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The map label for this gene is ilvA [H]

Identifier: 238916987

GI number: 238916987

Start: 1065595

End: 1066812

Strand: Reverse

Name: ilvA [H]

Synonym: EUBELI_01056

Alternate gene names: 238916987

Gene position: 1066812-1065595 (Counterclockwise)

Preceding gene: 238916988

Following gene: 238916986

Centisome position: 49.75

GC content: 38.75

Gene sequence:

>1218_bases
ATGGAAGAATTAACATTGAAAAGTTTCGAGGAAGCTGCCGAGAAGGTTAAGGAAGCAACACTTCCTACTAATCTGGTATA
TAGTGAGTATTTCAGCAGCCAGACTGGTAACAGAGTATACCTTAAGCCAGAGAATATGCAGTACACAGGTGCTTATAAGG
TAAGAGGTGCATATTACAAGATTAGTACGATGTCAGAGGAAGCAAGACAGAAGGGACTTATTACAGCTTCTGCCGGAAAT
CATGCACAGGGTGTTGCATTTGCAGCTAAGAAATATGGGGTTAAGGCAACAGTAGTTATGCCTACAACAACACCACTTAT
CAAGGTAAACAGAACTAAGGGATACGGTGCAGAGGTTATTCTTTACGGTAATGTTTATGATGAAGCATGTGAATATGCAA
TGAAGCTTGCCAAGGAGAAAGGACTTACATTTGTTCACCCATTTGATGATTTAGATGTTGCAACAGGTCAGGGTTCTATC
GCAATGGAGATTATTAAAGAGCTTCCAACTGTTGATTATATTCTTGTTCCTATTGGTGGTGGCGGACTTGCAACAGGTGT
ATCTACACTTGCAAAACTCCTTAATCCTAATATCAAGGTTATTGGTGTTGAGCCTTCCGGTGCTAACTGTCTTCAGGAAT
CTCTTAAGGCTGGAAAGGTTGTAACTCTTCCTACTGTAAGTACAATTGCAGACGGTACAGCTGTTAAGACTCCAGGAAGC
AAGTTATTCCCATATCTTCAGAAGAATCTTGATGATATTATTACAGTTCCTGATGAAGATTTAATAGTTGCATTCCTTGA
TATGGTAGAGAATCATAAGATGATTGTTGAGAATTCAGGTCTTCTTACAGTTGCAGCATTAAAGCAGCTTGATGTTAAGG
ATAAGAAGATTGTTTCAATTCTTTCTGGTGGTAATATGGATGTTATTACAATGTCATCTGTTGTTCAGCAGGGACTTGTA
CAGAGAAGCAGAATCTTCACTGTTTCTGTACTTCTTCCAGATAAGCCGGGTGAACTTGTAAGAGTTGCTTCTATTATTGC
AGAAGCTAACGGTAATGTAATCAAGCTTGAACATAACCAGTTCGTAAGCATTAACAGAAAAGCAACTGTTGAGCTTAGAA
TTACAATTGAAGCTTTCGGACATGAACACAAGGATGAGATTGTTGACAAGCTTGAAGCAGCAGGTTTAAGACCTAGAATT
GTTAAAGTAAACATTTAA

Upstream 100 bases:

>100_bases
AAGTTTGATTCAGACACATTTGTTAATGCATTATTCGATGTAGATAACGGCTCTGATGAAGATAGATAAGTTAATAAATT
AAGATGGGAGATTAAGTGTA

Downstream 100 bases:

>100_bases
TCACTATCTTCAGCAGAGGGAAATCTATGAAGAAATATTCTTTCAAAAGATATGCAGGAGTTACAATGGCATTATTTGGG
GCAGCTGCGCTGTCCCTATT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MEELTLKSFEEAAEKVKEATLPTNLVYSEYFSSQTGNRVYLKPENMQYTGAYKVRGAYYKISTMSEEARQKGLITASAGN
HAQGVAFAAKKYGVKATVVMPTTTPLIKVNRTKGYGAEVILYGNVYDEACEYAMKLAKEKGLTFVHPFDDLDVATGQGSI
AMEIIKELPTVDYILVPIGGGGLATGVSTLAKLLNPNIKVIGVEPSGANCLQESLKAGKVVTLPTVSTIADGTAVKTPGS
KLFPYLQKNLDDIITVPDEDLIVAFLDMVENHKMIVENSGLLTVAALKQLDVKDKKIVSILSGGNMDVITMSSVVQQGLV
QRSRIFTVSVLLPDKPGELVRVASIIAEANGNVIKLEHNQFVSINRKATVELRITIEAFGHEHKDEIVDKLEAAGLRPRI
VKVNI

Sequences:

>Translated_405_residues
MEELTLKSFEEAAEKVKEATLPTNLVYSEYFSSQTGNRVYLKPENMQYTGAYKVRGAYYKISTMSEEARQKGLITASAGN
HAQGVAFAAKKYGVKATVVMPTTTPLIKVNRTKGYGAEVILYGNVYDEACEYAMKLAKEKGLTFVHPFDDLDVATGQGSI
AMEIIKELPTVDYILVPIGGGGLATGVSTLAKLLNPNIKVIGVEPSGANCLQESLKAGKVVTLPTVSTIADGTAVKTPGS
KLFPYLQKNLDDIITVPDEDLIVAFLDMVENHKMIVENSGLLTVAALKQLDVKDKKIVSILSGGNMDVITMSSVVQQGLV
QRSRIFTVSVLLPDKPGELVRVASIIAEANGNVIKLEHNQFVSINRKATVELRITIEAFGHEHKDEIVDKLEAAGLRPRI
VKVNI
>Mature_405_residues
MEELTLKSFEEAAEKVKEATLPTNLVYSEYFSSQTGNRVYLKPENMQYTGAYKVRGAYYKISTMSEEARQKGLITASAGN
HAQGVAFAAKKYGVKATVVMPTTTPLIKVNRTKGYGAEVILYGNVYDEACEYAMKLAKEKGLTFVHPFDDLDVATGQGSI
AMEIIKELPTVDYILVPIGGGGLATGVSTLAKLLNPNIKVIGVEPSGANCLQESLKAGKVVTLPTVSTIADGTAVKTPGS
KLFPYLQKNLDDIITVPDEDLIVAFLDMVENHKMIVENSGLLTVAALKQLDVKDKKIVSILSGGNMDVITMSSVVQQGLV
QRSRIFTVSVLLPDKPGELVRVASIIAEANGNVIKLEHNQFVSINRKATVELRITIEAFGHEHKDEIVDKLEAAGLRPRI
VKVNI

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=325, Percent_Identity=32.6153846153846, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI19923959, Length=299, Percent_Identity=33.1103678929766, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI33469958, Length=276, Percent_Identity=30.0724637681159, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1790207, Length=384, Percent_Identity=37.2395833333333, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1789505, Length=308, Percent_Identity=35.0649350649351, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1789235, Length=198, Percent_Identity=27.7777777777778, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=389, Percent_Identity=34.4473007712082, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17537387, Length=384, Percent_Identity=35.4166666666667, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17508781, Length=310, Percent_Identity=29.3548387096774, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320930, Length=327, Percent_Identity=39.7553516819572, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322631, Length=307, Percent_Identity=38.4364820846906, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319788, Length=269, Percent_Identity=27.1375464684015, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322024, Length=146, Percent_Identity=31.5068493150685, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355833, Length=360, Percent_Identity=32.5, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24645328, Length=296, Percent_Identity=30.0675675675676, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43885; Mature: 43885

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELTLKSFEEAAEKVKEATLPTNLVYSEYFSSQTGNRVYLKPENMQYTGAYKVRGAYYK
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCEEEECEEEEEEEEEE
ISTMSEEARQKGLITASAGNHAQGVAFAAKKYGVKATVVMPTTTPLIKVNRTKGYGAEVI
EECCHHHHHHCCCEEECCCCCCCCCEEHHHHCCCEEEEEECCCCCEEEEECCCCCCEEEE
LYGNVYDEACEYAMKLAKEKGLTFVHPFDDLDVATGQGSIAMEIIKELPTVDYILVPIGG
EECCCHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCCHHHHHHHHHCCCCCEEEEEECC
GGLATGVSTLAKLLNPNIKVIGVEPSGANCLQESLKAGKVVTLPTVSTIADGTAVKTPGS
CHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCEEEECCHHHHCCCCEEECCCH
KLFPYLQKNLDDIITVPDEDLIVAFLDMVENHKMIVENSGLLTVAALKQLDVKDKKIVSI
HHHHHHHCCCCCEEECCCCHHHHHHHHHHCCCEEEEECCCEEEEEEHHHCCCCCHHEEEE
LSGGNMDVITMSSVVQQGLVQRSRIFTVSVLLPDKPGELVRVASIIAEANGNVIKLEHNQ
ECCCCEEEEEHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCC
FVSINRKATVELRITIEAFGHEHKDEIVDKLEAAGLRPRIVKVNI
EEEECCEEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MEELTLKSFEEAAEKVKEATLPTNLVYSEYFSSQTGNRVYLKPENMQYTGAYKVRGAYYK
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEECCCCEEEECEEEEEEEEEE
ISTMSEEARQKGLITASAGNHAQGVAFAAKKYGVKATVVMPTTTPLIKVNRTKGYGAEVI
EECCHHHHHHCCCEEECCCCCCCCCEEHHHHCCCEEEEEECCCCCEEEEECCCCCCEEEE
LYGNVYDEACEYAMKLAKEKGLTFVHPFDDLDVATGQGSIAMEIIKELPTVDYILVPIGG
EECCCHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCCHHHHHHHHHCCCCCEEEEEECC
GGLATGVSTLAKLLNPNIKVIGVEPSGANCLQESLKAGKVVTLPTVSTIADGTAVKTPGS
CHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCEEEECCHHHHCCCCEEECCCH
KLFPYLQKNLDDIITVPDEDLIVAFLDMVENHKMIVENSGLLTVAALKQLDVKDKKIVSI
HHHHHHHCCCCCEEECCCCHHHHHHHHHHCCCEEEEECCCEEEEEEHHHCCCCCHHEEEE
LSGGNMDVITMSSVVQQGLVQRSRIFTVSVLLPDKPGELVRVASIIAEANGNVIKLEHNQ
ECCCCEEEEEHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCC
FVSINRKATVELRITIEAFGHEHKDEIVDKLEAAGLRPRIVKVNI
EEEECCEEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]