFDQLRKFGGMSGFPKRNESHFDAFDTGHSSTSIS
CCCHHEEEECCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHH
AGLGLVKARDLKNEHYNVVSVIGDGALTGGMAYEALNNASSLKTNFIIVLNDNTMSIAKN
HCCCHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCEEEEEEECCCHHHHHHH
VGGVPHMLSNIRSSDSYYDLKENVTNTLYKLPGGDHIVERIKKTKSNLKQIILPGQMFEC
CCCHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHEECCCHHHHH
MGISYLGPVNGHDIEKLIKVFHVAKRINGAVIIHVVTHKGHGYKPAERNPAKFHGIGPFD
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCEECCCCEE
IVTGKELKSSDKPTYSDVFSEKICQLAKKDKSIVAVTAAMPDGTGLNKFSKWFPDRFFDV
EECCCHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCHHHHCC
GIAEEHAVTFSAGMAAGGLKPVFAVYSSFLQRAYDQILHDVCIQHLHVVFAIDRAGLVGS
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCC
DGETHQGIFDLSFLTSIPNMTVMAPKNGSELSAMLEFALLNFNSPVAIRYPRGQAYDGLE
CCCCCCCEEEHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHH
EHNAPIRYGKAEMIIEESDIAFVAAGNMLITAQAVREKLKEKGYNITIVNERFIKPVDTD
HCCCCCEECCEEEEEEECCEEEEEECCEEEEHHHHHHHHHHCCCEEEEECCCCCCCCCHH
MLDRLSESHRLIVTMEENVLSGGFGEAVCQYYDDTCNDIDVLNIALPDDYVEHGNVDILR
HHHHHCCCCEEEEEEECCHHCCCHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCEEEEE
RESGVDRDSIIAKVLNRWANVLNKDKRNE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MILEKINKPNDIKQLSPIEYNQLADEIRGFLIEKISKTGGHLASNLGVVELTMALHLAFN
CCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHC
LPQDKLIWDVGHQSYTHKILTGRKNQFDQLRKFGGMSGFPKRNESHFDAFDTGHSSTSIS
CCCHHEEEECCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHH
AGLGLVKARDLKNEHYNVVSVIGDGALTGGMAYEALNNASSLKTNFIIVLNDNTMSIAKN
HCCCHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCEEEEEEECCCHHHHHHH
VGGVPHMLSNIRSSDSYYDLKENVTNTLYKLPGGDHIVERIKKTKSNLKQIILPGQMFEC
CCCHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHEECCCHHHHH
MGISYLGPVNGHDIEKLIKVFHVAKRINGAVIIHVVTHKGHGYKPAERNPAKFHGIGPFD
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCEECCCCEE
IVTGKELKSSDKPTYSDVFSEKICQLAKKDKSIVAVTAAMPDGTGLNKFSKWFPDRFFDV
EECCCHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCHHHHCC
GIAEEHAVTFSAGMAAGGLKPVFAVYSSFLQRAYDQILHDVCIQHLHVVFAIDRAGLVGS
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCC
DGETHQGIFDLSFLTSIPNMTVMAPKNGSELSAMLEFALLNFNSPVAIRYPRGQAYDGLE
CCCCCCCEEEHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHH
EHNAPIRYGKAEMIIEESDIAFVAAGNMLITAQAVREKLKEKGYNITIVNERFIKPVDTD
HCCCCCEECCEEEEEEECCEEEEEECCEEEEHHHHHHHHHHCCCEEEEECCCCCCCCCHH
MLDRLSESHRLIVTMEENVLSGGFGEAVCQYYDDTCNDIDVLNIALPDDYVEHGNVDILR
HHHHHCCCCEEEEEEECCHHCCCHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCCEEEEE
RESGVDRDSIIAKVLNRWANVLNKDKRNE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA