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The map label for this gene is mrdA [H]

Identifier: 238916930

GI number: 238916930

Start: 1016722

End: 1019475

Strand: Direct

Name: mrdA [H]

Synonym: EUBELI_00999

Alternate gene names: 238916930

Gene position: 1016722-1019475 (Clockwise)

Preceding gene: 238916929

Following gene: 238916931

Centisome position: 47.42

GC content: 34.42

Gene sequence:

>2754_bases
ATGAAGGAAGTATTTGAGTATATTGTTAGTCTCCTGAAATCAAGGATTTTTCCTATGATTCTTGTGTTTATTATTATGAT
TTCCATTCTTGTACACAGATTATTTGTTCTTCAGATAGTAAATGGAGACTCATATGTAGAGGATTTATCCAGTTCTATTA
AAAAGGATATGAGCGTTGTGGCTGCGAGAGGCCGTATTTATGACAGAAATGGTGTGCTTCTTGCCTATAATGACTTATCT
TATGCCGTTAAAATAAGTGATTCAGGCAGATATTCAGATAATGCTGTAAAAAATAAAACTATTAATAATTCAATAGATAA
AACATTAACTATTATTGAAACGAATGGAGATACTTATTCTAATGATCTTCCAATTATCTATAATAATGGACAGTTTTCGT
ATAATGTTGAAGGAACCTCGCTTTTAAGGTTTTTAAGAGATTCTTATGGAACTGAGTCGATTGCAGCTTTAAGTGATGAA
CAGAAAGCTACATCTGCAGAGAATATGTTTAAATATCTCTGTGAAGTATACAGCATCAATTATGAAGAGTTTGGAATTGA
ACACTCTTTGATGATGGTTAATCTTAGAAGATATATGGCTGCCAATTCGTATAACAGATATCTTACATTTATTATTGCAA
ATGAAGTATCTGACAAGACAGTTGCAGCTATATTAGAAAACAGTGATGAGCTTGTAGGTGTTACGGTAGAAGAACAGTAT
ATCAGAAGATATGTCGACAGTGTCTATTGCTCACAGATTCTAGGATATACCGGTACTGTTTCTAATGCAGAACTTGAAGA
ACTTGGAGATGGATATGAAAGCAATGATATTGTAGGCAAGTCCGGTATTGAAAAGAGTATGGAAAGTGAGTTGTCAGGTT
CTAAGGGAGAAAAATCAGTATATGTTGATACTGTTGGAAGAATTACAGAAGTGCTTGATGAGGAAGATCCACAGGCAGGA
CATGATGTATATCTTACAATTGATATTAATCTTCAGAAATCTATTTATCATGCAATTGAAGACGAAATAACCAGTATTTT
TATGCAGTATTTTACGCCGGGAAATAATAAGATAACATATAATGGTTCAGGTGATGTTGATACTATATATATAACAGCTC
AGGAAGTATATTTTGCGCTTATTGATAATAACCTGGTTTCTTTAAAGCAGATACAGGAGCAGAATACAGCTAATGAAGCT
GAGATATACAGTCAGTTTGAGACTAAGAAATCAGAGACTCTTTCATGGTTGAAGGATGAGCTTACTTCTGGTGATACTGC
ATATGGAAAGTTATCAGAAGAGCAGAAACTGTATATATGGTATATCTATGATCTTTTAAGAAGTGAGAATATATTCAGTC
TTGCAAATGTTGATACAAGTGACAGTGTTTATTATGACTGGATATATGGAGATTCGACAAGTCTTTCACAGCTTCTTACT
TATGGTATATCTAAGAACTGGATTAATATGTCATCACTTACATCTGAGAAATATACGAGTCTTCAGGAGTCATATGATGC
GCTTGTTGATTATGTTATATCAGCGCTTGATTCAGATACTGCATTTTTTAAGAAGATGTATAAGTACATGATTAATGCAG
GCAGCATATCGGGCAGACAGGTGTGTATGTTATTATATGAGCAGGGTGTTCTTGATATTAATGCTGATGATTCAAAATAT
CAGGCTCTGGTATCTGGAAGCATGGGAGCATATGAATTTATGTCATATATTGTTTCTAATAAAATTATAACTGTTGGACA
GCTTGCTCTTAAGCCTTGTTCTGGTTCTGCTGTTGTAACTAATCCAAACAATGGTGATATTCTGGCACTTGTATCTTATC
CTAGTTATGATAATAATAAATTGTCAGGAACGGTTGATGCCAAATATTACAATTCTCTTGTAAGTGATAATGCGAGTCCG
CTTCTTAACCGGGCAACACAGTCATTTATAGCACCAGGTTCTACTTATAAACCTTGCACAATTATTGCTGGTATTGACAC
CGGCATAATATCATCATCTACTACATTTAATTGCTCTGGTGTGTTTGATAAGGTAACTCCTTCACCTAGATGCTGGCAGA
AATGGGGACATGGAAGTGAAACCCCTGTTACTGCAATCAGGGATTCATGTAATGTTTATATGTATAATGTTGGATATAAT
CTTGCATGCAGCAAAAATGGTTCGTATAATAGTACTTACGGAACTAATGTATTAAAAAAATATTCTGATATGCTTGGTCT
TTCTACAAAGTCAGGAATAGAGATAGAAGAAGGAACTCCTGGAGCTTCTTCGCAGAATGCAATTGCATCTGCAATCGGAC
AGGGTAACCACAGATACAGTACACTTAATCTTGCAAGATATGTTACAACTCTGGCAACATCAGGAACATGTTATAATCTT
ACACTTATTGATAAAATAACTGATTATGATGGTAATGTTTTAAGGGATAACAGTGCTGAGGTTAATAATAAAGTTGAGTT
AAGTTCTGATATCTGGAATACAGTTCATACAGGTATGAATCTTGCTGCAGGAACTTATTCAGCATTTTCATCATTGAAAA
TGTCAATTGCTGCAAAGACAGGTACTGCACAGGAAAAAACTACTGATCCTGACCATGCAACACTAATTACCTATGCGCCA
TATGAAAATCCTGAATATTGTATGGCAGTGCGTATCCAGAATGGTTATGCTTCAGGAAATGCTGTAACACTTGGTGCAGA
TATTTATAAAATGCTTTTTAATATTAGTGATTAA

Upstream 100 bases:

>100_bases
GTATATACAGCACTTGTTTCGTTATTGGTGTATCATCCGATACATTATTTGTGTGTTATAACGCAGCAGGGAAGAGAAAG
AAAAAAGAAGGGTAAGATTG

Downstream 100 bases:

>100_bases
TATGTACTAAAGAAATGATAATATGATATGAGAGGTGAATGTTTTGGATAATTCAGTAATAATCAAAGGAAGTAAGAATG
GAATTACAGTATTTCTTGAT

Product: penicillin binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 917; Mature: 917

Protein sequence:

>917_residues
MKEVFEYIVSLLKSRIFPMILVFIIMISILVHRLFVLQIVNGDSYVEDLSSSIKKDMSVVAARGRIYDRNGVLLAYNDLS
YAVKISDSGRYSDNAVKNKTINNSIDKTLTIIETNGDTYSNDLPIIYNNGQFSYNVEGTSLLRFLRDSYGTESIAALSDE
QKATSAENMFKYLCEVYSINYEEFGIEHSLMMVNLRRYMAANSYNRYLTFIIANEVSDKTVAAILENSDELVGVTVEEQY
IRRYVDSVYCSQILGYTGTVSNAELEELGDGYESNDIVGKSGIEKSMESELSGSKGEKSVYVDTVGRITEVLDEEDPQAG
HDVYLTIDINLQKSIYHAIEDEITSIFMQYFTPGNNKITYNGSGDVDTIYITAQEVYFALIDNNLVSLKQIQEQNTANEA
EIYSQFETKKSETLSWLKDELTSGDTAYGKLSEEQKLYIWYIYDLLRSENIFSLANVDTSDSVYYDWIYGDSTSLSQLLT
YGISKNWINMSSLTSEKYTSLQESYDALVDYVISALDSDTAFFKKMYKYMINAGSISGRQVCMLLYEQGVLDINADDSKY
QALVSGSMGAYEFMSYIVSNKIITVGQLALKPCSGSAVVTNPNNGDILALVSYPSYDNNKLSGTVDAKYYNSLVSDNASP
LLNRATQSFIAPGSTYKPCTIIAGIDTGIISSSTTFNCSGVFDKVTPSPRCWQKWGHGSETPVTAIRDSCNVYMYNVGYN
LACSKNGSYNSTYGTNVLKKYSDMLGLSTKSGIEIEEGTPGASSQNAIASAIGQGNHRYSTLNLARYVTTLATSGTCYNL
TLIDKITDYDGNVLRDNSAEVNNKVELSSDIWNTVHTGMNLAAGTYSAFSSLKMSIAAKTGTAQEKTTDPDHATLITYAP
YENPEYCMAVRIQNGYASGNAVTLGADIYKMLFNISD

Sequences:

>Translated_917_residues
MKEVFEYIVSLLKSRIFPMILVFIIMISILVHRLFVLQIVNGDSYVEDLSSSIKKDMSVVAARGRIYDRNGVLLAYNDLS
YAVKISDSGRYSDNAVKNKTINNSIDKTLTIIETNGDTYSNDLPIIYNNGQFSYNVEGTSLLRFLRDSYGTESIAALSDE
QKATSAENMFKYLCEVYSINYEEFGIEHSLMMVNLRRYMAANSYNRYLTFIIANEVSDKTVAAILENSDELVGVTVEEQY
IRRYVDSVYCSQILGYTGTVSNAELEELGDGYESNDIVGKSGIEKSMESELSGSKGEKSVYVDTVGRITEVLDEEDPQAG
HDVYLTIDINLQKSIYHAIEDEITSIFMQYFTPGNNKITYNGSGDVDTIYITAQEVYFALIDNNLVSLKQIQEQNTANEA
EIYSQFETKKSETLSWLKDELTSGDTAYGKLSEEQKLYIWYIYDLLRSENIFSLANVDTSDSVYYDWIYGDSTSLSQLLT
YGISKNWINMSSLTSEKYTSLQESYDALVDYVISALDSDTAFFKKMYKYMINAGSISGRQVCMLLYEQGVLDINADDSKY
QALVSGSMGAYEFMSYIVSNKIITVGQLALKPCSGSAVVTNPNNGDILALVSYPSYDNNKLSGTVDAKYYNSLVSDNASP
LLNRATQSFIAPGSTYKPCTIIAGIDTGIISSSTTFNCSGVFDKVTPSPRCWQKWGHGSETPVTAIRDSCNVYMYNVGYN
LACSKNGSYNSTYGTNVLKKYSDMLGLSTKSGIEIEEGTPGASSQNAIASAIGQGNHRYSTLNLARYVTTLATSGTCYNL
TLIDKITDYDGNVLRDNSAEVNNKVELSSDIWNTVHTGMNLAAGTYSAFSSLKMSIAAKTGTAQEKTTDPDHATLITYAP
YENPEYCMAVRIQNGYASGNAVTLGADIYKMLFNISD
>Mature_917_residues
MKEVFEYIVSLLKSRIFPMILVFIIMISILVHRLFVLQIVNGDSYVEDLSSSIKKDMSVVAARGRIYDRNGVLLAYNDLS
YAVKISDSGRYSDNAVKNKTINNSIDKTLTIIETNGDTYSNDLPIIYNNGQFSYNVEGTSLLRFLRDSYGTESIAALSDE
QKATSAENMFKYLCEVYSINYEEFGIEHSLMMVNLRRYMAANSYNRYLTFIIANEVSDKTVAAILENSDELVGVTVEEQY
IRRYVDSVYCSQILGYTGTVSNAELEELGDGYESNDIVGKSGIEKSMESELSGSKGEKSVYVDTVGRITEVLDEEDPQAG
HDVYLTIDINLQKSIYHAIEDEITSIFMQYFTPGNNKITYNGSGDVDTIYITAQEVYFALIDNNLVSLKQIQEQNTANEA
EIYSQFETKKSETLSWLKDELTSGDTAYGKLSEEQKLYIWYIYDLLRSENIFSLANVDTSDSVYYDWIYGDSTSLSQLLT
YGISKNWINMSSLTSEKYTSLQESYDALVDYVISALDSDTAFFKKMYKYMINAGSISGRQVCMLLYEQGVLDINADDSKY
QALVSGSMGAYEFMSYIVSNKIITVGQLALKPCSGSAVVTNPNNGDILALVSYPSYDNNKLSGTVDAKYYNSLVSDNASP
LLNRATQSFIAPGSTYKPCTIIAGIDTGIISSSTTFNCSGVFDKVTPSPRCWQKWGHGSETPVTAIRDSCNVYMYNVGYN
LACSKNGSYNSTYGTNVLKKYSDMLGLSTKSGIEIEEGTPGASSQNAIASAIGQGNHRYSTLNLARYVTTLATSGTCYNL
TLIDKITDYDGNVLRDNSAEVNNKVELSSDIWNTVHTGMNLAAGTYSAFSSLKMSIAAKTGTAQEKTTDPDHATLITYAP
YENPEYCMAVRIQNGYASGNAVTLGADIYKMLFNISD

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=348, Percent_Identity=27.2988505747126, Blast_Score=124, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 101599; Mature: 101599

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVFEYIVSLLKSRIFPMILVFIIMISILVHRLFVLQIVNGDSYVEDLSSSIKKDMSVV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHH
AARGRIYDRNGVLLAYNDLSYAVKISDSGRYSDNAVKNKTINNSIDKTLTIIETNGDTYS
HHCCEEEECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
NDLPIIYNNGQFSYNVEGTSLLRFLRDSYGTESIAALSDEQKATSAENMFKYLCEVYSIN
CCCCEEECCCEEEEECCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCC
YEEFGIEHSLMMVNLRRYMAANSYNRYLTFIIANEVSDKTVAAILENSDELVGVTVEEQY
HHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCCEEEEEEHHHH
IRRYVDSVYCSQILGYTGTVSNAELEELGDGYESNDIVGKSGIEKSMESELSGSKGEKSV
HHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEE
YVDTVGRITEVLDEEDPQAGHDVYLTIDINLQKSIYHAIEDEITSIFMQYFTPGNNKITY
EEHHHHHHHHHHCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
NGSGDVDTIYITAQEVYFALIDNNLVSLKQIQEQNTANEAEIYSQFETKKSETLSWLKDE
CCCCCEEEEEEEHHHEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LTSGDTAYGKLSEEQKLYIWYIYDLLRSENIFSLANVDTSDSVYYDWIYGDSTSLSQLLT
HCCCCCCCCCCCCCCEEEEEEEEHHHCCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHH
YGISKNWINMSSLTSEKYTSLQESYDALVDYVISALDSDTAFFKKMYKYMINAGSISGRQ
HCCCCCCEEHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHH
VCMLLYEQGVLDINADDSKYQALVSGSMGAYEFMSYIVSNKIITVGQLALKPCSGSAVVT
HHHEEHHCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHCCCEEEEHEEECCCCCCEEEE
NPNNGDILALVSYPSYDNNKLSGTVDAKYYNSLVSDNASPLLNRATQSFIAPGSTYKPCT
CCCCCCEEEEEECCCCCCCCCCEEECHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEE
IIAGIDTGIISSSTTFNCSGVFDKVTPSPRCWQKWGHGSETPVTAIRDSCNVYMYNVGYN
EEEECCCCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCCCHHHCCCCCCEEEEECCEE
LACSKNGSYNSTYGTNVLKKYSDMLGLSTKSGIEIEEGTPGASSQNAIASAIGQGNHRYS
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCEEE
TLNLARYVTTLATSGTCYNLTLIDKITDYDGNVLRDNSAEVNNKVELSSDIWNTVHTGMN
HHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCEEECCCCCCCCEEEECHHHHHHHHCCCC
LAAGTYSAFSSLKMSIAAKTGTAQEKTTDPDHATLITYAPYENPEYCMAVRIQNGYASGN
CCCCHHHHHHHHEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCC
AVTLGADIYKMLFNISD
EEEECHHHHHHHHCCCC
>Mature Secondary Structure
MKEVFEYIVSLLKSRIFPMILVFIIMISILVHRLFVLQIVNGDSYVEDLSSSIKKDMSVV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHH
AARGRIYDRNGVLLAYNDLSYAVKISDSGRYSDNAVKNKTINNSIDKTLTIIETNGDTYS
HHCCEEEECCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
NDLPIIYNNGQFSYNVEGTSLLRFLRDSYGTESIAALSDEQKATSAENMFKYLCEVYSIN
CCCCEEECCCEEEEECCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCC
YEEFGIEHSLMMVNLRRYMAANSYNRYLTFIIANEVSDKTVAAILENSDELVGVTVEEQY
HHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCCEEEEEEHHHH
IRRYVDSVYCSQILGYTGTVSNAELEELGDGYESNDIVGKSGIEKSMESELSGSKGEKSV
HHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEE
YVDTVGRITEVLDEEDPQAGHDVYLTIDINLQKSIYHAIEDEITSIFMQYFTPGNNKITY
EEHHHHHHHHHHCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
NGSGDVDTIYITAQEVYFALIDNNLVSLKQIQEQNTANEAEIYSQFETKKSETLSWLKDE
CCCCCEEEEEEEHHHEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LTSGDTAYGKLSEEQKLYIWYIYDLLRSENIFSLANVDTSDSVYYDWIYGDSTSLSQLLT
HCCCCCCCCCCCCCCEEEEEEEEHHHCCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHH
YGISKNWINMSSLTSEKYTSLQESYDALVDYVISALDSDTAFFKKMYKYMINAGSISGRQ
HCCCCCCEEHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHH
VCMLLYEQGVLDINADDSKYQALVSGSMGAYEFMSYIVSNKIITVGQLALKPCSGSAVVT
HHHEEHHCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHCCCEEEEHEEECCCCCCEEEE
NPNNGDILALVSYPSYDNNKLSGTVDAKYYNSLVSDNASPLLNRATQSFIAPGSTYKPCT
CCCCCCEEEEEECCCCCCCCCCEEECHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEE
IIAGIDTGIISSSTTFNCSGVFDKVTPSPRCWQKWGHGSETPVTAIRDSCNVYMYNVGYN
EEEECCCCCCCCCCEEEECCCCCCCCCCCHHHHHCCCCCCCCHHHCCCCCCEEEEECCEE
LACSKNGSYNSTYGTNVLKKYSDMLGLSTKSGIEIEEGTPGASSQNAIASAIGQGNHRYS
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCEEE
TLNLARYVTTLATSGTCYNLTLIDKITDYDGNVLRDNSAEVNNKVELSSDIWNTVHTGMN
HHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCEEECCCCCCCCEEEECHHHHHHHHCCCC
LAAGTYSAFSSLKMSIAAKTGTAQEKTTDPDHATLITYAPYENPEYCMAVRIQNGYASGN
CCCCHHHHHHHHEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCC
AVTLGADIYKMLFNISD
EEEECHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]