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The map label for this gene is glyA [H]

Identifier: 238916524

GI number: 238916524

Start: 594366

End: 595622

Strand: Direct

Name: glyA [H]

Synonym: EUBELI_00581

Alternate gene names: 238916524

Gene position: 594366-595622 (Clockwise)

Preceding gene: 238916523

Following gene: 238916525

Centisome position: 27.72

GC content: 41.77

Gene sequence:

>1257_bases
ATGGGAGGAAGTTATATGTATTCATTTGATGAAGTATTAAACTATGATCCAGACCTTGCTAAGGCTATGGATGATGAACT
TGGAAGGCAGAGAAGCCACATCGAGCTTATCGCTTCTGAGAACCTTGTAAGTAAGGCAGTTATGGCTGCTATGGGAAGCC
CTCTTACTAATAAGTATGCAGAAGGATATCCTGGAAAGAGATATTACGGTGGTTGTGAGTATGTCGATGTTGTTGAGACA
CTTGCAATTGAAAGAGCAAAGAAGCTTTTTGGCTGTGAATATGCAAATGTACAGCCACATTCAGGAGCACAGGCTAACTT
AGCTGTATTCTTCGCACTTGTTAATCCTGGAGATACAGTTATGGGTATGAGCCTTGACTGTGGTGGACATTTATCACACG
GTTCACCAGTTAATATTTCTGGAAAATACTTTAACATCGTTCCTTATGGTGTTACAGCAGACGGATTTATTGATTATGAT
GAAGTATTAAGAATTGCCAAGGAATGCAAGCCTAAGATGATTATTGCAGGAGCTTCTGCTTATGCAAGAACAATCGACTT
CAAGAAGTTCAGAGAAATCTGTGATGAAGTTGGCGCATTACTTATGGTAGATATGGCACATATTGCGGGTCTTGTAGCCG
GTGGTGCACACCCAAGCCCAATTCCATATGCAGATGTTACAACAACAACAACACATAAGACACTCCGTGGACCAAGAGGA
GGTATGATTCTTGCTTCAGCAGAGGCAGCAGAGAAGTTCAAGCTTAACAAGGCTGTATTCCCTGGAATTCAGGGCGGACC
TCTTATGCATGTTATTGCCGGTAAGGCAGTATGCTTAAAGGAAGCACTTGACCCAAGCTTTAAGGTGTATGCTGAAAATG
TTGTTAAGAACGCATCAGCACTTGCTAACGGACTTATGAACAGAGGCTTTGATATCGTATCTGGTGGTACAGATAACCAT
CTTATGCTTGTTAACCTCTTAAGCAAGGGCAAGACTGGTAAGGAAGTTGAGAAGCTTCTTGATGCAGCTAATATTACATG
TAACAAGAATACAATTCCTAATGACCCGGCTTCTCCATTCGTAACAAGCGGTATCAGACTTGGTACAGCAGCCGTTACAA
CAAGAGGCTTCAATGAGGCTGATATGGATGTTGTTGCAGAAGCAATTGCTATGCTTGTTGATGATGTAGATGCTAACCAG
GCTAAGGCAATGGAACTTGTTAAGGGACTTACAGATAAGTACCCACTTTATGAATAA

Upstream 100 bases:

>100_bases
CAAATATTAAAAAAAGCAGGAATTCACAACTTTAAATTGACTAATCCGTAATTTAATTATATCATAAGTAACTAGGGACA
CTTTGTTTCACTAAAGTATA

Downstream 100 bases:

>100_bases
AGATTTTTACTTATAATTACCTTAAGAATTAAAGAAAAAATGCATATTTTTGTTATTGCAATTTCAGGCACTTGGTACTA
TAGTTAATGGCGAAGTGCAA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MGGSYMYSFDEVLNYDPDLAKAMDDELGRQRSHIELIASENLVSKAVMAAMGSPLTNKYAEGYPGKRYYGGCEYVDVVET
LAIERAKKLFGCEYANVQPHSGAQANLAVFFALVNPGDTVMGMSLDCGGHLSHGSPVNISGKYFNIVPYGVTADGFIDYD
EVLRIAKECKPKMIIAGASAYARTIDFKKFREICDEVGALLMVDMAHIAGLVAGGAHPSPIPYADVTTTTTHKTLRGPRG
GMILASAEAAEKFKLNKAVFPGIQGGPLMHVIAGKAVCLKEALDPSFKVYAENVVKNASALANGLMNRGFDIVSGGTDNH
LMLVNLLSKGKTGKEVEKLLDAANITCNKNTIPNDPASPFVTSGIRLGTAAVTTRGFNEADMDVVAEAIAMLVDDVDANQ
AKAMELVKGLTDKYPLYE

Sequences:

>Translated_418_residues
MGGSYMYSFDEVLNYDPDLAKAMDDELGRQRSHIELIASENLVSKAVMAAMGSPLTNKYAEGYPGKRYYGGCEYVDVVET
LAIERAKKLFGCEYANVQPHSGAQANLAVFFALVNPGDTVMGMSLDCGGHLSHGSPVNISGKYFNIVPYGVTADGFIDYD
EVLRIAKECKPKMIIAGASAYARTIDFKKFREICDEVGALLMVDMAHIAGLVAGGAHPSPIPYADVTTTTTHKTLRGPRG
GMILASAEAAEKFKLNKAVFPGIQGGPLMHVIAGKAVCLKEALDPSFKVYAENVVKNASALANGLMNRGFDIVSGGTDNH
LMLVNLLSKGKTGKEVEKLLDAANITCNKNTIPNDPASPFVTSGIRLGTAAVTTRGFNEADMDVVAEAIAMLVDDVDANQ
AKAMELVKGLTDKYPLYE
>Mature_417_residues
GGSYMYSFDEVLNYDPDLAKAMDDELGRQRSHIELIASENLVSKAVMAAMGSPLTNKYAEGYPGKRYYGGCEYVDVVETL
AIERAKKLFGCEYANVQPHSGAQANLAVFFALVNPGDTVMGMSLDCGGHLSHGSPVNISGKYFNIVPYGVTADGFIDYDE
VLRIAKECKPKMIIAGASAYARTIDFKKFREICDEVGALLMVDMAHIAGLVAGGAHPSPIPYADVTTTTTHKTLRGPRGG
MILASAEAAEKFKLNKAVFPGIQGGPLMHVIAGKAVCLKEALDPSFKVYAENVVKNASALANGLMNRGFDIVSGGTDNHL
MLVNLLSKGKTGKEVEKLLDAANITCNKNTIPNDPASPFVTSGIRLGTAAVTTRGFNEADMDVVAEAIAMLVDDVDANQA
KAMELVKGLTDKYPLYE

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=397, Percent_Identity=47.6070528967254, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI261862352, Length=397, Percent_Identity=47.6070528967254, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI261862350, Length=397, Percent_Identity=47.6070528967254, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI261862348, Length=397, Percent_Identity=47.6070528967254, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI261862346, Length=396, Percent_Identity=46.7171717171717, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI22547186, Length=397, Percent_Identity=48.3627204030227, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI22547189, Length=384, Percent_Identity=46.3541666666667, Blast_Score=306, Evalue=3e-83,
Organism=Escherichia coli, GI1788902, Length=411, Percent_Identity=61.3138686131387, Blast_Score=498, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI25144729, Length=428, Percent_Identity=46.4953271028037, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI25144732, Length=428, Percent_Identity=46.4953271028037, Blast_Score=362, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319739, Length=397, Percent_Identity=47.8589420654912, Blast_Score=356, Evalue=4e-99,
Organism=Saccharomyces cerevisiae, GI6323087, Length=407, Percent_Identity=45.7002457002457, Blast_Score=343, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24640005, Length=396, Percent_Identity=47.979797979798, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221329721, Length=396, Percent_Identity=47.979797979798, Blast_Score=374, Evalue=1e-103,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44654; Mature: 44523

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGSYMYSFDEVLNYDPDLAKAMDDELGRQRSHIELIASENLVSKAVMAAMGSPLTNKYA
CCCCEEEEHHHHHCCCCHHHHHHHHHHCCCHHHEEEEEHHHHHHHHHHHHHCCCHHHHHH
EGYPGKRYYGGCEYVDVVETLAIERAKKLFGCEYANVQPHSGAQANLAVFFALVNPGDTV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEE
MGMSLDCGGHLSHGSPVNISGKYFNIVPYGVTADGFIDYDEVLRIAKECKPKMIIAGASA
EEEEECCCCCCCCCCCEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEECCHH
YARTIDFKKFREICDEVGALLMVDMAHIAGLVAGGAHPSPIPYADVTTTTTHKTLRGPRG
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCC
GMILASAEAAEKFKLNKAVFPGIQGGPLMHVIAGKAVCLKEALDPSFKVYAENVVKNASA
CEEEEECHHHHHHHHHHHHCCCCCCCCEEHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHH
LANGLMNRGFDIVSGGTDNHLMLVNLLSKGKTGKEVEKLLDAANITCNKNTIPNDPASPF
HHHHHHHCCCEEEECCCCCCEEEEEEHHCCCCHHHHHHHHHHHCCEECCCCCCCCCCCCH
VTSGIRLGTAAVTTRGFNEADMDVVAEAIAMLVDDVDANQAKAMELVKGLTDKYPLYE
HHCCEEECHHHHEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GGSYMYSFDEVLNYDPDLAKAMDDELGRQRSHIELIASENLVSKAVMAAMGSPLTNKYA
CCCEEEEHHHHHCCCCHHHHHHHHHHCCCHHHEEEEEHHHHHHHHHHHHHCCCHHHHHH
EGYPGKRYYGGCEYVDVVETLAIERAKKLFGCEYANVQPHSGAQANLAVFFALVNPGDTV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEE
MGMSLDCGGHLSHGSPVNISGKYFNIVPYGVTADGFIDYDEVLRIAKECKPKMIIAGASA
EEEEECCCCCCCCCCCEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEECCHH
YARTIDFKKFREICDEVGALLMVDMAHIAGLVAGGAHPSPIPYADVTTTTTHKTLRGPRG
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCC
GMILASAEAAEKFKLNKAVFPGIQGGPLMHVIAGKAVCLKEALDPSFKVYAENVVKNASA
CEEEEECHHHHHHHHHHHHCCCCCCCCEEHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHH
LANGLMNRGFDIVSGGTDNHLMLVNLLSKGKTGKEVEKLLDAANITCNKNTIPNDPASPF
HHHHHHHCCCEEEECCCCCCEEEEEEHHCCCCHHHHHHHHHHHCCEECCCCCCCCCCCCH
VTSGIRLGTAAVTTRGFNEADMDVVAEAIAMLVDDVDANQAKAMELVKGLTDKYPLYE
HHCCEEECHHHHEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA