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The map label for this gene is serA [H]

Identifier: 238916703

GI number: 238916703

Start: 776416

End: 777579

Strand: Direct

Name: serA [H]

Synonym: EUBELI_00765

Alternate gene names: 238916703

Gene position: 776416-777579 (Clockwise)

Preceding gene: 238916702

Following gene: 238916704

Centisome position: 36.21

GC content: 39.26

Gene sequence:

>1164_bases
ATGATTAATGTTAATTGTCTTAATAATATAGCAGCCTGCGGATTAAAGCTTTTTTCTGATGAGTATAATACAGAAAGCTC
ATTTGAAGACGCACAGGCTGTACTTGTAAGAAGTGCCAAGATGCATGATATGGAGCTTAGTGATAATCTTCTTGCAATTG
CAAGAGCAGGAGCTGGCGTTAATAATATTCCTCTTGACAAATGTGCAGAGGAAGGTATTGTTGTATTCAACACACCAGGA
GCTAATGCTAACGCAGTTAAGGAACAGGTTATTGCAGCTATGCTTTTAGCATCAAGAGATTTAATCGGTGGTAACAAGTG
GGTTGCAGATAATGCAGAAGACCCTGATATTGCCAAGGCAACTGAGAAGGCTAAGAAAGCATTTGCAGGACAGGAAATCA
AGGGCAAGAAGCTTGGCGTCATCGGACTTGGAGCAATTGGACAGTTAGTTGCCAATGCAGCTATAGCACTTGGAATGGAA
GTATACGGATATGACCCATATGTTTCAGTTAAGGCTGCATGGAATCTTTCAAGTGAAGTTAAGTACATATCTGATGTTAA
GGATATCTATAAGGAATGTAACTATATTACAGTTCATGTTCCTGCACTTGACAGCACTAAGGGAATGATTAATAAGGAAG
CGTTTGACCTTATGCAGGATGGAACAGTAATTATCAACTGTGCAAGAGATGTACTTGTTGATGAAGCTGCTATCGGTGAG
GCACTTAAGTCTGGAAGAGTTAAGACTTATGTTTCAGATTTCCCTAACCCAACAACAGCTAAGATGGAAGGAGCAATTGT
TCTTCCTCATCTTGGAGCTTCAACAGCAGAAGCTGAAGATAACTGTGCTATTATGGCAGTTAATGAGCTTAGAAACTTTA
TCGAGAACGGTAATATTGTTAATTCAGTTAATTACCCTAACTGTGATTGCGGAGTATGTGCAACTAAAGGAAGAATTACT
GTATGCCACAAGAATGTTCCAGCGGTTATTAGTAAGATAACAACAGTTCTTGGTGCTGCAGGCATCAATATATCATCTAT
GGCTAACCAGTCAAGAGGTGATTATGCATATTCTCTCTTAGATATTGAAGCATCTGCACCAGAGGCAGTAGTTGAAGAGC
TTTCAGCAATTGAAGGTGTTATCAAGGTAAGAGTTATTAAGTAA

Upstream 100 bases:

>100_bases
CAGTTGGCGGTATGAGAGCATCTATCTACAATGCTATGCCAATCGAAGGTGTAGAGAAGCTTGTTGAATTCATGAAGAAG
TTCGAGAAGGAGAATGCATA

Downstream 100 bases:

>100_bases
TCATATGTAATGAGAATAATATCAAAGACCAGTCATTTGTTGTAACATTTGGCTGGTCTTTCTTGTATTAAGGTTGTCTG
AATGTTAAAATGTATCTAAT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MINVNCLNNIAACGLKLFSDEYNTESSFEDAQAVLVRSAKMHDMELSDNLLAIARAGAGVNNIPLDKCAEEGIVVFNTPG
ANANAVKEQVIAAMLLASRDLIGGNKWVADNAEDPDIAKATEKAKKAFAGQEIKGKKLGVIGLGAIGQLVANAAIALGME
VYGYDPYVSVKAAWNLSSEVKYISDVKDIYKECNYITVHVPALDSTKGMINKEAFDLMQDGTVIINCARDVLVDEAAIGE
ALKSGRVKTYVSDFPNPTTAKMEGAIVLPHLGASTAEAEDNCAIMAVNELRNFIENGNIVNSVNYPNCDCGVCATKGRIT
VCHKNVPAVISKITTVLGAAGINISSMANQSRGDYAYSLLDIEASAPEAVVEELSAIEGVIKVRVIK

Sequences:

>Translated_387_residues
MINVNCLNNIAACGLKLFSDEYNTESSFEDAQAVLVRSAKMHDMELSDNLLAIARAGAGVNNIPLDKCAEEGIVVFNTPG
ANANAVKEQVIAAMLLASRDLIGGNKWVADNAEDPDIAKATEKAKKAFAGQEIKGKKLGVIGLGAIGQLVANAAIALGME
VYGYDPYVSVKAAWNLSSEVKYISDVKDIYKECNYITVHVPALDSTKGMINKEAFDLMQDGTVIINCARDVLVDEAAIGE
ALKSGRVKTYVSDFPNPTTAKMEGAIVLPHLGASTAEAEDNCAIMAVNELRNFIENGNIVNSVNYPNCDCGVCATKGRIT
VCHKNVPAVISKITTVLGAAGINISSMANQSRGDYAYSLLDIEASAPEAVVEELSAIEGVIKVRVIK
>Mature_387_residues
MINVNCLNNIAACGLKLFSDEYNTESSFEDAQAVLVRSAKMHDMELSDNLLAIARAGAGVNNIPLDKCAEEGIVVFNTPG
ANANAVKEQVIAAMLLASRDLIGGNKWVADNAEDPDIAKATEKAKKAFAGQEIKGKKLGVIGLGAIGQLVANAAIALGME
VYGYDPYVSVKAAWNLSSEVKYISDVKDIYKECNYITVHVPALDSTKGMINKEAFDLMQDGTVIINCARDVLVDEAAIGE
ALKSGRVKTYVSDFPNPTTAKMEGAIVLPHLGASTAEAEDNCAIMAVNELRNFIENGNIVNSVNYPNCDCGVCATKGRIT
VCHKNVPAVISKITTVLGAAGINISSMANQSRGDYAYSLLDIEASAPEAVVEELSAIEGVIKVRVIK

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=288, Percent_Identity=30.2083333333333, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI61743967, Length=277, Percent_Identity=28.8808664259928, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI4557497, Length=277, Percent_Identity=28.8808664259928, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI145580578, Length=275, Percent_Identity=28, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4557499, Length=275, Percent_Identity=28, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI145580575, Length=275, Percent_Identity=28, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=24.2063492063492, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1789279, Length=386, Percent_Identity=30.3108808290155, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1787645, Length=201, Percent_Identity=30.3482587064677, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082289, Length=272, Percent_Identity=23.1617647058824, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=266, Percent_Identity=36.0902255639098, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25147481, Length=219, Percent_Identity=28.310502283105, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6322116, Length=427, Percent_Identity=26.463700234192, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6320925, Length=387, Percent_Identity=27.390180878553, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6324055, Length=276, Percent_Identity=26.0869565217391, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=217, Percent_Identity=27.6497695852535, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921140, Length=285, Percent_Identity=31.5789473684211, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646446, Length=275, Percent_Identity=28.3636363636364, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646448, Length=275, Percent_Identity=28.3636363636364, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646452, Length=275, Percent_Identity=28.3636363636364, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646450, Length=275, Percent_Identity=28.3636363636364, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI62472511, Length=275, Percent_Identity=28.3636363636364, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585516, Length=262, Percent_Identity=23.6641221374046, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45552429, Length=253, Percent_Identity=25.296442687747, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24585514, Length=253, Percent_Identity=25.296442687747, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28574282, Length=253, Percent_Identity=25.296442687747, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI45551003, Length=253, Percent_Identity=25.296442687747, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28574284, Length=253, Percent_Identity=25.296442687747, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28574286, Length=245, Percent_Identity=24.0816326530612, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571528, Length=238, Percent_Identity=26.4705882352941, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 41035; Mature: 41035

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVNCLNNIAACGLKLFSDEYNTESSFEDAQAVLVRSAKMHDMELSDNLLAIARAGAGV
CEECHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
NNIPLDKCAEEGIVVFNTPGANANAVKEQVIAAMLLASRDLIGGNKWVADNAEDPDIAKA
CCCCHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHH
TEKAKKAFAGQEIKGKKLGVIGLGAIGQLVANAAIALGMEVYGYDPYVSVKAAWNLSSEV
HHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEECCCCEEEEEEEECCCCHH
KYISDVKDIYKECNYITVHVPALDSTKGMINKEAFDLMQDGTVIINCARDVLVDEAAIGE
HHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHCCEEEEEEHHHHHHHHHHHHH
ALKSGRVKTYVSDFPNPTTAKMEGAIVLPHLGASTAEAEDNCAIMAVNELRNFIENGNIV
HHHCCCEEEEHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHCCCEE
NSVNYPNCDCGVCATKGRITVCHKNVPAVISKITTVLGAAGINISSMANQSRGDYAYSLL
ECCCCCCCCCCCEECCCEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEE
DIEASAPEAVVEELSAIEGVIKVRVIK
EECCCCHHHHHHHHHHHCCEEEEEEEC
>Mature Secondary Structure
MINVNCLNNIAACGLKLFSDEYNTESSFEDAQAVLVRSAKMHDMELSDNLLAIARAGAGV
CEECHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
NNIPLDKCAEEGIVVFNTPGANANAVKEQVIAAMLLASRDLIGGNKWVADNAEDPDIAKA
CCCCHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHH
TEKAKKAFAGQEIKGKKLGVIGLGAIGQLVANAAIALGMEVYGYDPYVSVKAAWNLSSEV
HHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEECCCCEEEEEEEECCCCHH
KYISDVKDIYKECNYITVHVPALDSTKGMINKEAFDLMQDGTVIINCARDVLVDEAAIGE
HHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHCCEEEEEEHHHHHHHHHHHHH
ALKSGRVKTYVSDFPNPTTAKMEGAIVLPHLGASTAEAEDNCAIMAVNELRNFIENGNIV
HHHCCCEEEEHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHCCCEE
NSVNYPNCDCGVCATKGRITVCHKNVPAVISKITTVLGAAGINISSMANQSRGDYAYSLL
ECCCCCCCCCCCEECCCEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEE
DIEASAPEAVVEELSAIEGVIKVRVIK
EECCCCHHHHHHHHHHHCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]